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chr19:1,127,720-5,153,606

Best TWAS P=1.12e-14 · Best GWAS P=2.62e-15 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
41	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DOT1L	0.08	0.12	enet	8	0.10	2.5e-11	7.3	7.7	1.1e-14	0.84	0.02	0.98	TRUE
45	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	DOT1L	0.09	0.08	blup	60	0.07	4.1e-04	-6.4	7.2	4.8e-13	0.68	0.06	0.87	TRUE
39	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	UBXN6	0.05	0.01	blup	57	0.04	6.6e-05	5.5	-7.0	3.6e-12	0.10	0.01	0.97	TRUE
8	GTEx	Artery Tibial	DOT1L	0.09	0.06	lasso	5	0.05	7.3e-05	7.3	6.9	5.6e-12	0.78	0.05	0.93	TRUE
1	CommonMind	Brain Pre-frontal Cortex	REXO1	0.07	0.01	bslmm	391	0.01	1.7e-02	-2.4	6.7	1.6e-11	0.16	0.28	0.03	TRUE
47	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	JSRP1	0.03	0.00	blup	33	0.02	2.1e-03	-3.6	-6.0	2.4e-09	-0.52	0.01	0.25	TRUE
9	GTEx	Artery Tibial	NFIC	0.14	0.13	enet	11	0.12	7.6e-10	5.5	-5.7	1.4e-08	-0.02	0.40	0.60	TRUE
37	ROSMAP	Brain Pre-frontal Cortex	KLF16	0.12	0.08	bslmm	372	0.08	1.0e-10	-5.0	-5.6	1.7e-08	-0.01	1.00	0.00	TRUE
11	GTEx	Artery Tibial	AC005306.3	0.25	0.12	enet	59	0.11	3.9e-09	-3.2	-5.3	9.4e-08	-0.11	1.00	0.00	TRUE
19	GTEx	Brain Nucleus accumbens basal ganglia	CTB-50L17.9	0.45	0.25	lasso	8	0.23	8.6e-07	5.5	-6.3	2.9e-10	0.09	0.02	0.97	FALSE
10	GTEx	Artery Tibial	UBXN6	0.18	0.07	lasso	3	0.14	6.3e-11	5.6	-6.3	3.9e-10	0.11	0.00	0.99	FALSE
26	GTEx	Muscle Skeletal	UBXN6	0.19	0.14	lasso	5	0.18	4.1e-17	-5.0	-6.2	7.7e-10	0.08	0.07	0.93	FALSE
5	GTEx	Artery Aorta	UBXN6	0.13	0.02	lasso	5	0.03	5.7e-03	-5.0	-6.1	9.1e-10	0.09	0.02	0.95	FALSE
22	GTEx	Heart Atrial Appendage	UBXN6	0.34	0.12	lasso	6	0.21	6.5e-10	5.5	-6.0	2.7e-09	0.09	0.02	0.98	FALSE
50	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	UBXN6	0.23	0.11	lasso	5	0.12	2.5e-05	4.9	-5.9	4.7e-09	0.12	0.02	0.66	FALSE
24	GTEx	Heart Left Ventricle	UBXN6	0.21	0.14	lasso	6	0.16	5.6e-09	-5.0	-5.8	5.6e-09	0.08	0.03	0.97	FALSE
51	The Cancer Genome Atlas	Prostate Adenocarcinoma	UBXN6	0.13	0.10	lasso	2	0.10	1.3e-10	5.5	-5.8	6.8e-09	0.09	0.00	1.00	FALSE
52	The Cancer Genome Atlas	Testicular Germ Cell Tumors	DOT1L	0.40	-0.01	enet	20	0.03	3.6e-02	-3.9	5.8	7.0e-09	0.50	0.01	0.22	FALSE
49	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CHAF1A	0.20	0.11	lasso	2	0.11	5.6e-05	5.6	-5.7	1.0e-08	0.11	0.01	0.97	FALSE
33	GTEx	Testis	CTB-50L17.9	0.39	0.30	enet	36	0.34	9.4e-16	4.9	-5.7	1.1e-08	0.08	0.07	0.93	FALSE
2	CommonMind	Brain Pre-frontal Cortex	UBXN6	0.27	0.25	enet	28	0.29	4.6e-36	4.7	-5.7	1.2e-08	0.11	0.05	0.94	FALSE
53	The Cancer Genome Atlas	Thyroid Carcinoma	UBXN6	0.16	0.12	lasso	2	0.12	5.4e-12	5.5	-5.7	1.3e-08	0.09	0.00	1.00	FALSE
36	NTR	Blood	C19orf35	0.03	0.01	enet	9	0.02	3.7e-07	-2.5	-5.7	1.4e-08	-0.46	0.97	0.02	FALSE
4	GTEx	Adipose Visceral Omentum	NFIC	0.20	0.00	lasso	5	0.02	2.2e-02	5.5	-5.7	1.5e-08	-0.04	0.07	0.17	FALSE
27	GTEx	Nerve Tibial	UBXN6	0.17	0.08	enet	20	0.09	4.4e-07	5.0	-5.5	2.9e-08	0.13	0.02	0.98	FALSE
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CHAF1A	0.12	0.11	lasso	3	0.12	7.9e-13	5.2	-5.5	3.5e-08	0.10	0.02	0.98	FALSE
15	GTEx	Brain Cerebellum	CTB-50L17.9	0.53	0.41	lasso	2	0.50	3.6e-17	4.9	-5.5	3.6e-08	0.10	0.02	0.98	FALSE
31	GTEx	Stomach	AC007292.4	0.27	0.09	lasso	5	0.04	4.0e-03	-5.4	5.5	3.6e-08	-0.05	0.01	0.92	FALSE
20	GTEx	Colon Sigmoid	UBXN6	0.34	0.15	lasso	6	0.14	1.7e-05	4.9	-5.5	3.7e-08	0.09	0.03	0.96	FALSE
23	GTEx	Heart Left Ventricle	CHAF1A	0.17	0.12	lasso	2	0.11	1.9e-06	5.5	-5.5	3.9e-08	0.09	0.01	0.99	FALSE
34	GTEx	Thyroid	UBXN6	0.25	0.19	lasso	5	0.23	8.8e-18	5.6	-5.5	4.3e-08	0.11	0.01	0.99	FALSE
25	GTEx	Muscle Skeletal	CHAF1A	0.18	0.21	lasso	2	0.20	9.7e-20	5.5	-5.4	5.3e-08	0.09	0.01	0.99	FALSE
35	GTEx	Vagina	CTB-50L17.9	0.38	0.26	lasso	5	0.23	5.7e-06	5.5	-5.4	5.5e-08	0.11	0.02	0.96	FALSE
12	GTEx	Brain Caudate basal ganglia	CTB-50L17.9	0.27	0.25	lasso	2	0.24	1.8e-07	5.5	-5.4	6.0e-08	0.09	0.01	0.98	FALSE
17	GTEx	Brain Frontal Cortex BA9	CTB-50L17.9	0.27	0.21	lasso	3	0.19	7.9e-06	4.9	-5.4	6.4e-08	0.10	0.02	0.95	FALSE
13	GTEx	Brain Cerebellar Hemisphere	CHAF1A	0.62	0.40	lasso	8	0.36	3.5e-10	5.5	-5.4	7.5e-08	0.09	0.01	0.99	FALSE
14	GTEx	Brain Cerebellum	CHAF1A	0.51	0.35	lasso	4	0.34	9.7e-11	5.5	-5.4	7.9e-08	0.09	0.01	0.99	FALSE
6	GTEx	Artery Aorta	CTB-50L17.5	0.16	0.15	lasso	7	0.15	1.0e-08	5.5	-5.4	8.1e-08	0.09	0.01	0.99	FALSE
28	GTEx	Nerve Tibial	CTB-50L17.5	0.11	0.08	enet	4	0.08	1.6e-06	5.2	-5.3	9.6e-08	0.09	0.02	0.98	FALSE
38	The Cancer Genome Atlas	Breast Invasive Carcinoma	UBXN6	0.03	0.03	lasso	3	0.03	2.3e-06	-5.0	-5.3	1.1e-07	0.06	0.03	0.97	FALSE
48	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UBXN6	0.04	0.03	lasso	2	0.02	1.6e-03	4.9	-5.3	1.1e-07	0.09	0.01	0.82	FALSE
3	GTEx	Adipose Subcutaneous	AMH	0.18	0.05	lasso	8	0.06	1.9e-05	-3.8	5.3	1.3e-07	0.46	0.91	0.02	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	AC007292.6	0.11	0.08	lasso	6	0.07	7.8e-05	5.6	-5.3	1.3e-07	0.10	0.01	0.97	FALSE
42	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UBXN6	0.18	0.17	enet	18	0.18	9.9e-20	5.5	-5.3	1.4e-07	0.09	0.01	0.99	FALSE
43	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CHAF1A	0.15	0.12	lasso	2	0.12	3.2e-07	5.2	-5.3	1.5e-07	0.09	0.04	0.96	FALSE
30	GTEx	Skin Sun Exposed Lower leg	CHAF1A	0.19	0.18	lasso	1	0.17	5.1e-14	5.2	-5.2	1.7e-07	0.09	0.02	0.98	FALSE
7	GTEx	Artery Coronary	CTB-50L17.9	0.43	0.14	lasso	6	0.12	6.5e-05	4.9	-5.2	1.8e-07	0.07	0.06	0.74	FALSE
16	GTEx	Brain Frontal Cortex BA9	UBXN6	0.31	0.06	enet	5	0.12	3.5e-04	4.9	-5.2	1.8e-07	0.11	0.02	0.89	FALSE
18	GTEx	Brain Nucleus accumbens basal ganglia	CHAF1A	0.31	0.28	lasso	2	0.24	4.0e-07	5.2	-5.2	1.8e-07	0.09	0.01	0.97	FALSE
32	GTEx	Testis	CHAF1A	0.18	0.09	lasso	2	0.07	4.0e-04	5.5	-5.2	2.4e-07	0.08	0.01	0.91	FALSE
21	GTEx	Esophagus Muscularis	UBXN6	0.35	0.24	enet	20	0.29	3.7e-18	4.9	-5.1	2.7e-07	0.09	0.02	0.98	FALSE
44	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	JSRP1	0.07	0.04	blup	33	0.03	7.8e-03	-3.8	5.1	2.9e-07	0.44	0.01	0.10	FALSE
46	The Cancer Genome Atlas	Lung Adenocarcinoma	CHAF1A	0.05	0.04	lasso	4	0.03	2.3e-04	5.5	-5.1	3.0e-07	0.09	0.01	0.97	FALSE