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chr20:42,816,319-44,279,989

Best TWAS P=1.16e-14 · Best GWAS P=1.14e-13 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
10	GTEx	Brain Cerebellum	YWHAB	0.43	0.19	lasso	7	0.16	1.7e-05	7.3	-7.7	1.2e-14	-0.97	0.01	0.98	TRUE
7	GTEx	Artery Aorta	YWHAB	0.29	0.17	lasso	5	0.15	1.3e-08	7.4	-7.6	2.4e-14	-0.99	0.01	0.99	FALSE
9	GTEx	Brain Cerebellar Hemisphere	YWHAB	0.42	0.22	lasso	4	0.18	2.3e-05	7.3	-7.6	2.8e-14	-0.99	0.01	0.98	FALSE
3	GTEx	Adipose Visceral Omentum	YWHAB	0.19	0.07	lasso	4	0.05	1.1e-03	7.3	-7.6	3.7e-14	-0.99	0.01	0.98	FALSE
41	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	YWHAB	0.07	0.06	lasso	2	0.06	1.3e-04	7.3	-7.5	4.2e-14	-0.99	0.01	0.97	FALSE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	YWHAB	0.07	0.06	lasso	6	0.06	3.1e-07	7.3	-7.5	7.7e-14	-0.96	0.01	0.99	FALSE
32	ROSMAP	Brain Pre-frontal Cortex	YWHAB	0.56	0.58	bslmm	418	0.59	7.7e-94	7.4	-7.5	9.1e-14	-1.00	0.00	1.00	FALSE
8	GTEx	Artery Tibial	YWHAB	0.17	0.15	lasso	3	0.16	3.5e-12	7.4	-7.5	9.2e-14	-1.00	0.00	1.00	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	YWHAB	0.22	0.11	lasso	3	0.07	6.5e-03	7.3	-7.4	1.0e-13	-0.97	0.01	0.95	FALSE
21	GTEx	Muscle Skeletal	YWHAB	0.09	0.07	lasso	5	0.07	4.5e-07	7.3	-7.4	1.2e-13	-0.98	0.01	0.99	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	YWHAB	0.33	0.24	lasso	4	0.26	1.6e-14	7.3	-7.4	1.2e-13	-0.96	0.01	0.99	FALSE
25	GTEx	Skin Sun Exposed Lower leg	YWHAB	0.17	0.18	lasso	2	0.17	4.7e-14	7.4	-7.4	1.2e-13	-1.00	0.00	1.00	FALSE
27	GTEx	Thyroid	YWHAB	0.22	0.18	lasso	2	0.17	5.3e-13	7.4	-7.4	1.2e-13	-1.00	0.00	1.00	FALSE
2	GTEx	Adipose Subcutaneous	YWHAB	0.13	0.17	lasso	2	0.15	2.8e-12	7.4	-7.4	1.3e-13	-1.00	0.00	1.00	FALSE
18	GTEx	Esophagus Mucosa	YWHAB	0.25	0.27	enet	7	0.27	4.2e-18	7.4	-7.4	1.3e-13	-0.99	0.01	0.99	FALSE
20	GTEx	Lung	YWHAB	0.10	0.04	lasso	4	0.04	6.5e-04	7.4	-7.4	1.5e-13	-0.99	0.01	0.99	FALSE
5	GTEx	Adrenal Gland	YWHAB	0.23	0.15	lasso	3	0.10	1.4e-04	7.4	-7.4	1.8e-13	-1.00	0.01	0.99	FALSE
34	YFS	Blood	YWHAB	0.07	0.06	lasso	4	0.07	6.8e-21	7.1	7.3	2.3e-13	0.95	0.02	0.98	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	PABPC1L	0.20	0.21	lasso	3	0.21	5.5e-23	7.3	-7.3	2.3e-13	-0.99	0.01	0.99	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	YWHAB	0.06	0.07	enet	6	0.09	7.4e-11	6.1	-7.3	2.3e-13	-0.94	0.01	0.99	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	PABPC1L	0.08	0.14	lasso	4	0.14	4.2e-14	7.3	-7.3	2.3e-13	-0.99	0.01	0.99	FALSE
46	The Cancer Genome Atlas	Thyroid Carcinoma	YWHAB	0.12	0.13	lasso	5	0.12	4.3e-12	7.3	-7.3	2.4e-13	-0.99	0.01	0.99	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	YWHAB	0.27	0.12	enet	13	0.18	1.2e-06	6.7	-7.3	2.6e-13	-0.95	0.01	0.99	FALSE
30	NTR	Blood	YWHAB	0.16	0.19	lasso	5	0.19	2.2e-58	7.3	-7.3	2.6e-13	-0.99	0.01	0.99	FALSE
1	CommonMind	Brain Pre-frontal Cortex	PABPC1L	0.17	0.16	lasso	1	0.15	8.0e-18	7.3	-7.3	2.7e-13	-0.99	0.01	0.99	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	PABPC1L	0.02	0.02	lasso	4	0.02	2.2e-04	7.3	-7.3	2.8e-13	-0.99	0.01	0.99	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	YWHAB	0.31	0.18	lasso	5	0.14	9.9e-06	7.1	-7.3	3.2e-13	-0.95	0.01	0.99	FALSE
23	GTEx	Nerve Tibial	YWHAB	0.21	0.24	lasso	2	0.23	3.3e-16	7.1	-7.3	3.7e-13	-0.94	0.02	0.98	FALSE
26	GTEx	Testis	YWHAB	0.23	0.23	enet	14	0.23	1.8e-10	7.4	-7.2	4.1e-13	-0.97	0.00	1.00	FALSE
40	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	YWHAB	0.04	0.03	lasso	5	0.04	2.9e-05	7.1	-7.1	1.1e-12	-0.93	0.01	0.97	FALSE
19	GTEx	Esophagus Muscularis	YWHAB	0.16	0.11	lasso	3	0.14	1.5e-08	6.1	-7.1	1.3e-12	-0.92	0.01	0.99	FALSE
4	GTEx	Adrenal Gland	PABPC1L	0.32	0.07	lasso	8	0.07	1.9e-03	7.3	-7.1	1.5e-12	-0.88	0.01	0.94	FALSE
45	The Cancer Genome Atlas	Stomach Adenocarcinoma	YWHAB	0.04	0.05	enet	10	0.03	2.3e-03	6.7	-7.1	1.6e-12	-0.88	0.01	0.92	FALSE
28	GTEx	Whole Blood	YWHAB	0.20	0.10	lasso	9	0.10	1.6e-09	7.4	-6.9	4.1e-12	-0.98	0.01	0.99	FALSE
12	GTEx	Breast Mammary Tissue	YWHAB	0.18	0.09	lasso	6	0.08	5.2e-05	7.4	-6.9	6.5e-12	-0.97	0.01	0.99	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	PABPC1L	0.24	0.21	lasso	3	0.21	8.1e-27	7.3	-6.8	9.1e-12	-0.98	0.01	0.99	FALSE
37	The Cancer Genome Atlas	Esophageal Carcinoma	YWHAB	0.15	0.14	lasso	5	0.10	4.6e-04	6.7	-6.8	1.3e-11	-0.85	0.03	0.88	FALSE
16	GTEx	Colon Sigmoid	YWHAB	0.27	0.14	lasso	4	0.10	1.7e-04	7.3	-6.5	1.2e-10	-0.94	0.01	0.98	FALSE
15	GTEx	Cells Transformed fibroblasts	YWHAB	0.29	0.20	enet	21	0.26	1.5e-19	7.2	-6.4	1.4e-10	-0.84	0.01	0.99	FALSE
14	GTEx	Cells Transformed fibroblasts	PABPC1L	0.12	0.03	enet	22	0.08	2.0e-06	4.0	6.1	1.2e-09	0.72	0.04	0.96	FALSE
29	METSIM	Adipose	TOMM34	0.34	0.09	enet	73	0.16	2.5e-23	-5.2	5.7	1.2e-08	0.27	1.00	0.00	FALSE
22	GTEx	Nerve Tibial	TOMM34	0.11	0.02	lasso	4	0.03	6.0e-03	4.0	5.6	1.7e-08	0.67	0.03	0.84	FALSE
33	YFS	Blood	PABPC1L	0.17	0.13	enet	41	0.14	1.8e-43	6.1	5.5	3.2e-08	0.79	0.97	0.03	FALSE
42	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	YWHAB	0.16	-0.01	blup	52	0.03	2.1e-02	-5.1	-5.5	4.9e-08	-0.71	0.01	0.59	FALSE
36	The Cancer Genome Atlas	Colon Adenocarcinoma	PABPC1L	0.08	0.01	enet	8	0.02	3.6e-02	7.3	-5.3	1.2e-07	-0.78	0.01	0.86	FALSE
6	GTEx	Artery Aorta	PABPC1L	0.14	0.10	lasso	3	0.09	1.1e-05	6.1	5.3	1.4e-07	0.69	0.28	0.10	FALSE