Best TWAS P=5.92e-14 · Best GWAS P=3.76e-12 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | FAM208A | 0.12 | 0.09 | enet | 11 | 0.12 | 1.1e-09 | -3.8 | 5.8 | 7.3e-09 | -0.82 | 0.04 | 0.96 | FALSE |
2 | GTEx | Brain Hippocampus | CCDC66 | 0.23 | 0.23 | lasso | 3 | 0.20 | 2.1e-05 | -5.4 | 5.2 | 1.8e-07 | -0.64 | 0.24 | 0.18 | TRUE |
3 | GTEx | Cells Transformed fibroblasts | FAM208A | 0.10 | 0.00 | lasso | 4 | 0.00 | 1.3e-01 | -6.7 | 6.4 | 1.5e-10 | -0.82 | 0.02 | 0.95 | FALSE |
4 | GTEx | Pituitary | CCDC66 | 0.16 | 0.16 | enet | 31 | 0.12 | 6.8e-04 | -3.2 | 5.5 | 3.5e-08 | -0.68 | 0.03 | 0.90 | FALSE |
5 | GTEx | Skin Sun Exposed Lower leg | FAM208A | 0.06 | 0.04 | lasso | 2 | 0.03 | 2.0e-03 | -5.2 | 5.2 | 1.8e-07 | -0.65 | 0.17 | 0.57 | TRUE |
6 | YFS | Blood | CCDC66 | 0.11 | 0.09 | lasso | 8 | 0.11 | 6.0e-34 | -5.5 | -5.5 | 4.1e-08 | 0.53 | 0.97 | 0.03 | FALSE |
7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CCDC66 | 0.09 | 0.03 | lasso | 8 | 0.05 | 4.2e-11 | -4.6 | -6.4 | 1.5e-10 | 0.54 | 0.26 | 0.74 | FALSE |
8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CCDC66 | 0.05 | 0.05 | blup | 56 | 0.06 | 1.0e-07 | -6.7 | -7.4 | 1.0e-13 | 0.79 | 0.00 | 1.00 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C3orf63 | 0.03 | 0.01 | enet | 4 | 0.01 | 1.3e-02 | -6.7 | 6.2 | 6.8e-10 | -0.89 | 0.01 | 0.87 | FALSE |
10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CCDC66 | 0.09 | 0.05 | blup | 56 | 0.06 | 5.3e-07 | -5.5 | -5.6 | 2.5e-08 | 0.69 | 0.63 | 0.36 | FALSE |
11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CCDC66 | 0.16 | 0.13 | enet | 12 | 0.16 | 3.1e-17 | -5.5 | -5.2 | 2.0e-07 | 0.34 | 0.91 | 0.09 | FALSE |
12 | The Cancer Genome Atlas | Lung Adenocarcinoma | CCDC66 | 0.05 | 0.06 | blup | 56 | 0.05 | 9.7e-07 | -6.7 | -7.5 | 5.9e-14 | 0.73 | 0.00 | 1.00 | TRUE |
13 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CCDC66 | 0.03 | 0.03 | blup | 56 | 0.03 | 9.6e-05 | -4.9 | -6.0 | 1.6e-09 | 0.51 | 0.35 | 0.24 | FALSE |
14 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CCDC66 | 0.08 | 0.01 | blup | 56 | 0.07 | 7.2e-04 | -5.5 | -5.3 | 9.1e-08 | 0.32 | 0.12 | 0.08 | FALSE |
15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CCDC66 | 0.15 | 0.10 | enet | 11 | 0.13 | 7.3e-14 | -4.9 | -5.5 | 3.4e-08 | 0.48 | 0.94 | 0.06 | TRUE |
16 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CCDC66 | 0.05 | 0.01 | blup | 57 | 0.02 | 8.4e-03 | -4.6 | -6.1 | 8.6e-10 | 0.55 | 0.08 | 0.49 | FALSE |