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chr3:183,204,923-186,072,370

Best TWAS P=2.9e-21 · Best GWAS P=1.21e-21 conditioned to 0.000678

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
14	The Cancer Genome Atlas	Lung Adenocarcinoma	PSMD2	0.09	0.02	blup	50	0.05	1.2e-06	-8.6	9.5	2.9e-21	-0.73	0.03	0.84	TRUE
16	The Cancer Genome Atlas	Testicular Germ Cell Tumors	VWA5B2	0.10	0.04	blup	51	0.04	1.8e-02	5.0	-8.0	1.7e-15	0.43	0.03	0.33	TRUE
12	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ETV5	0.03	0.01	blup	55	0.02	1.3e-03	-7.4	-7.2	6.7e-13	-0.04	0.01	0.86	TRUE
2	CommonMind	Brain Pre-frontal Cortex	SENP2	0.21	0.18	enet	33	0.19	4.2e-22	-5.4	5.7	1.3e-08	0.02	1.00	0.00	TRUE
1	CommonMind	Brain Pre-frontal Cortex	ECE2	0.24	0.20	bslmm	542	0.19	1.6e-22	8.0	7.8	7.1e-15	-0.37	1.00	0.00	FALSE
13	The Cancer Genome Atlas	Brain Lower Grade Glioma	ECE2	0.04	0.02	blup	61	0.03	3.5e-04	8.0	7.6	3.9e-14	-0.24	0.54	0.02	FALSE
6	GTEx	Pituitary	ECE2	0.52	0.30	lasso	7	0.23	1.5e-06	8.0	7.0	2.4e-12	-0.31	0.39	0.23	FALSE
7	GTEx	Skin Sun Exposed Lower leg	ABCF3	0.13	0.08	lasso	4	0.11	1.6e-09	5.0	6.6	4.1e-11	-0.36	0.98	0.01	FALSE
15	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PSMD2	0.05	0.00	enet	10	0.01	3.6e-02	8.0	6.5	8.7e-11	-0.49	0.01	0.10	FALSE
4	GTEx	Brain Putamen basal ganglia	ECE2	0.38	0.03	enet	22	0.11	1.4e-03	8.0	6.2	5.9e-10	-0.28	0.08	0.16	FALSE
3	GTEx	Artery Tibial	PSMD2	0.13	0.09	lasso	5	0.08	1.3e-06	-5.8	6.0	1.5e-09	-0.42	0.88	0.02	FALSE
8	GTEx	Skin Sun Exposed Lower leg	PSMD2	0.13	0.14	lasso	4	0.15	1.4e-12	-5.8	5.9	4.5e-09	-0.39	1.00	0.00	FALSE
10	YFS	Blood	PSMD2	0.26	0.22	lasso	5	0.24	2.4e-77	-5.8	5.6	2.3e-08	-0.39	1.00	0.00	FALSE
5	GTEx	Pancreas	ECE2	0.26	0.04	enet	24	0.09	1.2e-04	8.0	5.5	3.1e-08	-0.24	0.16	0.09	FALSE
9	METSIM	Adipose	SENP2	0.06	0.04	lasso	5	0.03	6.2e-06	-5.4	-5.2	1.6e-07	-0.04	0.99	0.00	FALSE
11	The Cancer Genome Atlas	Breast Invasive Carcinoma	PSMD2	0.03	0.03	blup	50	0.03	4.8e-06	-5.8	5.2	2.1e-07	-0.48	0.66	0.27	FALSE