[Hub]/) : Traits : Basal metabolic rate : ← →

chr4:105,373,669-107,092,169

Best TWAS P=1.3e-21 · Best GWAS P=9.76e-24 conditioned to 9.53e-05

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PPA2 0.08 0.03 bslmm 429 0.04 2.2e-05 -6.3 -6.9 4.9e-12 0.61 0.06 0.91 FALSE
2 GTEx Artery Aorta PPA2 0.11 -0.01 enet 24 0.01 1.6e-01 -9.8 -7.1 1.5e-12 0.58 0.06 0.47 FALSE
3 GTEx Brain Cerebellum PPA2 0.22 0.01 lasso 4 0.03 3.7e-02 -6.9 -5.8 8.9e-09 0.55 0.09 0.14 FALSE
4 GTEx Brain Cortex PPA2 0.14 0.09 lasso 9 0.09 1.6e-03 -8.1 -8.2 3.2e-16 0.79 0.05 0.64 FALSE
5 GTEx Cells Transformed fibroblasts PPA2 0.11 0.03 lasso 3 0.01 6.5e-02 -6.6 -7.2 6.1e-13 0.59 0.40 0.15 FALSE
6 GTEx Esophagus Gastroesophageal Junction PPA2 0.29 0.15 lasso 5 0.14 8.8e-06 -9.8 -9.6 1.3e-21 0.81 0.03 0.94 TRUE
7 GTEx Esophagus Mucosa PPA2 0.18 0.06 enet 14 0.12 2.5e-08 7.5 -8.4 3.0e-17 0.68 0.06 0.94 FALSE
8 GTEx Heart Atrial Appendage PPA2 0.15 0.05 lasso 7 0.06 7.4e-04 -8.2 -6.3 3.5e-10 0.70 0.23 0.40 FALSE
9 GTEx Muscle Skeletal PPA2 0.19 0.06 enet 28 0.11 8.7e-11 -8.1 -5.6 1.7e-08 0.67 0.79 0.21 FALSE
10 GTEx Nerve Tibial PPA2 0.13 0.07 enet 23 0.07 2.1e-05 -6.9 -6.7 1.8e-11 0.63 0.42 0.37 FALSE
11 GTEx Ovary PPA2 0.18 0.10 lasso 3 0.14 2.2e-04 -6.9 -8.2 2.5e-16 0.72 0.05 0.71 FALSE
12 GTEx Skin Sun Exposed Lower leg TET2 0.09 0.01 enet 18 0.02 3.6e-03 -9.9 -6.4 1.2e-10 0.58 0.02 0.91 FALSE
13 GTEx Thyroid PPA2 0.22 0.01 enet 18 0.12 2.9e-09 5.6 -5.3 9.6e-08 0.50 0.73 0.08 FALSE
14 YFS Blood PPA2 0.22 0.05 lasso 19 0.12 9.7e-38 -3.0 5.2 2.2e-07 -0.40 1.00 0.00 FALSE
15 The Cancer Genome Atlas Thyroid Carcinoma PPA2 0.04 0.02 blup 84 0.04 6.1e-05 -8.1 -7.4 1.7e-13 0.74 0.14 0.65 FALSE