TWAS hub - TET2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Sun Exposed Lower leg	0.0860	0.0340	1.6e-03	0.006	NA	0.025	NA	0.023	0.10	NA	0.0036	NA	0.0049
2	GTEx	Small Intestine Terminal Ileum	0.2310	0.0930	7.6e-03	0.007	NA	0.012	NA	-0.011	0.22	NA	0.1700	NA	0.6700
3	YFS	Blood	0.0258	0.0094	1.6e-05	0.001	0.013	0.008	0.012	0.003	0.11	3e-05	0.0011	4.7e-05	0.0220

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2011)	8.2	8.0	13.6	-3.7	3.2	-0.0
Intelligence (Savage-Jansen 2018)	6.4	19.7	39.2	-6.3	-4.2	1.4
Verbal and Numeric Reasoning (VNR)	5.8	13.8	23.2	-4.8	-4.0	1.3
Sitting height	5.5	39.0	106.1	-10.3	-3.3	0.5
Number of incorrect matches in round	5.3	8.9	21.6	2.2	4.6	-0.5
Fluid intelligence score	5.3	11.0	20.4	-4.5	-3.3	1.3
Forced vital capacity (FVC)	4.9	19.1	49.3	-7.0	2.2	1.8
Standing height	4.8	47.7	132.2	-11.5	-3.3	-0.3
Had other major operations	4.5	5.5	9.6	-3.1	-2.3	1.3
Forced expiratory volume in 1-second (FEV1)	4.5	15.3	41.3	-6.4	1.9	0.9
Forced vital capacity (FVC), Best measure	4.5	16.5	42.6	-6.5	1.4	2.2
Medication: Omeprazole	4.5	5.4	11.7	-3.4	0.8	1.9
Number of operations (self-reported)	4.5	6.7	13.7	-3.7	-2.2	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	4.2	13.5	37.1	-6.1	0.6	1.7
Financial situation satisfaction	4.2	5.3	10.7	-3.3	0.8	2.1
Reaction Time	4.0	7.7	11.0	-2.5	-3.3	2.4
Chronotype (morning person)	4.0	9.3	10.2	2.9	-3.1	3.2
Supplements: Zinc	4.0	4.4	10.3	-3.2	0.5	-1.6
Trunk predicted mass	3.8	21.5	53.7	-7.3	-3.2	0.6
Risk taking	3.8	5.5	14.5	1.3	-3.8	0.6
Medication: Omeprazole (e.g. Zanprol)	3.8	4.7	8.9	-3.0	-0.2	2.3
Trunk fat-free mass	3.7	21.1	53.1	-7.3	-3.1	0.7
Alcohol drinker status: Previous	3.7	4.2	11.1	3.3	-0.7	1.0
Happiness	3.6	4.4	8.0	-2.8	2.2	0.3
Maternal smoking around birth	3.5	5.1	14.8	-0.7	-3.8	0.3
Leg predicted mass (left)	3.5	18.4	45.4	-6.7	-2.8	1.4
Birth weight	3.5	7.6	12.0	-3.1	-3.5	1.1
Whole body fat-free mass	3.5	20.1	49.6	-7.0	-3.1	1.0
Whole body water mass	3.5	20.2	49.3	-7.0	-3.2	1.1
Leg fat-free mass (left)	3.4	18.0	45.2	-6.7	-2.7	1.3
Average weekly red wine intake	3.4	5.0	14.3	0.8	-3.8	0.1
Heel bone mineral density (BMD) T-score, automated (left)	3.3	7.4	12.2	3.5	-3.1	-0.2
Leg fat-free mass (right)	3.3	17.5	42.5	-6.5	-2.7	1.7
Leg predicted mass (right)	3.3	17.5	42.4	-6.5	-2.7	1.7
Angina (self-reported)	3.2	4.2	6.7	2.4	0.3	-2.6
Height	3.1	59.5	146.4	-12.1	-5.0	-2.8
Lung FVC	3.1	15.7	32.8	-3.0	5.7	2.3
Angina	3.1	4.1	6.8	2.3	0.5	-2.6
Worry too long after embarrassment	3.1	5.2	13.0	-3.6	-1.0	1.3
Heart attack/myocardial infarction (self-reported)	3.1	4.1	10.1	1.0	1.0	-3.2
Basal metabolic rate	3.0	16.6	41.5	-6.4	-2.8	0.8
Irritability	3.0	5.0	6.9	-1.1	-2.6	2.6
Qualifications: College or University degree	2.9	9.0	11.3	-3.1	-3.4	2.5
Supplements: Calcium	2.9	3.2	9.5	-3.1	0.2	-0.4
Qualifications: None of the above	2.8	6.1	10.0	3.2	1.8	-2.3
Heart attack	2.8	3.6	9.1	1.2	0.5	-3.0
Bipolar Disorder (2018)	2.7	4.2	8.8	-3.0	1.8	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	2.7	6.3	10.6	3.2	-2.9	0.1
Qualifications: A levels/AS levels or equivalent	2.7	6.0	8.7	-2.5	-1.8	3.0
Arm fat-free mass (left)	2.7	13.5	31.0	-5.6	-2.9	0.9
Arm predicted mass (left)	2.7	13.9	32.0	-5.7	-3.0	0.9
Alcohol intake frequency.	2.6	6.1	17.5	4.2	0.9	-0.1
Waist Hip Ratio (WHR)	2.5	11.2	31.2	-0.6	1.4	-5.6
Birth weight of first child	2.5	4.5	8.2	-2.9	-2.2	-0.6
Arm fat-free mass (right)	2.5	12.7	30.5	-5.5	-2.6	0.9
Health satisfaction	2.5	3.2	5.8	-1.8	2.4	0.7
Mean time to correctly identify matches	2.5	4.8	7.5	-2.3	-2.7	1.3
Arm predicted mass (right)	2.5	12.5	25.9	-5.1	-3.2	1.1
Average weekly champagne plus white wine intake	2.5	3.4	5.3	-1.8	-2.3	1.2
Pain all over the body in last month	2.4	2.5	4.0	-1.9	-0.3	2.0
Chronic bronchitis/emphysema (mother)	2.4	2.8	6.4	0.9	-1.1	2.5
Qualifications: nursing, teaching	2.4	3.7	4.4	-2.0	-1.7	2.1
Other serious medical condition/disability diagnosed by doctor	2.3	2.9	8.2	-2.9	-0.8	-0.0
Worrier / anxious feelings	2.3	4.3	12.1	-0.3	-0.9	3.5
Lung cancer (father)	2.3	2.7	7.7	0.1	-2.8	0.5
Number of full sisters	2.3	2.8	8.0	-2.8	-0.6	0.4
Hearing aid user	2.3	2.6	3.2	1.8	-1.3	-1.6
Irritable Bowel Disease (IBD)	2.2	5.1	10.5	1.9	1.2	3.2
Neuroticism (2016)	2.2	3.1	7.3	-2.7	-0.1	1.4
Heel T-Score	2.2	17.6	35.2	4.2	-5.9	0.4
Systolic blood pressure, automated reading	2.2	6.3	8.0	2.8	2.5	-2.1
Medication: Atenolol	2.2	2.8	5.8	0.9	1.4	-2.4
High blood pressure (siblings)	2.2	3.2	7.9	-0.3	-2.8	1.3
Heart disease (mother)	2.2	2.7	5.1	-2.3	1.6	0.6
Comparative height size at age 10	2.2	12.4	33.2	-5.8	-2.0	-0.0
Loneliness, isolation	2.2	3.1	5.6	-1.9	-2.4	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.2	2.6	4.7	-1.6	-2.2	0.6
Sensitivity / hurt feelings	2.1	3.6	7.0	-1.8	-0.7	2.6
Stomach or abdominal pain in last month	2.1	2.7	4.8	-1.8	0.3	2.2
Medication: Ramipril	2.1	2.7	4.5	2.1	-1.0	-1.7
Smoking status: Previous	2.1	3.1	4.2	-1.8	-2.1	1.4
Breast cancer (self-reported)	2.1	2.5	5.2	-2.3	0.8	-1.2
Guilty feelings	2.1	3.1	8.4	-2.9	-0.1	0.9
Ulcerative Colitis (UC)	2.0	3.8	5.7	2.0	1.3	2.4
Number of full brothers	2.0	2.5	4.9	0.7	2.2	-1.4
Fractured/broken bones in last 5 years	2.0	2.5	4.6	-2.1	-1.4	1.0
Myopia	1.9	2.7	6.0	-1.5	2.5	0.0
Ever had hysterectomy (womb removed)	1.8	2.1	2.7	1.3	-1.3	1.6
Taking other prescription medications	1.8	2.7	8.0	-2.8	0.0	0.5
Serious illness, injury or assault to yourself	1.8	2.2	5.0	-2.2	1.2	-0.4
Prospective memory result	1.8	2.2	5.1	1.2	2.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.8	7.9	-2.8	-1.8	-0.5
Friendships satisfaction	1.8	2.3	4.0	-2.0	-0.5	1.6
Medication: Bendroflumethiazide	1.8	2.7	6.8	-0.8	2.6	-0.8
Body Mass Index (BMI) (2010)	1.7	2.3	6.5	0.6	-2.5	-0.2
Supplements: Glucosamine	1.7	2.2	6.3	0.3	-0.6	2.5
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	5.4	-0.6	-0.8	2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.7	4.6	-0.8	-1.6	2.1
Headache pain in last month	1.7	2.9	7.4	1.0	-0.6	2.7
Ever smoked	1.7	3.0	6.4	-2.5	-1.5	0.7
Prostate Cancer	1.6	2.3	4.4	0.1	1.6	-2.1
Crohns Disease (2012)	1.6	2.6	4.5	2.1	0.1	1.8
Ever used hormone-replacement therapy (HRT)	1.6	2.0	2.9	1.6	-1.7	0.7
Diabetes (mother)	1.6	2.0	3.5	-1.2	1.9	1.1
Pack years adult smoking proportion	1.6	2.5	4.7	-2.2	-1.4	-1.0
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	4.5	-2.1	0.3	1.3
Medication: Lansoprazole	1.6	1.8	5.2	-0.1	2.3	-0.4
Loud music exposure frequency	1.6	1.7	2.5	-1.2	1.0	-1.6
Ever had prostate specific antigen (PSA) test	1.6	1.9	4.3	0.9	0.7	-2.1
Pack years of smoking	1.6	2.3	4.7	-2.2	-0.9	-1.2
Neuroticism (Nagel 2018)	1.5	3.5	6.5	-1.0	-1.7	2.5
Average weekly spirits intake	1.5	1.9	5.6	-2.4	0.0	-0.0
Mouth/teeth dental problems: Bleeding gums	1.5	2.0	3.4	-1.2	-1.8	1.1
Comparative body size at age 10	1.5	4.1	6.3	2.5	-2.0	1.4
Number of children fathered	1.5	1.7	2.6	1.6	-0.9	1.3
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	3.7	0.6	-1.2	1.9
Mean Putamen Volume	1.4	1.6	2.7	-0.5	1.6	-1.4
Ulcerative Colitis	1.4	2.1	2.7	1.6	0.9	1.6
Blood White Count	1.4	10.4	18.8	2.2	4.3	-2.7
Multivitamins +/- minerals	1.4	1.8	2.8	-1.7	1.4	-0.7
Past tobacco smoking	1.4	2.6	4.1	2.0	1.7	-0.9
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	4.1	-2.0	-0.4	1.7
Noisy workplace	1.4	1.8	2.8	1.0	1.2	-1.7
Emphysema/chronic bronchitis	1.4	1.6	4.2	-2.1	-0.4	0.6
Long-standing illness, disability or infirmity	1.4	2.1	3.6	-1.7	0.0	-1.9
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	4.2	-1.1	-1.1	2.0
Asthma (self-reported)	1.4	2.8	4.9	0.9	-2.2	-1.6
Medication: Lisinopril	1.4	1.8	2.7	1.6	-0.4	-1.6
Ever depressed for a whole week	1.4	1.7	2.9	-1.1	1.0	1.7
Coronary Artery Disease (CAD)	1.3	1.6	2.9	-0.1	-1.7	-1.3
Asthma	1.3	2.7	6.0	0.7	-2.5	-1.2
Medication: Cholesterol lowering	1.3	2.1	5.3	0.3	0.9	-2.3
Hair/balding pattern: Pattern 4	1.3	3.1	7.2	-1.3	2.7	-0.5
Mouth/teeth dental problems: Loose teeth	1.3	1.6	2.7	1.6	1.2	-0.8
Medication: Blood pressure	1.3	2.3	6.6	0.0	0.5	-2.6
Bipolar Disorder or Schizophrenia	1.2	3.0	8.1	-2.9	0.8	0.5
Lung FEV1/FVC ratio	1.2	6.0	13.0	-3.6	0.9	-2.0
Vitamin and mineral supplements	1.2	1.6	4.0	2.0	-0.4	0.9
Impedance of leg (left)	1.2	5.8	8.3	2.5	1.7	-2.9
Alcohol usually taken with meals	1.2	1.9	2.9	1.6	-1.7	0.6
Illnesses of siblings	1.2	1.6	3.6	0.4	1.9	-1.1
Hair/balding pattern: Pattern 3	1.2	1.8	2.4	-1.1	1.6	-1.4
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	5.7	0.3	-0.5	2.4
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	4.7	-1.4	-2.2	0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	3.9	2.0	0.4	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	3.8	1.9	-0.0	-0.6
Suffer from ‘nerves’	1.2	1.8	2.1	-1.4	-1.3	1.3
Family relationship satisfaction	1.2	1.5	2.7	-1.6	0.5	1.2
Eye problems/disorders: Cataract	1.2	1.4	2.4	0.9	1.6	-1.0
Schizophrenia vs Biploar Disorder	1.1	1.4	3.2	1.8	-1.0	0.1
Rheumatoid Arthritis	1.1	1.5	4.0	0.5	-0.4	-2.0
Age when periods started (menarche)	1.1	2.8	4.2	0.7	2.1	-1.9
Peak expiratory flow (PEF)	1.1	2.5	6.8	-2.6	0.2	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	2.1	-1.5	-1.2	0.9
Shortness of breath walking on level ground	1.1	1.3	1.8	-1.3	-0.9	1.0
Illnesses of father: Heart disease	1.1	1.6	3.2	-1.2	-1.8	0.3
Miserableness	1.1	1.8	3.7	0.0	-1.3	1.9
Medication: Atorvastatin	1.1	1.4	2.5	0.1	1.3	-1.6
Crohns Disease (2017)	1.0	2.2	5.5	1.0	0.3	2.3
Age at First Birth	1.0	1.5	4.3	-2.1	-0.2	0.4
Systolic Blood Pressure	1.0	4.9	6.0	1.8	2.5	-2.3
Smoking Status	1.0	2.3	6.8	-2.6	0.2	-0.3
Respiratory disease	1.0	2.2	6.4	-0.2	-2.5	0.3
Number of treatments/medications taken	1.0	1.9	4.8	-2.2	0.7	-0.6
Neuroticism score	1.0	2.1	3.7	-1.4	-0.8	1.9
Weight	1.0	4.9	13.6	-3.7	-1.0	-0.4
Migraine (self-reported)	1.0	1.2	3.2	-0.7	-0.0	1.8
Chest pain or discomfort	1.0	1.5	3.6	-0.9	0.2	-1.9
Medication: Paracetamol	1.0	1.5	4.3	-0.2	2.1	-0.4
Leg fat percentage (left)	1.0	3.5	6.1	2.5	1.1	-1.8
Alzheimer’s Disease (including proxy)	0.9	1.3	2.1	0.9	1.5	-1.0
Primary Biliary Cirrhosis	0.9	1.3	1.4	-1.2	1.2	-1.2
Hypothyroidism (self reported)	0.9	2.1	4.9	-1.1	-2.2	0.5
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	2.1	-1.4	-0.5	0.7
Impedance of leg (right)	0.9	4.5	8.8	1.6	1.5	-3.0
Current tobacco smoking	0.9	1.4	2.0	-1.4	0.8	-1.3
Medication: Simvastatin	0.9	1.3	2.3	-1.5	-0.9	-0.8
Father’s age at death	0.9	1.2	2.2	0.1	1.5	1.2
Mouth/teeth dental problems: Dentures	0.9	1.5	2.6	1.2	1.6	-0.7
Pulse wave Arterial Stiffness index	0.9	1.0	1.6	-1.3	-0.7	-1.0
Glaucoma (self-reported)	0.9	1.1	2.4	-0.8	1.6	0.4
Illnesses of father: High blood pressure	0.9	1.1	1.6	1.3	-0.6	1.2
Alcohol drinker status: Never	0.9	1.1	3.3	1.8	-0.1	0.3
Cholesterol lowering medication	0.9	1.4	3.0	-1.1	-1.7	-0.0
Depressed Affect (Nagel 2018)	0.8	1.7	2.4	1.6	-0.6	1.5
Depression (Nagel 2018)	0.8	1.2	1.6	1.3	-0.9	1.0
LDL Cholesterol	0.8	1.2	2.2	-1.1	0.6	-1.5
Townsend deprivation index at recruitment	0.8	1.1	2.2	-1.0	0.1	-1.5
Had menopause	0.8	1.1	2.8	-0.4	-0.5	1.7
Breastfed as a baby	0.8	1.0	2.1	-0.8	-0.6	-1.5
Tense / ‘highly strung’	0.8	1.3	2.9	-0.4	-1.7	0.8
Leg fat percentage (right)	0.8	3.0	4.1	1.9	1.1	-2.0
Age at first live birth	0.8	1.5	3.0	-1.7	-0.9	0.8
Medication: Ibuprofen	0.8	1.0	1.8	-0.5	1.3	1.0
Had major operations	0.8	1.0	2.5	-1.6	0.7	0.2
Age at last live birth	0.8	1.2	2.7	-1.7	-0.9	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.4	-0.5	1.2	-1.2
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.4	1.6	-0.2	0.6
Mood swings	0.8	1.4	1.8	1.4	-1.0	1.2
Number of self-reported non-cancer illnesses	0.8	1.5	4.1	-2.0	-0.5	-0.1
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.9	0.6	0.6	-1.4
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.4	-1.5	0.2	0.8
Age started oral contraceptive pill	0.8	1.0	2.5	-1.6	0.5	0.5
Diastolic blood pressure, automated reading	0.8	2.5	3.7	1.0	1.9	-1.6
Pain experienced in last month	0.8	1.3	3.6	0.4	0.2	-1.9
Alzheimer’s Disease (in father)	0.7	0.8	1.2	1.1	-0.3	1.1
Breast Cancer	0.7	1.6	3.0	1.2	1.7	0.7
Neuroticism	0.7	1.7	3.6	-1.0	-0.7	1.9
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.5	0.7	-1.1	1.2
Medication: Co-codamol	0.7	0.8	2.4	-0.1	1.5	0.1
Diabetes (self-reported)	0.7	1.1	2.5	0.3	-1.6	0.8
Depression (self-reported)	0.7	0.8	1.6	-0.6	-1.3	0.6
Eye problems/disorders: None of the above	0.7	0.8	1.5	-1.2	-0.8	0.7
Medication for pain relief, constipation, heartburn	0.7	1.2	2.4	0.4	-1.0	-1.5
Pulse rate, automated reading	0.7	2.2	3.7	-0.7	1.5	-1.9
Ever had bowel cancer screening	0.7	0.8	1.0	-1.0	0.6	-0.9
Smoking status: Current	0.7	1.1	1.6	-1.3	1.0	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	2.2	-1.5	0.8	1.2
Ever taken oral contraceptive pill	0.7	0.8	1.5	-0.9	-1.2	0.4
Mother’s age at death	0.7	0.9	1.4	-0.9	-0.6	1.2
High cholesterol (Self-reported)	0.7	1.2	2.8	-0.4	-0.8	-1.7
Unable to work because of sickness or disability	0.7	0.9	2.5	1.6	0.4	0.1
Vascular/heart problems diagnosed by doctor	0.7	1.8	3.1	-1.5	-0.2	1.8
Worry (Nagel 2018)	0.6	1.2	2.5	0.3	-1.1	1.6
Schizophrenia (2014)	0.6	1.3	2.4	-1.6	0.2	1.2
Triglycerides	0.6	0.9	1.4	1.2	-1.1	-0.2
Type 2 Diabetes (T2D) (2012)	0.6	0.6	1.2	0.9	-1.1	-0.0
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.5	0.9	-1.6	0.3
Hearing difficulty/problems: Yes	0.6	0.9	1.5	-0.4	-1.0	-1.2
Hayfever, allergic rhinitis or eczema	0.6	1.2	2.4	-1.5	0.7	1.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.6	-0.4	1.2	-0.6
Hearing difficulty/problems with background noise	0.6	1.0	1.6	-1.3	-1.0	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.3	-0.3	1.0	1.1
Illnesses of siblings: Diabetes	0.6	0.7	2.0	-0.4	0.1	1.4
Average weekly beer plus cider intake	0.6	0.9	1.6	-1.0	-0.3	1.3
Schizophrenia (2018)	0.5	1.0	1.6	-1.2	-0.4	1.2
Ovarian Cancer	0.5	0.6	1.6	0.1	-0.5	1.3
HDL Cholesterol	0.5	0.9	2.4	0.4	1.6	0.2
Allergy or Eczema	0.5	1.2	1.8	-1.3	0.5	1.3
Hair Pigment	0.5	14.1	35.5	-1.8	1.9	-6.0
Relative age of first facial hair	0.5	1.0	2.1	-0.9	0.2	-1.5
Exposure to tobacco smoke at home	0.5	0.6	1.6	-0.0	0.1	1.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	0.9	-0.9	-0.1	0.9
Body fat percentage	0.5	2.2	3.6	1.2	1.1	-1.9
Wheeze or whistling in the chest in last year	0.5	0.9	1.3	-1.1	-1.0	-0.5
Supplements: Vitamin C	0.5	0.5	0.8	-0.9	-0.9	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	0.9	-0.8	1.0	0.1
Diabetes diagnosed by doctor	0.5	0.8	1.7	0.7	-1.3	-0.3
Osteoarthritis (self-reported)	0.5	0.7	1.3	1.1	0.8	-0.3
Illnesses of father: None of the above (group 1)	0.5	0.7	1.0	-1.0	0.8	-0.5
Wears glasses or contact lenses	0.5	0.6	1.8	-1.3	-0.1	-0.1
Medication: Blood pressure	0.5	0.9	2.3	0.2	1.5	-0.7
Impedance of whole body	0.5	2.6	3.8	0.9	1.8	-1.9
HbA1C	0.4	0.4	1.1	-0.1	0.4	-1.0
Medication for hormone replacement therapy	0.4	0.4	0.6	0.7	-0.5	-0.8
Medication: Metformin	0.4	0.5	1.3	1.1	-0.5	-0.0
Diabetes (father)	0.4	0.5	1.1	-0.6	1.1	0.4
Trunk fat percentage	0.4	1.5	3.1	0.7	0.9	-1.7
Average weekly fortified wine intake	0.4	0.5	0.9	-1.0	-0.7	-0.1
Fed-up feelings	0.4	0.7	1.3	1.2	0.6	-0.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.3	1.1	-0.1	-0.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.9	0.5	-0.9	0.2
Waist circumference	0.4	1.5	3.3	-1.0	0.1	-1.8
Nervous feelings	0.4	0.8	1.1	-1.0	1.0	0.5
Financial difficulties in last 2 years	0.4	0.5	0.7	-0.4	-0.9	-0.8
Pulse rate	0.4	0.7	1.5	-0.3	-0.8	-1.2
Pulse wave reflection index	0.4	0.5	0.6	-0.5	-0.8	0.8
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.8	0.5	-1.3	0.3
Exposure to tobacco smoke outside home	0.4	0.6	1.3	-1.1	-0.7	-0.0
Overall health rating	0.4	0.9	1.8	-1.4	0.8	-0.5
Commuting to job workplace: Public transport	0.4	0.5	1.2	-1.1	-0.0	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.0	1.0	-0.3	0.5
Heart disease (siblings)	0.4	0.5	1.1	-1.0	0.6	-0.2
Alzheimer’s Disease (in mother)	0.3	0.4	0.7	-0.6	0.8	-0.3
Fasting Glucose	0.3	0.3	0.6	-0.5	-0.8	0.4
Lupus	0.3	0.5	1.2	1.1	-0.5	-0.3
Blood Eosinophil Count	0.3	2.1	5.6	-0.7	-2.4	0.3
Blood Platelet Count	0.3	3.4	7.0	0.5	-2.6	-1.8
High blood pressure	0.3	0.8	1.5	1.0	0.1	-1.2
Trunk fat mass	0.3	1.4	2.3	-1.3	0.1	-1.5
Hair/balding pattern: Pattern 2	0.3	0.4	0.7	0.2	0.6	0.8
Impedance of arm (right)	0.3	1.3	2.0	-0.9	1.0	-1.4
Arm fat percentage (right)	0.3	1.0	1.4	1.0	0.8	-1.2
Hip circumference	0.3	1.3	3.3	-1.8	-0.3	0.7
Time employed in main current job	0.3	0.3	0.6	-0.5	0.8	-0.4
Blood clot in the leg (DVT)	0.3	0.3	0.7	0.8	-0.5	0.3
Medication: Paracetamol	0.3	0.4	0.7	-0.6	0.9	-0.4
Pulse wave peak to peak time	0.3	0.4	0.8	0.5	0.4	0.9
Medication: Allopurinol	0.3	0.4	0.7	0.2	-0.8	-0.6
Whole body fat mass	0.3	1.1	2.5	-1.0	0.1	-1.6
Hypertension (Self-reported)	0.3	0.8	2.0	0.7	0.2	-1.4
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.9	1.0	0.0	-0.3
Hand grip strength (left)	0.2	0.4	1.1	-0.2	1.0	0.3
Severe depression (siblings)	0.2	0.2	0.5	-0.7	-0.0	0.2
Relative age voice broke	0.2	0.3	0.8	-0.3	0.1	-0.9
Medication: Levothyroxine sodium	0.2	0.4	0.9	-0.9	-0.6	-0.0
Chronic bronchitis/emphysema (father)	0.2	0.3	0.5	-0.0	-0.7	0.6
High blood pressure (mother)	0.2	0.3	1.0	-0.1	-0.1	-1.0
Body mass index (BMI)	0.2	1.0	2.5	1.6	0.6	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.5	-0.6	-0.1	0.7
Mouth/teeth dental problems	0.2	0.3	0.3	-0.6	0.4	-0.6
Alcohol intake versus 10 years previously	0.2	0.3	0.4	0.6	0.5	-0.5
Falls in the last year	0.2	0.3	0.9	0.0	-0.9	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	0.0	-0.1	0.8
Length of working week for main job	0.2	0.3	0.7	-0.2	0.0	0.9
Medication: Amlodipine	0.2	0.3	0.8	-0.4	0.1	-0.9
Leg fat mass (right)	0.2	0.9	2.7	-0.3	0.1	-1.6
Knee pain experienced in last month	0.2	0.3	0.3	-0.5	0.6	-0.4
Arm fat percentage (left)	0.2	1.0	1.6	1.2	0.9	-0.8
Commuting to job workplace: Walk	0.2	0.2	0.5	-0.7	-0.5	0.0
Back pain experienced in last month	0.2	0.3	0.7	-0.8	-0.1	0.6
Mineral and other dietary supplements	0.2	0.3	0.6	0.7	0.5	0.2
Osteoporosis (self-reported)	0.2	0.3	0.5	-0.7	0.4	-0.4
Medication: Aspirin	0.2	0.3	0.7	0.8	-0.2	0.4
Eye problems/disorders: Glaucoma	0.2	0.3	0.7	0.2	0.8	0.4
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.3	0.2	-0.6	-0.5
Leg fat mass (left)	0.2	0.8	2.4	0.0	0.2	-1.5
Major Depression (MDD)	0.1	0.2	0.3	-0.1	0.6	-0.4
Blood Red Count	0.1	1.0	1.9	1.4	0.9	-0.4
Cardiovascular Disease	0.1	0.3	0.8	0.4	-0.0	-0.9
Hand grip strength (right)	0.1	0.4	0.5	0.4	0.7	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.4	0.5	-0.6	-0.1
Qualifications: CSEs or equivalent	0.1	0.2	0.3	0.3	0.5	-0.4
Allergy	0.1	0.3	1.0	1.0	0.0	-0.3
Number of live births	0.1	0.1	0.1	0.3	0.3	0.3
Illnesses of mother	0.1	0.1	0.4	0.1	-0.6	-0.2
Impedance of arm (left)	0.1	0.7	1.4	-0.4	1.2	-0.7
Arm fat mass (right)	0.1	0.6	1.0	-1.0	0.1	-0.8
Gout (self-reported)	0.1	0.1	0.3	0.3	0.2	0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	0.2	-0.3	-0.4
Medication: Seretide 50 evohaler	0.1	0.1	0.1	-0.3	0.2	0.4
Leg pain on walking	0.1	0.2	0.3	-0.4	-0.5	-0.2
Medication: Aspirin	0.1	0.1	0.2	0.2	0.2	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	0.1	-0.1	-0.5
Medication for cholesterol	0.1	0.1	0.3	0.3	-0.1	0.6
Medication: Gliclazide	0.1	0.1	0.2	0.4	-0.2	-0.4
Arm fat mass (left)	0.1	0.3	0.7	-0.8	0.1	-0.5
Basal cell carcinoma (self-reported)	0.1	0.2	0.2	0.4	-0.4	-0.4
BMI	0.0	0.2	0.4	0.7	0.3	0.2
Tanning	0.0	0.4	0.9	0.9	-0.4	0.1
Neck or shoulder pain in last month	0.0	0.1	0.2	0.4	-0.1	0.1
Commuting to job workplace: Cycle	0.0	0.0	0.1	-0.1	0.3	-0.2

Hub : Genes

TET2

Models

Trait associations