Best TWAS P=8.75e-10 · Best GWAS P=6.8e-07 conditioned to 0.616
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | FUT10 | 0.12 | 0.20 | lasso | 11 | 0.21 | 4.2e-25 | 4.9 | 5.8 | 5.2e-09 | 0.94 | 0.01 | 0.98 | FALSE |
2 | GTEx | Adrenal Gland | FUT10 | 0.18 | 0.10 | lasso | 9 | 0.09 | 3.7e-04 | 4.9 | 5.4 | 5.4e-08 | 0.92 | 0.02 | 0.92 | FALSE |
3 | GTEx | Breast Mammary Tissue (Female) | FUT10 | 0.18 | 0.13 | lasso | 5 | 0.13 | 9.5e-05 | 4.7 | 5.3 | 9.0e-08 | 0.83 | 0.04 | 0.83 | FALSE |
4 | GTEx | Liver | FUT10 | 0.16 | 0.05 | lasso | 9 | 0.06 | 9.7e-03 | 4.9 | 5.1 | 2.9e-07 | 0.89 | 0.03 | 0.91 | FALSE |
5 | GTEx | Lung | RP11-722E23.2 | 0.13 | 0.09 | lasso | 6 | 0.10 | 6.1e-08 | 4.8 | 5.4 | 7.8e-08 | 0.96 | 0.04 | 0.95 | FALSE |
6 | GTEx | Muscle Skeletal | FUT10 | 0.09 | 0.07 | enet | 17 | 0.07 | 1.7e-07 | 4.4 | 5.2 | 2.6e-07 | 0.89 | 0.03 | 0.96 | FALSE |
7 | GTEx | Nerve Tibial | FUT10 | 0.22 | 0.29 | enet | 18 | 0.32 | 1.3e-23 | 4.8 | 5.2 | 1.8e-07 | 0.96 | 0.02 | 0.98 | FALSE |
8 | GTEx | Pancreas | FUT10 | 0.28 | 0.23 | enet | 20 | 0.22 | 1.4e-09 | 4.7 | 6.1 | 8.7e-10 | 0.85 | 0.02 | 0.97 | TRUE |
9 | GTEx | Pancreas | MAK16 | 0.11 | 0.11 | lasso | 4 | 0.07 | 4.5e-04 | 4.4 | 5.1 | 3.1e-07 | 0.93 | 0.06 | 0.74 | FALSE |
10 | GTEx | Stomach | FUT10 | 0.21 | 0.16 | lasso | 4 | 0.15 | 1.5e-07 | 4.6 | 5.1 | 3.1e-07 | 0.98 | 0.03 | 0.96 | FALSE |
11 | GTEx | Thyroid | FUT10 | 0.22 | 0.20 | enet | 22 | 0.26 | 8.6e-20 | 4.9 | 5.2 | 2.1e-07 | 0.95 | 0.02 | 0.97 | FALSE |
12 | ROSMAP | Brain Pre-frontal Cortex | FUT10 | 0.04 | 0.04 | enet | 11 | 0.04 | 2.1e-05 | 4.6 | 5.4 | 6.7e-08 | 0.94 | 0.03 | 0.96 | FALSE |
13 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | FUT10 | 0.10 | 0.11 | enet | 14 | 0.12 | 1.2e-10 | 4.8 | 5.2 | 1.7e-07 | 0.95 | 0.02 | 0.97 | FALSE |
14 | The Cancer Genome Atlas | Glioblastoma Multiforme | FUT10 | 0.17 | 0.09 | lasso | 6 | 0.10 | 6.3e-04 | 4.7 | 5.7 | 1.5e-08 | 0.86 | 0.02 | 0.88 | FALSE |
15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FUT10 | 0.10 | 0.09 | blup | 68 | 0.12 | 1.2e-13 | 5.0 | 5.2 | 2.5e-07 | 0.91 | 0.02 | 0.97 | FALSE |
16 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | FUT10 | 0.12 | 0.10 | blup | 68 | 0.09 | 2.6e-04 | 4.9 | 5.7 | 1.3e-08 | 0.93 | 0.02 | 0.95 | FALSE |
17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FUT10 | 0.15 | 0.15 | blup | 67 | 0.13 | 1.6e-13 | 4.8 | 5.2 | 1.6e-07 | 0.85 | 0.02 | 0.97 | FALSE |
18 | The Cancer Genome Atlas | Thyroid Carcinoma | FUT10 | 0.18 | 0.24 | lasso | 7 | 0.26 | 2.6e-25 | 4.4 | 5.2 | 1.8e-07 | 0.87 | 0.08 | 0.89 | FALSE |