Best TWAS P=4.68e-10 · Best GWAS P=6.53e-10 conditioned to 0.0706
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DDHD2 | 0.04 | 0.04 | bslmm | 286 | 0.04 | 2.0e-05 | 6.2 | 5.9 | 4.0e-09 | 0.93 | 0.02 | 0.98 | FALSE |
2 | GTEx | Adrenal Gland | DDHD2 | 0.25 | 0.21 | lasso | 2 | 0.19 | 1.7e-07 | 6.0 | 6.1 | 1.0e-09 | 0.96 | 0.03 | 0.97 | FALSE |
3 | GTEx | Artery Tibial | DDHD2 | 0.07 | 0.07 | lasso | 2 | 0.05 | 7.3e-05 | 6.0 | 6.0 | 1.7e-09 | 0.97 | 0.03 | 0.97 | FALSE |
4 | GTEx | Breast Mammary Tissue | RP11-350N15.5 | 0.08 | 0.03 | enet | 12 | 0.02 | 1.9e-02 | 4.6 | -5.9 | 2.9e-09 | -0.87 | 0.03 | 0.91 | FALSE |
5 | GTEx | Breast Mammary Tissue (Female) | RP11-350N15.5 | 0.12 | 0.10 | lasso | 2 | 0.07 | 3.9e-03 | 5.9 | -6.0 | 2.0e-09 | -0.96 | 0.03 | 0.86 | FALSE |
6 | GTEx | Colon Sigmoid | DDHD2 | 0.15 | 0.15 | lasso | 3 | 0.12 | 7.5e-05 | 6.2 | 6.2 | 7.4e-10 | 1.00 | 0.02 | 0.95 | FALSE |
7 | GTEx | Esophagus Muscularis | DDHD2 | 0.12 | 0.13 | lasso | 2 | 0.12 | 5.7e-08 | 5.5 | 5.5 | 4.1e-08 | 0.98 | 0.05 | 0.95 | FALSE |
8 | GTEx | Liver | DDHD2 | 0.29 | 0.01 | lasso | 5 | -0.01 | 5.4e-01 | 5.9 | 5.8 | 6.7e-09 | 0.88 | 0.03 | 0.66 | FALSE |
9 | GTEx | Nerve Tibial | DDHD2 | 0.15 | 0.16 | enet | 26 | 0.16 | 2.3e-11 | 6.1 | 5.5 | 3.8e-08 | 0.94 | 0.02 | 0.98 | FALSE |
10 | GTEx | Pituitary | DDHD2 | 0.25 | 0.22 | lasso | 3 | 0.17 | 3.9e-05 | 5.9 | 5.2 | 1.7e-07 | 0.91 | 0.03 | 0.92 | FALSE |
11 | GTEx | Prostate | DDHD2 | 0.38 | 0.18 | lasso | 7 | 0.17 | 5.4e-05 | 5.5 | 5.5 | 3.7e-08 | 0.98 | 0.04 | 0.96 | FALSE |
12 | GTEx | Spleen | DDHD2 | 0.17 | 0.17 | lasso | 2 | 0.11 | 7.8e-04 | 6.0 | 6.1 | 1.4e-09 | 0.98 | 0.03 | 0.90 | FALSE |
13 | GTEx | Stomach | DDHD2 | 0.13 | 0.06 | lasso | 2 | 0.06 | 1.1e-03 | 5.5 | 5.6 | 2.8e-08 | 0.94 | 0.04 | 0.88 | FALSE |
14 | GTEx | Thyroid | DDHD2 | 0.11 | 0.10 | lasso | 4 | 0.09 | 3.8e-07 | 5.5 | 5.5 | 3.5e-08 | 0.98 | 0.04 | 0.96 | FALSE |
15 | GTEx | Thyroid | RP11-90P5.2 | 0.09 | 0.00 | enet | 12 | 0.01 | 1.1e-01 | 5.6 | -6.2 | 4.7e-10 | -0.83 | 0.04 | 0.83 | TRUE |
16 | NTR | Blood | BAG4 | 0.01 | 0.01 | blup | 253 | 0.01 | 3.9e-03 | 5.5 | -5.7 | 1.5e-08 | -0.93 | 0.04 | 0.94 | FALSE |
17 | ROSMAP | Brain Pre-frontal Cortex | DDHD2 | 0.05 | 0.01 | lasso | 5 | 0.02 | 1.6e-03 | 5.3 | 5.2 | 2.0e-07 | 0.87 | 0.07 | 0.87 | FALSE |
18 | ROSMAP | Brain Pre-frontal Cortex | PPAPDC1B | 0.06 | 0.08 | enet | 14 | 0.09 | 4.0e-11 | 6.0 | 5.8 | 5.9e-09 | 0.96 | 0.04 | 0.96 | FALSE |
19 | ROSMAP | Brain Pre-frontal Cortex | LSM1 | 0.09 | 0.16 | lasso | 6 | 0.16 | 7.3e-20 | 5.5 | -5.6 | 2.7e-08 | -0.98 | 0.11 | 0.89 | FALSE |
20 | ROSMAP | Brain Pre-frontal Cortex | RPS20P22 | 0.04 | 0.00 | blup | 267 | 0.02 | 2.9e-03 | 5.9 | 5.9 | 3.3e-09 | 0.74 | 0.03 | 0.86 | FALSE |
21 | YFS | Blood | BAG4 | 0.01 | 0.01 | bslmm | 234 | 0.00 | 2.6e-02 | 5.0 | 5.5 | 2.9e-08 | 0.86 | 0.04 | 0.79 | FALSE |
22 | YFS | Blood | LSM1 | 0.02 | 0.00 | bslmm | 218 | 0.01 | 4.1e-04 | 4.2 | -5.7 | 1.5e-08 | -0.82 | 0.05 | 0.93 | FALSE |
23 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DDHD2 | 0.01 | 0.01 | blup | 21 | 0.01 | 2.3e-03 | 6.0 | 6.0 | 2.0e-09 | 0.98 | 0.01 | 0.80 | FALSE |
24 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DDHD2 | 0.03 | 0.03 | blup | 21 | 0.03 | 3.5e-04 | 5.4 | 6.0 | 2.0e-09 | 0.98 | 0.02 | 0.98 | FALSE |
25 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PPAPDC1B | 0.02 | 0.00 | blup | 18 | 0.01 | 4.2e-02 | 6.0 | 6.0 | 1.7e-09 | 0.95 | 0.01 | 0.57 | FALSE |
26 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | DDHD2 | 0.07 | 0.05 | blup | 21 | 0.05 | 2.7e-03 | 6.2 | 5.9 | 3.8e-09 | 0.99 | 0.01 | 0.80 | FALSE |
27 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DDHD2 | 0.11 | 0.08 | lasso | 3 | 0.08 | 1.9e-08 | 6.2 | 6.2 | 6.5e-10 | 1.00 | 0.01 | 0.99 | FALSE |
28 | The Cancer Genome Atlas | Thyroid Carcinoma | DDHD2 | 0.02 | 0.01 | blup | 21 | 0.01 | 2.4e-02 | 6.0 | 5.9 | 3.0e-09 | 0.98 | 0.01 | 0.76 | FALSE |