Best TWAS P=2.73e-08 · Best GWAS P=2.03e-07 conditioned to 0.668
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue (Female) | YWHAZ | 0.27 | 0.00 | enet | 6 | 0.02 | 7.3e-02 | 5.1 | 5.2 | 2.3e-07 | 1.00 | 0.01 | 0.80 | FALSE |
| 2 | GTEx | Colon Transverse | YWHAZ | 0.33 | 0.23 | enet | 11 | 0.25 | 2.0e-12 | 5.1 | 5.3 | 1.0e-07 | 0.97 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | YWHAZ | 0.35 | 0.21 | lasso | 4 | 0.18 | 6.0e-07 | 5.2 | 5.2 | 2.3e-07 | 1.00 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Esophagus Mucosa | YWHAZ | 0.34 | 0.40 | lasso | 6 | 0.41 | 5.4e-29 | 5.2 | 5.2 | 2.6e-07 | 1.00 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Esophagus Muscularis | YWHAZ | 0.43 | 0.42 | lasso | 3 | 0.42 | 4.6e-27 | 5.2 | 5.1 | 2.9e-07 | 1.00 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Thyroid | YWHAZ | 0.26 | 0.21 | lasso | 5 | 0.22 | 1.9e-16 | 5.2 | 5.2 | 2.1e-07 | 0.99 | 0.01 | 0.99 | FALSE |
| 7 | GTEx | Whole Blood | YWHAZ | 0.11 | 0.06 | enet | 12 | 0.06 | 1.7e-06 | 5.0 | 5.6 | 2.7e-08 | 0.90 | 0.01 | 0.99 | TRUE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | YWHAZ | 0.03 | 0.04 | lasso | 2 | 0.03 | 1.2e-04 | 5.2 | 5.2 | 2.2e-07 | 1.00 | 0.00 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | YWHAZ | 0.07 | 0.07 | blup | 50 | 0.08 | 7.7e-09 | 5.1 | 5.3 | 1.4e-07 | 0.93 | 0.01 | 0.99 | FALSE |