Best TWAS P=1.36e-12 · Best GWAS P=6.81e-08 conditioned to 0.0205
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CTNNAL1 | 0.10 | 0.00 | lasso | 7 | 0.06 | 1.3e-07 | -4.2 | -5.8 | 6.1e-09 | -0.64 | 0.12 | 0.86 | FALSE |
2 | GTEx | Adipose Subcutaneous | IKBKAP | 0.08 | 0.08 | lasso | 4 | 0.07 | 4.6e-06 | 5.3 | 5.1 | 2.8e-07 | 0.98 | 0.01 | 0.98 | FALSE |
3 | GTEx | Artery Aorta | IKBKAP | 0.15 | 0.14 | lasso | 4 | 0.15 | 1.9e-08 | 5.3 | 5.3 | 1.1e-07 | 0.97 | 0.02 | 0.98 | FALSE |
4 | GTEx | Artery Aorta | CTNNAL1 | 0.17 | 0.06 | lasso | 6 | 0.05 | 9.5e-04 | -4.2 | -5.8 | 5.4e-09 | -0.49 | 0.09 | 0.78 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | CTNNAL1 | 0.22 | 0.08 | enet | 21 | 0.19 | 2.1e-14 | 4.3 | -5.1 | 3.0e-07 | -0.70 | 0.20 | 0.80 | FALSE |
6 | GTEx | Esophagus Muscularis | IKBKAP | 0.16 | 0.14 | lasso | 7 | 0.11 | 4.8e-07 | 5.3 | 5.4 | 5.0e-08 | 0.98 | 0.01 | 0.99 | FALSE |
7 | GTEx | Lung | IKBKAP | 0.11 | 0.11 | lasso | 5 | 0.10 | 1.9e-08 | 5.3 | 5.4 | 8.6e-08 | 0.98 | 0.01 | 0.99 | FALSE |
8 | GTEx | Muscle Skeletal | CTNNAL1 | 0.42 | 0.14 | lasso | 7 | 0.27 | 7.6e-27 | -4.2 | -5.9 | 3.6e-09 | -0.64 | 0.71 | 0.26 | FALSE |
9 | GTEx | Nerve Tibial | IKBKAP | 0.13 | 0.16 | lasso | 7 | 0.14 | 3.7e-10 | 5.3 | 5.5 | 4.0e-08 | 0.98 | 0.01 | 0.99 | FALSE |
10 | GTEx | Pancreas | CTNNAL1 | 0.41 | 0.18 | lasso | 9 | 0.19 | 2.6e-08 | 4.3 | -5.8 | 7.1e-09 | -0.87 | 0.33 | 0.64 | FALSE |
11 | GTEx | Whole Blood | CTNNAL1 | 0.14 | 0.07 | lasso | 6 | 0.07 | 9.4e-07 | -4.2 | -5.4 | 7.7e-08 | -0.05 | 0.04 | 0.94 | FALSE |
12 | YFS | Blood | CTNNAL1 | 0.15 | 0.07 | enet | 29 | 0.08 | 2.8e-26 | -4.2 | -5.3 | 1.4e-07 | -0.18 | 0.71 | 0.26 | FALSE |
13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CTNNAL1 | 0.29 | 0.06 | enet | 12 | 0.12 | 8.8e-14 | 4.3 | -5.6 | 1.9e-08 | -0.73 | 0.21 | 0.77 | FALSE |
14 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | CTNNAL1 | 0.21 | 0.02 | lasso | 3 | 0.06 | 2.1e-03 | 4.3 | -6.0 | 2.1e-09 | -0.73 | 0.02 | 0.60 | FALSE |
15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CTNNAL1 | 0.09 | 0.00 | blup | 83 | 0.04 | 1.0e-04 | -4.2 | -7.1 | 1.4e-12 | -0.47 | 0.02 | 0.55 | TRUE |