Best TWAS P=4.83e-08 · Best GWAS P=1.12e-07 conditioned to 2.26e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Sigmoid | MASTL | 0.27 | 0.30 | lasso | 14 | 0.27 | 6.0e-10 | -4.5 | 5.3 | 1.2e-07 | -0.05 | 0.11 | 0.88 | FALSE |
| 2 | GTEx | Pituitary | MASTL | 0.35 | 0.44 | enet | 39 | 0.39 | 8.4e-11 | -4.7 | 5.5 | 4.8e-08 | -0.11 | 0.11 | 0.87 | TRUE |
| 3 | The Cancer Genome Atlas | Glioblastoma Multiforme | MASTL | 0.14 | 0.14 | blup | 60 | 0.11 | 2.8e-04 | -4.7 | 5.2 | 2.1e-07 | -0.04 | 0.02 | 0.86 | FALSE |
| 4 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | MASTL | 0.13 | 0.05 | blup | 60 | 0.10 | 3.0e-05 | -4.6 | 5.2 | 1.5e-07 | -0.01 | 0.02 | 0.95 | FALSE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | ANKRD26 | 0.08 | 0.04 | blup | 81 | 0.07 | 3.8e-07 | -4.7 | 5.2 | 1.9e-07 | -0.03 | 0.02 | 0.96 | FALSE |