Hub : Genes

ANKRD26

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2110	0.0500	2.5e-12	0.105	0.106	0.139	0.138	0.155	9.1e-13	8.2e-13	1.5e-16	1.9e-16	1.8e-18
2	GTEx	Adipose Subcutaneous	0.1380	0.0540	6.4e-03	0.038	NA	-0.001	NA	0.005	4.4e-04	NA	4.0e-01	NA	1.1e-01
3	GTEx	Cells Transformed fibroblasts	0.2700	0.0660	6.3e-05	0.050	NA	0.123	NA	0.079	1.2e-04	NA	1.8e-09	NA	1.6e-06
4	GTEx	Esophagus Muscularis	0.2290	0.0720	4.6e-05	0.106	NA	0.021	NA	0.072	5.4e-07	NA	1.9e-02	NA	3.5e-05
5	GTEx	Muscle Skeletal	0.2352	0.0515	1.1e-06	0.069	NA	0.053	NA	0.062	2.5e-07	NA	5.7e-06	NA	9.5e-07
6	GTEx	Pituitary	0.1890	0.0750	5.4e-03	0.153	NA	0.010	NA	0.049	1.2e-04	NA	1.8e-01	NA	2.3e-02
7	GTEx	Testis	0.2430	0.0690	5.4e-04	0.029	NA	0.087	NA	0.072	2.0e-02	NA	1.1e-04	NA	4.0e-04
8	GTEx	Thyroid	0.0580	0.0250	4.6e-03	0.002	NA	0.023	NA	0.028	2.2e-01	NA	6.3e-03	NA	2.9e-03
9	METSIM	Adipose	0.0556	0.0202	3.2e-04	0.002	0.030	0.018	0.035	0.002	1.5e-01	2.4e-05	7.8e-04	5.5e-06	1.7e-01
10	ROSMAP	Brain Pre-frontal Cortex	0.1585	0.0353	5.9e-14	0.126	0.121	0.131	0.136	0.144	7.0e-16	3.0e-15	1.7e-16	4.5e-17	4.2e-18
11	TCGA	Thyroid Carcinoma	0.0770	0.0360	8.4e-07	0.042	0.067	0.056	NA	0.058	5.7e-05	3.8e-07	3.5e-06	NA	2.6e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.8	1.3	4.7	-0.7	0.9	1.8	1.5	0.3	0.4	-0.8	0.7	2.2	-0.9	0.6
Bipolar Disorder or Schizophrenia	0.8	1.9	6.5	-2.5	-0.2	0.3	1.5	-1.1	-0.3	1.1	2.1	1.8	-0.8	1.4
Depressed Affect (Nagel 2018)	0.8	1.7	4.2	-2.0	0.4	-1.5	1.8	-1.4	0.8	0.9	1.7	0.8	-1.1	0.9
Depression (Nagel 2018)	0.7	1.1	3.8	-0.5	0.9	0.9	1.9	0.1	0.1	-0.8	1.2	1.7	-0.9	0.4
Intelligence (Savage-Jansen 2018)	0.3	0.8	3.5	0.7	-0.8	-0.1	0.0	-0.1	-1.9	0.6	-1.2	-0.5	0.9	-1.0
Neuroticism (Nagel 2018)	0.8	1.9	5.4	-2.1	0.4	-1.4	2.3	-0.5	-0.5	-0.0	1.4	1.6	-1.5	1.3
Schizophrenia (2018)	1.0	2.2	7.3	-2.7	-1.0	-1.1	0.6	-1.6	-0.7	2.0	2.2	0.5	-0.3	1.3
Schizophrenia vs Biploar Disorder	1.7	2.2	4.4	-1.8	1.8	0.5	1.1	1.0	-0.3	-2.1	1.9	1.3	-1.7	1.4
Worry (Nagel 2018)	0.6	1.3	3.0	-1.2	0.6	-0.8	1.7	0.7	-1.6	-1.0	-0.2	1.6	-1.3	0.7
Alzheimer’s Disease (in mother)	2.0	2.4	6.0	1.7	-0.7	-0.1	-2.5	-0.5	-0.1	1.8	-2.0	-1.2	2.2	-1.8
Alzheimer’s Disease (in father)	1.2	1.3	3.4	-0.9	-1.0	-0.7	-1.6	-0.4	1.8	1.3	-1.0	-1.5	0.8	-0.3
Alzheimer’s Disease (including proxy)	1.4	2.0	5.4	0.5	-0.5	-0.3	-2.3	-0.5	1.5	2.1	-1.4	-1.3	1.8	-1.5
Crohns Disease (2017)	0.3	0.7	2.1	-0.3	0.8	1.4	0.3	1.0	0.2	-1.4	-0.3	0.4	-1.0	0.5
Irritable Bowel Disease (IBD)	0.2	0.5	2.1	0.5	-0.5	0.3	-0.7	-0.4	-0.3	-0.5	-1.3	-1.4	-0.2	0.4
Ulcerative Colitis (UC)	0.7	1.4	6.4	0.9	-1.5	0.1	-1.0	-1.2	-0.2	0.1	-1.7	-2.5	0.2	0.7
Major Depression (MDD)	0.5	0.6	2.6	-0.8	0.7	0.3	-0.3	0.8	-0.4	-0.0	1.2	1.6	0.2	-0.2
Reaction Time	0.4	0.8	2.9	0.1	-1.0	-0.0	0.4	-0.8	-1.7	1.6	-0.4	1.2	0.4	0.4
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.9	0.3	0.1	0.4	0.8	1.2	-1.3	-1.7	-1.0	-0.1	-1.1	0.3
Breast Cancer	0.6	1.4	7.8	0.9	-1.2	-0.5	-0.0	-0.9	0.2	-1.3	-2.8	-1.4	-0.4	0.1
Ovarian Cancer	2.5	3.3	8.6	-2.8	0.5	0.5	2.9	-0.9	1.0	-1.1	1.4	1.7	-2.9	1.7
Prostate Cancer	0.2	0.3	1.5	-1.2	-0.0	-0.4	0.9	-0.5	-0.1	0.1	0.6	0.0	-0.1	-0.2
Age at First Birth	1.2	1.7	4.0	-0.6	-2.0	-1.8	1.6	-2.0	-0.4	1.7	0.5	0.3	-0.4	1.1
Bipolar Disorder (2011)	3.3	3.2	8.2	-2.6	0.3	0.2	2.9	-0.5	0.7	-0.9	2.2	2.9	-1.9	1.2
Body Mass Index (BMI) (2010)	1.2	1.6	4.4	1.7	1.3	0.8	-2.1	1.6	-1.1	0.2	-0.2	-0.0	1.3	-1.7
Coronary Artery Disease (CAD)	0.3	0.4	1.1	-0.1	0.4	0.1	-0.6	-0.4	-0.8	0.5	-0.4	-0.8	0.9	-1.0
Crohns Disease (2012)	0.3	0.6	1.4	-0.8	0.5	0.9	0.8	-0.1	-0.5	-0.8	-0.1	1.0	-1.2	0.8
Mean Putamen Volume	0.8	0.9	4.4	-0.2	1.9	-0.3	0.4	0.3	2.1	-0.4	0.3	-0.2	-0.5	-1.1
Fasting Glucose	0.4	0.5	2.4	-0.8	0.4	-0.3	0.2	0.1	-1.6	-0.3	-0.1	1.3	-0.5	0.4
HbA1C	0.7	0.7	1.8	-1.2	1.1	0.6	0.4	0.3	1.1	-1.3	0.4	-0.3	-1.1	0.6
HDL Cholesterol	0.8	1.4	3.7	-1.9	-1.0	-1.5	1.3	-1.1	1.3	1.2	1.0	0.4	-0.6	1.0
LDL Cholesterol	0.5	0.8	3.1	-0.0	1.4	0.2	-0.1	1.2	-0.1	-0.2	1.3	1.7	0.2	-0.9
Lupus	0.7	1.1	2.7	0.9	-0.1	-0.7	-1.1	0.0	0.8	0.7	-1.4	-1.6	1.4	-1.3
Neuroticism (2016)	0.8	1.1	3.4	-1.8	-0.5	0.2	0.9	0.4	-1.8	-0.7	0.0	1.4	-0.5	1.3
Primary Biliary Cirrhosis	1.0	1.4	4.5	-0.3	1.0	2.1	0.8	1.5	0.7	-1.7	1.6	0.9	-0.3	0.3
Rheumatoid Arthritis	0.5	0.7	2.3	-0.9	-0.8	0.2	0.4	-0.0	-1.1	-0.3	-0.2	1.4	-0.5	1.5
Schizophrenia (2014)	1.2	2.6	9.5	-3.1	0.4	-0.3	1.5	-1.0	0.2	0.9	3.1	1.1	-1.1	1.7
Triglycerides	0.5	0.8	3.6	-0.9	0.6	0.7	-0.4	0.9	-1.9	-0.5	0.3	1.5	-0.2	0.3
Type 2 Diabetes (T2D) (2012)	0.7	0.8	4.2	-0.4	0.1	2.1	0.6	0.4	0.9	-0.3	1.4	0.8	-0.2	0.6
Ulcerative Colitis	0.9	1.2	2.9	1.4	-1.2	-0.0	-0.9	-0.7	-1.7	-0.1	-1.7	-1.6	0.8	-0.3
Blood Eosinophil Count	0.5	3.9	10.8	0.5	-0.5	-2.5	-2.4	-1.8	2.9	1.3	-2.4	-3.3	0.4	-1.0
Blood Platelet Count	0.6	7.3	23.5	-2.6	2.5	1.7	3.3	3.1	1.5	-1.0	4.0	4.8	-0.9	0.7
Blood Red Count	0.6	5.4	12.7	-0.5	-3.6	-2.5	-0.4	-2.9	3.2	-0.1	-0.8	-3.2	-1.7	2.9
Blood White Count	0.8	5.8	15.2	0.7	-0.9	-2.5	-3.5	-1.9	0.9	2.1	-3.9	-3.4	2.0	-2.1
Heel T-Score	0.5	4.1	19.8	-0.5	2.9	-0.4	-2.2	0.8	1.2	-1.3	-0.3	-4.5	0.5	-2.8
BMI	1.5	8.6	27.1	2.4	0.7	0.1	-4.8	-0.1	1.7	3.2	-1.4	-2.6	5.2	-4.1
Height	0.1	2.1	6.7	-0.7	-1.3	-2.6	-1.2	-1.3	-1.8	1.8	0.1	1.8	1.3	-0.4
Waist Hip Ratio (WHR)	0.3	1.2	8.1	-1.3	0.1	0.9	0.8	0.4	-0.5	0.5	0.6	2.9	0.5	-0.5
Systolic Blood Pressure	0.3	1.3	4.3	-1.3	0.6	2.1	1.6	0.9	-0.8	-1.2	-0.4	0.8	-1.0	0.8
Smoking Status	0.7	1.8	8.4	0.6	2.7	0.2	-1.1	-0.2	0.1	0.2	-0.8	-0.2	1.1	-2.9
Allergy or Eczema	0.2	0.5	1.6	-0.3	-0.5	0.2	1.1	0.1	0.1	-1.0	0.1	0.1	-1.3	0.9
Cardiovascular Disease	0.6	1.9	5.2	1.2	0.3	1.5	-0.8	1.0	-1.6	0.1	-1.5	0.5	2.1	-2.3
Hypothyroidism (self reported)	1.2	2.7	9.1	-0.5	-0.2	0.9	3.0	0.6	2.1	-1.1	1.7	1.2	-2.0	2.1
Respiratory disease	0.8	1.7	6.3	-0.9	-1.4	-2.4	-0.5	-2.5	0.2	1.2	-0.3	-1.4	0.3	-0.1
Type 2 Diabetes (T2D) (2018)	1.7	3.1	10.3	1.1	1.1	1.0	-3.2	2.4	-1.1	-1.0	-2.8	0.2	1.5	-1.7
Lung FEV1/FVC ratio	0.1	0.5	2.2	-0.9	-0.2	0.0	0.1	-0.8	-1.5	0.4	0.5	0.9	-0.0	0.6
Lung FVC	0.5	2.4	11.3	-1.2	-0.4	-0.6	0.7	-1.2	2.1	0.8	3.4	-1.6	-1.2	1.2
Neuroticism	1.0	2.5	8.1	-2.8	0.1	-2.8	1.8	-1.1	0.0	0.9	1.4	0.8	-1.4	1.2
Chronotype (morning person)	0.3	0.6	1.6	1.3	0.2	0.8	-0.8	0.4	0.5	0.6	-0.2	-0.7	1.2	-0.8
Hair Pigment	0.0	1.0	1.8	1.1	0.7	0.8	-1.1	1.3	1.1	-0.3	-0.2	0.9	1.3	-1.3
Tanning	0.0	0.3	1.0	-0.7	0.4	-0.1	1.0	-0.6	-0.8	-0.3	-0.0	0.4	-1.0	-0.1
Hand grip strength (left)	0.5	1.3	3.0	-1.5	-1.7	-1.0	-1.6	-0.1	1.2	0.6	0.5	-0.9	0.9	1.2
Number of treatments/medications taken	0.9	1.6	6.0	1.2	-1.2	-0.6	-0.9	0.0	-2.2	0.7	-2.4	-0.9	1.0	-0.9
Average weekly spirits intake	1.0	1.2	4.3	0.5	1.0	1.5	0.7	1.4	-0.2	-2.1	-0.4	1.7	-0.7	0.2
Sensitivity / hurt feelings	1.3	2.2	7.1	-2.7	-0.0	-1.1	2.1	0.4	0.4	-0.1	1.9	1.6	-1.1	1.7
Frequency of depressed mood in last 2 weeks	0.7	1.0	3.9	-0.9	0.4	0.9	2.0	0.5	0.2	-0.3	1.2	1.3	-0.8	0.8
Hearing difficulty/problems: Yes	0.5	0.8	2.3	0.0	1.2	-0.8	1.5	0.3	-1.1	-1.1	0.5	1.1	-0.8	-0.0
Relative age of first facial hair	0.3	0.6	2.1	-0.2	-0.2	-0.3	-1.5	-0.3	0.6	1.0	-0.2	-0.9	0.8	-1.0
Other serious medical condition/disability diagnosed by doctor	2.2	2.8	5.8	2.2	0.5	-1.5	-1.6	-2.2	-0.3	2.3	0.1	-0.6	2.4	-2.2
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.4	-1.2	0.5	-1.2	1.0	-1.1	-0.5	-0.0	-0.5	1.2	-1.2	-0.2
Ever had hysterectomy (womb removed)	0.1	0.2	0.7	-0.1	0.4	-0.2	-0.6	0.1	-0.5	0.1	-0.9	-0.4	0.3	-0.2
Systolic blood pressure, automated reading	0.3	0.9	3.2	-0.9	-1.0	1.5	1.8	0.4	0.3	-0.3	0.4	0.5	-0.5	1.1
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	3.8	-0.2	-0.3	0.5	-1.2	1.3	-1.4	-1.0	-2.0	-1.0	0.2	-0.4
Angina	0.6	0.7	2.9	-0.3	1.0	-0.7	0.0	-0.1	-1.7	-0.7	-1.7	0.1	-0.6	-0.2
Medication for hormone replacement therapy	0.9	1.0	3.4	-0.0	1.8	0.8	0.3	1.2	0.9	-1.2	0.4	1.6	-0.9	-0.2
Vitamin and mineral supplements	0.8	1.1	3.1	0.6	-0.9	-1.0	-1.4	-1.5	-0.3	1.8	-1.1	-1.1	0.9	0.1
Supplements: Zinc	0.2	0.3	1.2	-0.5	0.7	-0.4	-0.4	-0.3	0.6	0.0	1.1	-0.3	-0.1	-0.0
Medication: Co-codamol	2.0	2.4	9.4	1.0	1.2	0.3	-1.5	-0.3	-3.1	0.9	-1.4	-0.1	2.0	-2.2
Medication: Metformin	2.7	3.8	12.2	1.4	-0.2	-1.1	-3.5	0.1	-1.8	1.8	-2.3	-0.9	3.0	-2.2
Diabetes (father)	1.0	1.2	4.0	0.3	-1.6	0.3	-2.0	-0.5	-1.8	1.1	-1.1	-0.3	0.7	0.2
Diabetes (mother)	0.9	1.1	3.8	1.1	-1.1	0.8	-1.9	0.7	-0.5	-0.3	-1.5	-0.6	1.4	-0.6
Severe depression (siblings)	1.0	1.1	4.0	-0.9	0.5	-0.8	2.0	-0.6	0.6	-0.7	1.1	0.9	-1.6	0.8
Pack years adult smoking proportion	0.4	0.7	2.1	-0.4	1.0	0.6	-0.4	1.4	0.7	-0.5	0.2	1.1	0.3	-1.2
Impedance of leg (right)	2.3	11.3	27.2	-4.6	-1.4	0.5	5.0	-0.5	-0.2	-1.9	2.3	3.4	-5.2	5.2
Leg fat-free mass (left)	1.5	7.8	25.1	2.8	1.7	-0.3	-4.6	0.4	0.1	2.5	-0.9	-1.1	5.0	-4.5
Trunk fat percentage	0.2	0.7	1.8	-0.7	-0.0	-0.3	-1.1	-0.6	1.2	1.3	0.5	-0.1	1.3	-0.2
Hand grip strength (right)	0.3	0.7	2.1	-0.6	-1.4	-0.5	-1.1	0.3	1.3	0.4	0.4	-0.5	0.6	1.1
Townsend deprivation index at recruitment	0.4	0.6	1.5	0.4	1.0	0.8	1.2	-0.4	-0.9	-0.8	-0.3	1.1	-0.6	-0.2
Current tobacco smoking	0.8	1.3	6.7	0.4	2.6	0.8	-0.4	0.9	0.2	-1.5	-0.9	0.7	-0.4	-1.3
Average weekly fortified wine intake	1.0	1.2	3.2	-1.1	-1.3	-1.8	0.3	-0.7	0.6	0.1	1.2	-1.0	-1.3	1.4
Maternal smoking around birth	0.2	0.3	0.7	-0.3	0.9	0.5	0.5	-0.3	0.7	-0.4	-0.1	-0.6	-0.1	-0.6
Fed-up feelings	0.8	1.5	4.5	-1.8	0.7	-0.5	2.1	0.5	0.6	-1.1	1.4	0.6	-1.4	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.2	-1.4	0.2	0.4	1.5	-0.1	0.8	-0.6	0.7	0.9	-0.9	1.0
Relative age voice broke	1.2	1.9	3.8	1.9	1.6	1.2	-1.8	0.8	0.3	-0.4	-1.7	-0.3	1.4	-1.9
Taking other prescription medications	0.3	0.4	2.6	0.1	-0.3	0.1	-0.6	-0.1	-1.6	-0.2	-1.1	0.2	0.0	0.2
Age when periods started (menarche)	0.3	0.7	1.8	1.0	0.1	-0.1	-1.3	0.1	0.1	0.1	-1.3	-0.7	1.2	-1.3
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	2.3	-1.5	0.9	1.4	1.0	1.5	-0.3	-1.5	0.1	1.5	-1.1	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	8.9	-1.1	1.1	-1.0	-1.8	-0.4	2.2	0.2	0.6	-3.0	0.4	-1.0
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	5.0	1.1	-0.9	-2.2	-0.6	-1.4	0.2	1.1	-0.5	-1.0	0.5	-0.8
Qualifications: CSEs or equivalent	0.7	0.9	2.4	-0.6	-0.4	1.3	0.6	0.5	0.5	-1.1	0.7	1.5	-1.0	1.2
Serious illness, injury or assault to yourself	1.0	1.3	3.6	1.2	-0.0	-0.4	-0.8	-0.5	-1.7	1.3	-1.1	-0.2	1.9	-1.4
High blood pressure	0.4	1.1	3.8	0.7	-0.4	0.3	0.2	0.8	-2.0	-0.1	-1.9	0.3	0.9	-1.4
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.4	0.2	-0.5	0.8	0.9	0.7	0.7	-1.1	-0.1	0.5	-1.2	0.8
Multivitamins +/- minerals	0.9	1.2	2.8	-0.3	1.2	1.5	1.4	1.1	-0.6	-1.7	0.7	1.0	-1.2	-0.1
Stomach or abdominal pain in last month	0.5	0.6	1.7	-0.1	-0.6	0.0	0.7	-1.1	0.2	-0.3	1.3	0.9	-0.7	1.3
Supplements: Glucosamine	1.8	2.4	8.5	-1.6	0.1	0.1	2.0	1.0	1.6	-0.9	2.9	1.4	-1.3	1.7
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	3.9	-0.4	0.9	0.8	1.6	0.6	-0.6	-1.2	0.8	2.0	-1.3	0.5
Medication: Atenolol	0.6	0.7	2.4	-0.6	-0.8	-1.1	-0.3	-1.0	-1.6	1.1	-0.5	0.2	0.3	0.6
Medication: Levothyroxine sodium	0.9	1.6	4.5	-0.3	0.9	1.0	2.1	0.7	2.0	-1.1	1.1	1.1	-1.3	1.1
Sitting height	0.1	0.5	1.7	-0.6	0.2	-1.1	-1.3	-0.2	-1.2	-0.2	0.3	0.3	0.2	-0.0
Chronic bronchitis/emphysema (father)	0.9	1.0	4.2	-0.2	0.6	2.0	0.4	1.0	0.2	-1.3	0.2	1.5	-1.0	0.8
High blood pressure (mother)	0.8	1.2	3.8	-0.5	-2.0	-0.7	1.5	-0.9	-0.1	0.1	0.3	-0.6	-1.4	1.7
Body mass index (BMI)	0.8	3.5	11.9	1.8	1.3	0.6	-2.8	0.6	0.9	1.5	-0.8	-1.0	3.5	-3.0
Impedance of leg (left)	2.4	11.5	29.9	-4.0	-1.5	0.6	5.2	-0.4	0.2	-2.5	2.1	3.3	-5.5	5.4
Leg predicted mass (left)	1.5	7.8	25.0	2.8	1.7	-0.2	-4.6	0.4	0.1	2.5	-0.8	-1.0	5.0	-4.5
Trunk fat mass	0.4	1.8	7.3	0.5	0.5	-0.2	-2.4	-0.1	0.7	1.7	-0.2	-0.1	2.7	-1.7
Waist circumference	0.6	2.2	9.4	0.8	0.6	-0.1	-2.1	0.5	0.9	1.8	0.1	0.3	3.1	-2.3
Number of incorrect matches in round	0.6	0.9	3.3	0.1	-0.8	-1.8	1.3	-0.3	0.9	0.0	1.0	-0.7	-1.2	0.9
Past tobacco smoking	1.6	3.0	12.6	-1.1	-2.9	0.0	1.4	-0.9	1.0	0.4	2.2	0.4	-1.5	3.5
Alcohol usually taken with meals	0.8	1.3	5.9	1.1	-2.4	-0.7	-0.0	-0.7	-1.2	1.4	0.6	0.9	1.0	0.6
Nervous feelings	1.3	2.4	7.5	-2.3	-1.1	-2.7	2.0	-1.1	-1.4	0.3	0.3	0.4	-1.4	1.7
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	6.9	-0.1	1.1	0.5	2.6	1.0	1.0	-1.5	2.0	2.2	-1.6	1.2
Hearing difficulty/problems with background noise	0.8	1.2	3.0	-1.3	1.4	-1.5	1.0	-0.6	-0.9	-0.3	1.2	1.7	-0.8	-0.0
Hair/balding pattern: Pattern 2	6.5	8.2	19.3	-3.3	-0.5	-0.3	4.4	-1.4	0.0	-0.9	4.3	2.4	-4.1	4.0
Had menopause	1.6	2.1	9.2	-1.2	-1.2	-3.0	0.8	-1.4	1.9	0.3	0.4	-1.2	-1.0	1.4
Had other major operations	0.3	0.3	1.5	0.7	0.6	0.2	-0.0	-0.3	0.2	0.6	-0.0	-0.3	0.8	-1.2
Forced vital capacity (FVC)	0.5	1.8	4.3	-1.2	-0.9	-1.5	-1.1	-1.0	1.8	1.7	2.1	-1.4	0.8	0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.4	11.3	-1.1	0.6	-1.0	-2.2	-1.0	2.3	0.7	0.3	-3.4	0.6	-0.8
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.8	-0.4	-0.6	-0.1	-0.2	0.9	0.4	-0.0	-0.1	0.2	0.4	0.4
Qualifications: None of the above	0.2	0.5	1.1	0.8	0.8	1.0	0.0	0.8	0.9	-1.1	-0.0	0.7	-0.1	-0.5
Financial difficulties in last 2 years	0.3	0.4	1.4	-0.1	0.5	-0.4	0.8	-1.2	0.5	0.2	0.9	0.8	-0.4	-0.5
Mouth/teeth dental problems	1.1	1.6	4.1	0.3	1.3	0.4	-0.6	1.7	1.7	-2.0	-0.6	-1.9	-1.2	0.5
Heart attack	1.1	1.5	4.1	0.4	-1.0	-0.2	-1.5	-0.5	-0.7	1.4	-2.0	-1.2	1.9	-0.8
Allergy	0.2	0.4	2.3	-0.2	0.5	0.4	-0.4	0.9	-1.5	-0.2	0.1	0.6	0.4	0.1
Pain all over the body in last month	0.5	0.5	1.8	0.0	1.3	1.0	0.4	-0.0	-0.2	-0.2	0.1	0.7	0.7	-1.3
Diabetes (self-reported)	1.3	2.0	6.6	1.4	0.4	-0.0	-2.3	1.1	-0.1	-0.1	-2.6	-1.0	1.6	-1.7
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	2.1	1.1	-1.1	-0.6	0.2	-0.9	-0.1	0.2	-0.6	-1.4	-0.4	-0.2
Medication: Ramipril	0.9	1.2	6.1	0.4	-0.5	-0.8	-0.6	-0.3	-2.2	-0.2	-2.5	-0.1	-0.3	0.1
Medication: Simvastatin	0.9	1.3	3.9	-0.5	-0.7	-1.3	-0.6	-2.0	-2.0	1.7	-0.7	0.5	0.2	-0.4
Fluid intelligence score	0.4	0.9	3.6	0.0	0.4	1.2	0.6	1.0	-1.9	-1.0	-1.2	0.2	-1.0	0.2
Illnesses of siblings	0.4	0.5	1.8	-0.5	-1.3	0.4	0.6	0.8	0.5	-0.6	-0.4	0.2	-0.6	1.3
Neuroticism score	1.2	2.4	7.3	-2.7	0.7	-2.0	2.3	-0.1	0.8	-0.3	1.8	1.0	-1.6	1.4
Weight	0.9	4.6	17.7	1.8	1.1	-0.1	-3.5	0.4	0.3	2.2	-0.5	-0.2	4.2	-3.3
Impedance of arm (right)	1.1	5.0	12.6	-3.4	-1.5	-0.9	3.1	-1.7	-0.9	-0.3	1.7	1.4	-3.0	3.5
Arm fat percentage (right)	0.4	1.5	6.0	0.7	1.1	0.3	-1.9	0.1	0.2	1.1	-0.5	-0.6	2.5	-1.9
Trunk fat-free mass	1.0	5.7	16.6	2.7	1.8	0.3	-3.5	1.8	-1.4	1.1	-1.0	0.5	4.1	-3.9
Hip circumference	0.5	2.4	7.7	1.0	-0.1	-1.0	-2.6	-0.4	0.9	2.2	-0.2	-1.2	2.8	-1.5
Time employed in main current job	1.9	2.1	8.4	0.1	-2.0	-2.9	-1.2	-1.4	-1.1	1.4	-0.8	-1.9	0.7	-0.3
Alcohol intake versus 10 years previously	0.5	0.8	1.6	-0.9	0.9	0.4	1.2	-0.7	-0.7	-1.3	0.7	-0.4	-1.2	0.6
Father’s age at death	1.4	1.9	5.5	-0.5	-1.7	-1.5	-1.6	-1.2	1.4	1.9	0.1	-2.3	0.9	0.0
Worrier / anxious feelings	0.2	0.3	0.8	-0.4	0.5	-0.7	0.7	0.8	-0.2	-0.9	-0.8	-0.1	-0.4	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.5	-1.6	-0.2	-1.1	0.8	-0.9	0.6	1.0	1.5	0.5	-1.1	1.3
Falls in the last year	2.0	2.7	8.4	2.4	2.1	1.6	-0.7	0.6	0.0	0.9	-0.6	-0.8	2.4	-2.9
Hair/balding pattern: Pattern 3	1.7	2.6	6.1	2.1	1.8	1.6	-1.4	1.9	-0.3	-0.4	-1.3	0.7	2.0	-2.5
Number of live births	0.8	1.1	4.6	2.1	1.0	0.8	-0.6	0.3	0.1	-0.2	-0.8	0.6	1.1	-1.9
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	4.1	-1.8	-1.3	-1.6	-0.9	-1.3	1.1	1.9	2.0	-1.2	0.4	1.1
Pulse rate	0.6	1.0	4.7	0.7	-0.0	1.1	-0.3	-0.1	-2.2	0.8	0.7	1.5	0.9	-0.4
Happiness	0.2	0.2	0.6	0.2	-0.2	-0.1	-0.6	0.4	-0.4	0.0	-0.8	0.5	0.7	-0.3
Noisy workplace	0.6	0.8	2.9	0.6	0.9	0.5	-0.6	0.2	-0.6	0.8	-0.2	0.4	1.7	-1.7
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.9	0.4	0.7	0.1	1.0	0.5	-1.3	-0.7	1.4	0.7	-0.6	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.3	-0.1	-1.1	-1.4	-0.2	-1.3	0.2	0.9	0.2	-1.5	-0.5	0.4
Mouth/teeth dental problems: Dentures	0.9	1.5	6.9	-0.2	0.2	-0.3	-0.6	-0.4	-2.6	1.4	0.2	1.6	1.7	-1.0
Asthma	0.4	0.7	2.8	-1.0	-0.2	-1.7	-0.0	-1.6	0.2	0.2	-0.5	-0.9	-0.5	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.7	0.4	-1.3	-0.4	-0.2	-0.7	-0.1	1.2	0.1	-1.0	-0.2	0.5
Medication: Cholesterol lowering	1.5	2.3	7.8	0.6	-0.7	-1.2	-1.5	-1.4	-2.4	1.7	-2.8	-0.7	1.0	-1.2
Depression (self-reported)	1.3	1.6	4.3	-0.3	0.9	0.6	2.1	1.3	-0.5	-1.9	0.4	1.7	-1.2	1.5
Medication: Lansoprazole	0.3	0.4	1.1	-0.1	-0.2	0.6	-0.5	0.6	-1.0	-0.2	-1.0	0.5	0.3	-0.6
Prospective memory result	1.8	2.3	7.5	1.5	-0.3	0.1	-2.7	0.5	0.0	1.2	-2.0	-0.7	2.3	-1.9
Lung cancer (father)	1.2	1.4	7.0	-0.9	1.0	0.0	1.3	0.6	-0.3	-0.5	1.9	2.6	-0.5	0.3
Illnesses of mother	1.6	2.0	11.1	-0.9	3.3	1.2	0.3	0.6	-0.9	-1.1	0.7	2.3	-0.5	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	6.5	-1.0	-0.9	-1.0	-1.0	-1.0	1.2	1.6	2.6	-1.4	0.3	0.8
Pulse wave Arterial Stiffness index	1.3	1.6	4.4	0.7	-1.4	-2.1	-0.8	-0.6	-1.4	1.9	-0.4	-1.0	1.3	-0.9
Impedance of arm (left)	1.2	5.3	15.1	-3.5	-1.9	-1.0	2.9	-1.9	0.2	-0.1	2.0	1.1	-3.1	3.9
Arm fat mass (right)	0.8	3.1	11.3	1.4	1.5	0.1	-2.8	0.3	0.4	1.5	-0.6	-0.4	3.4	-2.9
Trunk predicted mass	1.0	5.8	16.9	2.8	1.8	0.4	-3.5	1.8	-1.6	1.1	-0.9	0.6	4.1	-4.0
Standing height	0.2	1.8	4.0	0.0	-0.2	-1.5	-1.6	-0.4	-1.6	1.8	0.7	1.9	2.0	-1.1
Length of working week for main job	1.0	1.1	3.4	-0.9	1.9	1.1	-0.1	1.2	1.1	0.1	0.4	1.5	0.6	-1.2
Exposure to tobacco smoke at home	2.2	2.5	9.5	0.8	0.1	0.4	-2.1	0.3	-0.8	1.5	-1.9	-0.8	3.1	-2.4
Breastfed as a baby	0.6	0.7	1.9	0.9	-1.3	-0.2	0.5	-0.7	-1.2	1.4	0.2	-0.3	1.2	-0.4
Tense / ‘highly strung’	0.3	0.6	2.4	-0.4	0.2	-1.6	1.1	0.4	-0.3	-0.5	0.5	1.0	-0.6	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.5	-1.2	1.0	-0.3	1.3	0.8	-1.6	-0.5	-0.1	1.0	-0.4	0.2
Hair/balding pattern: Pattern 4	0.4	1.0	3.0	-0.1	-1.7	0.0	-1.1	0.0	-0.5	0.8	-1.5	-1.7	0.4	0.3
Birth weight of first child	1.3	2.3	4.6	0.5	0.5	-2.1	-1.7	-1.6	-1.0	2.1	0.1	-1.4	2.0	-1.9
Peak expiratory flow (PEF)	0.2	0.4	1.0	-0.5	0.4	-1.0	-0.7	-0.2	0.1	0.7	1.0	-0.3	0.7	-0.7
Pulse wave reflection index	2.0	2.4	6.6	-2.2	-0.8	-2.4	1.9	-0.6	-0.2	0.5	2.6	-0.1	-1.5	1.3
Ever highly irritable/argumentative for 2 days	1.2	1.4	4.9	-1.0	0.4	0.7	1.1	1.6	-1.4	-1.2	0.8	2.2	-0.7	0.9
Loud music exposure frequency	0.4	0.5	2.7	0.5	0.9	1.6	-0.1	0.2	0.9	-0.0	0.8	0.0	0.2	-0.0
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.6	0.5	-0.5	-1.0	-0.6	-0.5	-1.3	0.7	-0.6	0.1	0.3	-0.6
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	5.1	-1.7	0.3	0.7	2.2	0.2	-0.3	-1.5	0.9	2.0	-1.4	0.6
Blood clot in the leg (DVT)	0.4	0.5	1.7	1.0	0.4	0.5	-0.5	-0.1	0.3	1.2	0.2	-0.3	1.3	-1.0
Medication: Paracetamol	0.5	0.8	3.7	-0.7	-1.1	-1.9	0.0	-1.1	0.3	1.0	0.2	-0.6	-0.2	0.7
Headache pain in last month	1.2	2.1	5.4	-1.4	-1.5	-0.0	2.3	-1.3	0.0	1.0	1.7	1.1	-1.3	2.1
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	5.5	-0.6	-0.0	0.4	0.6	0.7	2.4	-0.9	1.7	-0.7	-0.8	1.2
Glaucoma (self-reported)	0.3	0.4	1.1	0.1	-0.2	-0.6	0.5	-0.8	-1.0	0.4	0.9	0.7	-0.6	-0.1
Gout (self-reported)	0.5	0.7	3.0	-0.1	1.0	0.7	-0.4	0.9	-0.5	-0.3	0.4	1.7	1.0	-0.7
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	4.1	-0.1	-0.2	0.4	2.0	-0.0	2.0	-0.6	1.2	1.0	-1.4	1.7
Medication: Amlodipine	0.3	0.4	1.0	0.8	0.5	1.0	0.2	0.4	-0.4	0.1	-0.2	0.9	0.8	-0.8
Medication: Ventolin 100micrograms inhaler	0.5	0.6	2.5	0.1	-1.6	-1.6	0.1	-0.9	0.4	0.7	-0.4	-0.3	0.4	0.0
Birth weight	0.6	1.3	4.1	-1.0	-1.0	-0.6	1.3	-0.9	1.6	0.8	2.0	0.1	-0.9	1.0
Chronic bronchitis/emphysema (mother)	1.0	1.2	3.0	-1.7	-1.2	-1.6	0.8	-1.2	1.0	1.1	0.7	0.3	-0.6	1.1
High blood pressure (siblings)	0.2	0.3	1.2	0.6	1.1	0.3	-0.0	-0.3	-0.6	0.1	1.0	-0.3	0.2	-0.7
Forced vital capacity (FVC), Best measure	0.3	1.3	5.0	-0.7	-0.5	-0.9	-0.9	-0.7	1.5	1.4	2.2	-1.3	0.5	0.2
Body fat percentage	0.2	0.6	2.0	-0.4	0.2	0.1	-1.1	-0.4	1.2	1.2	0.2	-0.1	1.4	-0.5
Leg fat percentage (right)	0.1	0.4	0.8	-0.4	0.7	0.7	-0.2	0.3	0.9	0.5	0.3	0.8	0.9	-0.4
Arm fat-free mass (right)	1.0	5.2	15.7	2.7	1.7	0.3	-3.7	1.4	0.3	1.3	-0.7	0.0	4.0	-3.7
Exposure to tobacco smoke outside home	0.7	0.9	3.2	-1.3	0.6	-0.9	0.7	-1.2	-0.8	0.8	1.8	0.8	-0.1	0.4
Comparative body size at age 10	1.0	2.7	6.0	1.8	2.5	2.0	1.2	1.4	1.4	-0.8	2.3	2.2	0.1	-0.2
Number of full brothers	0.6	0.7	3.5	1.1	1.9	0.5	0.5	0.0	1.0	-0.6	0.6	-0.4	-0.3	-0.8
Worry too long after embarrassment	1.0	1.6	4.9	-1.2	0.1	-1.0	2.1	-0.5	-0.1	-0.8	2.2	1.0	-1.9	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.2	0.1	0.2	-0.7	0.4	-0.4	-1.1	1.0	0.5	-0.3	0.5	0.2
Wheeze or whistling in the chest in last year	0.4	0.6	3.2	0.6	1.4	-0.3	-0.1	-0.5	0.6	-0.4	-0.3	0.5	0.3	-1.8
Number of children fathered	1.9	2.1	7.5	-2.2	0.2	0.4	1.1	0.5	2.7	-0.8	2.2	-0.2	-1.5	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	2.1	0.6	0.3	-0.5	-0.1	-0.0	0.6	-0.3	-0.6	-0.4	0.8	-1.5
Age at first live birth	1.5	2.6	6.5	-1.0	-0.2	1.3	1.7	1.7	0.7	-2.0	1.5	0.7	-2.5	2.6
Pulse wave peak to peak time	1.5	1.7	4.0	-0.7	1.6	2.0	1.0	0.6	1.4	-1.9	0.7	1.2	-1.4	1.0
Health satisfaction	0.3	0.3	0.9	-0.8	0.1	0.6	0.3	0.4	0.9	0.3	1.0	0.7	0.4	0.5
Shortness of breath walking on level ground	1.5	1.7	5.4	-1.1	-0.5	-2.0	-0.9	-1.4	1.6	2.3	0.9	-0.2	1.2	-0.7
Qualifications: College or University degree	0.5	1.5	3.6	0.9	0.9	-1.1	-0.6	-0.3	-1.8	0.9	-1.0	-1.3	1.6	-1.9
Eye problems/disorders: None of the above	0.5	0.6	2.7	-0.1	1.2	0.8	0.8	0.0	1.7	-0.7	0.8	0.4	-0.3	-0.3
Mouth/teeth dental problems: Loose teeth	1.8	2.1	7.2	0.6	-0.4	-0.7	-1.8	-0.6	-0.4	1.8	-1.0	-0.0	2.7	-2.6
Emphysema/chronic bronchitis	0.2	0.2	1.0	0.2	-0.2	0.8	0.6	-0.6	0.2	0.2	1.0	0.0	0.1	0.3
Medication for pain relief, constipation, heartburn	0.8	1.4	4.5	0.1	2.1	1.7	0.5	1.1	0.5	-1.8	0.7	1.3	-0.2	-0.9
Neck or shoulder pain in last month	1.0	1.4	3.4	-1.8	0.4	-0.7	0.9	0.5	-1.4	-1.5	-0.4	1.5	-1.8	0.6
Medication: Blood pressure	0.5	0.9	4.5	0.6	-0.3	-0.3	0.1	-0.5	-2.1	0.6	-1.7	0.5	0.4	-0.9
Angina (self-reported)	0.6	0.8	3.0	-0.4	1.1	-0.6	-0.1	0.2	-1.7	-0.9	-1.7	0.2	-0.6	-0.2
Migraine (self-reported)	1.7	2.1	7.6	-2.8	-1.2	-1.7	1.1	-0.8	0.0	0.5	1.4	0.9	-1.0	2.2
Medication: Ibuprofen	0.4	0.5	1.8	0.4	-0.7	-0.4	0.4	-0.9	-0.1	1.3	1.0	-1.0	-0.2	0.2
Medication: Allopurinol	0.6	0.8	2.3	0.2	1.2	1.0	-0.8	0.9	-0.4	-0.3	-0.3	1.5	1.0	-1.3
Medication: Omeprazole	2.1	2.5	6.2	1.8	-0.0	-0.2	-2.3	-1.1	-0.6	0.8	-2.5	-2.0	1.9	-1.7
Medication: Seretide 50 evohaler	1.8	2.0	5.3	1.0	-1.3	-2.1	-1.5	-0.6	-0.6	1.2	-1.6	-2.3	1.4	-1.1
Mean time to correctly identify matches	0.7	1.4	5.1	-0.3	-1.9	-0.7	0.8	-0.9	-2.3	1.5	-0.6	0.8	-0.0	1.1
Heart disease (mother)	0.2	0.3	1.6	0.1	-0.2	-0.2	-0.3	1.3	0.6	-0.3	0.2	-0.2	0.4	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	3.7	-1.5	-0.4	-1.9	1.1	-1.3	1.0	-0.3	0.5	-0.3	-1.9	1.1
Whole body fat mass	0.6	2.4	8.8	0.9	1.1	-0.1	-2.5	0.1	0.9	1.6	-0.3	-0.1	3.0	-2.3
Leg fat mass (right)	0.6	2.2	7.4	0.9	1.4	0.7	-2.3	0.5	0.9	1.2	-0.6	0.2	2.7	-2.3
Arm predicted mass (right)	1.0	4.9	14.7	2.7	1.5	0.0	-3.6	1.2	0.2	1.3	-0.9	-0.1	3.8	-3.5
Pulse rate, automated reading	0.1	0.4	1.0	0.7	-0.5	0.9	-1.0	0.6	0.6	-0.2	0.3	0.7	0.2	0.2
Alcohol intake frequency.	0.1	0.2	0.4	0.3	0.5	-0.1	-0.5	-0.4	-0.1	0.5	0.6	-0.0	0.5	-0.3
Comparative height size at age 10	0.2	1.2	4.8	-0.8	-1.0	-0.2	0.2	0.4	-1.1	0.4	2.0	2.2	0.1	1.0
Number of full sisters	0.8	0.9	2.1	-0.7	-0.5	-1.0	1.2	-1.3	0.5	-0.3	1.0	-0.7	-1.4	1.3
Suffer from ‘nerves’	1.0	1.6	3.2	-1.2	0.2	0.7	1.5	1.7	-1.8	-1.5	0.1	1.6	-1.1	1.0
Overall health rating	0.2	0.5	1.4	-1.1	0.5	-0.3	-0.1	-0.6	-0.8	1.2	0.6	0.9	0.4	-0.2
Chest pain or discomfort	1.4	2.1	6.7	-0.5	0.5	-0.3	2.6	-0.7	0.9	-2.1	0.3	0.9	-2.6	1.6
Had major operations	0.6	0.7	3.2	-0.3	1.8	-1.2	0.2	0.1	0.8	-0.9	0.6	-0.0	-0.9	-0.5
Age at last live birth	0.7	1.1	2.8	-0.1	-0.5	1.0	1.7	0.7	-0.9	-0.7	0.8	1.1	-1.2	1.6
Family relationship satisfaction	1.3	1.6	4.5	0.4	-0.9	-1.1	-1.7	-0.5	0.5	1.1	-1.9	-2.1	1.3	-1.0
Leg pain on walking	1.2	1.5	8.0	-0.0	-0.6	-2.8	-0.7	-0.9	1.4	1.7	0.7	-0.6	0.8	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.2	-1.1	0.3	1.0	-0.5	0.2	0.8	-0.4	-0.8	-0.8	-0.1	-0.5
Commuting to job workplace: Car/motor vehicle	1.7	1.9	9.7	-3.1	-0.3	0.5	0.7	0.6	0.4	-0.6	1.4	1.9	-1.3	1.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.2	0.2	0.5	0.2	-0.3	1.5	0.0	-1.0	-0.8	-0.8	0.4	-0.7
Medication: Aspirin	0.2	0.3	1.7	-0.1	-0.0	0.8	-0.1	0.7	-1.3	0.2	-0.2	0.5	0.2	0.2
Supplements: Vitamin C	1.0	1.2	3.1	0.3	0.4	1.1	-0.9	1.8	1.5	-1.3	-0.5	-1.4	0.4	-1.1
Knee pain experienced in last month	1.7	2.6	6.8	1.5	0.2	-1.6	-2.5	-0.3	0.5	0.3	-2.0	-2.6	1.2	-2.1
Hypertension (Self-reported)	0.4	1.0	4.7	0.6	-0.1	0.3	0.6	0.6	-2.2	0.0	-1.5	0.7	0.9	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	6.2	0.5	0.1	0.4	-1.3	-0.2	-2.1	-0.5	-2.5	-0.2	0.4	-0.9
Illnesses of father: Heart disease	0.8	1.1	3.8	0.0	-1.3	-0.7	0.9	-0.6	2.0	0.9	1.6	0.7	-0.3	0.7
Illnesses of siblings: Diabetes	0.3	0.4	1.5	0.7	0.2	0.0	-0.1	-0.0	-0.7	0.6	-0.1	0.4	1.2	-1.1
Smoking status: Previous	0.7	1.0	3.9	-0.1	1.4	-0.4	-0.4	0.4	-1.3	-0.0	-1.2	0.1	1.0	-2.0
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	3.0	0.5	1.6	1.3	-0.8	0.4	-0.0	1.3	0.8	1.2	1.7	-1.2
Whole body fat-free mass	1.2	6.7	21.4	2.9	1.7	0.1	-4.1	1.2	-0.8	1.7	-1.1	-0.2	4.6	-4.2
Leg fat-free mass (right)	1.5	8.1	25.1	3.1	1.7	-0.2	-4.7	0.6	0.3	2.2	-1.0	-1.2	5.0	-4.6
Arm fat percentage (left)	0.4	1.7	6.1	0.7	1.0	0.4	-2.1	0.0	0.8	1.3	-0.4	-0.6	2.5	-1.8
Average weekly red wine intake	0.7	1.0	2.2	-1.1	0.0	1.0	1.4	1.4	0.6	-0.9	0.6	1.2	-1.5	0.6
Handedness (chirality/laterality): Left-handed	1.0	1.2	4.3	-0.3	-2.1	-1.6	0.1	-1.5	-0.5	1.1	0.5	-0.1	-0.0	1.6
Mood swings	0.8	1.4	5.0	-0.8	1.5	-0.8	1.8	-0.4	0.6	0.9	2.2	1.4	-0.1	-0.6
Loneliness, isolation	0.5	0.7	2.5	-1.6	-0.4	-0.6	1.4	-0.0	1.2	0.4	0.3	-0.0	-0.6	1.0
Long-standing illness, disability or infirmity	1.2	1.8	4.7	0.3	0.7	-2.1	-0.7	-1.9	-0.8	2.2	0.5	0.7	1.5	-1.5
Ever had bowel cancer screening	0.6	0.7	1.7	-1.2	-0.4	-0.6	1.2	-0.1	0.2	-0.3	1.3	0.2	-1.1	1.3
Diabetes diagnosed by doctor	1.5	2.5	7.8	1.2	1.0	0.3	-2.8	1.5	-0.1	-0.5	-2.6	-0.6	1.7	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	2.0	0.2	0.7	-0.6	-0.8	0.6	0.3	0.5	-0.2	0.2	0.8	-1.4
Friendships satisfaction	0.6	0.7	1.9	0.1	-1.4	-1.0	-0.6	-0.9	1.0	0.6	-0.8	-1.2	0.3	0.3
Qualifications: nursing, teaching	0.9	1.4	6.8	-1.1	-1.4	-1.0	0.9	-0.8	-0.6	-0.4	1.2	0.0	-1.2	2.6
Commuting to job workplace: Walk	0.3	0.3	1.7	-0.3	0.3	-0.2	-0.2	-0.3	-0.6	-0.2	-1.3	-0.8	-0.1	-0.9
Eye problems/disorders: Cataract	0.9	1.0	2.8	0.8	-1.0	-1.0	-1.7	0.2	-0.6	1.2	-0.5	-0.4	1.7	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.8	1.4	-0.2	1.1	0.8	-0.1	0.3	0.2	-0.1	-0.2	0.1	-0.7
Medication for cholesterol	0.3	0.5	1.6	0.3	-0.2	-0.9	-0.1	-1.3	-0.4	0.6	0.7	-1.2	-0.2	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.7	-0.7	-0.2	-1.6	0.7	-0.6	0.4	1.0	1.0	-0.7	-0.2	0.7
Back pain experienced in last month	0.8	1.1	4.9	-0.8	0.4	-0.6	0.6	-0.7	2.2	-1.3	0.1	-0.4	-1.6	0.9
Mineral and other dietary supplements	1.4	1.8	4.3	1.5	0.7	0.1	-2.1	-0.9	-1.1	1.2	-1.8	-0.7	1.5	-1.9
Breast cancer (self-reported)	1.0	1.2	5.5	-1.8	0.3	-0.1	0.9	-0.1	0.4	0.4	2.3	1.6	-0.6	0.4
Asthma (self-reported)	0.3	0.7	3.0	-0.9	-0.3	-1.7	0.1	-1.5	0.0	0.1	-0.4	-0.9	-0.6	-0.2
Osteoporosis (self-reported)	0.6	0.8	3.4	-0.4	0.6	-0.4	1.5	-0.9	0.7	0.5	1.8	0.3	-0.4	0.8
Osteoarthritis (self-reported)	0.9	1.2	3.1	1.2	0.6	0.7	-1.4	1.8	-0.5	-0.5	-1.3	-0.6	1.0	-1.5
Medication: Aspirin	0.3	0.3	1.9	-0.0	-0.4	0.5	-0.6	0.3	-1.4	0.7	-0.5	0.2	0.6	0.1
Medication: Gliclazide	0.9	1.0	3.3	0.7	0.8	-0.7	-1.8	0.3	-0.9	0.6	-0.6	0.4	1.6	-1.2
Illnesses of father: None of the above (group 1)	0.9	1.1	5.1	1.1	0.3	-1.0	-0.7	0.6	-2.2	-0.9	-1.1	-0.8	0.9	-1.0
Smoking status: Current	0.9	1.4	6.2	0.7	2.5	1.0	-0.8	0.8	0.6	-1.3	-1.2	0.3	-0.2	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	3.9	-1.4	-2.0	-1.0	-0.7	-1.0	0.2	0.8	1.5	-1.5	-0.2	1.5
Whole body water mass	1.2	6.8	21.7	3.0	1.8	0.2	-4.1	1.3	-0.7	1.7	-1.1	-0.1	4.7	-4.3
Leg predicted mass (right)	1.5	8.2	25.4	3.2	1.8	-0.1	-4.7	0.7	0.4	2.2	-1.1	-1.2	5.0	-4.6
Arm fat mass (left)	0.7	3.0	10.9	1.2	1.4	0.3	-2.8	0.4	0.6	1.5	-0.5	-0.2	3.3	-2.6
Number of self-reported non-cancer illnesses	0.8	1.4	5.3	0.5	0.4	-0.1	-1.1	-0.7	-2.3	0.5	-2.0	-0.4	0.9	-1.8
Average weekly champagne plus white wine intake	0.5	0.7	2.4	1.4	0.8	-0.6	-0.4	0.6	1.2	-0.0	-0.1	-0.3	0.8	-1.6
Miserableness	0.7	1.2	2.8	-1.7	1.1	-1.5	1.2	-1.2	0.4	0.7	1.6	0.8	-0.7	0.4
Guilty feelings	1.3	1.9	7.7	-1.2	0.6	-0.7	2.8	0.2	0.3	-0.2	2.1	0.8	-1.9	1.5
Wears glasses or contact lenses	1.0	1.1	4.5	-2.1	-1.2	-1.1	0.2	0.5	-1.4	-0.2	0.4	0.0	-0.7	1.5
Ever taken oral contraceptive pill	0.4	0.4	1.5	0.4	-0.0	0.3	-0.9	-0.2	1.2	0.3	-0.5	-0.2	0.9	-0.7
Hearing aid user	1.7	2.0	6.2	0.6	2.0	1.9	0.7	1.9	0.1	-2.5	0.1	1.2	-1.3	-0.4
Mother’s age at death	1.2	1.5	3.9	-0.6	-2.0	-1.9	0.5	-1.4	1.3	0.7	0.0	-1.9	-0.6	0.8
Financial situation satisfaction	0.4	0.5	2.6	0.6	-0.1	0.5	-0.3	-0.1	-1.6	0.8	0.4	1.0	0.7	0.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.4	-1.0	-0.9	0.7	1.5	-0.3	0.1	0.1	0.9	0.5	-0.9	1.1
Commuting to job workplace: Public transport	0.6	0.7	1.6	1.3	-0.2	-1.0	-0.1	-0.8	-1.0	1.3	0.2	-0.9	0.7	0.0
Eye problems/disorders: Glaucoma	0.3	0.3	1.4	0.1	0.3	-0.2	1.0	-0.5	-0.4	-0.5	0.4	0.4	-1.2	0.4
Medication: Blood pressure	0.2	0.4	2.0	-0.1	-0.7	-0.3	-0.3	0.3	-0.0	0.4	-1.4	0.0	0.9	-0.4
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.1	0.0	-0.2	-1.0	-0.9	-0.4	-0.0	0.1	-0.9	-1.1	0.0	-0.4
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.6	-1.3	-1.2	0.1	1.9	0.8	0.6	-0.7	1.3	0.7	-1.0	1.8
High cholesterol (Self-reported)	0.3	0.5	2.8	0.2	-0.3	0.3	0.1	-0.0	-1.7	-0.3	-1.3	0.9	-0.1	0.1
Medication: Bendroflumethiazide	1.0	1.5	6.1	1.9	-0.6	-0.2	-1.1	0.8	0.7	-1.0	-2.5	-1.4	0.9	-0.8
Medication: Paracetamol	0.4	0.6	3.2	-0.6	-0.6	-1.8	0.4	-1.0	0.5	1.0	0.6	-0.4	-0.2	0.4
Medication: Lisinopril	0.7	0.9	2.4	0.2	0.3	1.2	-0.4	1.1	-1.5	0.1	-1.6	0.2	0.9	-0.9
Medication: Atorvastatin	1.8	2.2	6.4	2.2	-0.9	0.2	-1.4	1.3	-0.4	0.5	-2.5	-0.8	2.5	-1.4
Illnesses of father: High blood pressure	0.2	0.2	1.0	-0.2	0.5	0.7	1.0	-0.1	0.3	0.0	0.2	0.0	-0.4	0.2
Alcohol drinker status: Never	0.5	0.6	2.1	0.9	-0.4	-0.8	-0.8	-0.4	-1.4	0.5	0.1	-0.6	0.9	-0.5
Ever smoked	1.7	3.0	11.6	1.4	2.9	0.5	-1.5	1.1	-0.9	-0.5	-1.8	0.1	1.6	-3.4
Basal metabolic rate	1.1	6.3	21.0	2.6	1.8	0.2	-4.0	1.0	-0.3	1.9	-0.7	-0.1	4.6	-4.1
Leg fat percentage (left)	0.1	0.4	1.1	0.1	0.7	0.7	-0.4	0.4	1.0	0.4	0.1	0.6	1.0	-0.6
Arm fat-free mass (left)	0.9	4.5	15.4	2.3	1.3	-0.0	-3.3	1.2	-0.2	1.6	-0.5	0.4	3.9	-3.5
Number of operations (self-reported)	1.1	1.7	5.1	1.1	0.9	-1.1	-1.3	-0.4	-1.3	0.3	-1.9	-1.2	1.1	-2.3
Average weekly beer plus cider intake	0.2	0.3	1.2	-0.8	-0.2	0.4	0.3	-0.2	0.5	-0.1	-0.4	-1.1	-0.6	0.3
Irritability	0.3	0.4	1.3	-0.2	1.2	-0.2	-0.1	0.9	-0.4	-0.4	0.1	0.8	0.7	-1.1
Risk taking	1.1	1.6	5.4	0.1	-0.6	-1.9	0.1	-1.3	0.9	2.3	0.7	-0.2	1.7	-1.4
Ever had prostate specific antigen (PSA) test	1.9	2.2	8.9	-0.2	-1.4	-0.3	3.0	-0.5	-0.1	-0.6	1.9	0.6	-1.5	2.5
Fractured/broken bones in last 5 years	1.2	1.5	3.7	0.1	1.1	1.6	1.6	1.9	-1.0	-1.9	0.3	1.5	-0.2	-0.3
Age started oral contraceptive pill	0.4	0.6	2.2	1.5	-0.8	-0.7	-0.1	-0.1	0.6	0.2	-0.5	-1.4	0.5	0.1
Diastolic blood pressure, automated reading	0.4	1.2	2.6	-1.4	-1.1	0.7	1.5	-1.0	0.6	1.5	1.6	0.2	0.3	0.9
Ever depressed for a whole week	0.8	1.0	4.0	1.0	0.3	0.7	-0.1	2.0	0.7	-1.8	-0.9	0.0	0.4	0.0
Unable to work because of sickness or disability	0.8	1.1	6.7	0.7	2.6	0.7	-0.4	0.9	0.4	-1.1	0.2	0.2	-0.7	-1.0
Commuting to job workplace: Cycle	1.5	1.8	7.7	1.9	2.5	0.6	-0.2	0.1	-0.7	-0.9	-0.7	-0.3	0.5	-2.8
Myopia	0.5	0.7	2.4	0.2	0.2	1.5	1.0	0.4	-0.4	-1.2	0.9	0.9	-1.0	0.3
Vascular/heart problems diagnosed by doctor	0.4	1.1	5.1	-0.2	0.4	-0.5	-0.4	-0.7	2.3	-0.0	1.9	-0.6	-0.7	1.1
Cholesterol lowering medication	0.6	0.9	3.7	0.7	0.1	1.6	-0.1	1.9	0.3	-0.4	0.2	1.4	1.1	-0.4
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	7.0	1.3	-0.5	-0.5	-1.9	-1.6	-0.2	0.1	-2.7	-2.5	0.9	-0.8
Pain experienced in last month	0.3	0.5	3.0	-0.1	0.0	1.1	-0.2	1.7	0.3	-0.7	0.3	-0.3	0.5	0.6
Supplements: Calcium	0.4	0.5	1.5	0.4	0.0	-0.9	-0.8	0.5	-0.5	-0.9	-0.7	-1.2	-0.1	0.3
Basal cell carcinoma (self-reported)	0.5	0.6	2.3	-1.5	-0.4	0.1	1.5	-0.1	-0.0	-0.2	0.5	1.1	-0.5	0.6
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.8	0.5	-1.1	-0.2	-1.6	-0.4	-0.6	1.3	-2.0	-1.2	1.9	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	2.1	0.9	0.5	0.3	-0.7	-0.2	0.3	1.4	0.2	-0.5	1.5	-1.2
Heart disease (siblings)	0.8	1.0	3.5	0.5	1.1	1.5	0.2	1.9	0.1	-0.9	-0.0	1.2	0.1	-1.1
Alcohol drinker status: Previous	0.2	0.2	0.4	-0.6	0.7	0.3	0.7	-0.3	0.4	0.1	0.1	0.5	-0.0	-0.0
Pack years of smoking	0.2	0.3	0.7	-0.7	0.4	0.1	-0.3	0.8	0.4	-0.1	0.1	0.7	0.1	-0.9
Impedance of whole body	1.9	9.6	27.1	-4.2	-2.2	-0.6	4.4	-1.7	0.2	-1.0	2.4	2.2	-4.7	5.2
Leg fat mass (left)	0.6	2.3	7.7	1.2	1.3	0.7	-2.2	0.5	1.1	1.2	-0.5	0.1	2.8	-2.3
Arm predicted mass (left)	0.9	4.5	15.0	2.4	1.4	-0.1	-3.3	1.2	0.0	1.6	-0.4	0.2	3.9	-3.5