Best TWAS P=2.74e-13 · Best GWAS P=2.92e-34 conditioned to 8.89e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | BDNFOS | 0.03 | 0.01 | blup | 83 | 0.02 | 1.4e-03 | 1.6 | -7.3 | 2.7e-13 | -0.76 | 0.02 | 0.96 | TRUE |
| 4 | GTEx | Thyroid | LIN7C | 0.08 | 0.04 | lasso | 4 | 0.04 | 6.0e-04 | -7.0 | -6.5 | 6.8e-11 | -0.14 | 0.81 | 0.01 | TRUE |
| 2 | GTEx | Brain Putamen basal ganglia | BDNF-AS | 0.22 | 0.17 | lasso | 4 | 0.13 | 5.5e-04 | 5.2 | -5.9 | 4.9e-09 | -0.65 | 0.04 | 0.81 | TRUE |
| 1 | GTEx | Adipose Subcutaneous | LIN7C | 0.08 | 0.06 | lasso | 1 | 0.04 | 4.1e-04 | -7.0 | -7.0 | 3.0e-12 | -0.26 | 0.86 | 0.00 | FALSE |
| 5 | NTR | Blood | LIN7C | 0.01 | 0.00 | lasso | 3 | 0.01 | 2.2e-03 | -7.3 | 6.7 | 2.0e-11 | 0.17 | 0.52 | 0.01 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LIN7C | 0.05 | 0.02 | lasso | 3 | 0.03 | 2.9e-04 | -7.0 | -6.1 | 1.0e-09 | -0.11 | 0.39 | 0.02 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | LIN7C | 0.26 | 0.22 | lasso | 6 | 0.25 | 1.4e-18 | -7.0 | -5.3 | 1.2e-07 | -0.06 | 1.00 | 0.00 | FALSE |