Best TWAS P=1.82e-08 · Best GWAS P=2.19e-09 conditioned to 0.304
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ELP4 | 0.03 | 0.03 | enet | 3 | 0.03 | 9.7e-04 | 5.6 | -5.6 | 1.8e-08 | -0.30 | 0.02 | 0.92 | TRUE |
| 4 | GTEx | Pituitary | ARL14EP | 0.30 | 0.28 | lasso | 4 | 0.22 | 3.0e-06 | -5.9 | 5.6 | 2.0e-08 | 0.03 | 0.04 | 0.92 | TRUE |
| 3 | GTEx | Muscle Skeletal | MPPED2 | 0.09 | 0.07 | lasso | 3 | 0.06 | 2.4e-06 | 5.4 | -5.4 | 5.9e-08 | -0.94 | 0.06 | 0.93 | TRUE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ELP4 | 0.05 | 0.00 | blup | 106 | 0.02 | 5.6e-03 | 4.6 | -5.6 | 2.0e-08 | -0.23 | 0.02 | 0.47 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | Z83001.1 | 0.07 | 0.03 | bslmm | 375 | 0.03 | 5.1e-05 | 5.8 | -5.5 | 3.0e-08 | -0.20 | 0.02 | 0.97 | FALSE |
| 2 | GTEx | Lung | ARL14EP | 0.10 | 0.06 | lasso | 8 | 0.11 | 1.1e-08 | 3.0 | 5.2 | 2.4e-07 | 0.00 | 0.77 | 0.23 | FALSE |
| 1 | GTEx | Breast Mammary Tissue | IMMP1L | 0.08 | 0.01 | enet | 18 | 0.00 | 2.1e-01 | 5.4 | -5.1 | 2.9e-07 | -0.39 | 0.11 | 0.34 | FALSE |