Best TWAS P=1.16e-10 · Best GWAS P=1.16e-10 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | ROM1 | 0.25 | 0.17 | lasso | 3 | 0.18 | 1.5e-14 | -5.4 | 5.6 | 2.3e-08 | -0.78 | 0.64 | 0.36 | FALSE |
2 | GTEx | Adipose Visceral Omentum | ROM1 | 0.29 | 0.16 | lasso | 8 | 0.23 | 3.7e-12 | -5.0 | 5.9 | 4.5e-09 | -0.81 | 0.22 | 0.78 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | MTA2 | 0.06 | 0.09 | lasso | 1 | 0.07 | 3.0e-06 | -5.4 | -5.4 | 7.2e-08 | 0.82 | 0.47 | 0.46 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | EML3 | 0.19 | 0.16 | lasso | 9 | 0.18 | 7.3e-14 | -5.4 | -5.5 | 4.0e-08 | 0.81 | 0.73 | 0.27 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | HNRNPUL2 | 0.11 | 0.04 | enet | 14 | 0.05 | 9.8e-05 | -3.7 | 5.5 | 4.2e-08 | -0.84 | 0.03 | 0.96 | FALSE |
6 | GTEx | Esophagus Mucosa | EML3 | 0.40 | 0.43 | lasso | 8 | 0.46 | 1.8e-33 | -5.0 | -5.2 | 2.3e-07 | 0.72 | 0.92 | 0.08 | FALSE |
7 | GTEx | Lung | ROM1 | 0.25 | 0.18 | enet | 13 | 0.20 | 2.2e-15 | -5.0 | 5.6 | 1.9e-08 | -0.78 | 0.87 | 0.13 | FALSE |
8 | GTEx | Nerve Tibial | EML3 | 0.17 | 0.10 | lasso | 4 | 0.09 | 3.9e-07 | -4.9 | -5.6 | 2.2e-08 | 0.77 | 0.14 | 0.86 | FALSE |
9 | GTEx | Nerve Tibial | B3GAT3 | 0.18 | 0.11 | lasso | 3 | 0.09 | 4.7e-07 | -6.4 | -6.3 | 3.5e-10 | 0.97 | 0.00 | 1.00 | FALSE |
10 | GTEx | Ovary | ROM1 | 0.25 | 0.00 | lasso | 5 | 0.00 | 3.3e-01 | -5.4 | 5.8 | 5.2e-09 | -0.81 | 0.07 | 0.27 | FALSE |
11 | GTEx | Pituitary | STX5 | 0.22 | 0.11 | lasso | 3 | 0.11 | 9.7e-04 | -2.4 | 5.4 | 6.2e-08 | -0.55 | 0.05 | 0.44 | FALSE |
12 | GTEx | Skin Not Sun Exposed Suprapubic | ROM1 | 0.15 | 0.08 | lasso | 1 | 0.06 | 2.8e-04 | -6.4 | 6.4 | 1.2e-10 | -1.00 | 0.00 | 0.97 | TRUE |
13 | GTEx | Skin Not Sun Exposed Suprapubic | EML3 | 0.20 | 0.19 | lasso | 3 | 0.24 | 2.7e-13 | -4.9 | -5.6 | 1.9e-08 | 0.78 | 0.15 | 0.85 | FALSE |
14 | GTEx | Skin Not Sun Exposed Suprapubic | B3GAT3 | 0.18 | 0.11 | lasso | 3 | 0.11 | 9.8e-07 | -6.4 | -6.3 | 4.0e-10 | 0.96 | 0.00 | 1.00 | FALSE |
15 | GTEx | Skin Sun Exposed Lower leg | EML3 | 0.32 | 0.25 | enet | 19 | 0.26 | 8.0e-22 | -4.9 | -5.7 | 1.5e-08 | 0.71 | 0.92 | 0.08 | FALSE |
16 | GTEx | Spleen | MTA2 | 0.26 | 0.07 | enet | 19 | 0.07 | 8.7e-03 | -5.0 | -5.3 | 9.6e-08 | 0.68 | 0.05 | 0.75 | FALSE |
17 | GTEx | Stomach | EML3 | 0.11 | 0.04 | enet | 5 | 0.03 | 2.1e-02 | -5.3 | -5.2 | 1.9e-07 | 0.79 | 0.09 | 0.43 | FALSE |
18 | GTEx | Testis | EML3 | 0.27 | 0.22 | enet | 15 | 0.29 | 2.7e-13 | -5.0 | -5.5 | 4.0e-08 | 0.82 | 0.37 | 0.63 | FALSE |
19 | GTEx | Thyroid | ROM1 | 0.17 | 0.16 | lasso | 8 | 0.16 | 3.6e-12 | -4.9 | 5.2 | 2.3e-07 | -0.72 | 0.81 | 0.19 | FALSE |
20 | GTEx | Thyroid | B3GAT3 | 0.18 | 0.09 | lasso | 5 | 0.12 | 1.4e-09 | -6.4 | -6.4 | 1.8e-10 | 0.90 | 0.00 | 1.00 | FALSE |
21 | GTEx | Whole Blood | EML3 | 0.17 | 0.09 | lasso | 7 | 0.08 | 6.3e-08 | -5.0 | -5.1 | 2.8e-07 | 0.74 | 0.76 | 0.24 | FALSE |
22 | METSIM | Adipose | B3GAT3 | 0.08 | 0.06 | enet | 16 | 0.07 | 5.4e-11 | -5.9 | -5.6 | 2.1e-08 | 0.82 | 0.02 | 0.98 | FALSE |
23 | YFS | Blood | EML3 | 0.20 | 0.31 | lasso | 12 | 0.33 | 1.3e-110 | -5.4 | -5.5 | 3.4e-08 | 0.76 | 0.76 | 0.24 | FALSE |
24 | YFS | Blood | INTS5 | 0.09 | 0.12 | lasso | 4 | 0.12 | 1.9e-38 | -6.4 | -6.4 | 1.4e-10 | 0.97 | 0.01 | 0.99 | FALSE |
25 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | EEF1G | 0.04 | 0.05 | lasso | 1 | 0.04 | 1.1e-04 | -5.4 | 5.4 | 5.7e-08 | -0.73 | 0.06 | 0.86 | FALSE |
26 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C11orf83 | 0.01 | 0.00 | blup | 23 | 0.01 | 4.2e-03 | -5.9 | 6.0 | 2.2e-09 | -0.86 | 0.01 | 0.62 | FALSE |
27 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EML3 | 0.02 | 0.02 | lasso | 4 | 0.02 | 2.5e-05 | -5.4 | -5.4 | 8.1e-08 | 0.73 | 0.34 | 0.64 | FALSE |
28 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ROM1 | 0.01 | 0.02 | enet | 4 | 0.02 | 2.4e-04 | -5.4 | 5.7 | 1.6e-08 | -0.74 | 0.11 | 0.71 | FALSE |
29 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | EML3 | 0.06 | 0.05 | blup | 27 | 0.06 | 7.6e-07 | -6.0 | -5.3 | 1.1e-07 | 0.77 | 0.03 | 0.97 | FALSE |
30 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | EEF1G | 0.11 | 0.12 | blup | 27 | 0.13 | 5.5e-14 | -5.0 | 5.2 | 1.8e-07 | -0.73 | 0.18 | 0.82 | FALSE |
31 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | EEF1G | 0.07 | 0.04 | blup | 28 | 0.07 | 9.8e-05 | -5.4 | 5.5 | 4.9e-08 | -0.74 | 0.05 | 0.78 | FALSE |
32 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | EML3 | 0.06 | 0.09 | lasso | 2 | 0.08 | 1.6e-05 | -5.9 | -5.9 | 2.7e-09 | 0.79 | 0.02 | 0.97 | FALSE |
33 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C11orf83 | 0.02 | 0.01 | blup | 24 | 0.01 | 1.5e-02 | -6.0 | 6.3 | 2.6e-10 | -0.86 | 0.01 | 0.84 | FALSE |
34 | The Cancer Genome Atlas | Brain Lower Grade Glioma | EML3 | 0.03 | 0.04 | blup | 28 | 0.03 | 7.6e-05 | -5.4 | -5.2 | 2.3e-07 | 0.74 | 0.22 | 0.74 | FALSE |
35 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | EEF1G | 0.06 | 0.03 | blup | 27 | 0.04 | 4.5e-03 | -5.9 | 5.7 | 1.2e-08 | -0.78 | 0.01 | 0.80 | FALSE |
36 | The Cancer Genome Atlas | Lung Adenocarcinoma | EEF1G | 0.06 | 0.08 | lasso | 8 | 0.08 | 5.9e-10 | -5.0 | 5.3 | 1.1e-07 | -0.78 | 0.10 | 0.90 | FALSE |
37 | The Cancer Genome Atlas | Lung Adenocarcinoma | EML3 | 0.03 | 0.03 | blup | 28 | 0.03 | 8.4e-05 | -5.0 | -5.7 | 1.5e-08 | 0.76 | 0.31 | 0.67 | FALSE |
38 | The Cancer Genome Atlas | Lung Adenocarcinoma | ROM1 | 0.04 | 0.04 | blup | 23 | 0.04 | 9.5e-06 | -5.0 | 5.4 | 5.2e-08 | -0.80 | 0.26 | 0.74 | FALSE |
39 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | EML3 | 0.03 | 0.02 | blup | 27 | 0.03 | 3.5e-03 | -5.4 | -5.8 | 5.1e-09 | 0.81 | 0.02 | 0.73 | FALSE |
40 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C11orf83 | 0.03 | 0.03 | blup | 24 | 0.02 | 5.5e-03 | -6.4 | 6.1 | 1.0e-09 | -0.94 | 0.00 | 0.99 | FALSE |
41 | The Cancer Genome Atlas | Prostate Adenocarcinoma | EML3 | 0.09 | 0.14 | lasso | 1 | 0.14 | 3.4e-14 | -5.4 | -5.4 | 5.7e-08 | 0.73 | 0.32 | 0.68 | FALSE |
42 | The Cancer Genome Atlas | Soft Tissue Sarcoma | ROM1 | 0.06 | 0.05 | blup | 24 | 0.03 | 8.1e-03 | -5.0 | 5.4 | 8.3e-08 | -0.73 | 0.06 | 0.24 | FALSE |
43 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | TTC9C | 0.25 | 0.03 | enet | 13 | 0.04 | 1.8e-02 | 3.2 | -5.2 | 1.5e-07 | 0.43 | 0.00 | 0.01 | FALSE |
44 | The Cancer Genome Atlas | Thyroid Carcinoma | EML3 | 0.11 | 0.10 | blup | 28 | 0.12 | 2.3e-11 | -5.4 | -6.4 | 1.4e-10 | 0.78 | 0.03 | 0.97 | FALSE |
45 | The Cancer Genome Atlas | Thyroid Carcinoma | ROM1 | 0.03 | 0.02 | blup | 23 | 0.02 | 1.1e-02 | -5.0 | 5.4 | 6.4e-08 | -0.77 | 0.05 | 0.61 | FALSE |