Hub : Genes

STX5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0820	0.0350	0.0037	0.006	NA	-0.004	NA	-0.002	1.0e-01	NA	0.970	NA	0.49000
2	GTEx	Pituitary	0.2240	0.0830	0.0046	0.106	NA	0.064	NA	0.112	1.3e-03	NA	0.011	NA	0.00097
3	GTEx	Skin Sun Exposed Lower leg	0.1050	0.0380	0.0013	0.053	NA	0.011	NA	0.039	3.3e-05	NA	0.039	NA	0.00034
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0402	0.0318	0.0015	0.013	0.008	0.011	NA	0.006	1.2e-02	0.041	0.016	NA	0.06900

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.9	1.5	3.0	1.1	-1.3	1.7	0.3
Bipolar Disorder or Schizophrenia	0.4	1.0	2.9	0.9	-0.3	0.5	1.7
Depressed Affect (Nagel 2018)	1.3	2.7	6.0	2.4	-2.0	0.0	-1.0
Depression (Nagel 2018)	0.4	0.6	1.1	1.1	-0.7	-0.0	-0.9
Intelligence (Savage-Jansen 2018)	0.8	2.4	4.6	0.3	2.1	1.9	-1.2
Neuroticism (Nagel 2018)	1.1	2.6	7.6	2.8	-1.4	0.6	-0.8
Schizophrenia (2018)	0.5	1.0	2.9	0.2	0.7	-0.7	1.7
Schizophrenia vs Biploar Disorder	0.7	0.9	3.4	0.3	0.2	-1.8	0.5
Worry (Nagel 2018)	1.5	3.2	9.7	3.1	-1.1	0.2	-1.3
Alzheimer’s Disease (in mother)	0.8	1.0	2.1	-1.4	-1.2	0.6	-0.3
Alzheimer’s Disease (in father)	0.5	0.5	1.9	1.4	-0.0	0.5	-0.1
Alzheimer’s Disease (including proxy)	0.4	0.6	1.5	-0.8	-0.6	1.2	-0.0
Crohns Disease (2017)	0.8	1.8	6.5	-0.4	0.3	-0.8	2.5
Irritable Bowel Disease (IBD)	0.5	1.2	4.1	-0.6	0.6	-0.3	2.0
Ulcerative Colitis (UC)	0.3	0.6	1.3	-0.4	1.1	0.4	0.9
Major Depression (MDD)	1.4	1.7	4.1	0.9	-2.0	-0.6	1.3
Reaction Time	0.8	1.5	4.5	1.1	-2.1	0.1	-0.6
Verbal and Numeric Reasoning (VNR)	0.8	2.0	5.4	0.6	1.5	2.3	-0.1
Breast Cancer	1.2	2.9	4.3	1.8	2.0	-2.1	0.4
Ovarian Cancer	1.3	1.8	3.6	1.3	-1.9	-0.5	1.2
Prostate Cancer	0.2	0.3	1.1	1.0	-0.3	-0.3	-0.3
Age at First Birth	0.8	1.1	2.0	0.3	1.1	1.4	-1.1
Bipolar Disorder (2011)	2.0	2.0	6.7	0.8	0.2	0.8	2.6
Body Mass Index (BMI) (2010)	1.3	1.7	4.9	-0.4	1.2	-0.6	-2.2
Coronary Artery Disease (CAD)	0.7	0.8	1.7	1.3	-1.0	-0.5	-0.6
Crohns Disease (2012)	2.1	3.3	11.5	0.7	0.1	-1.2	3.4
Mean Putamen Volume	1.2	1.3	3.1	0.3	-1.4	-1.8	-0.6
Fasting Glucose	1.5	1.8	3.3	-1.2	1.6	0.5	-1.8
HbA1C	1.3	1.5	2.0	-1.3	1.4	1.3	0.7
HDL Cholesterol	1.0	1.7	3.9	-2.0	1.5	0.6	-0.4
LDL Cholesterol	0.6	0.9	2.3	-1.0	-0.5	-1.5	-0.3
Lupus	0.3	0.5	1.2	0.2	0.5	0.8	-1.1
Neuroticism (2016)	0.4	0.5	1.1	-1.1	-0.0	0.8	0.6
Primary Biliary Cirrhosis	0.1	0.1	0.4	0.1	-0.7	-0.1	0.2
Rheumatoid Arthritis	0.9	1.2	2.4	1.1	-0.6	-1.0	1.5
Schizophrenia (2014)	0.6	1.3	2.9	-0.1	1.4	0.5	1.7
Triglycerides	1.3	2.2	5.3	0.1	-0.4	-2.3	-1.8
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.7	-1.3	-0.1	1.2	-0.4
Ulcerative Colitis	0.5	0.7	1.5	-1.2	1.0	0.2	0.6
Blood Eosinophil Count	0.2	1.7	5.7	0.5	-2.4	1.0	-0.0
Blood Platelet Count	0.2	2.6	7.5	-0.6	-1.5	-2.7	0.5
Blood Red Count	0.2	1.5	3.7	0.4	1.4	0.4	-1.9
Blood White Count	0.1	1.0	2.3	-0.6	0.5	1.5	1.1
Heel T-Score	1.6	13.0	29.2	3.5	5.4	-1.8	-2.7
BMI	0.1	0.9	1.1	1.0	1.1	0.8	0.9
Height	0.1	1.3	3.2	-1.2	1.8	-0.3	0.7
Waist Hip Ratio (WHR)	4.5	20.0	59.3	1.8	-7.7	-4.2	-0.5
Systolic Blood Pressure	0.2	0.8	2.0	-0.1	-0.8	-1.4	0.6
Smoking Status	0.7	1.6	3.0	-1.7	-0.5	-1.7	0.4
Allergy or Eczema	0.3	0.9	2.4	-0.9	1.5	0.4	-0.3
Cardiovascular Disease	0.1	0.3	0.9	-0.1	0.2	-0.6	1.0
Hypothyroidism (self reported)	0.3	0.7	2.8	0.1	0.3	-0.1	1.7
Respiratory disease	1.0	2.1	4.1	0.9	1.7	2.0	-0.9
Type 2 Diabetes (T2D) (2018)	1.0	1.8	4.0	1.4	2.0	1.0	0.5
Lung FEV1/FVC ratio	1.4	7.3	19.1	-0.1	-4.4	-3.1	-0.7
Lung FVC	2.4	12.3	45.4	0.5	-6.7	-0.2	-1.9
Neuroticism	1.1	2.8	7.0	2.6	-1.5	-0.2	-1.3
Chronotype (morning person)	0.6	1.3	2.9	-1.7	-0.3	1.6	0.0
Hair Pigment	0.1	2.4	5.4	-2.3	1.6	-0.0	-1.4
Tanning	0.1	1.7	2.3	1.1	-1.0	1.4	1.5
Hand grip strength (left)	0.8	2.0	5.6	1.3	2.4	-0.8	0.1
Number of treatments/medications taken	0.4	0.7	1.5	1.0	-0.7	1.2	-0.2
Average weekly spirits intake	1.4	1.8	4.2	1.2	2.1	0.8	-0.8
Sensitivity / hurt feelings	0.3	0.5	1.0	0.6	-1.0	0.4	-0.6
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	0.8	-0.1	-0.3	-0.7
Hearing difficulty/problems: Yes	0.4	0.5	0.9	0.5	-1.0	0.2	-1.0
Relative age of first facial hair	0.5	0.9	1.6	0.9	-1.1	1.3	0.4
Other serious medical condition/disability diagnosed by doctor	2.6	3.4	7.9	0.0	2.8	1.5	1.8
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.4	-0.5	-0.4	0.5	-0.6
Ever had hysterectomy (womb removed)	0.5	0.5	1.2	0.5	-0.3	-1.1	-0.8
Systolic blood pressure, automated reading	0.3	0.8	1.9	-0.5	-0.8	-1.4	-0.7
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.5	1.2	-0.1	-0.2	0.1
Angina	0.1	0.1	0.3	0.6	0.2	-0.3	0.3
Medication for hormone replacement therapy	0.9	1.0	2.5	-0.6	-1.6	-0.9	0.7
Vitamin and mineral supplements	0.3	0.4	1.1	0.6	0.3	-1.0	-0.2
Supplements: Zinc	0.2	0.2	0.6	0.0	-0.5	-0.3	-0.8
Medication: Co-codamol	0.6	0.7	1.5	1.2	0.6	0.7	-0.7
Medication: Metformin	0.3	0.4	1.1	1.0	-0.4	-0.1	0.6
Diabetes (father)	0.6	0.7	2.1	-0.2	0.5	1.4	0.6
Diabetes (mother)	0.6	0.7	1.4	-0.3	-1.1	1.2	-0.5
Severe depression (siblings)	0.1	0.1	0.2	0.2	-0.3	0.3	0.4
Pack years adult smoking proportion	0.7	1.1	3.3	0.3	-0.5	-1.8	0.9
Impedance of leg (right)	0.7	3.2	9.3	0.1	3.1	1.9	0.1
Leg fat-free mass (left)	0.2	0.8	2.5	0.5	-0.1	-0.7	1.6
Trunk fat percentage	0.8	3.1	8.4	0.2	2.9	1.4	-1.4
Hand grip strength (right)	1.2	3.1	8.1	1.3	2.8	-1.2	1.1
Townsend deprivation index at recruitment	0.3	0.4	0.6	0.0	-0.7	-0.8	-0.7
Current tobacco smoking	0.5	0.8	1.8	-0.6	-0.5	-1.4	0.8
Average weekly fortified wine intake	0.7	0.8	1.8	0.7	0.3	0.9	1.4
Maternal smoking around birth	0.2	0.3	0.8	-0.4	-0.0	-0.6	0.9
Fed-up feelings	0.5	1.0	2.2	1.0	-1.5	0.4	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.4	-0.2	0.3	0.6	-0.6
Relative age voice broke	0.5	0.7	2.6	0.5	-1.6	0.4	0.1
Taking other prescription medications	1.3	2.1	4.0	1.8	-2.0	0.1	1.0
Age when periods started (menarche)	0.0	0.1	0.2	0.3	-0.4	-0.2	-0.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.6	-0.4	0.1	-0.8	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	3.6	0.7	1.6	-1.9	-1.5
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.9	0.2	0.3	-1.5	1.7
Qualifications: CSEs or equivalent	0.5	0.7	2.5	-1.6	-0.3	-0.3	0.0
Serious illness, injury or assault to yourself	1.9	2.3	6.2	-1.0	2.5	-1.2	0.8
High blood pressure	0.2	0.6	2.4	-0.1	-0.3	0.0	-1.5
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.5	-0.3	1.2	-0.1	1.1
Multivitamins +/- minerals	0.7	0.9	1.6	-1.3	-0.7	0.6	-1.1
Stomach or abdominal pain in last month	0.9	1.1	3.9	0.1	-0.5	-2.0	0.3
Supplements: Glucosamine	1.9	2.5	4.4	-1.2	-1.0	2.1	-1.8
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	0.7	0.7	-0.2	-0.1
Medication: Atenolol	0.2	0.3	1.0	0.1	0.2	-1.0	-0.5
Medication: Levothyroxine sodium	0.5	0.9	3.0	1.7	-0.3	0.2	0.6
Sitting height	0.8	5.7	17.6	-1.0	4.2	1.2	1.7
Chronic bronchitis/emphysema (father)	0.5	0.6	0.7	-0.9	0.7	0.7	-0.9
High blood pressure (mother)	0.4	0.5	1.0	-0.3	-1.0	0.0	1.0
Body mass index (BMI)	0.1	0.5	0.8	0.7	-0.9	-0.1	-0.9
Impedance of leg (left)	0.4	1.7	6.1	-0.6	2.5	0.8	0.0
Leg predicted mass (left)	0.1	0.8	2.3	0.5	-0.2	-0.7	1.5
Trunk fat mass	0.3	1.4	4.5	0.2	2.1	0.7	-0.9
Waist circumference	0.5	1.8	4.2	1.1	-2.1	-0.4	-1.2
Number of incorrect matches in round	1.2	1.9	3.4	-1.9	-0.9	-1.5	-1.1
Past tobacco smoking	0.4	0.7	1.6	0.5	0.2	1.3	0.9
Alcohol usually taken with meals	1.2	2.0	3.0	1.2	-1.3	1.4	1.7
Nervous feelings	0.8	1.6	2.7	1.6	0.9	-0.2	1.7
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.8	0.8	-0.1	-0.1	-0.9
Hearing difficulty/problems with background noise	0.6	1.0	2.3	0.4	-1.5	0.1	-1.2
Hair/balding pattern: Pattern 2	1.1	1.4	4.0	2.0	-0.5	0.4	-1.2
Had menopause	1.5	1.9	4.4	0.2	0.4	1.7	-2.1
Had other major operations	0.2	0.2	0.5	0.7	-0.4	-0.3	0.4
Forced vital capacity (FVC)	0.2	0.9	3.3	0.2	-1.8	0.4	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.0	4.6	1.0	2.1	-1.7	-1.8
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	5.6	-0.9	0.7	-2.4	-1.0
Qualifications: None of the above	2.1	4.4	12.1	-0.2	-3.5	-1.6	-1.7
Financial difficulties in last 2 years	0.4	0.5	1.4	-0.6	0.0	-1.2	-0.6
Mouth/teeth dental problems	0.3	0.5	1.1	-1.1	0.6	-0.1	-0.7
Heart attack	0.4	0.5	1.2	-1.1	0.7	-0.5	-0.3
Allergy	0.7	1.5	4.5	-0.4	-2.1	-1.1	-0.6
Pain all over the body in last month	0.2	0.2	0.4	-0.3	-0.6	-0.4	-0.5
Diabetes (self-reported)	1.1	1.7	4.3	2.1	1.5	0.0	-0.3
Hayfever/allergic rhinitis (self-reported)	1.3	1.8	2.7	0.7	1.7	1.6	1.2
Medication: Ramipril	0.1	0.2	0.4	0.0	-0.0	-0.5	-0.6
Medication: Simvastatin	0.5	0.8	2.9	0.6	-1.7	0.0	-0.1
Fluid intelligence score	0.8	1.6	4.6	0.8	0.9	2.1	0.6
Illnesses of siblings	0.8	1.1	2.4	0.5	-0.3	1.6	1.2
Neuroticism score	0.9	1.8	5.7	2.4	-0.7	0.0	-1.1
Weight	0.0	0.2	0.5	0.7	0.3	-0.2	0.2
Impedance of arm (right)	2.8	13.1	42.7	-0.2	6.5	3.0	-1.0
Arm fat percentage (right)	0.6	2.3	4.5	0.6	2.1	1.2	-1.6
Trunk fat-free mass	0.4	2.3	4.5	-0.1	-2.1	-1.4	1.7
Hip circumference	0.6	2.6	6.0	-0.0	2.5	2.0	-0.5
Time employed in main current job	3.7	4.3	7.3	1.8	0.4	2.6	-2.7
Alcohol intake versus 10 years previously	1.7	2.5	6.2	2.5	1.0	-1.1	1.3
Father’s age at death	0.9	1.2	2.5	-0.4	-0.4	-1.4	1.6
Worrier / anxious feelings	1.1	2.1	5.2	1.5	-2.3	-0.1	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.4	-0.4	1.2	-0.0	-0.7
Falls in the last year	0.6	0.9	3.0	-0.7	0.0	1.7	-0.1
Hair/balding pattern: Pattern 3	0.3	0.5	1.0	-0.2	-0.7	-0.6	1.0
Number of live births	0.6	0.9	1.4	-1.2	-0.7	1.0	0.8
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	7.0	-0.0	-2.6	-0.5	0.3
Pulse rate	1.0	1.6	5.3	-0.9	2.3	0.6	-0.3
Happiness	1.7	2.1	6.9	0.5	-0.0	-1.0	-2.6
Noisy workplace	1.5	1.9	4.1	-1.2	-2.0	-1.4	0.1
Qualifications: A levels/AS levels or equivalent	1.9	4.3	5.7	2.4	2.2	2.2	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.8	0.2	0.3	0.1	0.9
Mouth/teeth dental problems: Dentures	0.6	1.0	1.8	-1.2	-0.4	-0.7	-1.3
Asthma	1.1	2.2	3.9	1.2	1.6	2.0	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.8	-0.2	-0.8	0.7	0.9
Medication: Cholesterol lowering	0.2	0.3	0.9	0.2	-0.2	-1.0	-0.3
Depression (self-reported)	1.7	2.0	4.4	0.2	-2.1	0.6	-1.8
Medication: Lansoprazole	0.6	0.7	2.0	1.4	-0.5	-0.4	-0.5
Prospective memory result	0.2	0.3	1.1	-0.1	-0.2	-0.1	-1.1
Lung cancer (father)	0.2	0.3	0.5	-0.6	0.7	-0.1	-0.5
Illnesses of mother	1.0	1.2	3.0	1.2	0.2	-0.6	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	10.0	1.0	-3.2	-0.9	0.1
Pulse wave Arterial Stiffness index	1.2	1.4	3.0	0.8	-0.9	1.7	1.1
Impedance of arm (left)	2.5	11.7	35.8	-0.2	6.0	3.2	-0.7
Arm fat mass (right)	0.1	0.4	1.0	0.4	1.0	0.6	-0.5
Trunk predicted mass	0.4	2.5	4.6	-0.1	-2.1	-1.4	1.8
Standing height	0.3	2.8	6.0	-0.1	2.5	0.1	2.3
Length of working week for main job	1.1	1.3	2.5	-0.8	-0.2	-1.4	-1.6
Exposure to tobacco smoke at home	2.5	2.8	8.9	0.5	-3.0	-1.3	-0.6
Breastfed as a baby	0.3	0.3	0.7	-0.7	0.8	0.2	-0.3
Tense / ‘highly strung’	0.6	0.9	2.3	1.0	0.6	-0.1	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	2.2	3.4	8.3	0.7	-1.4	-1.7	-2.9
Hair/balding pattern: Pattern 4	0.4	1.0	1.7	-0.6	-1.2	1.3	-0.7
Birth weight of first child	1.2	2.1	6.9	1.2	-0.2	-0.3	2.6
Peak expiratory flow (PEF)	0.1	0.2	0.5	-0.1	-0.2	0.4	0.7
Pulse wave reflection index	0.9	1.2	2.3	1.3	-0.6	0.5	1.5
Ever highly irritable/argumentative for 2 days	1.4	1.6	3.0	-1.3	-1.4	-1.7	0.2
Loud music exposure frequency	0.9	1.0	1.4	-1.2	1.0	0.8	1.0
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.3	0.7	0.6	0.4	1.5
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.0	1.4	-0.6	0.8	1.3
Blood clot in the leg (DVT)	1.1	1.5	3.0	-0.0	1.6	-0.4	1.7
Medication: Paracetamol	0.2	0.3	0.7	0.7	-0.4	-0.1	-0.8
Headache pain in last month	0.2	0.3	0.8	0.5	-0.6	-0.9	-0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	0.2	0.4	0.6	0.1
Glaucoma (self-reported)	0.8	0.9	1.8	-0.2	0.4	1.3	-1.3
Gout (self-reported)	0.4	0.6	1.8	0.0	-0.5	-1.3	0.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.1	0.2	0.2	0.5	1.4
Medication: Amlodipine	0.8	1.1	4.2	0.2	-0.4	-2.0	-0.3
Medication: Ventolin 100micrograms inhaler	1.6	2.1	5.7	2.4	1.3	-0.2	-1.0
Birth weight	0.5	1.1	2.2	-0.7	0.4	-1.3	1.5
Chronic bronchitis/emphysema (mother)	0.5	0.6	2.0	-1.4	0.2	-0.4	-0.3
High blood pressure (siblings)	0.5	0.7	2.8	-0.2	1.7	-0.1	-0.4
Forced vital capacity (FVC), Best measure	0.6	2.0	6.9	0.8	-2.6	-0.7	-0.3
Body fat percentage	0.5	2.0	5.0	0.4	2.2	1.0	-1.3
Leg fat percentage (right)	0.2	0.8	2.0	0.6	0.8	0.5	-1.4
Arm fat-free mass (right)	0.6	2.9	5.2	-0.2	-2.3	-2.0	1.6
Exposure to tobacco smoke outside home	1.1	1.5	3.0	-0.4	-1.7	0.4	-1.6
Comparative body size at age 10	1.4	4.0	9.5	-1.2	-2.0	-3.1	-0.9
Number of full brothers	1.1	1.4	3.8	-0.9	-0.9	-0.5	-1.9
Worry too long after embarrassment	1.4	2.3	6.4	1.3	-1.0	-0.5	-2.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	1.8	1.2	-0.7	-0.8	-1.4
Wheeze or whistling in the chest in last year	0.1	0.3	0.7	0.1	0.3	-0.9	0.4
Number of children fathered	0.7	0.8	2.4	-0.5	-1.6	0.1	0.6
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.5	6.0	1.4	2.4	1.5	0.3
Age at first live birth	1.1	1.9	3.0	1.7	0.9	1.0	1.7
Pulse wave peak to peak time	1.4	1.6	3.9	-0.8	0.9	-2.0	-1.1
Health satisfaction	0.2	0.3	0.4	0.5	0.4	-0.5	-0.6
Shortness of breath walking on level ground	0.4	0.5	1.3	0.7	-0.0	0.3	-1.2
Qualifications: College or University degree	0.8	2.4	8.0	-0.1	2.8	1.2	-0.4
Eye problems/disorders: None of the above	0.6	0.7	1.5	-1.2	1.2	0.2	-0.0
Mouth/teeth dental problems: Loose teeth	0.9	1.0	3.2	1.8	0.6	-0.6	0.5
Emphysema/chronic bronchitis	1.0	1.1	3.0	-0.6	0.9	-0.5	-1.7
Medication for pain relief, constipation, heartburn	0.3	0.6	1.1	-0.9	1.1	-0.1	-0.5
Neck or shoulder pain in last month	0.9	1.2	2.5	1.6	-0.1	1.2	-1.1
Medication: Blood pressure	0.4	0.7	1.5	-1.1	0.2	-0.4	-1.2
Angina (self-reported)	0.0	0.0	0.1	0.3	-0.0	-0.1	0.1
Migraine (self-reported)	1.4	1.7	6.9	-0.1	0.1	0.2	2.6
Medication: Ibuprofen	0.9	1.1	2.7	-0.5	0.0	1.6	1.2
Medication: Allopurinol	0.6	0.8	1.5	0.0	-1.1	-1.2	0.6
Medication: Omeprazole	1.4	1.7	3.5	1.9	-1.4	0.6	0.9
Medication: Seretide 50 evohaler	1.4	1.6	5.3	0.7	2.3	0.7	0.5
Mean time to correctly identify matches	1.2	2.3	6.5	1.1	-2.6	0.2	-1.1
Heart disease (mother)	0.4	0.5	1.5	-1.2	-0.5	0.1	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.9	5.9	22.2	-1.1	4.7	0.0	-0.1
Whole body fat mass	0.2	0.7	2.2	0.2	1.5	0.6	-0.4
Leg fat mass (right)	0.0	0.1	0.2	0.4	0.3	-0.1	-0.1
Arm predicted mass (right)	0.7	3.6	6.0	-0.1	-2.5	-2.0	2.0
Pulse rate, automated reading	0.5	1.8	5.5	-1.1	2.4	-0.3	-0.6
Alcohol intake frequency.	0.3	0.7	1.4	-0.1	-0.4	1.1	-1.2
Comparative height size at age 10	0.2	1.1	1.8	0.7	0.9	-1.1	1.4
Number of full sisters	0.8	1.0	3.6	-0.3	-1.9	-0.5	-0.2
Suffer from ‘nerves’	1.2	1.8	5.4	2.3	-1.1	-0.2	-0.9
Overall health rating	0.4	0.9	2.0	0.9	-0.3	1.4	0.7
Chest pain or discomfort	1.5	2.2	6.0	-1.7	2.4	-0.2	0.1
Had major operations	1.5	1.8	5.3	1.0	-2.3	0.6	0.7
Age at last live birth	1.6	2.4	6.7	0.3	1.2	1.1	2.6
Family relationship satisfaction	0.3	0.4	1.3	0.1	0.1	-1.2	-0.3
Leg pain on walking	1.2	1.6	3.0	-1.2	-1.7	-1.1	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.9	-0.3	-0.9	-0.3	0.8
Commuting to job workplace: Car/motor vehicle	1.0	1.2	2.5	-0.6	-1.6	0.1	-1.4
Illness, injury, bereavement, stress in last 2 years	1.0	1.3	3.1	0.2	0.9	1.8	-1.1
Medication: Aspirin	0.1	0.1	0.5	0.7	0.1	0.0	0.1
Supplements: Vitamin C	1.8	2.1	4.0	1.4	0.6	1.4	2.0
Knee pain experienced in last month	0.4	0.7	1.0	0.7	-0.9	0.6	-1.0
Hypertension (Self-reported)	0.4	1.0	3.8	-0.5	-0.1	-0.1	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.1	1.4	0.6	1.1	0.3
Illnesses of father: Heart disease	0.2	0.3	0.9	1.0	0.3	-0.0	-0.2
Illnesses of siblings: Diabetes	0.9	1.1	4.1	0.4	0.2	-2.0	-0.4
Smoking status: Previous	0.5	0.7	2.1	-0.6	-0.5	-0.6	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.6	10.2	0.8	2.7	-0.6	3.2
Whole body fat-free mass	0.3	1.9	3.1	0.1	-1.6	-1.5	1.8
Leg fat-free mass (right)	0.2	1.3	2.4	0.4	-0.7	-1.4	1.6
Arm fat percentage (left)	0.5	2.1	3.7	0.6	1.9	1.4	-1.4
Average weekly red wine intake	1.1	1.7	5.1	-0.4	-1.0	0.6	2.3
Handedness (chirality/laterality): Left-handed	1.3	1.5	5.5	-0.5	-0.2	-0.6	2.3
Mood swings	1.9	3.4	10.7	3.3	-1.7	0.2	-0.1
Loneliness, isolation	0.8	1.1	2.0	1.0	-1.1	0.2	-1.4
Long-standing illness, disability or infirmity	1.1	1.7	5.4	0.9	2.3	0.6	0.3
Ever had bowel cancer screening	0.9	1.1	2.8	1.0	-0.5	-0.4	1.7
Diabetes diagnosed by doctor	1.0	1.6	4.6	2.1	1.3	-0.1	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	3.2	3.4	9.4	1.3	-1.5	-0.2	3.1
Friendships satisfaction	0.2	0.2	0.9	0.2	1.0	-0.2	-0.1
Qualifications: nursing, teaching	1.3	2.1	4.0	1.4	2.0	0.8	1.2
Commuting to job workplace: Walk	1.7	1.9	5.1	0.4	2.3	1.0	1.1
Eye problems/disorders: Cataract	0.2	0.2	0.3	0.6	-0.3	-0.2	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.4	1.2	-0.3	-0.1	1.0
Medication for cholesterol	0.6	0.9	2.2	-0.1	1.5	-1.0	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.5	5.9	2.4	-1.9	0.6	0.2
Back pain experienced in last month	0.5	0.7	2.1	1.4	-0.7	-0.5	0.3
Mineral and other dietary supplements	0.8	1.1	2.3	0.9	0.8	-0.8	1.5
Breast cancer (self-reported)	0.1	0.1	0.3	0.2	-0.5	-0.3	-0.3
Asthma (self-reported)	1.2	2.5	3.8	1.5	1.6	1.9	-1.0
Osteoporosis (self-reported)	0.8	1.0	2.4	-0.7	-0.8	1.6	-0.7
Osteoarthritis (self-reported)	0.3	0.3	0.6	0.4	-0.7	-0.7	0.3
Medication: Aspirin	0.2	0.2	0.4	0.6	-0.3	0.0	-0.6
Medication: Gliclazide	1.0	1.2	3.5	1.9	-0.5	0.0	-0.9
Illnesses of father: None of the above (group 1)	0.4	0.5	1.5	-0.5	0.0	-0.7	1.2
Smoking status: Current	0.4	0.6	1.7	-0.6	-0.3	-1.3	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.0	6.4	22.6	1.6	-4.8	-0.3	0.4
Whole body water mass	0.3	1.9	2.8	0.1	-1.6	-1.5	1.7
Leg predicted mass (right)	0.2	1.2	2.3	0.3	-0.7	-1.4	1.5
Arm fat mass (left)	0.1	0.4	0.7	0.3	0.8	0.7	-0.5
Number of self-reported non-cancer illnesses	0.6	1.0	2.0	1.4	0.4	1.0	1.0
Average weekly champagne plus white wine intake	1.1	1.5	4.0	0.5	2.0	1.3	0.5
Miserableness	0.3	0.5	1.6	1.3	0.0	-0.0	-0.8
Guilty feelings	0.7	1.0	3.8	1.9	-0.1	0.4	-0.0
Wears glasses or contact lenses	0.9	1.0	2.6	1.0	-1.6	0.1	-0.6
Ever taken oral contraceptive pill	0.4	0.5	0.8	0.9	0.7	0.8	-0.1
Hearing aid user	0.4	0.4	1.3	-0.5	-1.2	0.0	0.3
Mother’s age at death	0.7	0.9	2.0	-0.7	-1.4	1.0	-0.4
Financial situation satisfaction	0.2	0.3	0.9	-0.1	-0.1	-0.4	-0.9
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.1	-0.7	-0.4	-1.4	-0.2
Commuting to job workplace: Public transport	0.7	0.9	1.7	0.5	0.1	1.3	-1.2
Eye problems/disorders: Glaucoma	0.9	1.1	4.2	0.2	-0.4	0.3	-2.0
Medication: Blood pressure	0.8	1.5	2.9	1.7	-0.8	1.1	-1.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.1	-0.0	0.4	1.1	-0.8
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.0	-1.0	-0.8	-0.1	-0.7
High cholesterol (Self-reported)	0.3	0.6	2.0	0.2	-1.4	-0.5	-0.2
Medication: Bendroflumethiazide	1.7	2.6	8.1	-0.4	1.5	2.8	0.3
Medication: Paracetamol	0.5	0.8	1.8	0.2	0.1	1.1	-1.3
Medication: Lisinopril	0.2	0.3	0.9	0.3	0.1	0.2	0.9
Medication: Atorvastatin	0.3	0.4	0.7	0.7	0.5	-0.3	-0.8
Illnesses of father: High blood pressure	1.3	1.6	3.1	0.4	-1.7	-1.4	1.1
Alcohol drinker status: Never	0.6	0.8	2.4	-1.6	0.6	0.2	-0.5
Ever smoked	0.7	1.3	3.3	0.1	-1.3	-1.8	-0.4
Basal metabolic rate	0.2	1.1	2.0	0.2	-1.1	-1.1	1.4
Leg fat percentage (left)	0.2	0.8	2.8	0.2	0.6	-0.3	-1.7
Arm fat-free mass (left)	0.4	2.2	4.5	-0.1	-2.1	-1.7	1.2
Number of operations (self-reported)	0.5	0.7	1.2	0.8	-0.8	-0.5	1.1
Average weekly beer plus cider intake	1.2	1.7	4.3	-1.3	-0.1	-2.1	0.9
Irritability	0.8	1.4	3.6	1.4	1.9	0.3	-0.0
Risk taking	0.8	1.1	3.4	-0.4	1.8	0.8	0.4
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.3	0.3	-0.4	-0.6	0.5
Fractured/broken bones in last 5 years	0.6	0.7	1.4	0.8	-1.2	-0.6	-0.7
Age started oral contraceptive pill	2.6	3.2	10.3	1.1	-0.9	0.8	-3.2
Diastolic blood pressure, automated reading	0.5	1.4	5.2	-0.6	-0.2	-2.3	-0.2
Ever depressed for a whole week	0.6	0.7	1.1	-0.8	1.0	-0.3	-1.0
Unable to work because of sickness or disability	0.3	0.4	0.6	-0.7	-0.7	-0.7	0.1
Commuting to job workplace: Cycle	1.4	1.7	2.5	-1.6	1.3	-1.2	-1.2
Myopia	0.8	1.1	3.7	-0.7	1.9	0.3	-0.5
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.9	0.3	0.3	0.1	1.4
Cholesterol lowering medication	1.0	1.4	3.9	0.5	-2.0	0.9	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.1	1.0	-0.9	0.1	1.0
Pain experienced in last month	0.1	0.2	0.8	-0.1	0.9	0.3	0.1
Supplements: Calcium	1.7	1.8	3.5	-0.6	-0.5	1.9	-1.8
Basal cell carcinoma (self-reported)	1.0	1.2	4.0	-2.0	0.8	-0.0	-0.6
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.1	-1.0	1.0	-0.5	-0.4
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	3.2	0.1	1.8	-0.5	1.5
Heart disease (siblings)	1.3	1.5	3.9	-0.9	-1.0	0.7	-2.0
Alcohol drinker status: Previous	0.4	0.4	1.0	-0.6	-0.1	1.0	0.5
Pack years of smoking	0.4	0.6	2.2	-0.2	-0.5	-1.5	0.1
Impedance of whole body	1.7	8.8	29.3	-0.4	5.4	2.3	-0.6
Leg fat mass (left)	0.0	0.1	0.3	0.3	0.1	-0.5	-0.5
Arm predicted mass (left)	0.4	2.1	3.4	0.0	-1.9	-1.7	1.4