Hub : Genes

STX5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.0820 0.0350 0.0037 0.006 NA -0.004 NA -0.002 1.0e-01 NA 0.970 NA 0.49000
2 GTEx Pituitary 0.2240 0.0830 0.0046 0.106 NA 0.064 NA 0.112 1.3e-03 NA 0.011 NA 0.00097
3 GTEx Skin Sun Exposed Lower leg 0.1050 0.0380 0.0013 0.053 NA 0.011 NA 0.039 3.3e-05 NA 0.039 NA 0.00034
4 TCGA Kidney Renal Clear Cell Carcinoma 0.0402 0.0318 0.0015 0.013 0.008 0.011 NA 0.006 1.2e-02 0.041 0.016 NA 0.06900

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.9 1.5 3.0 1.1 -1.3 1.7 0.3
Bipolar Disorder or Schizophrenia 0.4 1.0 2.9 0.9 -0.3 0.5 1.7
Depressed Affect (Nagel 2018) 1.3 2.7 6.0 2.4 -2.0 0.0 -1.0
Depression (Nagel 2018) 0.4 0.6 1.1 1.1 -0.7 -0.0 -0.9
Intelligence (Savage-Jansen 2018) 0.8 2.4 4.6 0.3 2.1 1.9 -1.2
Neuroticism (Nagel 2018) 1.1 2.6 7.6 2.8 -1.4 0.6 -0.8
Schizophrenia (2018) 0.5 1.0 2.9 0.2 0.7 -0.7 1.7
Schizophrenia vs Biploar Disorder 0.7 0.9 3.4 0.3 0.2 -1.8 0.5
Worry (Nagel 2018) 1.5 3.2 9.7 3.1 -1.1 0.2 -1.3
Alzheimer’s Disease (in mother) 0.8 1.0 2.1 -1.4 -1.2 0.6 -0.3
Alzheimer’s Disease (in father) 0.5 0.5 1.9 1.4 -0.0 0.5 -0.1
Alzheimer’s Disease (including proxy) 0.4 0.6 1.5 -0.8 -0.6 1.2 -0.0
Crohns Disease (2017) 0.8 1.8 6.5 -0.4 0.3 -0.8 2.5
Irritable Bowel Disease (IBD) 0.5 1.2 4.1 -0.6 0.6 -0.3 2.0
Ulcerative Colitis (UC) 0.3 0.6 1.3 -0.4 1.1 0.4 0.9
Major Depression (MDD) 1.4 1.7 4.1 0.9 -2.0 -0.6 1.3
Reaction Time 0.8 1.5 4.5 1.1 -2.1 0.1 -0.6
Verbal and Numeric Reasoning (VNR) 0.8 2.0 5.4 0.6 1.5 2.3 -0.1
Breast Cancer 1.2 2.9 4.3 1.8 2.0 -2.1 0.4
Ovarian Cancer 1.3 1.8 3.6 1.3 -1.9 -0.5 1.2
Prostate Cancer 0.2 0.3 1.1 1.0 -0.3 -0.3 -0.3
Age at First Birth 0.8 1.1 2.0 0.3 1.1 1.4 -1.1
Bipolar Disorder (2011) 2.0 2.0 6.7 0.8 0.2 0.8 2.6
Body Mass Index (BMI) (2010) 1.3 1.7 4.9 -0.4 1.2 -0.6 -2.2
Coronary Artery Disease (CAD) 0.7 0.8 1.7 1.3 -1.0 -0.5 -0.6
Crohns Disease (2012) 2.1 3.3 11.5 0.7 0.1 -1.2 3.4
Mean Putamen Volume 1.2 1.3 3.1 0.3 -1.4 -1.8 -0.6
Fasting Glucose 1.5 1.8 3.3 -1.2 1.6 0.5 -1.8
HbA1C 1.3 1.5 2.0 -1.3 1.4 1.3 0.7
HDL Cholesterol 1.0 1.7 3.9 -2.0 1.5 0.6 -0.4
LDL Cholesterol 0.6 0.9 2.3 -1.0 -0.5 -1.5 -0.3
Lupus 0.3 0.5 1.2 0.2 0.5 0.8 -1.1
Neuroticism (2016) 0.4 0.5 1.1 -1.1 -0.0 0.8 0.6
Primary Biliary Cirrhosis 0.1 0.1 0.4 0.1 -0.7 -0.1 0.2
Rheumatoid Arthritis 0.9 1.2 2.4 1.1 -0.6 -1.0 1.5
Schizophrenia (2014) 0.6 1.3 2.9 -0.1 1.4 0.5 1.7
Triglycerides 1.3 2.2 5.3 0.1 -0.4 -2.3 -1.8
Type 2 Diabetes (T2D) (2012) 0.7 0.8 1.7 -1.3 -0.1 1.2 -0.4
Ulcerative Colitis 0.5 0.7 1.5 -1.2 1.0 0.2 0.6
Blood Eosinophil Count 0.2 1.7 5.7 0.5 -2.4 1.0 -0.0
Blood Platelet Count 0.2 2.6 7.5 -0.6 -1.5 -2.7 0.5
Blood Red Count 0.2 1.5 3.7 0.4 1.4 0.4 -1.9
Blood White Count 0.1 1.0 2.3 -0.6 0.5 1.5 1.1
Heel T-Score 1.6 13.0 29.2 3.5 5.4 -1.8 -2.7
BMI 0.1 0.9 1.1 1.0 1.1 0.8 0.9
Height 0.1 1.3 3.2 -1.2 1.8 -0.3 0.7
Waist Hip Ratio (WHR) 4.5 20.0 59.3 1.8 -7.7 -4.2 -0.5
Systolic Blood Pressure 0.2 0.8 2.0 -0.1 -0.8 -1.4 0.6
Smoking Status 0.7 1.6 3.0 -1.7 -0.5 -1.7 0.4
Allergy or Eczema 0.3 0.9 2.4 -0.9 1.5 0.4 -0.3
Cardiovascular Disease 0.1 0.3 0.9 -0.1 0.2 -0.6 1.0
Hypothyroidism (self reported) 0.3 0.7 2.8 0.1 0.3 -0.1 1.7
Respiratory disease 1.0 2.1 4.1 0.9 1.7 2.0 -0.9
Type 2 Diabetes (T2D) (2018) 1.0 1.8 4.0 1.4 2.0 1.0 0.5
Lung FEV1/FVC ratio 1.4 7.3 19.1 -0.1 -4.4 -3.1 -0.7
Lung FVC 2.4 12.3 45.4 0.5 -6.7 -0.2 -1.9
Neuroticism 1.1 2.8 7.0 2.6 -1.5 -0.2 -1.3
Chronotype (morning person) 0.6 1.3 2.9 -1.7 -0.3 1.6 0.0
Hair Pigment 0.1 2.4 5.4 -2.3 1.6 -0.0 -1.4
Tanning 0.1 1.7 2.3 1.1 -1.0 1.4 1.5
Hand grip strength (left) 0.8 2.0 5.6 1.3 2.4 -0.8 0.1
Number of treatments/medications taken 0.4 0.7 1.5 1.0 -0.7 1.2 -0.2
Average weekly spirits intake 1.4 1.8 4.2 1.2 2.1 0.8 -0.8
Sensitivity / hurt feelings 0.3 0.5 1.0 0.6 -1.0 0.4 -0.6
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.6 0.8 -0.1 -0.3 -0.7
Hearing difficulty/problems: Yes 0.4 0.5 0.9 0.5 -1.0 0.2 -1.0
Relative age of first facial hair 0.5 0.9 1.6 0.9 -1.1 1.3 0.4
Other serious medical condition/disability diagnosed by doctor 2.6 3.4 7.9 0.0 2.8 1.5 1.8
Ever used hormone-replacement therapy (HRT) 0.2 0.3 0.4 -0.5 -0.4 0.5 -0.6
Ever had hysterectomy (womb removed) 0.5 0.5 1.2 0.5 -0.3 -1.1 -0.8
Systolic blood pressure, automated reading 0.3 0.8 1.9 -0.5 -0.8 -1.4 -0.7
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 1.5 1.2 -0.1 -0.2 0.1
Angina 0.1 0.1 0.3 0.6 0.2 -0.3 0.3
Medication for hormone replacement therapy 0.9 1.0 2.5 -0.6 -1.6 -0.9 0.7
Vitamin and mineral supplements 0.3 0.4 1.1 0.6 0.3 -1.0 -0.2
Supplements: Zinc 0.2 0.2 0.6 0.0 -0.5 -0.3 -0.8
Medication: Co-codamol 0.6 0.7 1.5 1.2 0.6 0.7 -0.7
Medication: Metformin 0.3 0.4 1.1 1.0 -0.4 -0.1 0.6
Diabetes (father) 0.6 0.7 2.1 -0.2 0.5 1.4 0.6
Diabetes (mother) 0.6 0.7 1.4 -0.3 -1.1 1.2 -0.5
Severe depression (siblings) 0.1 0.1 0.2 0.2 -0.3 0.3 0.4
Pack years adult smoking proportion 0.7 1.1 3.3 0.3 -0.5 -1.8 0.9
Impedance of leg (right) 0.7 3.2 9.3 0.1 3.1 1.9 0.1
Leg fat-free mass (left) 0.2 0.8 2.5 0.5 -0.1 -0.7 1.6
Trunk fat percentage 0.8 3.1 8.4 0.2 2.9 1.4 -1.4
Hand grip strength (right) 1.2 3.1 8.1 1.3 2.8 -1.2 1.1
Townsend deprivation index at recruitment 0.3 0.4 0.6 0.0 -0.7 -0.8 -0.7
Current tobacco smoking 0.5 0.8 1.8 -0.6 -0.5 -1.4 0.8
Average weekly fortified wine intake 0.7 0.8 1.8 0.7 0.3 0.9 1.4
Maternal smoking around birth 0.2 0.3 0.8 -0.4 -0.0 -0.6 0.9
Fed-up feelings 0.5 1.0 2.2 1.0 -1.5 0.4 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.4 -0.2 0.3 0.6 -0.6
Relative age voice broke 0.5 0.7 2.6 0.5 -1.6 0.4 0.1
Taking other prescription medications 1.3 2.1 4.0 1.8 -2.0 0.1 1.0
Age when periods started (menarche) 0.0 0.1 0.2 0.3 -0.4 -0.2 -0.3
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.6 -0.4 0.1 -0.8 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.3 3.6 0.7 1.6 -1.9 -1.5
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 2.9 0.2 0.3 -1.5 1.7
Qualifications: CSEs or equivalent 0.5 0.7 2.5 -1.6 -0.3 -0.3 0.0
Serious illness, injury or assault to yourself 1.9 2.3 6.2 -1.0 2.5 -1.2 0.8
High blood pressure 0.2 0.6 2.4 -0.1 -0.3 0.0 -1.5
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.5 -0.3 1.2 -0.1 1.1
Multivitamins +/- minerals 0.7 0.9 1.6 -1.3 -0.7 0.6 -1.1
Stomach or abdominal pain in last month 0.9 1.1 3.9 0.1 -0.5 -2.0 0.3
Supplements: Glucosamine 1.9 2.5 4.4 -1.2 -1.0 2.1 -1.8
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.5 0.7 0.7 -0.2 -0.1
Medication: Atenolol 0.2 0.3 1.0 0.1 0.2 -1.0 -0.5
Medication: Levothyroxine sodium 0.5 0.9 3.0 1.7 -0.3 0.2 0.6
Sitting height 0.8 5.7 17.6 -1.0 4.2 1.2 1.7
Chronic bronchitis/emphysema (father) 0.5 0.6 0.7 -0.9 0.7 0.7 -0.9
High blood pressure (mother) 0.4 0.5 1.0 -0.3 -1.0 0.0 1.0
Body mass index (BMI) 0.1 0.5 0.8 0.7 -0.9 -0.1 -0.9
Impedance of leg (left) 0.4 1.7 6.1 -0.6 2.5 0.8 0.0
Leg predicted mass (left) 0.1 0.8 2.3 0.5 -0.2 -0.7 1.5
Trunk fat mass 0.3 1.4 4.5 0.2 2.1 0.7 -0.9
Waist circumference 0.5 1.8 4.2 1.1 -2.1 -0.4 -1.2
Number of incorrect matches in round 1.2 1.9 3.4 -1.9 -0.9 -1.5 -1.1
Past tobacco smoking 0.4 0.7 1.6 0.5 0.2 1.3 0.9
Alcohol usually taken with meals 1.2 2.0 3.0 1.2 -1.3 1.4 1.7
Nervous feelings 0.8 1.6 2.7 1.6 0.9 -0.2 1.7
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.8 0.8 -0.1 -0.1 -0.9
Hearing difficulty/problems with background noise 0.6 1.0 2.3 0.4 -1.5 0.1 -1.2
Hair/balding pattern: Pattern 2 1.1 1.4 4.0 2.0 -0.5 0.4 -1.2
Had menopause 1.5 1.9 4.4 0.2 0.4 1.7 -2.1
Had other major operations 0.2 0.2 0.5 0.7 -0.4 -0.3 0.4
Forced vital capacity (FVC) 0.2 0.9 3.3 0.2 -1.8 0.4 -0.2
Heel bone mineral density (BMD) T-score, automated (right) 1.3 3.0 4.6 1.0 2.1 -1.7 -1.8
Ever unenthusiastic/disinterested for a whole week 1.6 2.0 5.6 -0.9 0.7 -2.4 -1.0
Qualifications: None of the above 2.1 4.4 12.1 -0.2 -3.5 -1.6 -1.7
Financial difficulties in last 2 years 0.4 0.5 1.4 -0.6 0.0 -1.2 -0.6
Mouth/teeth dental problems 0.3 0.5 1.1 -1.1 0.6 -0.1 -0.7
Heart attack 0.4 0.5 1.2 -1.1 0.7 -0.5 -0.3
Allergy 0.7 1.5 4.5 -0.4 -2.1 -1.1 -0.6
Pain all over the body in last month 0.2 0.2 0.4 -0.3 -0.6 -0.4 -0.5
Diabetes (self-reported) 1.1 1.7 4.3 2.1 1.5 0.0 -0.3
Hayfever/allergic rhinitis (self-reported) 1.3 1.8 2.7 0.7 1.7 1.6 1.2
Medication: Ramipril 0.1 0.2 0.4 0.0 -0.0 -0.5 -0.6
Medication: Simvastatin 0.5 0.8 2.9 0.6 -1.7 0.0 -0.1
Fluid intelligence score 0.8 1.6 4.6 0.8 0.9 2.1 0.6
Illnesses of siblings 0.8 1.1 2.4 0.5 -0.3 1.6 1.2
Neuroticism score 0.9 1.8 5.7 2.4 -0.7 0.0 -1.1
Weight 0.0 0.2 0.5 0.7 0.3 -0.2 0.2
Impedance of arm (right) 2.8 13.1 42.7 -0.2 6.5 3.0 -1.0
Arm fat percentage (right) 0.6 2.3 4.5 0.6 2.1 1.2 -1.6
Trunk fat-free mass 0.4 2.3 4.5 -0.1 -2.1 -1.4 1.7
Hip circumference 0.6 2.6 6.0 -0.0 2.5 2.0 -0.5
Time employed in main current job 3.7 4.3 7.3 1.8 0.4 2.6 -2.7
Alcohol intake versus 10 years previously 1.7 2.5 6.2 2.5 1.0 -1.1 1.3
Father’s age at death 0.9 1.2 2.5 -0.4 -0.4 -1.4 1.6
Worrier / anxious feelings 1.1 2.1 5.2 1.5 -2.3 -0.1 -1.0
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.4 -0.4 1.2 -0.0 -0.7
Falls in the last year 0.6 0.9 3.0 -0.7 0.0 1.7 -0.1
Hair/balding pattern: Pattern 3 0.3 0.5 1.0 -0.2 -0.7 -0.6 1.0
Number of live births 0.6 0.9 1.4 -1.2 -0.7 1.0 0.8
Forced expiratory volume in 1-second (FEV1) 0.5 1.8 7.0 -0.0 -2.6 -0.5 0.3
Pulse rate 1.0 1.6 5.3 -0.9 2.3 0.6 -0.3
Happiness 1.7 2.1 6.9 0.5 -0.0 -1.0 -2.6
Noisy workplace 1.5 1.9 4.1 -1.2 -2.0 -1.4 0.1
Qualifications: A levels/AS levels or equivalent 1.9 4.3 5.7 2.4 2.2 2.2 1.1
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.8 0.2 0.3 0.1 0.9
Mouth/teeth dental problems: Dentures 0.6 1.0 1.8 -1.2 -0.4 -0.7 -1.3
Asthma 1.1 2.2 3.9 1.2 1.6 2.0 -0.9
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 0.8 -0.2 -0.8 0.7 0.9
Medication: Cholesterol lowering 0.2 0.3 0.9 0.2 -0.2 -1.0 -0.3
Depression (self-reported) 1.7 2.0 4.4 0.2 -2.1 0.6 -1.8
Medication: Lansoprazole 0.6 0.7 2.0 1.4 -0.5 -0.4 -0.5
Prospective memory result 0.2 0.3 1.1 -0.1 -0.2 -0.1 -1.1
Lung cancer (father) 0.2 0.3 0.5 -0.6 0.7 -0.1 -0.5
Illnesses of mother 1.0 1.2 3.0 1.2 0.2 -0.6 1.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.9 10.0 1.0 -3.2 -0.9 0.1
Pulse wave Arterial Stiffness index 1.2 1.4 3.0 0.8 -0.9 1.7 1.1
Impedance of arm (left) 2.5 11.7 35.8 -0.2 6.0 3.2 -0.7
Arm fat mass (right) 0.1 0.4 1.0 0.4 1.0 0.6 -0.5
Trunk predicted mass 0.4 2.5 4.6 -0.1 -2.1 -1.4 1.8
Standing height 0.3 2.8 6.0 -0.1 2.5 0.1 2.3
Length of working week for main job 1.1 1.3 2.5 -0.8 -0.2 -1.4 -1.6
Exposure to tobacco smoke at home 2.5 2.8 8.9 0.5 -3.0 -1.3 -0.6
Breastfed as a baby 0.3 0.3 0.7 -0.7 0.8 0.2 -0.3
Tense / ‘highly strung’ 0.6 0.9 2.3 1.0 0.6 -0.1 -1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 2.2 3.4 8.3 0.7 -1.4 -1.7 -2.9
Hair/balding pattern: Pattern 4 0.4 1.0 1.7 -0.6 -1.2 1.3 -0.7
Birth weight of first child 1.2 2.1 6.9 1.2 -0.2 -0.3 2.6
Peak expiratory flow (PEF) 0.1 0.2 0.5 -0.1 -0.2 0.4 0.7
Pulse wave reflection index 0.9 1.2 2.3 1.3 -0.6 0.5 1.5
Ever highly irritable/argumentative for 2 days 1.4 1.6 3.0 -1.3 -1.4 -1.7 0.2
Loud music exposure frequency 0.9 1.0 1.4 -1.2 1.0 0.8 1.0
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 2.3 0.7 0.6 0.4 1.5
Mouth/teeth dental problems: Bleeding gums 0.9 1.2 2.0 1.4 -0.6 0.8 1.3
Blood clot in the leg (DVT) 1.1 1.5 3.0 -0.0 1.6 -0.4 1.7
Medication: Paracetamol 0.2 0.3 0.7 0.7 -0.4 -0.1 -0.8
Headache pain in last month 0.2 0.3 0.8 0.5 -0.6 -0.9 -0.1
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.4 0.2 0.4 0.6 0.1
Glaucoma (self-reported) 0.8 0.9 1.8 -0.2 0.4 1.3 -1.3
Gout (self-reported) 0.4 0.6 1.8 0.0 -0.5 -1.3 0.5
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 2.1 0.2 0.2 0.5 1.4
Medication: Amlodipine 0.8 1.1 4.2 0.2 -0.4 -2.0 -0.3
Medication: Ventolin 100micrograms inhaler 1.6 2.1 5.7 2.4 1.3 -0.2 -1.0
Birth weight 0.5 1.1 2.2 -0.7 0.4 -1.3 1.5
Chronic bronchitis/emphysema (mother) 0.5 0.6 2.0 -1.4 0.2 -0.4 -0.3
High blood pressure (siblings) 0.5 0.7 2.8 -0.2 1.7 -0.1 -0.4
Forced vital capacity (FVC), Best measure 0.6 2.0 6.9 0.8 -2.6 -0.7 -0.3
Body fat percentage 0.5 2.0 5.0 0.4 2.2 1.0 -1.3
Leg fat percentage (right) 0.2 0.8 2.0 0.6 0.8 0.5 -1.4
Arm fat-free mass (right) 0.6 2.9 5.2 -0.2 -2.3 -2.0 1.6
Exposure to tobacco smoke outside home 1.1 1.5 3.0 -0.4 -1.7 0.4 -1.6
Comparative body size at age 10 1.4 4.0 9.5 -1.2 -2.0 -3.1 -0.9
Number of full brothers 1.1 1.4 3.8 -0.9 -0.9 -0.5 -1.9
Worry too long after embarrassment 1.4 2.3 6.4 1.3 -1.0 -0.5 -2.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 1.8 1.2 -0.7 -0.8 -1.4
Wheeze or whistling in the chest in last year 0.1 0.3 0.7 0.1 0.3 -0.9 0.4
Number of children fathered 0.7 0.8 2.4 -0.5 -1.6 0.1 0.6
Reason for reducing amount of alcohol drunk: Health precaution 2.2 2.5 6.0 1.4 2.4 1.5 0.3
Age at first live birth 1.1 1.9 3.0 1.7 0.9 1.0 1.7
Pulse wave peak to peak time 1.4 1.6 3.9 -0.8 0.9 -2.0 -1.1
Health satisfaction 0.2 0.3 0.4 0.5 0.4 -0.5 -0.6
Shortness of breath walking on level ground 0.4 0.5 1.3 0.7 -0.0 0.3 -1.2
Qualifications: College or University degree 0.8 2.4 8.0 -0.1 2.8 1.2 -0.4
Eye problems/disorders: None of the above 0.6 0.7 1.5 -1.2 1.2 0.2 -0.0
Mouth/teeth dental problems: Loose teeth 0.9 1.0 3.2 1.8 0.6 -0.6 0.5
Emphysema/chronic bronchitis 1.0 1.1 3.0 -0.6 0.9 -0.5 -1.7
Medication for pain relief, constipation, heartburn 0.3 0.6 1.1 -0.9 1.1 -0.1 -0.5
Neck or shoulder pain in last month 0.9 1.2 2.5 1.6 -0.1 1.2 -1.1
Medication: Blood pressure 0.4 0.7 1.5 -1.1 0.2 -0.4 -1.2
Angina (self-reported) 0.0 0.0 0.1 0.3 -0.0 -0.1 0.1
Migraine (self-reported) 1.4 1.7 6.9 -0.1 0.1 0.2 2.6
Medication: Ibuprofen 0.9 1.1 2.7 -0.5 0.0 1.6 1.2
Medication: Allopurinol 0.6 0.8 1.5 0.0 -1.1 -1.2 0.6
Medication: Omeprazole 1.4 1.7 3.5 1.9 -1.4 0.6 0.9
Medication: Seretide 50 evohaler 1.4 1.6 5.3 0.7 2.3 0.7 0.5
Mean time to correctly identify matches 1.2 2.3 6.5 1.1 -2.6 0.2 -1.1
Heart disease (mother) 0.4 0.5 1.5 -1.2 -0.5 0.1 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 4.9 5.9 22.2 -1.1 4.7 0.0 -0.1
Whole body fat mass 0.2 0.7 2.2 0.2 1.5 0.6 -0.4
Leg fat mass (right) 0.0 0.1 0.2 0.4 0.3 -0.1 -0.1
Arm predicted mass (right) 0.7 3.6 6.0 -0.1 -2.5 -2.0 2.0
Pulse rate, automated reading 0.5 1.8 5.5 -1.1 2.4 -0.3 -0.6
Alcohol intake frequency. 0.3 0.7 1.4 -0.1 -0.4 1.1 -1.2
Comparative height size at age 10 0.2 1.1 1.8 0.7 0.9 -1.1 1.4
Number of full sisters 0.8 1.0 3.6 -0.3 -1.9 -0.5 -0.2
Suffer from ‘nerves’ 1.2 1.8 5.4 2.3 -1.1 -0.2 -0.9
Overall health rating 0.4 0.9 2.0 0.9 -0.3 1.4 0.7
Chest pain or discomfort 1.5 2.2 6.0 -1.7 2.4 -0.2 0.1
Had major operations 1.5 1.8 5.3 1.0 -2.3 0.6 0.7
Age at last live birth 1.6 2.4 6.7 0.3 1.2 1.1 2.6
Family relationship satisfaction 0.3 0.4 1.3 0.1 0.1 -1.2 -0.3
Leg pain on walking 1.2 1.6 3.0 -1.2 -1.7 -1.1 -0.7
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 0.9 -0.3 -0.9 -0.3 0.8
Commuting to job workplace: Car/motor vehicle 1.0 1.2 2.5 -0.6 -1.6 0.1 -1.4
Illness, injury, bereavement, stress in last 2 years 1.0 1.3 3.1 0.2 0.9 1.8 -1.1
Medication: Aspirin 0.1 0.1 0.5 0.7 0.1 0.0 0.1
Supplements: Vitamin C 1.8 2.1 4.0 1.4 0.6 1.4 2.0
Knee pain experienced in last month 0.4 0.7 1.0 0.7 -0.9 0.6 -1.0
Hypertension (Self-reported) 0.4 1.0 3.8 -0.5 -0.1 -0.1 -1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 2.1 1.4 0.6 1.1 0.3
Illnesses of father: Heart disease 0.2 0.3 0.9 1.0 0.3 -0.0 -0.2
Illnesses of siblings: Diabetes 0.9 1.1 4.1 0.4 0.2 -2.0 -0.4
Smoking status: Previous 0.5 0.7 2.1 -0.6 -0.5 -0.6 -1.4
Forced expiratory volume in 1-second (FEV1), predicted 2.2 4.6 10.2 0.8 2.7 -0.6 3.2
Whole body fat-free mass 0.3 1.9 3.1 0.1 -1.6 -1.5 1.8
Leg fat-free mass (right) 0.2 1.3 2.4 0.4 -0.7 -1.4 1.6
Arm fat percentage (left) 0.5 2.1 3.7 0.6 1.9 1.4 -1.4
Average weekly red wine intake 1.1 1.7 5.1 -0.4 -1.0 0.6 2.3
Handedness (chirality/laterality): Left-handed 1.3 1.5 5.5 -0.5 -0.2 -0.6 2.3
Mood swings 1.9 3.4 10.7 3.3 -1.7 0.2 -0.1
Loneliness, isolation 0.8 1.1 2.0 1.0 -1.1 0.2 -1.4
Long-standing illness, disability or infirmity 1.1 1.7 5.4 0.9 2.3 0.6 0.3
Ever had bowel cancer screening 0.9 1.1 2.8 1.0 -0.5 -0.4 1.7
Diabetes diagnosed by doctor 1.0 1.6 4.6 2.1 1.3 -0.1 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 3.2 3.4 9.4 1.3 -1.5 -0.2 3.1
Friendships satisfaction 0.2 0.2 0.9 0.2 1.0 -0.2 -0.1
Qualifications: nursing, teaching 1.3 2.1 4.0 1.4 2.0 0.8 1.2
Commuting to job workplace: Walk 1.7 1.9 5.1 0.4 2.3 1.0 1.1
Eye problems/disorders: Cataract 0.2 0.2 0.3 0.6 -0.3 -0.2 -0.5
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.4 1.2 -0.3 -0.1 1.0
Medication for cholesterol 0.6 0.9 2.2 -0.1 1.5 -1.0 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.1 2.5 5.9 2.4 -1.9 0.6 0.2
Back pain experienced in last month 0.5 0.7 2.1 1.4 -0.7 -0.5 0.3
Mineral and other dietary supplements 0.8 1.1 2.3 0.9 0.8 -0.8 1.5
Breast cancer (self-reported) 0.1 0.1 0.3 0.2 -0.5 -0.3 -0.3
Asthma (self-reported) 1.2 2.5 3.8 1.5 1.6 1.9 -1.0
Osteoporosis (self-reported) 0.8 1.0 2.4 -0.7 -0.8 1.6 -0.7
Osteoarthritis (self-reported) 0.3 0.3 0.6 0.4 -0.7 -0.7 0.3
Medication: Aspirin 0.2 0.2 0.4 0.6 -0.3 0.0 -0.6
Medication: Gliclazide 1.0 1.2 3.5 1.9 -0.5 0.0 -0.9
Illnesses of father: None of the above (group 1) 0.4 0.5 1.5 -0.5 0.0 -0.7 1.2
Smoking status: Current 0.4 0.6 1.7 -0.6 -0.3 -1.3 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.0 6.4 22.6 1.6 -4.8 -0.3 0.4
Whole body water mass 0.3 1.9 2.8 0.1 -1.6 -1.5 1.7
Leg predicted mass (right) 0.2 1.2 2.3 0.3 -0.7 -1.4 1.5
Arm fat mass (left) 0.1 0.4 0.7 0.3 0.8 0.7 -0.5
Number of self-reported non-cancer illnesses 0.6 1.0 2.0 1.4 0.4 1.0 1.0
Average weekly champagne plus white wine intake 1.1 1.5 4.0 0.5 2.0 1.3 0.5
Miserableness 0.3 0.5 1.6 1.3 0.0 -0.0 -0.8
Guilty feelings 0.7 1.0 3.8 1.9 -0.1 0.4 -0.0
Wears glasses or contact lenses 0.9 1.0 2.6 1.0 -1.6 0.1 -0.6
Ever taken oral contraceptive pill 0.4 0.5 0.8 0.9 0.7 0.8 -0.1
Hearing aid user 0.4 0.4 1.3 -0.5 -1.2 0.0 0.3
Mother’s age at death 0.7 0.9 2.0 -0.7 -1.4 1.0 -0.4
Financial situation satisfaction 0.2 0.3 0.9 -0.1 -0.1 -0.4 -0.9
Tinnitus: Yes, now most or all of the time 0.6 0.7 2.1 -0.7 -0.4 -1.4 -0.2
Commuting to job workplace: Public transport 0.7 0.9 1.7 0.5 0.1 1.3 -1.2
Eye problems/disorders: Glaucoma 0.9 1.1 4.2 0.2 -0.4 0.3 -2.0
Medication: Blood pressure 0.8 1.5 2.9 1.7 -0.8 1.1 -1.1
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.1 -0.0 0.4 1.1 -0.8
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.0 -1.0 -0.8 -0.1 -0.7
High cholesterol (Self-reported) 0.3 0.6 2.0 0.2 -1.4 -0.5 -0.2
Medication: Bendroflumethiazide 1.7 2.6 8.1 -0.4 1.5 2.8 0.3
Medication: Paracetamol 0.5 0.8 1.8 0.2 0.1 1.1 -1.3
Medication: Lisinopril 0.2 0.3 0.9 0.3 0.1 0.2 0.9
Medication: Atorvastatin 0.3 0.4 0.7 0.7 0.5 -0.3 -0.8
Illnesses of father: High blood pressure 1.3 1.6 3.1 0.4 -1.7 -1.4 1.1
Alcohol drinker status: Never 0.6 0.8 2.4 -1.6 0.6 0.2 -0.5
Ever smoked 0.7 1.3 3.3 0.1 -1.3 -1.8 -0.4
Basal metabolic rate 0.2 1.1 2.0 0.2 -1.1 -1.1 1.4
Leg fat percentage (left) 0.2 0.8 2.8 0.2 0.6 -0.3 -1.7
Arm fat-free mass (left) 0.4 2.2 4.5 -0.1 -2.1 -1.7 1.2
Number of operations (self-reported) 0.5 0.7 1.2 0.8 -0.8 -0.5 1.1
Average weekly beer plus cider intake 1.2 1.7 4.3 -1.3 -0.1 -2.1 0.9
Irritability 0.8 1.4 3.6 1.4 1.9 0.3 -0.0
Risk taking 0.8 1.1 3.4 -0.4 1.8 0.8 0.4
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.3 0.3 -0.4 -0.6 0.5
Fractured/broken bones in last 5 years 0.6 0.7 1.4 0.8 -1.2 -0.6 -0.7
Age started oral contraceptive pill 2.6 3.2 10.3 1.1 -0.9 0.8 -3.2
Diastolic blood pressure, automated reading 0.5 1.4 5.2 -0.6 -0.2 -2.3 -0.2
Ever depressed for a whole week 0.6 0.7 1.1 -0.8 1.0 -0.3 -1.0
Unable to work because of sickness or disability 0.3 0.4 0.6 -0.7 -0.7 -0.7 0.1
Commuting to job workplace: Cycle 1.4 1.7 2.5 -1.6 1.3 -1.2 -1.2
Myopia 0.8 1.1 3.7 -0.7 1.9 0.3 -0.5
Vascular/heart problems diagnosed by doctor 0.2 0.5 1.9 0.3 0.3 0.1 1.4
Cholesterol lowering medication 1.0 1.4 3.9 0.5 -2.0 0.9 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.6 0.8 1.1 1.0 -0.9 0.1 1.0
Pain experienced in last month 0.1 0.2 0.8 -0.1 0.9 0.3 0.1
Supplements: Calcium 1.7 1.8 3.5 -0.6 -0.5 1.9 -1.8
Basal cell carcinoma (self-reported) 1.0 1.2 4.0 -2.0 0.8 -0.0 -0.6
Heart attack/myocardial infarction (self-reported) 0.5 0.6 1.1 -1.0 1.0 -0.5 -0.4
Deep venous thrombosis (DVT) (self-reported) 1.1 1.5 3.2 0.1 1.8 -0.5 1.5
Heart disease (siblings) 1.3 1.5 3.9 -0.9 -1.0 0.7 -2.0
Alcohol drinker status: Previous 0.4 0.4 1.0 -0.6 -0.1 1.0 0.5
Pack years of smoking 0.4 0.6 2.2 -0.2 -0.5 -1.5 0.1
Impedance of whole body 1.7 8.8 29.3 -0.4 5.4 2.3 -0.6
Leg fat mass (left) 0.0 0.1 0.3 0.3 0.1 -0.5 -0.5
Arm predicted mass (left) 0.4 2.1 3.4 0.0 -1.9 -1.7 1.4