TWAS
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Usage
Models
Genes
Traits
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Traits
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Impedance of whole body
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chr12:104,871,892-106,319,548
Best TWAS P=1.93e-08 · Best GWAS P=5.76e-08 conditioned to 0.0485
104.8M
105M
105.2M
105.4M
105.6M
105.8M
106M
106.2M
106.4M
0
2
4
6
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Bladder Urothelial Carcinoma
APPL2
0.05
0.02
blup
94
0.02
9.1e-03
-4.5
5.6
1.9e-08
-0.72
0.03
0.84
TRUE
1
GTEx
Cells Transformed fibroblasts
APPL2
0.20
0.24
lasso
3
0.24
4.1e-18
-4.5
5.2
1.6e-07
-0.58
0.10
0.89
FALSE
2
GTEx
Whole Blood
APPL2
0.09
0.10
lasso
4
0.11
3.3e-10
-4.7
-5.2
1.7e-07
0.91
0.02
0.98
FALSE