Best TWAS P=1.93e-08 · Best GWAS P=5.76e-08 conditioned to 0.0485
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | APPL2 | 0.20 | 0.24 | lasso | 3 | 0.24 | 4.1e-18 | -4.5 | 5.2 | 1.6e-07 | -0.58 | 0.10 | 0.89 | FALSE |
| 2 | GTEx | Whole Blood | APPL2 | 0.09 | 0.10 | lasso | 4 | 0.11 | 3.3e-10 | -4.7 | -5.2 | 1.7e-07 | 0.91 | 0.02 | 0.98 | FALSE |
| 3 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | APPL2 | 0.05 | 0.02 | blup | 94 | 0.02 | 9.1e-03 | -4.5 | 5.6 | 1.9e-08 | -0.72 | 0.03 | 0.84 | TRUE |