Best TWAS P=2.56e-11 · Best GWAS P=6.89e-11 conditioned to 1.67e-07
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CCDC92 | 0.09 | 0.01 | bslmm | 438 | 0.03 | 3.1e-04 | 5.5 | -6.7 | 2.6e-11 | 0.21 | 0.37 | 0.56 | TRUE |
2 | GTEx | Adipose Subcutaneous | RP11-380L11.3 | 0.09 | 0.03 | lasso | 3 | 0.03 | 1.4e-03 | 5.2 | 5.8 | 5.1e-09 | -0.12 | 0.52 | 0.32 | FALSE |
3 | GTEx | Adipose Visceral Omentum | RP11-380L11.3 | 0.15 | 0.03 | lasso | 5 | 0.01 | 1.4e-01 | 3.4 | 5.5 | 4.3e-08 | -0.06 | 0.15 | 0.10 | FALSE |
4 | GTEx | Artery Tibial | RP11-380L11.4 | 0.14 | 0.12 | lasso | 4 | 0.12 | 2.2e-09 | 5.2 | 5.4 | 7.5e-08 | -0.13 | 0.69 | 0.31 | FALSE |
5 | GTEx | Breast Mammary Tissue (Male) | CCDC92 | 0.06 | -0.01 | lasso | 3 | 0.00 | 4.3e-01 | 5.6 | 5.2 | 1.9e-07 | -0.09 | 0.04 | 0.07 | FALSE |
6 | GTEx | Breast Mammary Tissue (Female) | CCDC92 | 0.05 | -0.01 | enet | 2 | -0.01 | 6.2e-01 | 5.5 | 5.5 | 3.2e-08 | -0.11 | 0.05 | 0.07 | FALSE |
7 | GTEx | Esophagus Mucosa | CCDC92 | 0.11 | 0.02 | lasso | 4 | 0.02 | 1.9e-02 | 5.5 | 5.5 | 4.8e-08 | -0.10 | 0.24 | 0.47 | FALSE |
8 | GTEx | Esophagus Muscularis | RP11-380L11.4 | 0.27 | 0.29 | lasso | 8 | 0.27 | 1.0e-16 | 5.2 | 5.3 | 1.4e-07 | -0.13 | 0.74 | 0.26 | FALSE |
9 | GTEx | Heart Left Ventricle | CCDC92 | 0.26 | 0.19 | lasso | 4 | 0.21 | 1.9e-11 | 5.5 | 5.7 | 9.3e-09 | -0.10 | 0.38 | 0.62 | FALSE |
10 | GTEx | Lung | RP11-380L11.4 | 0.07 | 0.07 | lasso | 3 | 0.07 | 8.2e-06 | 5.1 | 5.3 | 1.1e-07 | -0.11 | 0.56 | 0.41 | FALSE |
11 | GTEx | Muscle Skeletal | RP11-380L11.4 | 0.14 | 0.03 | lasso | 8 | 0.03 | 4.0e-04 | 5.2 | 5.4 | 8.0e-08 | -0.15 | 0.65 | 0.26 | FALSE |
12 | GTEx | Thyroid | ZNF664 | 0.13 | 0.06 | lasso | 11 | 0.08 | 6.7e-07 | 5.5 | -5.6 | 2.1e-08 | 0.11 | 0.46 | 0.54 | FALSE |
13 | METSIM | Adipose | DNAH10 | 0.03 | 0.00 | bslmm | 475 | 0.01 | 3.2e-03 | 5.3 | 5.3 | 8.9e-08 | -0.14 | 0.17 | 0.11 | FALSE |
14 | The Cancer Genome Atlas | Glioblastoma Multiforme | CCDC92 | 0.07 | 0.02 | blup | 52 | 0.04 | 1.8e-02 | 5.5 | 5.2 | 1.9e-07 | -0.11 | 0.02 | 0.79 | FALSE |
15 | The Cancer Genome Atlas | Soft Tissue Sarcoma | CCDC92 | 0.05 | 0.03 | blup | 52 | 0.03 | 5.8e-03 | 4.8 | 5.5 | 4.1e-08 | -0.12 | 0.02 | 0.82 | FALSE |
16 | The Cancer Genome Atlas | Thyroid Carcinoma | DNAH10 | 0.04 | 0.03 | lasso | 5 | 0.02 | 4.6e-03 | 5.5 | 5.3 | 1.1e-07 | -0.09 | 0.02 | 0.83 | FALSE |