Best TWAS P=2.44e-10 · Best GWAS P=3.05e-09 conditioned to 0.243
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adrenal Gland | HEATR3 | 0.33 | 0.30 | lasso | 9 | 0.31 | 1.3e-11 | 5.2 | -5.3 | 1.2e-07 | -0.83 | 0.24 | 0.76 | FALSE |
2 | GTEx | Artery Aorta | HEATR3 | 0.41 | 0.41 | enet | 62 | 0.42 | 5.4e-25 | 5.2 | -6.0 | 2.4e-09 | -0.76 | 0.23 | 0.76 | FALSE |
3 | GTEx | Artery Aorta | RP11-429P3.3 | 0.15 | 0.15 | lasso | 4 | 0.14 | 5.6e-08 | 5.2 | -5.5 | 4.7e-08 | -0.87 | 0.12 | 0.88 | FALSE |
4 | GTEx | Artery Coronary | HEATR3 | 0.30 | 0.25 | lasso | 5 | 0.25 | 6.0e-09 | 5.2 | -5.2 | 1.9e-07 | -0.81 | 0.19 | 0.80 | FALSE |
5 | GTEx | Artery Tibial | RP11-429P3.3 | 0.09 | 0.05 | lasso | 3 | 0.04 | 5.9e-04 | 5.0 | -5.1 | 2.8e-07 | -0.74 | 0.15 | 0.59 | FALSE |
6 | GTEx | Brain Caudate basal ganglia | HEATR3 | 0.36 | 0.14 | lasso | 12 | 0.20 | 2.6e-06 | 5.1 | -5.4 | 8.3e-08 | -0.80 | 0.22 | 0.70 | FALSE |
7 | GTEx | Brain Cortex | HEATR3 | 0.51 | 0.46 | lasso | 11 | 0.47 | 8.5e-15 | 5.2 | -5.6 | 1.7e-08 | -0.81 | 0.23 | 0.77 | FALSE |
8 | GTEx | Brain Frontal Cortex BA9 | HEATR3 | 0.30 | 0.20 | lasso | 10 | 0.16 | 5.6e-05 | 5.1 | -5.5 | 5.1e-08 | -0.81 | 0.18 | 0.53 | FALSE |
9 | GTEx | Brain Putamen basal ganglia | HEATR3 | 0.27 | 0.16 | lasso | 6 | 0.15 | 2.3e-04 | 5.2 | -5.1 | 3.0e-07 | -0.81 | 0.05 | 0.66 | FALSE |
10 | GTEx | Cells Transformed fibroblasts | HEATR3 | 0.22 | 0.18 | lasso | 15 | 0.20 | 1.4e-14 | 5.9 | -5.9 | 4.6e-09 | -0.97 | 0.01 | 0.99 | FALSE |
11 | GTEx | Colon Transverse | HEATR3 | 0.36 | 0.36 | lasso | 7 | 0.36 | 9.1e-18 | 5.1 | -5.1 | 2.9e-07 | -0.83 | 0.28 | 0.72 | FALSE |
12 | GTEx | Esophagus Muscularis | HEATR3 | 0.40 | 0.38 | lasso | 8 | 0.39 | 6.1e-25 | 5.1 | -5.2 | 2.1e-07 | -0.82 | 0.29 | 0.71 | FALSE |
13 | GTEx | Heart Atrial Appendage | HEATR3 | 0.30 | 0.30 | lasso | 8 | 0.27 | 1.1e-12 | 5.2 | -5.2 | 2.2e-07 | -0.82 | 0.22 | 0.78 | FALSE |
14 | GTEx | Lung | HEATR3 | 0.34 | 0.40 | enet | 19 | 0.41 | 6.4e-34 | 5.2 | -5.5 | 3.7e-08 | -0.83 | 0.22 | 0.78 | FALSE |
15 | GTEx | Ovary | HEATR3 | 0.30 | 0.14 | lasso | 11 | 0.16 | 1.2e-04 | 5.1 | -5.4 | 5.9e-08 | -0.87 | 0.06 | 0.77 | FALSE |
16 | GTEx | Ovary | RP11-429P3.3 | 0.27 | 0.11 | enet | 15 | 0.15 | 1.9e-04 | 5.7 | -6.3 | 2.4e-10 | -0.84 | 0.02 | 0.91 | TRUE |
17 | GTEx | Pancreas | HEATR3 | 0.37 | 0.20 | lasso | 10 | 0.24 | 2.1e-10 | 5.1 | -5.2 | 2.6e-07 | -0.84 | 0.17 | 0.83 | FALSE |
18 | GTEx | Spleen | HEATR3 | 0.43 | 0.13 | lasso | 9 | 0.13 | 2.7e-04 | 5.1 | -5.5 | 4.6e-08 | -0.80 | 0.12 | 0.80 | FALSE |
19 | GTEx | Stomach | HEATR3 | 0.36 | 0.27 | enet | 14 | 0.28 | 1.6e-13 | 4.9 | -5.2 | 2.0e-07 | -0.77 | 0.34 | 0.66 | FALSE |
20 | The Cancer Genome Atlas | Glioblastoma Multiforme | HEATR3 | 0.13 | 0.07 | blup | 39 | 0.10 | 5.1e-04 | 5.2 | -6.2 | 4.3e-10 | -0.84 | 0.02 | 0.84 | FALSE |
21 | The Cancer Genome Atlas | Thyroid Carcinoma | PAPD5 | 0.02 | 0.03 | lasso | 1 | 0.02 | 1.8e-03 | 5.4 | -5.4 | 7.8e-08 | -0.39 | 0.01 | 0.89 | FALSE |