TWAS hub - PAPD5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0274	0.0095	0.00024	0.012	0.012	0.021	0.013	0.017	5.2e-05	5.3e-05	1.4e-07	3.8e-05	2.7e-06
2	TCGA	Thyroid Carcinoma	0.0210	0.0130	0.00610	0.029	0.023	-0.001	NA	0.024	7.8e-04	2.4e-03	3.7e-01	NA	1.8e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Crohns Disease (2017)	17.2	37.8	48.6	-7.0	-5.2
Crohns Disease (2012)	15.1	24.2	36.2	-6.0	-3.5
Irritable Bowel Disease (IBD)	9.9	23.7	38.4	-6.2	-3.0
Hypothyroidism (self reported)	7.1	16.3	31.1	-5.6	1.2
Hypothyroidism/myxoedema (self-reported)	6.1	12.0	19.7	-4.4	2.1
Shortness of breath walking on level ground	5.3	6.3	12.7	-3.6	0.1
Financial difficulties in last 2 years	5.2	6.9	13.8	-0.3	3.7
Medication: Levothyroxine sodium	5.1	8.7	14.2	-3.8	1.8
Ulcerative Colitis	4.8	7.0	13.0	-3.6	1.0
Ovarian Cancer	4.2	5.5	6.8	2.6	2.0
Fluid intelligence score	4.1	8.6	17.1	4.1	0.2
Asthma	4.1	8.1	8.4	-2.8	-2.9
Mouth/teeth dental problems: Mouth ulcers	4.0	6.3	12.6	-3.6	0.0
Asthma (self-reported)	3.8	7.6	8.5	-2.6	-2.9
Impedance of arm (left)	3.7	17.1	23.4	-3.3	-4.8
Exposure to tobacco smoke outside home	3.7	5.0	6.0	-2.4	2.0
Smoking status: Current	3.7	5.9	10.3	-3.2	1.2
Impedance of whole body	3.7	19.1	28.8	-3.0	-5.4
Blood White Count	3.4	25.2	31.8	4.3	5.6
Smoking Status	3.4	8.1	10.0	-2.5	3.2
Tinnitus: Yes, but not now, but have in the past	3.3	3.5	4.9	-2.2	-1.4
Impedance of arm (right)	3.3	15.6	20.7	-3.2	-4.5
Lung FVC	3.2	16.5	20.2	3.6	4.5
Medication: Gliclazide	3.2	3.7	7.0	2.6	0.6
Current tobacco smoking	3.0	4.9	8.9	-3.0	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.0	6.3	10.0	3.2	1.6
Pack years adult smoking proportion	2.8	4.3	7.7	-2.8	1.0
Age when periods started (menarche)	2.6	6.3	12.5	-0.2	-3.5
Mean time to correctly identify matches	2.6	4.9	7.6	1.5	2.8
Ulcerative Colitis (UC)	2.5	4.6	9.3	-3.0	-0.2
Respiratory disease	2.5	5.6	6.3	-2.2	-2.5
Impedance of leg (left)	2.5	12.4	21.6	-1.8	-4.7
Happiness	2.5	3.0	5.9	2.4	0.3
Commuting to job workplace: Car/motor vehicle	2.5	2.9	5.7	-0.2	-2.4
Average weekly beer plus cider intake	2.5	3.6	4.6	-2.1	-1.6
Basal cell carcinoma (self-reported)	2.5	2.9	3.1	1.7	1.8
Ever used hormone-replacement therapy (HRT)	2.4	3.1	3.1	-1.8	-1.8
High blood pressure (siblings)	2.4	3.5	3.5	1.9	1.9
Eye problems/disorders: Diabetes related eye disease	2.3	2.6	3.1	1.8	1.4
Number of live births	2.2	3.1	3.9	-2.0	-1.6
Pulse wave reflection index	2.2	2.7	3.3	-1.8	1.4
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.5	4.9	-0.3	2.2
Mouth/teeth dental problems: Loose teeth	2.2	2.6	5.1	0.3	2.3
Back pain experienced in last month	2.2	3.2	6.1	-2.5	0.6
Lupus	2.1	3.1	3.6	-1.9	1.6
Leg pain on walking	2.1	2.6	3.2	-1.4	1.8
Long-standing illness, disability or infirmity	2.1	3.2	4.8	-2.2	1.3
Friendships satisfaction	2.1	2.6	5.0	2.2	0.5
Reaction Time	2.0	3.8	6.4	1.1	2.5
Impedance of leg (right)	2.0	9.4	17.7	-1.1	-4.2
Average weekly spirits intake	1.9	2.4	4.7	0.2	2.2
Medication: Co-codamol	1.9	2.2	4.1	-2.0	0.5
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	5.0	-2.2	1.1
Pulse wave Arterial Stiffness index	1.8	2.2	4.2	-2.1	0.2
Birth weight of first child	1.8	3.3	3.5	1.8	-1.9
Medication: Ventolin 100micrograms inhaler	1.8	2.3	4.3	-2.1	-0.5
Birth weight	1.8	3.8	7.1	0.8	-2.7
Qualifications: College or University degree	1.8	5.6	11.0	3.3	0.4
Neck or shoulder pain in last month	1.8	2.6	4.1	-2.0	1.0
Illness, injury, bereavement, stress in last 2 years	1.8	2.1	3.9	0.6	-2.0
Depression (Nagel 2018)	1.7	2.6	3.9	2.0	1.1
Verbal and Numeric Reasoning (VNR)	1.7	4.1	8.0	2.8	-0.5
Primary Biliary Cirrhosis	1.7	2.4	3.3	-1.8	1.2
Blood Platelet Count	1.7	19.7	31.9	2.8	5.7
Allergy or Eczema	1.7	4.4	7.5	2.7	-1.1
Relative age voice broke	1.7	2.6	5.2	-0.1	-2.3
Medication: Atenolol	1.7	2.1	4.0	2.0	-0.4
Alcohol intake versus 10 years previously	1.7	2.5	5.0	-2.2	-0.0
Commuting to job workplace: Public transport	1.7	2.1	3.8	0.6	2.0
Pack years of smoking	1.7	2.5	4.2	-2.1	0.9
Alzheimer’s Disease (in mother)	1.6	1.9	3.7	-1.9	0.3
Alzheimer’s Disease (in father)	1.6	1.7	2.0	-1.2	-1.4
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	3.7	-1.9	0.7
Maternal smoking around birth	1.6	2.3	4.2	-0.7	2.0
Medication: Cholesterol lowering	1.6	2.5	4.8	2.2	-0.5
Diabetes (mother)	1.5	2.0	3.5	-0.7	-1.9
Hayfever, allergic rhinitis or eczema	1.5	3.2	5.0	2.2	-1.2
Breastfed as a baby	1.5	1.9	3.8	2.0	-0.0
Peak expiratory flow (PEF)	1.5	3.5	3.9	1.8	2.0
Medication: Paracetamol	1.5	2.5	4.7	-2.2	-0.5
Age at first live birth	1.5	2.6	3.8	1.9	-1.2
Average weekly champagne plus white wine intake	1.5	2.0	3.8	1.9	-0.6
Medication: Paracetamol	1.5	2.3	3.1	-1.8	-1.2
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	3.0	0.8	1.7
Pain experienced in last month	1.5	2.6	3.5	1.9	1.3
Schizophrenia vs Biploar Disorder	1.4	1.9	3.5	-0.5	1.9
Frequency of depressed mood in last 2 weeks	1.4	1.9	2.9	1.7	1.0
Medication: Metformin	1.4	2.0	2.1	1.4	1.4
Allergy	1.4	3.3	6.6	0.2	2.6
Prospective memory result	1.4	1.8	3.4	-1.8	0.3
Pulse wave peak to peak time	1.4	1.6	3.1	1.8	-0.4
Handedness (chirality/laterality): Left-handed	1.4	1.6	3.3	-0.0	1.8
Mineral and other dietary supplements	1.4	1.9	3.8	1.9	0.1
Osteoporosis (self-reported)	1.4	1.8	2.9	-0.8	-1.7
Diabetes (father)	1.3	1.6	2.9	1.7	-0.5
Stomach or abdominal pain in last month	1.3	1.6	2.5	-0.9	-1.6
Forced vital capacity (FVC), Best measure	1.3	4.7	5.6	2.0	2.4
Health satisfaction	1.3	1.7	2.5	-1.6	1.0
Ever smoked	1.3	2.3	4.3	0.5	2.1
Medication: Omeprazole	1.2	1.4	2.2	0.7	1.5
Supplements: Fish oil (including cod liver oil)	1.2	1.6	2.8	-1.7	-0.6
Commuting to job workplace: Cycle	1.2	1.5	2.9	0.2	1.7
Bipolar Disorder (2018)	1.1	1.7	3.3	-0.2	-1.8
Past tobacco smoking	1.1	2.0	3.5	-0.7	-1.9
Hearing difficulty/problems with background noise	1.1	1.7	2.4	1.5	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.5	3.8	1.8	1.9
Hair/balding pattern: Pattern 4	1.1	2.6	4.2	-1.0	-2.1
Neuroticism (2016)	1.0	1.5	2.2	1.5	0.9
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	3.7	1.9	1.0
Qualifications: CSEs or equivalent	1.0	1.3	2.4	-1.5	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	4.0	2.0	0.8
Illnesses of siblings	1.0	1.4	2.0	-1.4	-0.9
Forced expiratory volume in 1-second (FEV1)	1.0	3.5	4.5	1.6	2.1
Medication: Seretide 50 evohaler	1.0	1.1	2.2	-1.5	0.0
Suffer from ‘nerves’	1.0	1.6	2.0	1.1	1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	2.3	-1.4	-1.5
Osteoarthritis (self-reported)	1.0	1.4	2.7	0.2	1.6
Ever depressed for a whole week	1.0	1.2	2.4	1.6	-0.2
Myopia	1.0	1.4	2.0	1.4	-0.9
Alzheimer’s Disease (including proxy)	0.9	1.3	2.6	-1.6	-0.1
Hearing difficulty/problems: Yes	0.9	1.3	2.0	0.8	1.4
Medication for hormone replacement therapy	0.9	1.0	1.0	0.9	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	1.4	1.0	1.2
Forced vital capacity (FVC)	0.9	3.5	5.8	1.2	2.4
Qualifications: None of the above	0.9	1.9	3.6	-1.9	0.2
Mouth/teeth dental problems	0.9	1.4	1.9	1.4	1.0
Standing height	0.9	8.7	10.8	-3.3	-2.6
Headache pain in last month	0.9	1.5	2.6	-0.7	-1.6
Wheeze or whistling in the chest in last year	0.9	1.5	2.9	-1.7	0.3
Supplements: Vitamin C	0.9	1.1	2.0	-0.5	-1.4
Medication: Aspirin	0.9	1.2	1.8	1.3	-0.8
Worry (Nagel 2018)	0.8	1.6	3.1	1.8	0.4
Height	0.8	16.2	18.8	-4.3	-3.7
Trunk fat percentage	0.8	3.1	5.9	-0.6	-2.4
Supplements: Glucosamine	0.8	1.0	1.9	-1.4	0.5
High blood pressure (mother)	0.8	1.1	2.2	1.5	-0.0
Pain all over the body in last month	0.8	0.9	1.8	-1.3	0.1
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	1.9	1.4	0.6
Falls in the last year	0.8	1.1	1.6	-1.2	0.7
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.1	1.8	0.6
Tense / ‘highly strung’	0.8	1.3	2.2	0.6	1.5
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.0	0.1	-1.4
Glaucoma (self-reported)	0.8	1.0	1.3	1.1	-0.8
Medication: Amlodipine	0.8	1.1	1.3	1.1	0.9
Medication: Allopurinol	0.8	1.0	1.7	0.6	1.3
Alcohol intake frequency.	0.8	1.9	2.7	-1.1	-1.6
Chest pain or discomfort	0.8	1.1	1.1	-1.1	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.1	-0.9	1.1
Smoking status: Previous	0.8	1.3	1.3	1.1	1.1
Major Depression (MDD)	0.7	0.9	1.7	0.2	-1.3
Blood Eosinophil Count	0.7	5.2	5.9	2.1	2.4
Multivitamins +/- minerals	0.7	0.8	1.6	-0.4	-1.2
Body mass index (BMI)	0.7	2.8	3.7	1.9	1.4
Medication: Ramipril	0.7	0.9	1.7	-1.3	0.3
Father’s age at death	0.7	0.9	1.8	1.3	-0.1
Hair/balding pattern: Pattern 3	0.7	1.0	1.7	-1.3	0.6
Depression (self-reported)	0.7	0.8	1.4	-0.4	-1.2
Gout (self-reported)	0.7	1.0	2.1	0.0	1.4
Number of full brothers	0.7	0.9	1.5	-1.2	-0.4
Diabetes diagnosed by doctor	0.7	1.1	1.9	0.6	1.4
Alcohol drinker status: Never	0.7	0.8	1.6	0.2	-1.2
Unable to work because of sickness or disability	0.7	0.9	1.0	-1.0	0.8
Heart disease (siblings)	0.7	0.8	0.9	0.9	0.8
Alcohol drinker status: Previous	0.7	0.8	1.1	0.7	1.0
Systolic Blood Pressure	0.6	2.8	3.6	1.4	-1.9
Lung FEV1/FVC ratio	0.6	3.0	6.0	0.1	-2.4
Severe depression (siblings)	0.6	0.6	1.1	1.1	-0.3
Number of incorrect matches in round	0.6	1.0	1.3	-0.9	1.1
Had menopause	0.6	0.7	1.1	-0.5	-1.1
Diabetes (self-reported)	0.6	1.0	1.8	1.3	0.4
Illnesses of mother	0.6	0.8	1.1	-0.7	1.1
Loud music exposure frequency	0.6	0.7	1.3	-1.1	0.3
Medication for cholesterol, blood pressure or diabetes	0.6	1.1	2.0	-1.4	-0.3
Number of children fathered	0.6	0.7	1.3	1.1	0.3
Average weekly red wine intake	0.6	0.9	0.9	1.0	-0.9
Mother’s age at death	0.6	0.8	1.2	1.1	-0.6
BMI	0.5	2.9	3.5	1.9	1.6
Chronotype (morning person)	0.5	1.3	1.4	1.2	1.1
Relative age of first facial hair	0.5	0.9	1.2	-0.8	-1.1
Vitamin and mineral supplements	0.5	0.7	1.1	1.1	0.6
Medication: Simvastatin	0.5	0.8	1.6	1.2	-0.2
Trunk fat-free mass	0.5	3.0	5.8	0.5	2.4
Worrier / anxious feelings	0.5	0.9	1.6	1.2	-0.4
Lung cancer (father)	0.5	0.6	1.2	0.2	-1.1
Trunk predicted mass	0.5	3.0	5.8	0.6	2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.3	1.1	0.6
Body fat percentage	0.5	1.9	3.8	0.2	-1.9
Leg fat percentage (right)	0.5	1.7	2.3	1.5	-1.1
Comparative body size at age 10	0.5	1.4	2.7	0.3	1.6
Family relationship satisfaction	0.5	0.7	1.3	1.1	-0.0
Medication: Aspirin	0.5	0.7	1.1	1.1	-0.4
Hypertension (Self-reported)	0.5	1.4	2.6	0.4	1.6
Qualifications: nursing, teaching	0.5	0.7	1.4	0.3	-1.2
Wears glasses or contact lenses	0.5	0.6	0.7	0.8	0.8
Ever taken oral contraceptive pill	0.5	0.5	1.0	0.1	-1.0
Tinnitus: Yes, now most or all of the time	0.5	0.5	0.6	-0.6	-0.8
Illnesses of father: High blood pressure	0.5	0.6	0.7	0.8	0.7
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.1	0.2	-1.1
Diastolic blood pressure, automated reading	0.5	1.5	3.0	0.3	-1.7
Intelligence (Savage-Jansen 2018)	0.4	1.4	2.6	1.6	-0.4
Prostate Cancer	0.4	0.5	0.5	0.7	0.7
Coronary Artery Disease (CAD)	0.4	0.5	0.7	-0.8	0.6
Cardiovascular Disease	0.4	1.3	2.1	0.7	1.4
Hand grip strength (left)	0.4	1.1	1.6	-0.8	1.3
Systolic blood pressure, automated reading	0.4	1.1	1.2	1.1	-1.0
Fed-up feelings	0.4	0.8	1.5	-0.3	1.2
Taking other prescription medications	0.4	0.6	1.0	-0.5	1.0
Alcohol usually taken with meals	0.4	0.6	1.1	1.0	-0.4
Neuroticism score	0.4	0.7	1.3	1.1	0.4
Time employed in main current job	0.4	0.4	0.8	-0.9	-0.3
Pulse rate	0.4	0.7	1.2	1.1	-0.5
Noisy workplace	0.4	0.5	0.8	-0.5	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.9	-1.0	0.1
Length of working week for main job	0.4	0.4	0.8	0.4	0.9
Medication: Blood pressure	0.4	0.8	1.3	0.5	1.1
Migraine (self-reported)	0.4	0.5	0.5	-0.7	0.7
Comparative height size at age 10	0.4	2.2	3.8	-1.9	-0.8
Number of full sisters	0.4	0.5	0.7	-0.8	-0.6
Overall health rating	0.4	0.9	1.2	-1.1	0.8
Knee pain experienced in last month	0.4	0.6	0.9	-0.9	-0.5
Whole body fat-free mass	0.4	2.3	4.5	-0.1	2.1
Ever had bowel cancer screening	0.4	0.5	1.0	1.0	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.5	-0.7	0.5
Whole body water mass	0.4	2.4	4.7	-0.1	2.2
Fractured/broken bones in last 5 years	0.4	0.6	1.1	-1.0	0.2
Neuroticism (Nagel 2018)	0.3	0.8	1.6	1.3	0.1
Breast Cancer	0.3	0.6	1.3	0.1	-1.1
Mean Putamen Volume	0.3	0.4	0.6	-0.8	0.4
Schizophrenia (2014)	0.3	0.6	1.3	0.1	1.1
Triglycerides	0.3	0.5	1.0	-1.0	-0.2
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.7	0.3	-0.8
Waist Hip Ratio (WHR)	0.3	1.5	2.8	1.7	-0.5
Number of treatments/medications taken	0.3	0.6	1.1	-1.1	-0.0
Ever had hysterectomy (womb removed)	0.3	0.3	0.6	0.3	0.8
High blood pressure	0.3	1.0	1.9	0.1	1.4
Trunk fat mass	0.3	1.3	2.5	-0.2	-1.6
Nervous feelings	0.3	0.5	0.6	0.8	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.0	0.0	1.0
Hair/balding pattern: Pattern 2	0.3	0.3	0.6	0.3	0.8
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.4	0.6	-0.5
Mouth/teeth dental problems: Dentures	0.3	0.6	1.0	-0.4	-1.0
Arm fat-free mass (right)	0.3	1.8	3.5	0.3	1.9
Worry too long after embarrassment	0.3	0.5	0.7	0.8	0.4
Arm predicted mass (right)	0.3	1.6	3.0	0.4	1.7
Pulse rate, automated reading	0.3	1.1	1.1	1.0	1.0
Illnesses of siblings: Diabetes	0.3	0.4	0.7	0.8	0.2
Leg fat-free mass (right)	0.3	1.5	2.2	-0.9	1.5
Mood swings	0.3	0.5	0.6	0.7	0.6
Medication for cholesterol	0.3	0.4	0.5	-0.7	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.3	-0.6	0.6
Leg predicted mass (right)	0.3	1.5	2.1	-0.9	1.4
Number of self-reported non-cancer illnesses	0.3	0.5	1.0	-1.0	0.1
Hearing aid user	0.3	0.4	0.4	-0.6	0.6
Leg fat percentage (left)	0.3	1.2	1.3	1.0	-1.1
Arm fat-free mass (left)	0.3	1.5	2.9	0.3	1.7
Irritability	0.3	0.5	0.8	0.9	0.6
Arm predicted mass (left)	0.3	1.7	3.3	0.2	1.8
Bipolar Disorder or Schizophrenia	0.2	0.5	1.1	0.0	-1.0
Depressed Affect (Nagel 2018)	0.2	0.4	0.5	0.7	0.6
HDL Cholesterol	0.2	0.3	0.3	-0.5	0.5
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.5	-0.2	0.7
Tanning	0.2	2.3	3.9	0.9	2.0
Sensitivity / hurt feelings	0.2	0.4	0.5	0.7	-0.5
Angina	0.2	0.3	0.6	0.8	0.2
Supplements: Zinc	0.2	0.3	0.5	0.7	0.3
Leg fat-free mass (left)	0.2	1.0	1.7	-0.6	1.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.3	0.5	0.5
Serious illness, injury or assault to yourself	0.2	0.2	0.2	-0.5	0.4
Sitting height	0.2	1.4	2.1	-1.5	-0.8
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	-0.6	0.3
Leg predicted mass (left)	0.2	1.0	1.7	-0.6	1.3
Waist circumference	0.2	0.7	1.4	1.2	-0.0
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.2	-0.4	-0.5
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.3	0.6	-0.5
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	-0.6	0.2
Angina (self-reported)	0.2	0.2	0.4	0.7	0.0
Medication: Ibuprofen	0.2	0.3	0.3	-0.5	-0.5
Leg fat mass (right)	0.2	0.7	1.2	1.1	-0.4
Had major operations	0.2	0.3	0.4	0.7	-0.3
Basal metabolic rate	0.2	1.3	2.6	-0.1	1.6
Number of operations (self-reported)	0.2	0.3	0.5	0.2	-0.7
Risk taking	0.2	0.3	0.6	0.8	0.1
Age started oral contraceptive pill	0.2	0.2	0.3	-0.5	0.4
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.0	0.1	-1.0
Cholesterol lowering medication	0.2	0.3	0.3	0.4	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.4	-0.7	0.1
Age at First Birth	0.1	0.1	0.1	0.3	0.4
Bipolar Disorder (2011)	0.1	0.1	0.1	-0.3	-0.1
Body Mass Index (BMI) (2010)	0.1	0.2	0.3	0.0	0.6
Fasting Glucose	0.1	0.2	0.2	0.3	0.5
HbA1C	0.1	0.1	0.1	0.4	0.3
LDL Cholesterol	0.1	0.1	0.2	-0.4	0.2
Rheumatoid Arthritis	0.1	0.2	0.2	0.4	0.4
Heel T-Score	0.1	0.5	1.0	1.0	0.0
Neuroticism	0.1	0.3	0.6	0.8	-0.2
Hair Pigment	0.1	2.1	3.7	-0.7	-1.9
Townsend deprivation index at recruitment	0.1	0.2	0.3	-0.6	-0.3
Average weekly fortified wine intake	0.1	0.2	0.3	0.2	0.5
Had other major operations	0.1	0.1	0.2	0.5	-0.2
Heart attack	0.1	0.2	0.3	-0.5	-0.3
Arm fat percentage (right)	0.1	0.3	0.4	0.5	-0.6
Blood clot in the leg (DVT)	0.1	0.2	0.4	-0.6	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.4	0.1
Eye problems/disorders: None of the above	0.1	0.2	0.3	-0.1	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	0.2	0.4
Whole body fat mass	0.1	0.6	1.0	0.4	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	-0.3	-0.4
Illnesses of father: Heart disease	0.1	0.2	0.2	-0.4	0.4
Arm fat percentage (left)	0.1	0.3	0.4	0.5	-0.6
Loneliness, isolation	0.1	0.2	0.4	-0.1	0.6
Commuting to job workplace: Walk	0.1	0.1	0.2	0.1	0.4
Eye problems/disorders: Cataract	0.1	0.1	0.1	0.3	0.3
Illnesses of father: None of the above (group 1)	0.1	0.1	0.1	0.3	0.3
Arm fat mass (left)	0.1	0.2	0.4	0.6	0.3
Miserableness	0.1	0.2	0.4	0.7	-0.2
Financial situation satisfaction	0.1	0.1	0.1	0.4	0.2
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.4	0.0
Medication: Blood pressure	0.1	0.2	0.2	0.4	0.4
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	-0.5	0.1
High cholesterol (Self-reported)	0.1	0.2	0.3	0.5	0.4
Medication: Lisinopril	0.1	0.2	0.2	0.5	0.4
Medication: Atorvastatin	0.1	0.1	0.1	0.3	-0.4
Supplements: Calcium	0.1	0.1	0.1	0.4	0.1
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.4	-0.3
Leg fat mass (left)	0.1	0.3	0.6	0.8	-0.3
Schizophrenia (2018)	0.0	0.0	0.0	0.2	0.2
Blood Red Count	0.0	0.0	0.0	-0.1	0.2
Hand grip strength (right)	0.0	0.0	0.1	0.1	0.3
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	0.1	0.1
Weight	0.0	0.1	0.1	0.4	0.2
Hip circumference	0.0	0.2	0.2	0.4	0.5
Medication: Lansoprazole	0.0	0.0	0.1	-0.1	0.2
Arm fat mass (right)	0.0	0.2	0.3	0.5	0.2
Exposure to tobacco smoke at home	0.0	0.0	0.1	-0.1	0.2
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	-0.0	-0.1
Emphysema/chronic bronchitis	0.0	0.0	0.1	-0.3	-0.1
Medication for pain relief, constipation, heartburn	0.0	0.0	0.1	0.1	0.2
Heart disease (mother)	0.0	0.0	0.0	0.1	-0.0
Age at last live birth	0.0	0.0	0.1	0.1	-0.3
Breast cancer (self-reported)	0.0	0.1	0.1	-0.3	0.0
Guilty feelings	0.0	0.1	0.1	0.3	-0.2
Medication: Bendroflumethiazide	0.0	0.0	0.0	-0.2	0.1

Hub : Genes

PAPD5

Models

Trait associations