Hub : Genes

PAPD5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 YFS Blood 0.0274 0.0095 0.00024 0.012 0.012 0.021 0.013 0.017 5.2e-05 5.3e-05 1.4e-07 3.8e-05 2.7e-06
2 TCGA Thyroid Carcinoma 0.0210 0.0130 0.00610 0.029 0.023 -0.001 NA 0.024 7.8e-04 2.4e-03 3.7e-01 NA 1.8e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.1 1.7 3.3 -0.2 -1.8
Bipolar Disorder or Schizophrenia 0.2 0.5 1.1 0.0 -1.0
Depressed Affect (Nagel 2018) 0.2 0.4 0.5 0.7 0.6
Depression (Nagel 2018) 1.7 2.6 3.9 2.0 1.1
Intelligence (Savage-Jansen 2018) 0.4 1.4 2.6 1.6 -0.4
Neuroticism (Nagel 2018) 0.3 0.8 1.6 1.3 0.1
Schizophrenia (2018) 0.0 0.0 0.0 0.2 0.2
Schizophrenia vs Biploar Disorder 1.4 1.9 3.5 -0.5 1.9
Worry (Nagel 2018) 0.8 1.6 3.1 1.8 0.4
Alzheimer’s Disease (in mother) 1.6 1.9 3.7 -1.9 0.3
Alzheimer’s Disease (in father) 1.6 1.7 2.0 -1.2 -1.4
Alzheimer’s Disease (including proxy) 0.9 1.3 2.6 -1.6 -0.1
Crohns Disease (2017) 17.2 37.8 48.6 -7.0 -5.2
Irritable Bowel Disease (IBD) 9.9 23.7 38.4 -6.2 -3.0
Ulcerative Colitis (UC) 2.5 4.6 9.3 -3.0 -0.2
Major Depression (MDD) 0.7 0.9 1.7 0.2 -1.3
Reaction Time 2.0 3.8 6.4 1.1 2.5
Verbal and Numeric Reasoning (VNR) 1.7 4.1 8.0 2.8 -0.5
Breast Cancer 0.3 0.6 1.3 0.1 -1.1
Ovarian Cancer 4.2 5.5 6.8 2.6 2.0
Prostate Cancer 0.4 0.5 0.5 0.7 0.7
Age at First Birth 0.1 0.1 0.1 0.3 0.4
Bipolar Disorder (2011) 0.1 0.1 0.1 -0.3 -0.1
Body Mass Index (BMI) (2010) 0.1 0.2 0.3 0.0 0.6
Coronary Artery Disease (CAD) 0.4 0.5 0.7 -0.8 0.6
Crohns Disease (2012) 15.1 24.2 36.2 -6.0 -3.5
Mean Putamen Volume 0.3 0.4 0.6 -0.8 0.4
Fasting Glucose 0.1 0.2 0.2 0.3 0.5
HbA1C 0.1 0.1 0.1 0.4 0.3
HDL Cholesterol 0.2 0.3 0.3 -0.5 0.5
LDL Cholesterol 0.1 0.1 0.2 -0.4 0.2
Lupus 2.1 3.1 3.6 -1.9 1.6
Neuroticism (2016) 1.0 1.5 2.2 1.5 0.9
Primary Biliary Cirrhosis 1.7 2.4 3.3 -1.8 1.2
Rheumatoid Arthritis 0.1 0.2 0.2 0.4 0.4
Schizophrenia (2014) 0.3 0.6 1.3 0.1 1.1
Triglycerides 0.3 0.5 1.0 -1.0 -0.2
Type 2 Diabetes (T2D) (2012) 0.3 0.4 0.7 0.3 -0.8
Ulcerative Colitis 4.8 7.0 13.0 -3.6 1.0
Blood Eosinophil Count 0.7 5.2 5.9 2.1 2.4
Blood Platelet Count 1.7 19.7 31.9 2.8 5.7
Blood Red Count 0.0 0.0 0.0 -0.1 0.2
Blood White Count 3.4 25.2 31.8 4.3 5.6
Heel T-Score 0.1 0.5 1.0 1.0 0.0
BMI 0.5 2.9 3.5 1.9 1.6
Height 0.8 16.2 18.8 -4.3 -3.7
Waist Hip Ratio (WHR) 0.3 1.5 2.8 1.7 -0.5
Systolic Blood Pressure 0.6 2.8 3.6 1.4 -1.9
Smoking Status 3.4 8.1 10.0 -2.5 3.2
Allergy or Eczema 1.7 4.4 7.5 2.7 -1.1
Cardiovascular Disease 0.4 1.3 2.1 0.7 1.4
Hypothyroidism (self reported) 7.1 16.3 31.1 -5.6 1.2
Respiratory disease 2.5 5.6 6.3 -2.2 -2.5
Type 2 Diabetes (T2D) (2018) 0.2 0.3 0.5 -0.2 0.7
Lung FEV1/FVC ratio 0.6 3.0 6.0 0.1 -2.4
Lung FVC 3.2 16.5 20.2 3.6 4.5
Neuroticism 0.1 0.3 0.6 0.8 -0.2
Chronotype (morning person) 0.5 1.3 1.4 1.2 1.1
Hair Pigment 0.1 2.1 3.7 -0.7 -1.9
Tanning 0.2 2.3 3.9 0.9 2.0
Hand grip strength (left) 0.4 1.1 1.6 -0.8 1.3
Number of treatments/medications taken 0.3 0.6 1.1 -1.1 -0.0
Average weekly spirits intake 1.9 2.4 4.7 0.2 2.2
Sensitivity / hurt feelings 0.2 0.4 0.5 0.7 -0.5
Frequency of depressed mood in last 2 weeks 1.4 1.9 2.9 1.7 1.0
Hearing difficulty/problems: Yes 0.9 1.3 2.0 0.8 1.4
Relative age of first facial hair 0.5 0.9 1.2 -0.8 -1.1
Other serious medical condition/disability diagnosed by doctor 1.6 2.1 3.7 -1.9 0.7
Ever used hormone-replacement therapy (HRT) 2.4 3.1 3.1 -1.8 -1.8
Ever had hysterectomy (womb removed) 0.3 0.3 0.6 0.3 0.8
Systolic blood pressure, automated reading 0.4 1.1 1.2 1.1 -1.0
Eye problems/disorders: Diabetes related eye disease 2.3 2.6 3.1 1.8 1.4
Angina 0.2 0.3 0.6 0.8 0.2
Medication for hormone replacement therapy 0.9 1.0 1.0 0.9 -1.0
Vitamin and mineral supplements 0.5 0.7 1.1 1.1 0.6
Supplements: Zinc 0.2 0.3 0.5 0.7 0.3
Medication: Co-codamol 1.9 2.2 4.1 -2.0 0.5
Medication: Metformin 1.4 2.0 2.1 1.4 1.4
Diabetes (father) 1.3 1.6 2.9 1.7 -0.5
Diabetes (mother) 1.5 2.0 3.5 -0.7 -1.9
Severe depression (siblings) 0.6 0.6 1.1 1.1 -0.3
Pack years adult smoking proportion 2.8 4.3 7.7 -2.8 1.0
Impedance of leg (right) 2.0 9.4 17.7 -1.1 -4.2
Leg fat-free mass (left) 0.2 1.0 1.7 -0.6 1.3
Trunk fat percentage 0.8 3.1 5.9 -0.6 -2.4
Hand grip strength (right) 0.0 0.0 0.1 0.1 0.3
Townsend deprivation index at recruitment 0.1 0.2 0.3 -0.6 -0.3
Current tobacco smoking 3.0 4.9 8.9 -3.0 0.9
Average weekly fortified wine intake 0.1 0.2 0.3 0.2 0.5
Maternal smoking around birth 1.6 2.3 4.2 -0.7 2.0
Fed-up feelings 0.4 0.8 1.5 -0.3 1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 1.4 1.0 1.2
Relative age voice broke 1.7 2.6 5.2 -0.1 -2.3
Taking other prescription medications 0.4 0.6 1.0 -0.5 1.0
Age when periods started (menarche) 2.6 6.3 12.5 -0.2 -3.5
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 0.3 0.5 0.5
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.3 3.7 1.9 1.0
Tinnitus: Yes, but not now, but have in the past 3.3 3.5 4.9 -2.2 -1.4
Qualifications: CSEs or equivalent 1.0 1.3 2.4 -1.5 -0.4
Serious illness, injury or assault to yourself 0.2 0.2 0.2 -0.5 0.4
High blood pressure 0.3 1.0 1.9 0.1 1.4
Hayfever, allergic rhinitis or eczema 1.5 3.2 5.0 2.2 -1.2
Multivitamins +/- minerals 0.7 0.8 1.6 -0.4 -1.2
Stomach or abdominal pain in last month 1.3 1.6 2.5 -0.9 -1.6
Supplements: Glucosamine 0.8 1.0 1.9 -1.4 0.5
Diverticular disease/diverticulitis (self-reported) 0.0 0.0 0.0 0.1 0.1
Medication: Atenolol 1.7 2.1 4.0 2.0 -0.4
Medication: Levothyroxine sodium 5.1 8.7 14.2 -3.8 1.8
Sitting height 0.2 1.4 2.1 -1.5 -0.8
Chronic bronchitis/emphysema (father) 0.2 0.2 0.4 -0.6 0.3
High blood pressure (mother) 0.8 1.1 2.2 1.5 -0.0
Body mass index (BMI) 0.7 2.8 3.7 1.9 1.4
Impedance of leg (left) 2.5 12.4 21.6 -1.8 -4.7
Leg predicted mass (left) 0.2 1.0 1.7 -0.6 1.3
Trunk fat mass 0.3 1.3 2.5 -0.2 -1.6
Waist circumference 0.2 0.7 1.4 1.2 -0.0
Number of incorrect matches in round 0.6 1.0 1.3 -0.9 1.1
Past tobacco smoking 1.1 2.0 3.5 -0.7 -1.9
Alcohol usually taken with meals 0.4 0.6 1.1 1.0 -0.4
Nervous feelings 0.3 0.5 0.6 0.8 0.7
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.0 0.0 1.0
Hearing difficulty/problems with background noise 1.1 1.7 2.4 1.5 1.0
Hair/balding pattern: Pattern 2 0.3 0.3 0.6 0.3 0.8
Had menopause 0.6 0.7 1.1 -0.5 -1.1
Had other major operations 0.1 0.1 0.2 0.5 -0.2
Forced vital capacity (FVC) 0.9 3.5 5.8 1.2 2.4
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.3 4.0 2.0 0.8
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 0.4 0.6 -0.5
Qualifications: None of the above 0.9 1.9 3.6 -1.9 0.2
Financial difficulties in last 2 years 5.2 6.9 13.8 -0.3 3.7
Mouth/teeth dental problems 0.9 1.4 1.9 1.4 1.0
Heart attack 0.1 0.2 0.3 -0.5 -0.3
Allergy 1.4 3.3 6.6 0.2 2.6
Pain all over the body in last month 0.8 0.9 1.8 -1.3 0.1
Diabetes (self-reported) 0.6 1.0 1.8 1.3 0.4
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 1.9 1.4 0.6
Medication: Ramipril 0.7 0.9 1.7 -1.3 0.3
Medication: Simvastatin 0.5 0.8 1.6 1.2 -0.2
Fluid intelligence score 4.1 8.6 17.1 4.1 0.2
Illnesses of siblings 1.0 1.4 2.0 -1.4 -0.9
Neuroticism score 0.4 0.7 1.3 1.1 0.4
Weight 0.0 0.1 0.1 0.4 0.2
Impedance of arm (right) 3.3 15.6 20.7 -3.2 -4.5
Arm fat percentage (right) 0.1 0.3 0.4 0.5 -0.6
Trunk fat-free mass 0.5 3.0 5.8 0.5 2.4
Hip circumference 0.0 0.2 0.2 0.4 0.5
Time employed in main current job 0.4 0.4 0.8 -0.9 -0.3
Alcohol intake versus 10 years previously 1.7 2.5 5.0 -2.2 -0.0
Father’s age at death 0.7 0.9 1.8 1.3 -0.1
Worrier / anxious feelings 0.5 0.9 1.6 1.2 -0.4
Frequency of tiredness / lethargy in last 2 weeks 1.9 3.1 5.0 -2.2 1.1
Falls in the last year 0.8 1.1 1.6 -1.2 0.7
Hair/balding pattern: Pattern 3 0.7 1.0 1.7 -1.3 0.6
Number of live births 2.2 3.1 3.9 -2.0 -1.6
Forced expiratory volume in 1-second (FEV1) 1.0 3.5 4.5 1.6 2.1
Pulse rate 0.4 0.7 1.2 1.1 -0.5
Happiness 2.5 3.0 5.9 2.4 0.3
Noisy workplace 0.4 0.5 0.8 -0.5 0.9
Qualifications: A levels/AS levels or equivalent 0.8 1.7 3.1 1.8 0.6
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 0.9 -1.0 0.1
Mouth/teeth dental problems: Dentures 0.3 0.6 1.0 -0.4 -1.0
Asthma 4.1 8.1 8.4 -2.8 -2.9
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.2 -0.4 -0.5
Medication: Cholesterol lowering 1.6 2.5 4.8 2.2 -0.5
Depression (self-reported) 0.7 0.8 1.4 -0.4 -1.2
Medication: Lansoprazole 0.0 0.0 0.1 -0.1 0.2
Prospective memory result 1.4 1.8 3.4 -1.8 0.3
Lung cancer (father) 0.5 0.6 1.2 0.2 -1.1
Illnesses of mother 0.6 0.8 1.1 -0.7 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.1 3.5 3.8 1.8 1.9
Pulse wave Arterial Stiffness index 1.8 2.2 4.2 -2.1 0.2
Impedance of arm (left) 3.7 17.1 23.4 -3.3 -4.8
Arm fat mass (right) 0.0 0.2 0.3 0.5 0.2
Trunk predicted mass 0.5 3.0 5.8 0.6 2.4
Standing height 0.9 8.7 10.8 -3.3 -2.6
Length of working week for main job 0.4 0.4 0.8 0.4 0.9
Exposure to tobacco smoke at home 0.0 0.0 0.1 -0.1 0.2
Breastfed as a baby 1.5 1.9 3.8 2.0 -0.0
Tense / ‘highly strung’ 0.8 1.3 2.2 0.6 1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 1.3 1.1 0.6
Hair/balding pattern: Pattern 4 1.1 2.6 4.2 -1.0 -2.1
Birth weight of first child 1.8 3.3 3.5 1.8 -1.9
Peak expiratory flow (PEF) 1.5 3.5 3.9 1.8 2.0
Pulse wave reflection index 2.2 2.7 3.3 -1.8 1.4
Ever highly irritable/argumentative for 2 days 0.0 0.0 0.0 -0.0 -0.1
Loud music exposure frequency 0.6 0.7 1.3 -1.1 0.3
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.3 0.6 -0.5
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 2.0 0.1 -1.4
Blood clot in the leg (DVT) 0.1 0.2 0.4 -0.6 0.0
Medication: Paracetamol 1.5 2.5 4.7 -2.2 -0.5
Headache pain in last month 0.9 1.5 2.6 -0.7 -1.6
Medication for cholesterol, blood pressure or diabetes 0.6 1.1 2.0 -1.4 -0.3
Glaucoma (self-reported) 0.8 1.0 1.3 1.1 -0.8
Gout (self-reported) 0.7 1.0 2.1 0.0 1.4
Hypothyroidism/myxoedema (self-reported) 6.1 12.0 19.7 -4.4 2.1
Medication: Amlodipine 0.8 1.1 1.3 1.1 0.9
Medication: Ventolin 100micrograms inhaler 1.8 2.3 4.3 -2.1 -0.5
Birth weight 1.8 3.8 7.1 0.8 -2.7
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.4 -0.6 0.2
High blood pressure (siblings) 2.4 3.5 3.5 1.9 1.9
Forced vital capacity (FVC), Best measure 1.3 4.7 5.6 2.0 2.4
Body fat percentage 0.5 1.9 3.8 0.2 -1.9
Leg fat percentage (right) 0.5 1.7 2.3 1.5 -1.1
Arm fat-free mass (right) 0.3 1.8 3.5 0.3 1.9
Exposure to tobacco smoke outside home 3.7 5.0 6.0 -2.4 2.0
Comparative body size at age 10 0.5 1.4 2.7 0.3 1.6
Number of full brothers 0.7 0.9 1.5 -1.2 -0.4
Worry too long after embarrassment 0.3 0.5 0.7 0.8 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.2 0.4 0.1
Wheeze or whistling in the chest in last year 0.9 1.5 2.9 -1.7 0.3
Number of children fathered 0.6 0.7 1.3 1.1 0.3
Reason for reducing amount of alcohol drunk: Health precaution 2.2 2.5 4.9 -0.3 2.2
Age at first live birth 1.5 2.6 3.8 1.9 -1.2
Pulse wave peak to peak time 1.4 1.6 3.1 1.8 -0.4
Health satisfaction 1.3 1.7 2.5 -1.6 1.0
Shortness of breath walking on level ground 5.3 6.3 12.7 -3.6 0.1
Qualifications: College or University degree 1.8 5.6 11.0 3.3 0.4
Eye problems/disorders: None of the above 0.1 0.2 0.3 -0.1 -0.6
Mouth/teeth dental problems: Loose teeth 2.2 2.6 5.1 0.3 2.3
Emphysema/chronic bronchitis 0.0 0.0 0.1 -0.3 -0.1
Medication for pain relief, constipation, heartburn 0.0 0.0 0.1 0.1 0.2
Neck or shoulder pain in last month 1.8 2.6 4.1 -2.0 1.0
Medication: Blood pressure 0.4 0.8 1.3 0.5 1.1
Angina (self-reported) 0.2 0.2 0.4 0.7 0.0
Migraine (self-reported) 0.4 0.5 0.5 -0.7 0.7
Medication: Ibuprofen 0.2 0.3 0.3 -0.5 -0.5
Medication: Allopurinol 0.8 1.0 1.7 0.6 1.3
Medication: Omeprazole 1.2 1.4 2.2 0.7 1.5
Medication: Seretide 50 evohaler 1.0 1.1 2.2 -1.5 0.0
Mean time to correctly identify matches 2.6 4.9 7.6 1.5 2.8
Heart disease (mother) 0.0 0.0 0.0 0.1 -0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.2 0.2 0.4
Whole body fat mass 0.1 0.6 1.0 0.4 -1.0
Leg fat mass (right) 0.2 0.7 1.2 1.1 -0.4
Arm predicted mass (right) 0.3 1.6 3.0 0.4 1.7
Pulse rate, automated reading 0.3 1.1 1.1 1.0 1.0
Alcohol intake frequency. 0.8 1.9 2.7 -1.1 -1.6
Comparative height size at age 10 0.4 2.2 3.8 -1.9 -0.8
Number of full sisters 0.4 0.5 0.7 -0.8 -0.6
Suffer from ‘nerves’ 1.0 1.6 2.0 1.1 1.4
Overall health rating 0.4 0.9 1.2 -1.1 0.8
Chest pain or discomfort 0.8 1.1 1.1 -1.1 1.0
Had major operations 0.2 0.3 0.4 0.7 -0.3
Age at last live birth 0.0 0.0 0.1 0.1 -0.3
Family relationship satisfaction 0.5 0.7 1.3 1.1 -0.0
Leg pain on walking 2.1 2.6 3.2 -1.4 1.8
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.1 -0.3 -0.4
Commuting to job workplace: Car/motor vehicle 2.5 2.9 5.7 -0.2 -2.4
Illness, injury, bereavement, stress in last 2 years 1.8 2.1 3.9 0.6 -2.0
Medication: Aspirin 0.5 0.7 1.1 1.1 -0.4
Supplements: Vitamin C 0.9 1.1 2.0 -0.5 -1.4
Knee pain experienced in last month 0.4 0.6 0.9 -0.9 -0.5
Hypertension (Self-reported) 0.5 1.4 2.6 0.4 1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 1.1 -0.9 1.1
Illnesses of father: Heart disease 0.1 0.2 0.2 -0.4 0.4
Illnesses of siblings: Diabetes 0.3 0.4 0.7 0.8 0.2
Smoking status: Previous 0.8 1.3 1.3 1.1 1.1
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.1 2.3 -1.4 -1.5
Whole body fat-free mass 0.4 2.3 4.5 -0.1 2.1
Leg fat-free mass (right) 0.3 1.5 2.2 -0.9 1.5
Arm fat percentage (left) 0.1 0.3 0.4 0.5 -0.6
Average weekly red wine intake 0.6 0.9 0.9 1.0 -0.9
Handedness (chirality/laterality): Left-handed 1.4 1.6 3.3 -0.0 1.8
Mood swings 0.3 0.5 0.6 0.7 0.6
Loneliness, isolation 0.1 0.2 0.4 -0.1 0.6
Long-standing illness, disability or infirmity 2.1 3.2 4.8 -2.2 1.3
Ever had bowel cancer screening 0.4 0.5 1.0 1.0 0.1
Diabetes diagnosed by doctor 0.7 1.1 1.9 0.6 1.4
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.5 -0.7 0.5
Friendships satisfaction 2.1 2.6 5.0 2.2 0.5
Qualifications: nursing, teaching 0.5 0.7 1.4 0.3 -1.2
Commuting to job workplace: Walk 0.1 0.1 0.2 0.1 0.4
Eye problems/disorders: Cataract 0.1 0.1 0.1 0.3 0.3
Mouth/teeth dental problems: Mouth ulcers 4.0 6.3 12.6 -3.6 0.0
Medication for cholesterol 0.3 0.4 0.5 -0.7 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.3 -0.6 0.6
Back pain experienced in last month 2.2 3.2 6.1 -2.5 0.6
Mineral and other dietary supplements 1.4 1.9 3.8 1.9 0.1
Breast cancer (self-reported) 0.0 0.1 0.1 -0.3 0.0
Asthma (self-reported) 3.8 7.6 8.5 -2.6 -2.9
Osteoporosis (self-reported) 1.4 1.8 2.9 -0.8 -1.7
Osteoarthritis (self-reported) 1.0 1.4 2.7 0.2 1.6
Medication: Aspirin 0.9 1.2 1.8 1.3 -0.8
Medication: Gliclazide 3.2 3.7 7.0 2.6 0.6
Illnesses of father: None of the above (group 1) 0.1 0.1 0.1 0.3 0.3
Smoking status: Current 3.7 5.9 10.3 -3.2 1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.0 6.3 10.0 3.2 1.6
Whole body water mass 0.4 2.4 4.7 -0.1 2.2
Leg predicted mass (right) 0.3 1.5 2.1 -0.9 1.4
Arm fat mass (left) 0.1 0.2 0.4 0.6 0.3
Number of self-reported non-cancer illnesses 0.3 0.5 1.0 -1.0 0.1
Average weekly champagne plus white wine intake 1.5 2.0 3.8 1.9 -0.6
Miserableness 0.1 0.2 0.4 0.7 -0.2
Guilty feelings 0.0 0.1 0.1 0.3 -0.2
Wears glasses or contact lenses 0.5 0.6 0.7 0.8 0.8
Ever taken oral contraceptive pill 0.5 0.5 1.0 0.1 -1.0
Hearing aid user 0.3 0.4 0.4 -0.6 0.6
Mother’s age at death 0.6 0.8 1.2 1.1 -0.6
Financial situation satisfaction 0.1 0.1 0.1 0.4 0.2
Tinnitus: Yes, now most or all of the time 0.5 0.5 0.6 -0.6 -0.8
Commuting to job workplace: Public transport 1.7 2.1 3.8 0.6 2.0
Eye problems/disorders: Glaucoma 0.1 0.1 0.2 0.4 0.0
Medication: Blood pressure 0.1 0.2 0.2 0.4 0.4
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.3 -0.5 0.1
Supplements: Fish oil (including cod liver oil) 1.2 1.6 2.8 -1.7 -0.6
High cholesterol (Self-reported) 0.1 0.2 0.3 0.5 0.4
Medication: Bendroflumethiazide 0.0 0.0 0.0 -0.2 0.1
Medication: Paracetamol 1.5 2.3 3.1 -1.8 -1.2
Medication: Lisinopril 0.1 0.2 0.2 0.5 0.4
Medication: Atorvastatin 0.1 0.1 0.1 0.3 -0.4
Illnesses of father: High blood pressure 0.5 0.6 0.7 0.8 0.7
Alcohol drinker status: Never 0.7 0.8 1.6 0.2 -1.2
Ever smoked 1.3 2.3 4.3 0.5 2.1
Basal metabolic rate 0.2 1.3 2.6 -0.1 1.6
Leg fat percentage (left) 0.3 1.2 1.3 1.0 -1.1
Arm fat-free mass (left) 0.3 1.5 2.9 0.3 1.7
Number of operations (self-reported) 0.2 0.3 0.5 0.2 -0.7
Average weekly beer plus cider intake 2.5 3.6 4.6 -2.1 -1.6
Irritability 0.3 0.5 0.8 0.9 0.6
Risk taking 0.2 0.3 0.6 0.8 0.1
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.1 0.2 -1.1
Fractured/broken bones in last 5 years 0.4 0.6 1.1 -1.0 0.2
Age started oral contraceptive pill 0.2 0.2 0.3 -0.5 0.4
Diastolic blood pressure, automated reading 0.5 1.5 3.0 0.3 -1.7
Ever depressed for a whole week 1.0 1.2 2.4 1.6 -0.2
Unable to work because of sickness or disability 0.7 0.9 1.0 -1.0 0.8
Commuting to job workplace: Cycle 1.2 1.5 2.9 0.2 1.7
Myopia 1.0 1.4 2.0 1.4 -0.9
Vascular/heart problems diagnosed by doctor 0.2 0.5 1.0 0.1 -1.0
Cholesterol lowering medication 0.2 0.3 0.3 0.4 -0.6
Medication: Omeprazole (e.g. Zanprol) 1.5 1.8 3.0 0.8 1.7
Pain experienced in last month 1.5 2.6 3.5 1.9 1.3
Supplements: Calcium 0.1 0.1 0.1 0.4 0.1
Basal cell carcinoma (self-reported) 2.5 2.9 3.1 1.7 1.8
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.2 -0.4 -0.3
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.4 -0.7 0.1
Heart disease (siblings) 0.7 0.8 0.9 0.9 0.8
Alcohol drinker status: Previous 0.7 0.8 1.1 0.7 1.0
Pack years of smoking 1.7 2.5 4.2 -2.1 0.9
Impedance of whole body 3.7 19.1 28.8 -3.0 -5.4
Leg fat mass (left) 0.1 0.3 0.6 0.8 -0.3
Arm predicted mass (left) 0.3 1.7 3.3 0.2 1.8