Best TWAS P=2.43e-08 · Best GWAS P=7.74e-08 conditioned to 0.254
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | EXOSC6 | 0.24 | 0.25 | enet | 14 | 0.24 | 1.5e-29 | 4.9 | 5.2 | 2.0e-07 | 0.88 | 0.02 | 0.97 | FALSE |
2 | GTEx | Brain Cerebellar Hemisphere | EXOSC6 | 0.51 | 0.15 | lasso | 11 | 0.26 | 2.9e-07 | 4.8 | 5.2 | 2.3e-07 | 0.72 | 0.04 | 0.93 | FALSE |
3 | GTEx | Brain Cerebellar Hemisphere | RP11-296I10.6 | 0.19 | 0.20 | lasso | 5 | 0.19 | 1.5e-05 | 4.8 | 5.2 | 2.3e-07 | 0.87 | 0.02 | 0.94 | FALSE |
4 | GTEx | Brain Nucleus accumbens basal ganglia | EXOSC6 | 0.22 | 0.12 | enet | 12 | 0.12 | 3.3e-04 | 4.8 | 5.2 | 1.7e-07 | 0.76 | 0.02 | 0.92 | FALSE |
5 | GTEx | Brain Nucleus accumbens basal ganglia | RP11-296I10.6 | 0.15 | 0.11 | lasso | 3 | 0.08 | 3.0e-03 | 4.7 | 5.1 | 2.9e-07 | 0.84 | 0.02 | 0.82 | FALSE |
6 | GTEx | Esophagus Muscularis | RP11-296I10.6 | 0.32 | 0.27 | enet | 24 | 0.32 | 4.0e-20 | 4.7 | 5.2 | 1.5e-07 | 0.88 | 0.03 | 0.96 | FALSE |
7 | GTEx | Heart Atrial Appendage | RP11-296I10.6 | 0.18 | 0.19 | enet | 16 | 0.16 | 1.1e-07 | 4.8 | 5.1 | 2.8e-07 | 0.85 | 0.02 | 0.97 | FALSE |
8 | GTEx | Muscle Skeletal | RP11-296I10.6 | 0.11 | 0.15 | enet | 16 | 0.15 | 1.8e-14 | 4.7 | 5.2 | 2.3e-07 | 0.86 | 0.02 | 0.97 | FALSE |
9 | GTEx | Nerve Tibial | RP11-296I10.6 | 0.32 | 0.40 | enet | 23 | 0.43 | 5.1e-33 | 4.7 | 5.3 | 9.6e-08 | 0.86 | 0.03 | 0.96 | FALSE |
10 | GTEx | Testis | RP11-296I10.6 | 0.10 | 0.04 | enet | 7 | 0.07 | 6.2e-04 | 4.8 | 5.6 | 2.4e-08 | 0.86 | 0.01 | 0.95 | TRUE |