Best TWAS P=2.14e-10 · Best GWAS P=3.03e-11 conditioned to 0.129
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PRMT7 | 0.23 | 0.19 | bslmm | 319 | 0.19 | 2.2e-22 | 5.6 | 5.8 | 5.3e-09 | -0.36 | 0.47 | 0.53 | FALSE |
2 | GTEx | Artery Aorta | PLA2G15 | 0.11 | 0.03 | lasso | 7 | 0.07 | 1.4e-04 | 4.2 | -5.5 | 4.5e-08 | 0.58 | 0.17 | 0.57 | FALSE |
3 | GTEx | Lung | NFATC3 | 0.04 | 0.01 | lasso | 4 | 0.01 | 4.1e-02 | -5.8 | 6.2 | 7.5e-10 | -0.89 | 0.03 | 0.91 | FALSE |
4 | GTEx | Pituitary | ZDHHC1 | 0.23 | 0.13 | lasso | 4 | 0.08 | 4.0e-03 | -3.6 | -5.3 | 1.1e-07 | 0.02 | 0.05 | 0.33 | FALSE |
5 | GTEx | Skin Sun Exposed Lower leg | NFATC3 | 0.06 | 0.04 | enet | 9 | 0.05 | 6.6e-05 | -6.2 | 6.1 | 8.6e-10 | -0.81 | 0.04 | 0.89 | TRUE |
6 | GTEx | Testis | NFATC3 | 0.23 | 0.16 | lasso | 7 | 0.17 | 6.0e-08 | 4.3 | 5.8 | 5.4e-09 | -0.29 | 0.96 | 0.02 | FALSE |
7 | GTEx | Testis | RP11-67A1.2 | 0.20 | 0.02 | lasso | 6 | 0.09 | 8.3e-05 | 4.3 | 5.1 | 2.8e-07 | -0.10 | 0.68 | 0.02 | FALSE |
8 | GTEx | Thyroid | PLA2G15 | 0.06 | 0.04 | enet | 5 | 0.04 | 5.7e-04 | -6.6 | -5.2 | 2.7e-07 | 0.92 | 0.00 | 0.99 | FALSE |
9 | GTEx | Whole Blood | ATP6V0D1 | 0.08 | 0.00 | enet | 13 | 0.00 | 3.6e-01 | -4.3 | 5.2 | 2.4e-07 | 0.01 | 0.16 | 0.28 | FALSE |
10 | METSIM | Adipose | NFATC3 | 0.03 | 0.00 | blup | 298 | 0.00 | 3.4e-01 | 3.2 | 5.5 | 3.4e-08 | -0.51 | 0.06 | 0.18 | FALSE |
11 | METSIM | Adipose | PLA2G15 | 0.03 | 0.01 | blup | 287 | 0.01 | 4.8e-03 | -6.0 | -5.6 | 2.3e-08 | 0.73 | 0.03 | 0.88 | FALSE |
12 | NTR | Blood | ATP6V0D1 | 0.02 | 0.01 | bslmm | 220 | 0.01 | 1.6e-04 | -4.3 | 5.4 | 5.2e-08 | 0.02 | 0.27 | 0.44 | TRUE |
13 | NTR | Blood | ESRP2 | 0.03 | 0.03 | lasso | 5 | 0.02 | 7.7e-08 | 4.1 | -5.2 | 2.4e-07 | 0.36 | 0.98 | 0.02 | FALSE |
14 | The Cancer Genome Atlas | Colon Adenocarcinoma | NFATC3 | 0.22 | 0.05 | lasso | 3 | 0.06 | 3.6e-04 | -3.5 | 5.4 | 5.5e-08 | -0.84 | 0.00 | 0.99 | FALSE |
15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NFATC3 | 0.11 | 0.04 | enet | 4 | 0.04 | 2.8e-05 | -6.4 | 5.9 | 3.9e-09 | -0.86 | 0.00 | 1.00 | FALSE |
16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NFATC3 | 0.23 | 0.05 | lasso | 2 | 0.06 | 8.5e-08 | -6.4 | 5.5 | 3.7e-08 | -0.85 | 0.00 | 1.00 | FALSE |
17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PRMT7 | 0.19 | 0.14 | enet | 5 | 0.15 | 6.9e-17 | 5.6 | 6.3 | 2.1e-10 | -0.30 | 0.42 | 0.58 | TRUE |
18 | The Cancer Genome Atlas | Lung Adenocarcinoma | PRMT7 | 0.05 | 0.05 | lasso | 1 | 0.04 | 5.3e-06 | 5.6 | 5.6 | 2.7e-08 | -0.29 | 0.40 | 0.42 | FALSE |
19 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | NFATC3 | 0.23 | 0.05 | enet | 17 | 0.06 | 1.5e-03 | -2.7 | 6.0 | 1.4e-09 | -0.32 | 0.01 | 0.09 | FALSE |
20 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | NFATC3 | 0.26 | 0.09 | enet | 4 | 0.13 | 9.8e-06 | -6.4 | 5.2 | 1.6e-07 | -0.83 | 0.00 | 0.98 | FALSE |
21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NFATC3 | 0.18 | 0.05 | blup | 61 | 0.06 | 6.0e-07 | -3.3 | 5.1 | 2.9e-07 | -0.74 | 0.03 | 0.97 | FALSE |