Best TWAS P=2.85e-11 · Best GWAS P=7.33e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TCAM1P | 0.05 | 0.03 | enet | 8 | 0.04 | 4.1e-06 | 6.8 | -5.5 | 3.9e-08 | -0.85 | 0.04 | 0.96 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | CD79B | 0.15 | 0.16 | enet | 9 | 0.17 | 3.5e-14 | 6.8 | -6.6 | 4.2e-11 | -0.82 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | CD79B | 0.15 | 0.00 | lasso | 6 | 0.02 | 4.1e-02 | 6.8 | -6.6 | 5.3e-11 | -0.68 | 0.02 | 0.89 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | CD79B | 0.04 | 0.07 | lasso | 2 | 0.03 | 4.2e-02 | 6.8 | -6.0 | 1.8e-09 | -0.92 | 0.02 | 0.59 | FALSE |
| 5 | GTEx | Esophagus Mucosa | PSMC5 | 0.11 | 0.09 | lasso | 4 | 0.14 | 1.1e-09 | -4.2 | 5.6 | 1.7e-08 | 0.80 | 0.16 | 0.84 | FALSE |
| 6 | GTEx | Esophagus Mucosa | STRADA | 0.05 | 0.07 | lasso | 2 | 0.05 | 1.9e-04 | 6.2 | 6.2 | 4.8e-10 | 0.97 | 0.03 | 0.89 | FALSE |
| 7 | GTEx | Esophagus Muscularis | PSMC5 | 0.12 | 0.08 | lasso | 3 | 0.07 | 3.8e-05 | 6.9 | 6.3 | 3.6e-10 | 0.96 | 0.02 | 0.97 | FALSE |
| 8 | GTEx | Lung | PSMC5 | 0.04 | 0.00 | enet | 5 | 0.01 | 4.1e-02 | -4.2 | 5.2 | 2.2e-07 | 0.85 | 0.06 | 0.83 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CD79B | 0.02 | 0.02 | lasso | 2 | 0.01 | 3.0e-03 | 6.7 | -6.4 | 1.7e-10 | -0.75 | 0.02 | 0.45 | FALSE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TCAM1P | 0.04 | 0.07 | blup | 26 | 0.07 | 4.9e-15 | -4.2 | -5.3 | 1.1e-07 | -0.68 | 1.00 | 0.00 | FALSE |
| 11 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | CSH2 | 0.09 | 0.01 | blup | 37 | 0.08 | 5.7e-05 | -4.2 | -5.9 | 3.2e-09 | -0.77 | 0.12 | 0.79 | FALSE |
| 12 | The Cancer Genome Atlas | Colon Adenocarcinoma | TCAM1P | 0.05 | 0.03 | blup | 26 | 0.05 | 6.0e-04 | -4.7 | -6.2 | 5.0e-10 | -0.80 | 0.03 | 0.79 | FALSE |
| 13 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | STRADA | 0.05 | 0.03 | lasso | 1 | 0.02 | 1.7e-03 | 6.3 | 6.3 | 2.7e-10 | 0.98 | 0.00 | 0.92 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | STRADA | 0.07 | 0.01 | blup | 57 | 0.03 | 5.5e-04 | -3.4 | -6.0 | 1.7e-09 | -0.94 | 0.01 | 0.89 | FALSE |
| 15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | STRADA | 0.03 | 0.00 | blup | 57 | 0.01 | 5.2e-02 | 6.3 | -6.4 | 1.6e-10 | -0.96 | 0.00 | 0.85 | FALSE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TCAM1P | 0.02 | 0.03 | blup | 26 | 0.02 | 9.4e-04 | -4.5 | -6.1 | 9.3e-10 | -0.81 | 0.03 | 0.61 | FALSE |
| 17 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | FTSJ3 | 0.30 | 0.12 | enet | 10 | 0.18 | 6.7e-08 | -4.2 | 5.4 | 7.8e-08 | 0.74 | 0.20 | 0.79 | FALSE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PSMC5 | 0.04 | 0.03 | lasso | 1 | 0.03 | 5.6e-04 | 6.7 | 6.7 | 2.8e-11 | 1.00 | 0.01 | 0.96 | TRUE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | TCAM1P | 0.07 | 0.07 | blup | 26 | 0.08 | 2.8e-08 | -4.3 | -6.0 | 2.4e-09 | -0.83 | 0.10 | 0.90 | FALSE |