Best TWAS P=4.51e-13 · Best GWAS P=9.69e-12 conditioned to 0.00297
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | UBXN6 | 0.27 | 0.25 | enet | 28 | 0.29 | 4.6e-36 | -4.4 | 5.5 | 4.9e-08 | 0.51 | 1.00 | 0.00 | FALSE |
2 | GTEx | Adipose Subcutaneous | UBXN6 | 0.10 | 0.00 | enet | 21 | 0.02 | 8.0e-03 | 6.8 | 5.7 | 1.2e-08 | 0.66 | 0.01 | 0.95 | FALSE |
3 | GTEx | Artery Aorta | UBXN6 | 0.13 | 0.02 | lasso | 5 | 0.03 | 5.7e-03 | 6.8 | 7.0 | 3.2e-12 | 0.89 | 0.01 | 0.98 | FALSE |
4 | GTEx | Artery Tibial | UBXN6 | 0.18 | 0.07 | lasso | 3 | 0.14 | 6.3e-11 | -4.9 | 6.4 | 1.6e-10 | 0.74 | 0.02 | 0.98 | FALSE |
5 | GTEx | Brain Caudate basal ganglia | CTB-50L17.9 | 0.27 | 0.25 | lasso | 2 | 0.24 | 1.8e-07 | -5.3 | 5.5 | 3.2e-08 | 0.54 | 0.26 | 0.39 | FALSE |
6 | GTEx | Brain Cerebellar Hemisphere | CHAF1A | 0.62 | 0.40 | lasso | 8 | 0.36 | 3.5e-10 | -5.3 | 5.3 | 9.2e-08 | 0.54 | 0.95 | 0.04 | FALSE |
7 | GTEx | Brain Cerebellum | CTB-50L17.9 | 0.53 | 0.41 | lasso | 2 | 0.50 | 3.6e-17 | -4.5 | 5.5 | 3.1e-08 | 0.65 | 0.85 | 0.14 | FALSE |
8 | GTEx | Brain Frontal Cortex BA9 | CTB-50L17.9 | 0.27 | 0.21 | lasso | 3 | 0.19 | 7.9e-06 | -4.5 | 5.4 | 8.3e-08 | 0.62 | 0.15 | 0.72 | FALSE |
9 | GTEx | Brain Nucleus accumbens basal ganglia | CTB-50L17.9 | 0.45 | 0.25 | lasso | 8 | 0.23 | 8.6e-07 | -5.3 | 6.7 | 2.8e-11 | 0.71 | 0.06 | 0.89 | FALSE |
10 | GTEx | Cells Transformed fibroblasts | UBXN6 | 0.09 | 0.10 | lasso | 1 | 0.08 | 1.5e-06 | 6.8 | 6.8 | 1.1e-11 | 0.99 | 0.01 | 0.99 | FALSE |
11 | GTEx | Cells Transformed fibroblasts | AC007292.4 | 0.19 | 0.07 | enet | 29 | 0.07 | 3.6e-06 | 5.4 | -5.3 | 1.3e-07 | -0.68 | 0.05 | 0.93 | FALSE |
12 | GTEx | Colon Sigmoid | UBXN6 | 0.34 | 0.15 | lasso | 6 | 0.14 | 1.7e-05 | -4.5 | 5.4 | 6.3e-08 | 0.65 | 0.08 | 0.89 | FALSE |
13 | GTEx | Esophagus Muscularis | UBXN6 | 0.35 | 0.24 | enet | 20 | 0.29 | 3.7e-18 | -4.5 | 5.3 | 1.2e-07 | 0.57 | 0.99 | 0.01 | FALSE |
14 | GTEx | Heart Atrial Appendage | UBXN6 | 0.34 | 0.12 | lasso | 6 | 0.21 | 6.5e-10 | -5.3 | 6.6 | 3.6e-11 | 0.86 | 0.01 | 0.99 | FALSE |
15 | GTEx | Heart Left Ventricle | CHAF1A | 0.17 | 0.12 | lasso | 2 | 0.11 | 1.9e-06 | -5.3 | 5.3 | 1.0e-07 | 0.54 | 0.80 | 0.06 | FALSE |
16 | GTEx | Heart Left Ventricle | UBXN6 | 0.21 | 0.14 | lasso | 6 | 0.16 | 5.6e-09 | 6.8 | 7.0 | 2.7e-12 | 0.95 | 0.01 | 0.99 | FALSE |
17 | GTEx | Muscle Skeletal | CHAF1A | 0.18 | 0.21 | lasso | 2 | 0.20 | 9.7e-20 | -5.3 | 5.2 | 2.2e-07 | 0.54 | 0.99 | 0.01 | FALSE |
18 | GTEx | Muscle Skeletal | UBXN6 | 0.19 | 0.14 | lasso | 5 | 0.18 | 4.1e-17 | 6.8 | 7.0 | 2.2e-12 | 0.92 | 0.00 | 1.00 | FALSE |
19 | GTEx | Nerve Tibial | UBXN6 | 0.17 | 0.08 | enet | 20 | 0.09 | 4.4e-07 | -4.6 | 5.2 | 1.7e-07 | 0.46 | 0.89 | 0.07 | FALSE |
20 | GTEx | Prostate | MIR637 | 0.30 | -0.01 | lasso | 6 | -0.01 | 5.5e-01 | 6.8 | 5.5 | 2.9e-08 | 0.83 | 0.02 | 0.55 | FALSE |
21 | GTEx | Stomach | AC007292.4 | 0.27 | 0.09 | lasso | 5 | 0.04 | 4.0e-03 | 6.6 | -6.0 | 1.9e-09 | -0.81 | 0.02 | 0.85 | FALSE |
22 | GTEx | Testis | CHAF1A | 0.18 | 0.09 | lasso | 2 | 0.07 | 4.0e-04 | -5.3 | 5.2 | 1.7e-07 | 0.53 | 0.08 | 0.50 | FALSE |
23 | GTEx | Vagina | CTB-50L17.9 | 0.38 | 0.26 | lasso | 5 | 0.23 | 5.7e-06 | -5.3 | 5.2 | 1.5e-07 | 0.56 | 0.26 | 0.35 | FALSE |
24 | GTEx | Whole Blood | UBXN6 | 0.06 | 0.03 | lasso | 4 | 0.01 | 4.1e-02 | 6.5 | 6.1 | 9.2e-10 | 0.91 | 0.01 | 0.97 | FALSE |
25 | The Cancer Genome Atlas | Breast Invasive Carcinoma | UBXN6 | 0.03 | 0.03 | lasso | 3 | 0.03 | 2.3e-06 | 6.8 | 7.0 | 3.1e-12 | 0.97 | 0.01 | 0.99 | FALSE |
26 | The Cancer Genome Atlas | Glioblastoma Multiforme | SEMA6B | 0.24 | -0.01 | blup | 42 | 0.05 | 1.1e-02 | -4.1 | -5.3 | 1.1e-07 | -0.26 | 0.00 | 0.38 | FALSE |
27 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | UBXN6 | 0.05 | 0.01 | blup | 57 | 0.04 | 6.6e-05 | -5.3 | 7.2 | 4.5e-13 | 0.62 | 0.03 | 0.92 | TRUE |
28 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CHAF1A | 0.20 | 0.11 | lasso | 2 | 0.11 | 5.6e-05 | -4.9 | 5.2 | 2.0e-07 | 0.49 | 0.28 | 0.16 | FALSE |
29 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | UBXN6 | 0.23 | 0.11 | lasso | 5 | 0.12 | 2.5e-05 | -4.5 | 5.1 | 2.8e-07 | 0.42 | 0.04 | 0.35 | FALSE |
30 | The Cancer Genome Atlas | Prostate Adenocarcinoma | UBXN6 | 0.13 | 0.10 | lasso | 2 | 0.10 | 1.3e-10 | -5.3 | 5.7 | 9.2e-09 | 0.56 | 0.97 | 0.03 | FALSE |
31 | The Cancer Genome Atlas | Thyroid Carcinoma | UBXN6 | 0.16 | 0.12 | lasso | 2 | 0.12 | 5.4e-12 | -5.3 | 5.7 | 1.1e-08 | 0.62 | 0.95 | 0.05 | FALSE |