Best TWAS P=5.51e-12 · Best GWAS P=4.46e-10 conditioned to 0.00101
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | REXO1 | 0.07 | 0.01 | bslmm | 391 | 0.01 | 1.7e-02 | 3.6 | -6.9 | 5.5e-12 | -0.51 | 0.12 | 0.59 | TRUE |
| 2 | GTEx | Artery Aorta | AP3D1 | 0.27 | 0.12 | lasso | 3 | 0.13 | 1.3e-07 | -5.4 | 5.1 | 3.1e-07 | -0.03 | 0.25 | 0.74 | FALSE |
| 3 | GTEx | Esophagus Mucosa | AP3D1 | 0.18 | 0.21 | lasso | 3 | 0.21 | 2.4e-14 | -5.4 | 5.2 | 1.6e-07 | -0.02 | 0.20 | 0.80 | TRUE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | KLF16 | 0.12 | 0.08 | bslmm | 372 | 0.08 | 1.0e-10 | 6.2 | 5.8 | 5.2e-09 | 0.85 | 0.00 | 1.00 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ATP8B3 | 0.04 | 0.01 | blup | 49 | 0.02 | 2.2e-03 | 6.2 | 5.7 | 1.1e-08 | 0.84 | 0.00 | 0.76 | FALSE |