TWAS
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Usage
Models
Genes
Traits
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Traits
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Impedance of whole body
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chr19:1,127,720-2,862,806
Best TWAS P=5.51e-12 · Best GWAS P=4.46e-10 conditioned to 0.00101
1.2M
1.4M
1.6M
1.8M
2M
2.2M
2.4M
2.6M
2.8M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
CommonMind
Brain Pre-frontal Cortex
REXO1
0.07
0.01
bslmm
391
0.01
1.7e-02
3.6
-6.9
5.5e-12
-0.51
0.12
0.59
TRUE
3
GTEx
Esophagus Mucosa
AP3D1
0.18
0.21
lasso
3
0.21
2.4e-14
-5.4
5.2
1.6e-07
-0.02
0.20
0.80
TRUE
4
ROSMAP
Brain Pre-frontal Cortex
KLF16
0.12
0.08
bslmm
372
0.08
1.0e-10
6.2
5.8
5.2e-09
0.85
0.00
1.00
FALSE
5
The Cancer Genome Atlas
Lung Squamous Cell Carcinoma
ATP8B3
0.04
0.01
blup
49
0.02
2.2e-03
6.2
5.7
1.1e-08
0.84
0.00
0.76
FALSE
2
GTEx
Artery Aorta
AP3D1
0.27
0.12
lasso
3
0.13
1.3e-07
-5.4
5.1
3.1e-07
-0.03
0.25
0.74
FALSE