Best TWAS P=3.65e-13 · Best GWAS P=4.45e-13 conditioned to 0.119
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HHATL | 0.25 | 0.22 | lasso | 8 | 0.27 | 5.5e-33 | -7.2 | -7.3 | 3.7e-13 | 0.90 | 0.00 | 1.00 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | HIGD1A | 0.27 | 0.24 | bslmm | 455 | 0.24 | 5.6e-29 | -5.0 | 5.1 | 2.7e-07 | -0.82 | 0.99 | 0.01 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | RP4-613B23.1 | 0.07 | 0.02 | lasso | 2 | 0.02 | 9.0e-03 | -5.8 | -5.7 | 1.1e-08 | 0.53 | 0.15 | 0.26 | FALSE |
| 4 | GTEx | Brain Cortex | HIGD1A | 0.28 | 0.02 | enet | 36 | 0.12 | 3.6e-04 | -7.1 | 5.3 | 9.4e-08 | -0.60 | 0.01 | 0.94 | FALSE |
| 5 | GTEx | Muscle Skeletal | CCDC13 | 0.08 | 0.00 | enet | 5 | 0.00 | 5.8e-01 | -5.6 | -5.5 | 3.3e-08 | 0.65 | 0.06 | 0.47 | FALSE |
| 6 | GTEx | Thyroid | HIGD1A | 0.10 | 0.09 | lasso | 5 | 0.07 | 2.5e-06 | -5.0 | 5.2 | 1.5e-07 | -0.86 | 0.02 | 0.98 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | HHATL | 0.21 | 0.15 | bslmm | 465 | 0.18 | 1.3e-22 | 3.8 | -6.7 | 2.8e-11 | 0.75 | 0.61 | 0.39 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | HIGD1A | 0.40 | 0.38 | enet | 35 | 0.41 | 3.1e-56 | -5.0 | 5.2 | 1.5e-07 | -0.82 | 1.00 | 0.00 | FALSE |
| 9 | The Cancer Genome Atlas | Glioblastoma Multiforme | HHATL | 0.18 | 0.12 | enet | 7 | 0.21 | 5.2e-07 | 2.9 | -5.9 | 3.0e-09 | 0.74 | 0.02 | 0.94 | FALSE |
| 10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HHATL | 0.09 | 0.05 | enet | 10 | 0.10 | 7.4e-12 | -7.1 | -6.3 | 2.6e-10 | 0.78 | 0.01 | 0.99 | FALSE |