Hub : Genes

HIGD1A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2750	0.0470	0.0e+00	0.241	0.196	0.217	0.241	0.238	4.6e-29	2.7e-23	5.4e-26	5.6e-29	1.4e-28
2	GTEx	Adipose Subcutaneous	0.1150	0.0470	1.7e-03	0.013	NA	0.000	NA	-0.001	2.7e-02	NA	3.0e-01	NA	4.3e-01
3	GTEx	Brain Cortex	0.2770	0.0840	3.7e-04	0.024	NA	0.119	NA	0.100	7.1e-02	NA	3.6e-04	NA	1.0e-03
4	GTEx	Esophagus Muscularis	0.1770	0.0540	2.6e-05	0.004	NA	0.045	NA	0.023	1.9e-01	NA	9.8e-04	NA	1.5e-02
5	GTEx	Heart Atrial Appendage	0.2140	0.0830	4.9e-03	0.007	NA	-0.006	NA	0.009	1.6e-01	NA	8.4e-01	NA	1.2e-01
6	GTEx	Lung	0.1120	0.0482	6.1e-03	-0.002	NA	0.002	NA	-0.004	5.1e-01	NA	2.0e-01	NA	9.3e-01
7	GTEx	Thyroid	0.1030	0.0380	1.2e-03	0.092	NA	0.055	NA	0.074	1.5e-07	NA	4.6e-05	NA	2.5e-06
8	METSIM	Adipose	0.0375	0.0164	3.1e-03	0.048	0.018	0.037	0.027	0.040	9.1e-08	8.7e-04	2.4e-06	5.4e-05	1.2e-06
9	ROSMAP	Brain Pre-frontal Cortex	0.3954	0.0456	0.0e+00	0.377	0.319	0.407	0.375	0.398	3.6e-51	5.8e-42	3.1e-56	8.9e-51	9.4e-55
10	TCGA	Thyroid Carcinoma	0.1470	0.0550	1.7e-08	0.122	0.096	0.110	NA	0.120	6.4e-12	1.3e-09	7.2e-11	NA	1.1e-11

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.1	1.7	3.9	1.7	1.3	1.1	0.7	-0.3	2.0	1.3	1.4	1.2	1.4
Bipolar Disorder or Schizophrenia	0.3	0.8	1.4	1.1	0.8	0.8	1.2	0.8	0.1	0.9	1.0	0.9	0.9
Depressed Affect (Nagel 2018)	1.1	2.3	6.4	-1.1	-1.9	-1.5	-2.5	0.4	-1.5	-1.4	-1.2	-1.3	-1.3
Depression (Nagel 2018)	1.2	1.8	3.6	-1.4	-1.9	-1.0	-1.7	0.9	0.2	-1.4	-1.3	-1.5	-1.4
Intelligence (Savage-Jansen 2018)	0.3	1.0	3.0	-1.0	-0.6	-1.0	0.3	0.1	-1.7	-1.0	-1.0	-1.4	-1.0
Neuroticism (Nagel 2018)	0.7	1.7	3.0	-1.1	-1.3	-1.4	-1.7	1.2	-0.9	-1.4	-1.3	-1.2	-1.3
Schizophrenia (2018)	0.2	0.4	1.6	0.0	-0.2	0.3	0.9	1.3	-1.2	0.1	0.1	0.2	0.1
Schizophrenia vs Biploar Disorder	0.4	0.6	1.7	-0.5	1.0	-0.3	1.1	1.3	-1.1	-0.2	-0.2	-0.5	-0.3
Worry (Nagel 2018)	0.2	0.4	1.0	-0.4	0.5	0.0	0.7	1.0	0.6	-0.7	-0.6	-0.3	-0.7
Alzheimer’s Disease (in mother)	0.9	1.1	2.3	-1.3	-0.1	-0.1	0.0	1.1	-0.0	-1.5	-1.5	-1.1	-1.5
Alzheimer’s Disease (in father)	0.1	0.1	0.5	-0.1	-0.3	-0.7	-0.4	0.2	-0.3	-0.3	-0.2	-0.1	-0.2
Alzheimer’s Disease (including proxy)	0.4	0.5	1.3	-0.5	0.2	-0.6	0.0	1.2	-0.6	-1.0	-0.8	-0.7	-0.9
Crohns Disease (2017)	1.4	3.1	5.6	1.8	0.7	1.3	2.4	0.8	2.0	2.0	2.0	1.8	2.0
Irritable Bowel Disease (IBD)	2.0	4.7	7.6	2.6	-0.1	1.8	2.8	1.1	1.4	2.5	2.6	2.3	2.7
Ulcerative Colitis (UC)	1.4	2.6	4.4	2.1	-0.7	1.7	1.8	0.4	0.8	1.9	2.0	1.8	2.0
Major Depression (MDD)	0.2	0.3	2.1	-0.1	0.3	-0.4	0.1	1.4	-0.4	-0.3	-0.2	-0.5	-0.2
Reaction Time	0.1	0.2	0.7	-0.1	-0.0	0.8	0.8	-0.5	0.3	0.3	0.3	0.1	0.2
Verbal and Numeric Reasoning (VNR)	0.3	0.8	4.0	-0.4	0.1	-1.0	1.0	0.1	-2.0	-0.5	-0.4	-0.9	-0.5
Breast Cancer	0.2	0.6	2.6	0.2	1.1	0.8	1.6	-0.8	0.7	0.2	0.2	0.4	0.2
Ovarian Cancer	0.2	0.2	0.8	0.3	0.4	0.7	-0.6	0.5	-0.9	0.3	0.2	0.1	0.2
Prostate Cancer	0.5	0.6	3.3	-0.3	-0.4	-0.7	-0.1	-1.8	-1.5	-0.1	-0.1	-0.4	-0.1
Age at First Birth	1.1	1.6	7.4	1.1	2.1	-0.0	2.7	0.1	1.0	0.9	0.8	0.6	0.8
Bipolar Disorder (2011)	0.6	0.6	2.7	-0.1	1.2	1.6	1.0	-0.6	-0.1	-0.5	-0.5	0.1	-0.3
Body Mass Index (BMI) (2010)	1.4	2.0	7.2	-0.9	0.3	-2.7	-1.0	0.4	-1.9	-1.3	-1.2	-1.6	-1.2
Coronary Artery Disease (CAD)	0.5	0.6	1.6	-0.9	-0.6	-1.3	-0.3	0.7	-0.2	-1.0	-0.9	-0.5	-1.0
Crohns Disease (2012)	0.5	0.8	2.8	0.5	0.0	0.5	1.3	0.5	1.7	0.8	0.7	0.9	0.7
Mean Putamen Volume	0.3	0.4	3.4	-0.1	-0.2	-0.4	-0.2	-1.9	-0.3	-0.2	-0.1	-0.4	-0.2
Fasting Glucose	4.2	5.0	8.7	-2.8	-2.3	-1.2	-1.8	0.6	0.2	-3.0	-2.9	-2.6	-2.9
HbA1C	1.9	2.1	4.0	-1.7	-0.7	-1.7	-0.2	0.2	-0.9	-2.0	-2.0	-1.6	-1.9
HDL Cholesterol	0.2	0.4	0.9	0.6	-0.2	0.9	0.1	-0.4	-0.2	0.6	0.6	1.0	0.7
LDL Cholesterol	0.6	1.0	4.4	-0.4	-1.1	-2.1	-0.9	1.0	-0.3	-0.7	-0.6	-0.9	-0.6
Lupus	0.1	0.2	1.0	-0.2	-0.3	-0.8	-1.0	0.1	-0.0	-0.3	-0.2	-0.2	-0.3
Neuroticism (2016)	0.4	0.6	2.5	0.1	-1.4	0.0	-0.9	0.6	-1.6	0.1	0.2	0.3	0.2
Primary Biliary Cirrhosis	0.2	0.2	0.5	-0.6	0.1	0.4	-0.1	0.2	0.1	-0.7	-0.7	-0.3	-0.7
Rheumatoid Arthritis	0.3	0.4	1.8	0.3	0.3	1.4	0.8	0.9	0.1	0.3	0.5	0.6	0.3
Schizophrenia (2014)	0.7	1.6	6.2	-1.1	0.1	-1.3	0.0	1.1	-2.5	-1.2	-1.1	-1.0	-1.2
Triglycerides	1.8	2.9	5.3	-2.0	-1.6	-2.1	-1.0	-0.6	-0.6	-1.9	-1.9	-2.3	-1.9
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.5	-0.4	-0.4	-0.8	-0.0	-1.2	0.3	-0.5	-0.4	-0.7	-0.5
Ulcerative Colitis	0.8	1.1	3.1	1.3	-1.8	-0.3	0.6	1.1	-0.3	1.1	1.2	0.7	1.2
Blood Eosinophil Count	2.8	21.9	47.1	-4.4	-6.5	-6.9	-6.5	0.1	-1.2	-3.2	-3.2	-6.1	-3.3
Blood Platelet Count	0.1	1.0	5.5	0.4	-2.4	1.5	0.6	1.0	-0.9	0.1	0.2	0.3	0.3
Blood Red Count	0.3	2.4	5.0	-1.7	-0.3	-1.6	0.1	-0.4	-1.4	-2.2	-2.1	-1.9	-1.9
Blood White Count	2.3	16.8	45.2	-3.9	-4.8	-4.9	-6.7	-1.8	-1.1	-3.2	-3.1	-5.1	-3.1
Heel T-Score	0.3	2.0	10.1	-1.0	-0.6	-1.6	-1.4	0.7	-3.2	-1.0	-1.0	-0.9	-1.0
BMI	0.8	4.8	7.5	-2.7	-0.1	-2.7	-1.2	1.6	-2.6	-2.5	-2.5	-2.1	-2.5
Height	0.3	4.9	15.8	1.6	3.0	2.1	2.1	-0.2	4.0	1.9	1.6	1.8	1.6
Waist Hip Ratio (WHR)	0.6	2.7	5.2	-1.9	-2.3	0.8	-0.4	1.3	1.2	-2.0	-2.0	-1.4	-2.1
Systolic Blood Pressure	0.2	0.8	3.2	0.4	-0.9	1.8	0.9	0.6	1.3	0.4	0.3	0.7	0.5
Smoking Status	0.1	0.2	0.6	0.4	-0.5	-0.3	0.0	0.6	-0.3	-0.3	-0.1	-0.8	-0.1
Allergy or Eczema	0.4	0.9	1.7	0.9	-0.1	-0.9	0.4	-0.9	0.8	1.3	1.3	1.0	1.3
Cardiovascular Disease	1.9	6.3	11.7	-2.9	-2.1	-0.9	-1.9	0.7	-2.6	-3.4	-3.3	-2.3	-3.3
Hypothyroidism (self reported)	0.2	0.4	1.1	0.7	0.2	0.6	1.1	0.1	-0.2	0.4	0.5	1.1	0.5
Respiratory disease	0.1	0.3	0.9	0.9	0.1	-0.2	0.5	-0.2	0.1	0.6	0.7	0.5	0.6
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.9	-0.5	-0.4	-0.5	-0.4	1.0	0.0	-0.4	-0.4	0.6	-0.3
Lung FEV1/FVC ratio	0.1	0.7	1.1	1.0	1.1	0.6	0.3	-0.4	-1.0	1.0	1.0	0.7	0.9
Lung FVC	0.5	2.4	4.6	1.7	1.3	0.6	2.1	-1.2	1.0	1.8	1.9	1.2	2.0
Neuroticism	0.6	1.5	2.7	-1.5	-1.0	-0.9	-1.0	1.1	0.2	-1.6	-1.6	-1.3	-1.6
Chronotype (morning person)	0.7	1.6	3.3	-1.6	-1.5	-1.8	-0.4	-0.2	0.1	-1.3	-1.4	-1.6	-1.4
Hair Pigment	0.5	13.0	21.1	3.8	2.2	2.7	0.9	-2.2	4.6	4.6	4.5	3.8	4.5
Tanning	0.1	1.6	3.8	-1.4	0.4	-1.9	-0.0	0.1	0.5	-1.5	-1.5	-1.6	-1.6
Hand grip strength (left)	0.1	0.4	2.3	0.1	0.9	-0.5	-0.4	-1.5	-0.1	0.1	0.2	-0.3	0.2
Number of treatments/medications taken	1.2	2.1	3.4	-1.7	-1.3	-1.8	-1.1	1.0	-0.6	-1.7	-1.6	-1.4	-1.6
Average weekly spirits intake	1.2	1.5	5.4	-0.8	-0.8	-2.3	-1.5	-0.4	-1.4	-0.9	-0.9	-1.0	-0.9
Sensitivity / hurt feelings	0.3	0.6	2.3	-0.4	-0.1	-0.6	-1.5	-0.0	-1.0	-0.8	-0.7	-0.6	-0.6
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.3	-0.9	-1.5	-0.6	-1.5	0.6	-0.0	-1.0	-0.9	-0.9	-0.9
Hearing difficulty/problems: Yes	0.6	0.8	2.0	1.2	0.3	-1.4	0.3	1.3	0.4	0.9	0.9	0.9	0.9
Relative age of first facial hair	0.2	0.4	0.9	-0.4	-0.2	0.1	1.0	0.9	-0.7	-0.7	-0.5	-0.9	-0.5
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.7	-1.6	-1.0	-0.1	-0.1	-0.5	-0.3	-1.4	-1.3	-0.9	-1.3
Ever used hormone-replacement therapy (HRT)	0.3	0.4	2.2	0.0	-1.5	-0.6	-0.3	0.9	-0.2	-0.0	0.2	0.2	0.2
Ever had hysterectomy (womb removed)	0.3	0.3	1.0	0.3	0.2	-1.0	-0.8	0.3	0.6	-0.2	-0.1	-0.9	-0.1
Systolic blood pressure, automated reading	1.0	2.9	6.6	1.6	0.8	2.6	2.4	0.9	1.7	1.6	1.5	1.6	1.6
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	5.5	-0.5	0.0	-0.1	-0.3	2.4	0.7	-0.8	-0.6	-0.1	-0.6
Angina	1.2	1.6	6.8	-1.1	0.1	-2.0	-2.6	0.5	-0.2	-0.9	-1.0	-0.8	-1.1
Medication for hormone replacement therapy	0.2	0.2	1.4	0.1	-1.2	0.0	0.8	0.4	-0.0	-0.1	-0.1	-0.1	-0.2
Vitamin and mineral supplements	0.3	0.5	2.1	-0.2	-0.4	0.3	-1.0	1.0	-1.4	-0.2	-0.1	0.3	-0.2
Supplements: Zinc	0.6	0.7	2.4	-0.2	-0.0	-1.5	0.7	0.9	-0.9	-0.5	-0.4	-1.1	-0.5
Medication: Co-codamol	0.2	0.2	0.8	-0.1	-0.2	-0.9	-0.9	0.3	-0.5	-0.2	-0.2	-0.2	-0.2
Medication: Metformin	0.4	0.6	2.4	0.2	1.6	0.7	1.3	1.0	-0.2	0.3	0.3	0.7	0.2
Diabetes (father)	0.3	0.3	1.0	0.5	1.0	0.2	-0.1	0.7	-1.0	0.2	0.3	0.7	0.2
Diabetes (mother)	0.7	0.9	2.2	1.3	1.5	0.3	1.1	0.8	-0.2	0.9	0.9	0.8	0.9
Severe depression (siblings)	0.4	0.5	1.1	-0.7	1.0	-0.4	0.8	0.2	0.3	-0.8	-0.6	-0.7	-0.7
Pack years adult smoking proportion	0.7	1.0	3.1	-0.9	-1.6	-0.2	-1.8	-0.6	1.2	-0.8	-0.7	-0.7	-0.7
Impedance of leg (right)	2.3	11.4	17.5	4.1	1.2	4.0	1.0	-2.6	2.7	4.2	4.1	3.9	4.0
Leg fat-free mass (left)	0.5	2.5	4.6	-2.2	-0.3	-2.1	-1.1	0.7	-0.7	-1.8	-1.9	-2.0	-1.8
Trunk fat percentage	0.2	0.8	1.5	0.7	0.1	0.2	-0.7	-0.8	0.7	1.2	1.2	1.1	1.2
Hand grip strength (right)	0.3	0.8	2.7	-0.3	0.3	-1.4	-1.6	-1.6	0.1	-0.4	-0.3	-0.8	-0.3
Townsend deprivation index at recruitment	0.7	1.0	1.9	-1.3	-0.7	-0.6	-0.9	-0.2	0.3	-1.4	-1.4	-1.0	-1.3
Current tobacco smoking	1.1	1.8	3.3	1.7	-0.5	0.9	0.1	0.1	1.6	1.8	1.8	1.2	1.8
Average weekly fortified wine intake	0.2	0.3	1.6	-0.1	-1.0	0.3	-0.3	-0.3	1.3	0.2	0.0	-0.1	0.0
Maternal smoking around birth	0.3	0.4	1.0	0.1	1.0	0.8	0.9	0.9	0.2	0.5	0.4	0.5	0.3
Fed-up feelings	0.6	1.1	4.3	-0.6	-2.1	-0.1	-1.6	0.1	-1.4	-0.8	-0.7	-0.7	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.1	-1.3	-1.8	-0.9	-1.5	0.2	-0.0	-1.3	-1.3	-1.4	-1.3
Relative age voice broke	0.4	0.6	2.0	-0.1	0.9	-0.5	1.4	-1.0	-1.3	-0.2	-0.2	-0.6	-0.2
Taking other prescription medications	0.6	0.9	3.4	-0.8	-0.7	-1.9	-1.3	0.2	0.8	-0.6	-0.6	-0.8	-0.6
Age when periods started (menarche)	0.1	0.2	0.8	-0.1	-0.9	0.6	-0.5	-0.0	0.3	0.1	0.0	-0.4	-0.0
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	3.7	1.9	0.5	0.6	-0.8	0.4	0.2	1.5	1.6	1.1	1.7
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	5.7	-1.5	-1.7	-1.8	-2.0	-0.8	-2.4	-1.4	-1.4	-1.5	-1.4
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	2.3	0.3	-1.1	-0.8	-1.5	1.4	0.4	0.3	0.3	0.2	0.4
Qualifications: CSEs or equivalent	0.3	0.4	1.0	0.5	0.9	1.0	0.7	-0.8	0.4	0.4	0.4	0.5	0.4
Serious illness, injury or assault to yourself	3.2	3.9	7.8	-2.8	-1.1	-2.1	-1.1	-0.9	-0.7	-2.3	-2.4	-2.5	-2.4
High blood pressure	0.6	1.8	3.5	-1.7	-1.1	-0.3	-0.9	1.0	-0.6	-1.9	-1.9	-1.2	-1.8
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.7	0.7	0.3	-0.5	0.4	-1.3	0.3	0.9	0.9	0.8	0.9
Multivitamins +/- minerals	0.7	0.9	4.2	0.4	0.6	-0.1	2.0	-1.1	1.7	0.4	0.3	-0.0	0.4
Stomach or abdominal pain in last month	1.3	1.7	7.8	-1.3	-1.3	0.0	-2.8	-0.4	1.1	-1.0	-1.1	-0.5	-1.2
Supplements: Glucosamine	0.3	0.4	1.8	-0.1	-0.0	0.8	0.7	-1.2	-1.3	0.1	0.0	0.5	0.0
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.3	-1.0	-1.1	0.9	1.1	-0.4	1.0	-0.9	-0.8	-0.8	-0.9
Medication: Atenolol	2.7	3.4	5.9	-1.9	-1.9	-1.0	-2.0	0.3	-2.4	-2.1	-2.2	-1.4	-2.1
Medication: Levothyroxine sodium	0.4	0.6	1.5	0.7	1.0	1.2	0.7	1.1	0.1	0.4	0.4	1.0	0.5
Sitting height	0.4	2.6	4.5	1.8	2.1	1.5	1.1	-0.6	2.1	1.6	1.5	1.6	1.5
Chronic bronchitis/emphysema (father)	0.3	0.4	2.0	-0.0	-0.8	-0.6	-1.4	0.3	0.9	-0.1	-0.1	0.2	-0.1
High blood pressure (mother)	0.6	0.8	2.8	0.2	-0.5	1.7	-0.6	-1.4	1.0	0.7	0.5	0.9	0.5
Body mass index (BMI)	1.2	5.2	8.9	-2.9	-0.5	-3.0	-2.0	-0.0	-2.1	-2.6	-2.5	-2.7	-2.5
Impedance of leg (left)	1.9	9.0	13.8	3.6	1.1	3.4	1.1	-2.4	2.4	3.7	3.7	3.4	3.5
Leg predicted mass (left)	0.5	2.4	4.4	-2.1	-0.3	-2.0	-1.1	0.8	-0.8	-1.8	-1.8	-1.9	-1.7
Trunk fat mass	0.0	0.2	0.5	-0.2	0.3	-0.4	-0.7	-0.7	0.2	0.4	0.3	0.2	0.3
Waist circumference	0.8	3.1	6.3	-2.5	-0.8	-1.7	-1.3	0.1	-0.6	-2.2	-2.2	-2.1	-2.2
Number of incorrect matches in round	0.4	0.7	3.1	0.8	0.5	0.7	0.4	-0.3	1.8	0.9	0.8	0.7	0.8
Past tobacco smoking	0.3	0.5	2.1	-0.4	-0.1	1.4	1.1	0.1	1.1	0.4	0.1	0.2	0.2
Alcohol usually taken with meals	4.1	6.7	12.7	2.4	3.4	2.9	3.6	-0.2	1.9	2.5	2.3	2.7	2.4
Nervous feelings	0.2	0.3	0.7	-0.7	0.0	-0.2	0.2	-0.2	-0.3	-0.8	-0.8	-0.7	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	3.9	-0.2	-1.5	-1.3	-2.0	1.1	-0.1	-0.4	-0.3	-0.9	-0.2
Hearing difficulty/problems with background noise	0.2	0.4	3.3	0.1	0.5	-1.8	-0.0	-0.4	0.1	0.0	0.1	-0.1	0.1
Hair/balding pattern: Pattern 2	2.0	2.6	7.7	0.9	1.9	2.3	2.8	1.0	1.3	1.0	0.9	1.7	0.9
Had menopause	0.4	0.5	2.2	-0.3	-0.2	-1.0	0.0	1.5	1.1	-0.4	-0.4	-0.3	-0.4
Had other major operations	1.4	1.8	4.9	-1.4	-1.0	-1.8	-2.2	-0.1	0.4	-1.2	-1.4	-1.2	-1.2
Forced vital capacity (FVC)	1.3	4.9	7.3	2.5	2.1	1.7	1.6	-1.1	2.3	2.7	2.6	2.2	2.6
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.7	9.1	-1.8	-2.2	-1.6	-2.4	-0.7	-3.0	-1.7	-1.6	-1.7	-1.6
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	5.3	0.2	2.3	-0.5	-0.6	0.1	0.9	0.1	0.1	0.0	0.0
Qualifications: None of the above	0.4	0.8	1.5	-0.8	-0.7	-1.0	-0.9	-0.6	1.2	-0.8	-0.8	-1.0	-0.8
Financial difficulties in last 2 years	3.2	4.3	12.6	-1.9	-3.6	-1.0	-3.5	-0.7	-0.4	-1.8	-1.7	-2.0	-1.7
Mouth/teeth dental problems	0.8	1.3	5.1	0.8	0.8	0.5	2.3	1.1	-1.7	0.7	0.6	0.8	0.5
Heart attack	0.4	0.5	1.5	-0.5	-0.1	-1.2	-1.2	0.2	-0.7	-0.7	-0.6	-0.4	-0.6
Allergy	0.2	0.4	1.9	-0.1	0.4	1.2	0.7	1.4	0.2	-0.3	-0.3	-0.0	-0.3
Pain all over the body in last month	0.1	0.1	0.8	-0.0	0.1	-0.1	-0.9	0.4	-0.6	0.2	0.1	-0.1	0.1
Diabetes (self-reported)	0.7	1.2	3.1	0.9	1.0	0.7	0.8	1.8	0.7	0.9	1.0	1.6	0.9
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.1	0.5	-1.0	0.3	1.1	0.6	0.7	0.8	0.7	0.6	0.7
Medication: Ramipril	0.2	0.2	0.8	-0.0	-0.9	0.6	0.3	0.8	-0.7	-0.1	-0.1	0.1	0.0
Medication: Simvastatin	0.4	0.6	1.6	-0.6	-1.3	-0.6	-0.7	-0.1	-1.1	-1.0	-0.8	-0.2	-0.7
Fluid intelligence score	0.3	0.6	3.9	0.2	2.0	-0.3	0.7	0.2	-1.2	0.1	0.1	-0.0	0.0
Illnesses of siblings	0.2	0.3	1.7	0.1	-0.3	0.1	-0.5	-0.4	1.3	0.5	0.3	0.3	0.3
Neuroticism score	0.5	1.0	1.8	-1.2	-0.3	-1.1	-0.9	0.7	0.2	-1.3	-1.3	-1.0	-1.3
Weight	0.4	2.0	3.8	-1.9	0.2	-1.9	-1.3	-0.5	-0.9	-1.5	-1.5	-1.7	-1.5
Impedance of arm (right)	4.0	18.7	37.5	5.0	0.8	6.1	2.1	-1.4	3.6	5.1	4.9	5.4	4.9
Arm fat percentage (right)	0.1	0.2	0.9	-0.8	0.1	-0.4	-0.5	-0.3	-0.9	-0.3	-0.4	-0.3	-0.3
Trunk fat-free mass	0.9	5.4	9.0	-3.0	0.2	-3.0	-0.7	0.2	-1.7	-2.8	-2.8	-3.0	-2.8
Hip circumference	0.1	0.5	1.1	-1.1	0.9	-1.0	-0.2	-0.6	-0.8	-0.6	-0.7	-0.6	-0.6
Time employed in main current job	1.8	2.1	9.4	0.9	1.1	1.7	3.1	-0.6	0.6	1.2	1.1	1.5	1.1
Alcohol intake versus 10 years previously	0.7	1.1	2.7	1.3	0.0	-0.7	-1.6	0.3	1.4	1.0	1.0	0.8	1.1
Father’s age at death	0.9	1.1	2.0	-1.1	-0.2	-1.4	0.6	1.2	0.9	-1.2	-1.2	-1.2	-1.2
Worrier / anxious feelings	1.2	2.2	4.5	-1.7	0.2	-0.7	1.0	-0.4	-1.4	-2.0	-2.1	-1.7	-2.1
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	4.3	-1.2	-1.4	-0.6	-2.1	-1.9	-0.8	-1.0	-0.9	-1.2	-1.0
Falls in the last year	0.4	0.5	3.2	0.4	0.7	0.3	-0.6	-0.3	1.8	0.4	0.4	0.6	0.4
Hair/balding pattern: Pattern 3	0.2	0.2	0.5	0.7	-0.5	-0.3	-0.4	-0.0	0.2	0.6	0.7	0.0	0.7
Number of live births	1.7	2.4	5.9	-1.4	0.2	-2.4	-1.7	-1.1	0.4	-1.6	-1.6	-2.0	-1.6
Forced expiratory volume in 1-second (FEV1)	1.3	4.5	6.8	2.2	2.3	1.7	1.5	-1.8	1.8	2.6	2.5	2.0	2.5
Pulse rate	0.3	0.6	2.2	-0.5	-0.8	-1.5	-0.6	0.7	-0.2	-0.8	-0.7	-0.2	-0.7
Happiness	0.7	0.8	1.4	1.0	-0.2	-0.1	-1.2	0.6	-0.3	1.1	1.1	1.2	1.2
Noisy workplace	0.5	0.6	1.9	0.1	1.4	-1.3	-0.7	-1.1	1.0	-0.1	-0.1	-0.6	-0.2
Qualifications: A levels/AS levels or equivalent	0.2	0.5	0.9	0.9	-0.7	0.3	0.7	0.2	-0.6	0.8	0.8	0.5	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.9	6.2	-0.0	-2.5	0.7	-1.1	-0.6	0.5	-0.1	-0.1	0.2	-0.1
Mouth/teeth dental problems: Dentures	0.2	0.3	1.3	-0.5	-0.3	-0.0	-0.1	-1.1	0.9	-0.4	-0.3	-0.1	-0.3
Asthma	0.1	0.2	0.9	-0.1	0.4	-0.6	0.0	-0.9	-0.6	-0.5	-0.5	-0.3	-0.5
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.6	5.3	-1.1	-0.1	-0.6	-0.2	1.0	-2.3	-1.3	-1.3	-1.5	-1.3
Medication: Cholesterol lowering	0.7	1.1	3.6	-1.1	-0.7	-1.0	-1.0	-0.0	-1.9	-1.2	-1.1	-0.5	-1.0
Depression (self-reported)	1.9	2.3	4.4	-1.6	-2.1	-1.2	-2.0	-0.5	-0.5	-1.6	-1.5	-1.6	-1.6
Medication: Lansoprazole	0.7	0.9	2.7	-0.7	-1.4	-0.5	-1.7	-1.0	0.4	-0.6	-0.7	-0.9	-0.6
Prospective memory result	0.3	0.3	0.9	-0.8	-0.6	-0.6	-0.9	0.1	0.4	-0.5	-0.5	-0.5	-0.5
Lung cancer (father)	0.7	0.8	3.5	-0.4	-1.4	-1.0	-0.9	0.0	-1.9	-0.5	-0.6	-0.2	-0.5
Illnesses of mother	0.5	0.6	3.6	0.5	-1.9	-0.8	-0.5	-0.4	-0.2	0.5	0.6	0.2	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.8	6.1	1.9	2.1	0.9	0.7	-2.1	1.8	2.5	2.3	1.8	2.4
Pulse wave Arterial Stiffness index	0.5	0.6	1.9	1.2	1.4	-0.2	0.6	0.9	0.3	0.5	0.8	0.7	0.6
Impedance of arm (left)	3.9	18.3	31.2	4.9	0.5	5.6	1.8	-0.8	4.6	5.1	4.9	5.3	4.9
Arm fat mass (right)	0.3	1.1	2.2	-1.5	0.0	-1.4	-0.9	-0.1	-1.4	-1.1	-1.1	-1.1	-1.0
Trunk predicted mass	1.0	5.8	9.6	-3.0	0.2	-3.1	-0.8	0.3	-1.7	-2.9	-2.9	-3.1	-2.9
Standing height	0.3	2.7	6.1	1.4	1.4	1.7	1.3	-1.3	2.5	1.8	1.6	1.6	1.5
Length of working week for main job	0.2	0.2	0.9	0.2	-0.9	0.8	0.1	-0.5	-0.4	0.3	0.2	0.4	0.3
Exposure to tobacco smoke at home	0.2	0.2	0.5	0.6	-0.5	0.3	-0.1	0.3	-0.3	0.5	0.5	0.7	0.6
Breastfed as a baby	1.0	1.2	2.4	-1.5	-0.6	-0.7	0.2	-0.9	-0.3	-1.3	-1.3	-1.5	-1.4
Tense / ‘highly strung’	0.3	0.4	1.7	0.3	-1.0	-0.0	-1.3	0.6	1.2	0.0	0.1	-0.1	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.5	-0.4	-0.5	-0.4	-0.4	0.3	0.7	-0.5	-0.4	-0.6	-0.5
Hair/balding pattern: Pattern 4	0.1	0.2	0.6	0.3	0.0	-0.1	-0.3	-0.8	-0.8	0.2	0.1	0.7	0.1
Birth weight of first child	0.8	1.5	5.9	-0.2	0.1	-0.8	1.2	2.2	-2.4	-0.9	-0.7	-0.5	-0.7
Peak expiratory flow (PEF)	0.2	0.5	1.8	0.5	0.1	0.2	0.2	-1.3	-0.9	0.9	0.8	0.4	0.8
Pulse wave reflection index	0.2	0.2	0.9	-0.2	0.7	-0.1	0.0	-0.7	-0.9	-0.4	-0.3	-0.4	-0.4
Ever highly irritable/argumentative for 2 days	0.4	0.5	3.1	-0.4	-0.5	-0.6	-1.8	0.3	-0.4	-0.7	-0.4	-0.6	-0.4
Loud music exposure frequency	0.2	0.2	1.0	-0.0	0.7	-0.8	-1.0	0.3	0.0	0.0	-0.1	0.2	-0.1
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	2.4	1.3	0.2	0.8	1.5	-0.6	-0.8	1.3	1.4	1.5	1.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.7	0.4	-0.3	-0.0	-0.2	-0.9	0.4	0.2	0.4	-0.2	0.4
Blood clot in the leg (DVT)	1.5	1.9	3.1	-1.5	-1.7	-0.8	-1.8	0.1	-1.8	-1.4	-1.3	-1.2	-1.3
Medication: Paracetamol	0.8	1.3	3.3	-1.1	-0.4	-1.6	-0.2	-0.3	-1.8	-1.1	-1.0	-1.3	-1.1
Headache pain in last month	0.4	0.7	1.7	-1.0	-0.1	0.0	0.1	-0.2	-0.3	-1.1	-1.2	-1.3	-1.3
Medication for cholesterol, blood pressure or diabetes	1.9	3.1	5.0	2.1	1.6	1.5	1.2	0.0	2.1	2.2	2.1	1.6	2.1
Glaucoma (self-reported)	0.2	0.2	0.6	-0.1	-0.8	-0.5	-0.1	0.7	0.7	-0.1	-0.1	-0.5	-0.0
Gout (self-reported)	0.8	1.1	2.5	0.8	1.6	0.9	1.4	0.9	0.5	1.1	1.0	1.1	1.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.8	0.5	0.5	0.5	0.7	0.2	-0.1	0.2	0.3	0.9	0.3
Medication: Amlodipine	0.8	1.1	2.1	-1.4	-0.7	0.6	1.4	-0.1	-0.8	-1.4	-1.4	-0.6	-1.4
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.7	0.1	0.4	-0.6	-0.8	-0.4	0.1	0.0	-0.0	-0.4	-0.0
Birth weight	0.9	2.0	4.0	-2.0	0.2	-1.2	-0.8	0.6	-0.4	-1.9	-2.0	-1.5	-1.9
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.2	0.7	0.6	1.1	-0.1	0.2	0.1	0.6	0.7	0.4	0.6
High blood pressure (siblings)	0.1	0.2	1.0	0.0	1.0	-0.5	0.5	0.2	-0.8	-0.2	-0.0	-0.1	-0.0
Forced vital capacity (FVC), Best measure	1.6	5.9	9.0	2.6	2.6	1.5	1.3	-1.9	2.2	3.0	2.9	2.6	3.0
Body fat percentage	0.1	0.3	0.9	0.1	0.1	-0.1	-0.8	-1.0	0.1	0.6	0.6	0.5	0.6
Leg fat percentage (right)	0.2	0.7	1.6	-0.9	0.3	-1.1	-1.2	-1.3	-0.7	-0.4	-0.4	-0.8	-0.4
Arm fat-free mass (right)	1.3	6.7	15.5	-3.1	0.0	-3.9	-1.6	0.7	-1.7	-3.0	-2.9	-3.3	-2.9
Exposure to tobacco smoke outside home	1.1	1.5	5.5	0.8	-0.5	0.8	-2.4	-1.4	1.1	0.9	0.9	1.3	1.0
Comparative body size at age 10	0.5	1.5	7.7	-1.2	0.5	-2.8	0.3	0.8	-0.1	-1.0	-1.0	-1.2	-0.9
Number of full brothers	0.5	0.6	4.0	-0.3	0.1	0.2	0.0	2.0	-0.3	-0.7	-0.6	-0.5	-0.6
Worry too long after embarrassment	0.5	0.9	2.2	-1.5	-0.7	-0.5	-0.2	-0.3	0.0	-1.2	-1.3	-0.8	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.6	0.1	-0.4	0.1	-0.1	-0.7	0.8	0.3	0.2	0.1	0.2
Wheeze or whistling in the chest in last year	0.5	0.9	3.6	0.1	-1.2	-1.9	-1.9	-0.5	-0.7	-0.0	0.1	-0.4	0.0
Number of children fathered	0.1	0.2	0.6	0.3	-0.6	-0.2	-0.7	-0.1	-0.1	0.3	0.4	0.3	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.3	-0.6	-0.5	-0.3	-0.3	-0.2	0.1	-0.5	-0.5	-0.5	-0.4
Age at first live birth	0.4	0.8	1.4	0.9	0.6	-1.1	0.9	-0.5	-0.1	1.2	1.2	0.3	1.1
Pulse wave peak to peak time	0.4	0.4	1.3	-0.9	-1.1	0.3	-0.6	-1.1	0.0	-0.2	-0.4	-0.5	-0.3
Health satisfaction	0.6	0.8	5.3	-0.3	-0.6	-0.7	-2.3	0.9	-0.9	-0.4	-0.3	-0.1	-0.3
Shortness of breath walking on level ground	0.6	0.7	4.4	0.6	-0.8	-0.2	-2.1	0.7	-0.6	0.4	0.5	0.7	0.5
Qualifications: College or University degree	0.2	0.5	1.9	0.2	1.2	-0.4	0.5	1.4	-1.1	0.1	0.1	0.5	0.1
Eye problems/disorders: None of the above	2.0	2.3	4.0	1.4	1.2	0.9	1.5	-1.7	0.7	2.0	1.9	1.3	1.9
Mouth/teeth dental problems: Loose teeth	0.8	0.9	6.3	-0.4	-0.4	-1.0	-2.5	0.4	0.6	-0.6	-0.5	-0.9	-0.4
Emphysema/chronic bronchitis	0.2	0.3	0.7	0.2	-0.8	0.2	-0.4	0.8	0.8	0.4	0.3	-0.2	0.3
Medication for pain relief, constipation, heartburn	2.0	3.5	7.8	2.0	1.1	2.0	1.3	0.2	2.8	2.1	2.0	1.9	2.0
Neck or shoulder pain in last month	1.3	1.9	4.3	-1.4	-0.1	-0.6	-2.1	0.4	-0.9	-1.6	-1.5	-2.0	-1.6
Medication: Blood pressure	0.7	1.3	2.2	-1.4	-1.5	-1.4	-0.6	-0.3	-0.4	-1.3	-1.3	-1.0	-1.3
Angina (self-reported)	1.4	1.9	6.9	-1.2	0.2	-2.1	-2.6	0.7	-0.6	-1.1	-1.1	-1.0	-1.2
Migraine (self-reported)	0.6	0.7	2.1	-0.8	-0.3	-0.6	0.7	-1.4	0.2	-0.9	-0.9	-1.0	-0.9
Medication: Ibuprofen	1.1	1.3	4.0	-0.9	-0.3	-0.8	-0.1	1.3	-2.0	-1.1	-1.1	-1.4	-1.1
Medication: Allopurinol	0.6	0.8	2.6	0.4	1.4	0.6	1.6	0.5	1.1	0.5	0.4	0.5	0.5
Medication: Omeprazole	1.1	1.3	2.7	1.4	-0.4	0.1	-0.8	-0.4	-0.7	1.5	1.6	1.5	1.6
Medication: Seretide 50 evohaler	1.5	1.7	2.7	1.6	0.2	1.2	-0.2	0.6	1.5	1.6	1.6	1.6	1.6
Mean time to correctly identify matches	0.2	0.3	2.1	-0.2	0.2	0.5	1.4	-0.9	0.3	0.2	0.2	0.2	0.0
Heart disease (mother)	1.7	2.1	3.0	-1.7	1.4	-1.6	-1.2	-0.4	-1.1	-1.5	-1.5	-1.7	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.4	1.2	-0.1	-0.5	-0.6	0.9	-0.1	0.9	0.9	0.7	0.8
Whole body fat mass	0.1	0.3	0.7	-0.8	0.3	-0.8	-0.8	-0.6	-0.3	-0.2	-0.2	-0.3	-0.2
Leg fat mass (right)	0.3	1.1	2.4	-1.4	0.2	-1.6	-1.5	-1.0	-0.8	-0.8	-0.8	-1.1	-0.8
Arm predicted mass (right)	1.2	6.3	13.7	-3.1	0.1	-3.7	-1.4	0.8	-1.5	-2.9	-2.9	-3.2	-2.8
Pulse rate, automated reading	1.4	4.4	7.8	-2.3	-2.0	-2.3	-0.2	1.8	-1.1	-2.8	-2.6	-1.9	-2.6
Alcohol intake frequency.	0.2	0.4	1.3	-0.6	-0.2	-0.4	-0.7	0.1	1.2	-0.7	-0.8	-0.3	-0.8
Comparative height size at age 10	0.4	2.1	4.3	1.4	2.1	1.1	2.0	-0.1	1.1	1.4	1.2	1.9	1.2
Number of full sisters	2.3	2.8	8.6	-1.3	-1.4	-2.9	-1.9	-1.2	-1.4	-1.4	-1.4	-1.9	-1.3
Suffer from ‘nerves’	0.0	0.0	0.2	-0.2	0.1	0.2	0.2	0.4	0.1	-0.2	-0.1	0.2	-0.2
Overall health rating	1.0	2.2	4.2	-1.9	-1.2	-0.6	-2.1	0.3	-1.0	-2.0	-1.9	-0.9	-1.9
Chest pain or discomfort	0.6	0.8	4.8	-0.3	-0.1	-1.1	-2.2	-0.6	-1.1	-0.3	-0.3	-0.3	-0.3
Had major operations	0.4	0.5	2.3	-0.3	0.0	0.8	0.6	1.5	-0.8	-0.1	-0.1	0.8	-0.1
Age at last live birth	0.3	0.4	3.2	-0.2	-0.1	-1.8	-0.7	-0.7	0.2	0.1	0.1	-0.4	0.1
Family relationship satisfaction	0.2	0.3	1.1	-0.0	-0.7	-0.9	-1.1	0.5	-0.0	-0.1	-0.2	0.1	-0.1
Leg pain on walking	0.3	0.4	1.8	-0.8	-1.3	-0.3	-0.7	0.2	0.3	-0.5	-0.5	-0.5	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.5	-0.7	-0.5	-0.1	-1.2	-0.6	0.4	-0.7	-0.7	-0.6	-0.7
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.3	0.4	1.2	-0.3	0.1	-0.6	-1.0	0.6	0.6	0.4	0.6
Illness, injury, bereavement, stress in last 2 years	2.7	3.2	11.8	1.3	3.3	0.3	3.4	1.0	-1.0	1.2	1.3	1.2	1.2
Medication: Aspirin	0.8	1.1	2.2	-1.0	-1.5	-1.0	-0.8	-0.5	-0.7	-1.3	-1.1	-0.8	-1.1
Supplements: Vitamin C	0.2	0.2	1.1	0.0	-0.4	1.1	-0.3	0.3	-0.1	-0.3	-0.3	-0.2	-0.3
Knee pain experienced in last month	6.2	9.6	19.2	-3.6	-3.8	-1.7	-4.4	-1.7	-1.4	-3.2	-3.3	-3.2	-3.2
Hypertension (Self-reported)	0.6	1.6	3.3	-1.5	-0.9	-0.5	-0.7	1.2	-0.9	-1.8	-1.7	-1.1	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.3	0.8	-0.3	-0.7	-1.4	-1.5	-0.2	0.9	1.0	0.1	1.0
Illnesses of father: Heart disease	1.4	2.0	3.9	2.0	-0.3	-0.6	-0.4	-1.9	0.6	1.7	1.8	1.2	1.9
Illnesses of siblings: Diabetes	0.0	0.0	0.1	0.0	0.1	-0.1	0.0	-0.0	-0.1	-0.3	-0.2	-0.0	-0.1
Smoking status: Previous	0.4	0.6	1.3	-0.3	-0.1	-1.2	-0.9	0.3	-1.1	-1.1	-0.8	-0.5	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.6	0.3	0.1	0.2	-0.3	-1.3	0.0	0.9	0.6	0.7	0.6
Whole body fat-free mass	0.9	5.0	8.8	-2.9	-0.0	-3.0	-1.0	0.6	-1.4	-2.7	-2.7	-2.9	-2.6
Leg fat-free mass (right)	0.6	3.3	5.7	-2.4	-0.3	-2.4	-1.0	1.0	-1.0	-2.1	-2.2	-2.2	-2.1
Arm fat percentage (left)	0.1	0.3	0.8	-0.8	-0.1	-0.8	-0.9	-0.0	-0.5	-0.4	-0.4	-0.4	-0.4
Average weekly red wine intake	0.4	0.6	2.0	0.5	1.4	0.0	1.4	0.5	-0.6	0.6	0.6	0.7	0.6
Handedness (chirality/laterality): Left-handed	1.4	1.7	4.1	1.6	1.4	0.8	2.0	0.6	0.1	1.4	1.4	1.0	1.4
Mood swings	0.9	1.6	2.8	-1.7	0.1	-1.5	-1.0	0.3	-0.7	-1.6	-1.5	-1.5	-1.6
Loneliness, isolation	0.4	0.5	1.4	0.7	-0.3	-1.2	-1.2	0.1	0.1	0.7	0.7	0.6	0.7
Long-standing illness, disability or infirmity	0.6	1.0	2.8	-1.2	-1.7	-1.1	-1.1	-0.8	-0.6	-0.8	-0.7	0.0	-0.8
Ever had bowel cancer screening	1.0	1.1	3.0	-1.4	-1.6	-1.0	0.2	-1.7	0.1	-0.8	-0.9	-0.4	-0.9
Diabetes diagnosed by doctor	0.2	0.4	1.8	0.3	0.3	-0.1	0.2	1.3	0.4	0.4	0.5	1.0	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	2.3	-0.4	-0.8	-0.6	-0.7	-1.5	0.2	-0.1	-0.2	-1.0	-0.2
Friendships satisfaction	1.1	1.4	3.5	1.9	0.7	-0.3	0.6	1.2	0.5	1.3	1.4	1.4	1.4
Qualifications: nursing, teaching	1.8	2.8	7.9	1.5	2.8	0.6	2.2	-0.8	-1.7	1.5	1.6	1.5	1.5
Commuting to job workplace: Walk	0.6	0.7	3.9	0.4	0.1	0.4	-0.6	1.4	2.0	-0.2	-0.2	0.5	0.0
Eye problems/disorders: Cataract	2.4	2.7	5.3	-1.8	-0.9	-1.0	-1.2	0.8	-1.0	-2.3	-2.3	-1.9	-2.2
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	2.3	-0.9	0.2	0.3	-1.5	-0.2	1.1	-0.4	-0.5	-0.1	-0.4
Medication for cholesterol	0.9	1.4	5.1	1.0	2.2	0.1	0.2	-1.6	0.3	1.2	1.1	0.9	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	5.2	-0.7	-1.1	-2.3	-1.7	-0.2	0.8	-0.6	-0.6	-0.7	-0.5
Back pain experienced in last month	1.2	1.7	3.0	-1.3	-1.6	-0.7	-1.7	-1.4	-0.9	-1.3	-1.2	-1.4	-1.2
Mineral and other dietary supplements	1.3	1.8	3.0	1.5	0.2	1.4	1.1	1.7	0.6	1.6	1.6	1.4	1.5
Breast cancer (self-reported)	0.9	1.1	3.3	-1.1	-1.1	0.2	-0.8	-1.1	1.8	-0.9	-0.9	-0.9	-0.8
Asthma (self-reported)	0.1	0.3	0.8	-0.2	0.2	-0.8	-0.3	-0.9	-0.5	-0.6	-0.6	-0.4	-0.6
Osteoporosis (self-reported)	0.5	0.6	2.4	0.4	1.5	1.2	0.4	1.6	-0.3	-0.1	-0.0	-0.0	-0.0
Osteoarthritis (self-reported)	0.8	1.1	2.9	-1.1	-0.7	-1.1	0.3	-0.4	-1.7	-1.1	-1.1	-1.2	-1.1
Medication: Aspirin	0.3	0.4	0.9	-0.5	-0.7	-1.0	-0.5	-0.1	-0.6	-0.8	-0.6	-0.4	-0.6
Medication: Gliclazide	1.1	1.3	2.0	-1.3	-1.2	-0.9	-1.4	-1.1	-0.4	-1.3	-1.2	-1.0	-1.2
Illnesses of father: None of the above (group 1)	1.6	2.0	5.4	-2.3	-0.6	-0.2	-0.1	-1.3	-0.7	-1.7	-1.8	-1.7	-1.8
Smoking status: Current	1.0	1.6	3.3	1.7	-0.2	0.5	0.1	-0.1	1.8	1.7	1.7	0.9	1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.5	0.9	1.2	-0.1	0.9	0.5	-0.2	1.0	0.9	0.4	0.9
Whole body water mass	0.8	4.5	7.9	-2.7	0.1	-2.8	-0.9	0.5	-1.5	-2.5	-2.5	-2.7	-2.5
Leg predicted mass (right)	0.6	3.3	5.8	-2.4	-0.3	-2.3	-0.9	0.9	-1.0	-2.1	-2.2	-2.3	-2.1
Arm fat mass (left)	0.3	1.2	2.7	-1.5	0.1	-1.6	-1.1	0.2	-0.9	-1.1	-1.1	-1.1	-1.0
Number of self-reported non-cancer illnesses	3.0	5.2	9.2	-2.7	-2.3	-2.1	-1.3	0.8	-1.0	-3.0	-2.9	-2.5	-2.9
Average weekly champagne plus white wine intake	0.5	0.7	1.3	1.0	0.6	0.7	-0.5	-0.3	-0.1	1.1	1.1	0.8	1.1
Miserableness	0.7	1.3	2.5	-0.9	-1.4	-0.5	-1.6	0.3	-1.4	-1.2	-1.1	-1.1	-1.1
Guilty feelings	0.4	0.6	2.6	-0.6	-0.6	-1.6	-0.9	0.2	-0.3	-0.6	-0.6	-0.6	-0.6
Wears glasses or contact lenses	0.1	0.1	1.0	-0.2	-0.3	-1.0	-0.5	0.2	0.0	-0.1	-0.2	0.2	-0.0
Ever taken oral contraceptive pill	1.0	1.1	4.5	-1.0	-0.7	-0.6	-0.6	-1.4	-2.1	-0.8	-0.8	-0.6	-0.9
Hearing aid user	0.6	0.7	5.2	0.1	0.5	0.7	0.8	2.3	-0.2	0.3	0.2	0.4	0.2
Mother’s age at death	0.2	0.3	1.2	0.4	1.1	-0.9	0.7	0.2	0.2	0.2	0.2	-0.3	0.3
Financial situation satisfaction	1.5	1.9	6.9	-0.5	-2.3	-1.2	-2.6	0.1	-1.3	-0.9	-0.8	-1.0	-0.8
Tinnitus: Yes, now most or all of the time	1.3	1.5	7.3	1.1	-0.3	-1.1	-1.4	0.7	2.7	0.9	0.9	0.4	0.9
Commuting to job workplace: Public transport	0.9	1.1	3.6	0.5	0.5	1.5	0.9	1.9	1.3	0.5	0.3	1.1	0.5
Eye problems/disorders: Glaucoma	0.4	0.5	1.3	-0.4	-1.2	-0.1	-0.6	1.1	0.8	-0.4	-0.4	-0.6	-0.3
Medication: Blood pressure	1.5	2.9	7.5	-1.9	-2.7	-0.5	-1.5	1.5	-0.1	-2.1	-2.0	-1.2	-1.9
Pain type(s) experienced in last month: Hip pain	1.4	1.7	6.9	-1.3	-1.5	-0.8	-1.2	-0.9	-2.6	-1.1	-1.0	-0.8	-1.0
Supplements: Fish oil (including cod liver oil)	1.7	2.2	5.3	-1.7	-0.0	-1.5	-1.2	-2.3	-0.5	-1.6	-1.6	-1.5	-1.5
High cholesterol (Self-reported)	1.3	2.2	3.9	-1.7	-1.4	-0.4	0.1	1.2	-1.7	-2.0	-1.9	-1.5	-1.8
Medication: Bendroflumethiazide	1.5	2.3	4.7	-1.7	-0.9	-0.7	0.7	1.6	-2.2	-1.8	-1.8	-1.0	-1.8
Medication: Paracetamol	1.3	2.0	3.3	-1.7	-0.7	-1.8	-0.3	0.2	-1.4	-1.6	-1.6	-1.8	-1.7
Medication: Lisinopril	0.7	0.9	1.9	-1.3	-0.4	-1.4	-1.1	0.2	-0.2	-0.9	-0.9	-1.0	-1.0
Medication: Atorvastatin	0.4	0.5	1.3	-1.1	0.0	-0.8	-0.1	0.1	-0.8	-0.9	-0.9	-0.6	-0.9
Illnesses of father: High blood pressure	0.9	1.1	3.2	1.2	-0.0	-0.5	-1.8	-0.3	-0.5	1.1	1.1	1.2	1.2
Alcohol drinker status: Never	1.3	1.6	5.3	1.4	0.6	1.1	0.8	0.7	2.3	1.2	1.1	1.4	1.1
Ever smoked	0.1	0.3	1.0	0.7	0.1	-0.7	-0.4	0.7	-1.0	-0.0	0.2	0.0	0.1
Basal metabolic rate	0.7	3.7	7.0	-2.5	0.1	-2.6	-1.0	0.4	-1.4	-2.2	-2.3	-2.4	-2.2
Leg fat percentage (left)	0.3	1.1	2.0	-1.3	0.3	-1.4	-1.1	-0.9	-0.9	-0.9	-0.9	-1.2	-0.9
Arm fat-free mass (left)	1.1	5.7	12.1	-2.8	-0.1	-3.5	-1.1	0.5	-2.0	-2.8	-2.7	-3.0	-2.6
Number of operations (self-reported)	0.6	0.9	3.4	-0.5	-0.5	-1.9	-1.2	0.7	-1.3	-0.7	-0.7	-0.5	-0.6
Average weekly beer plus cider intake	0.4	0.6	4.0	-0.1	-0.3	0.2	-2.0	-1.0	1.0	0.2	0.2	0.1	0.3
Irritability	0.8	1.3	4.5	-1.0	-0.8	-2.1	-0.8	0.9	0.1	-1.0	-0.9	-1.7	-0.9
Risk taking	0.3	0.5	2.6	0.3	0.0	-0.3	-0.7	0.2	1.6	0.6	0.7	0.5	0.6
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.2	1.0	0.3	-0.9	0.4	0.7	-0.2	1.1	1.1	1.1	1.1
Fractured/broken bones in last 5 years	0.2	0.3	1.0	-0.3	0.0	0.2	-0.5	-1.0	-0.7	-0.4	-0.4	-0.2	-0.5
Age started oral contraceptive pill	0.4	0.5	1.6	-0.4	-0.7	-1.3	0.1	1.1	-0.8	-0.4	-0.4	-0.8	-0.4
Diastolic blood pressure, automated reading	0.3	0.9	1.7	0.9	0.6	1.1	-0.2	0.2	0.6	1.3	1.2	1.2	1.3
Ever depressed for a whole week	0.3	0.4	0.8	-0.8	0.7	-0.1	-0.0	-0.1	0.6	-0.9	-0.9	-0.4	-0.9
Unable to work because of sickness or disability	0.8	1.0	4.9	-1.1	-1.0	-0.4	-2.2	-1.3	-0.1	-0.5	-0.6	-0.3	-0.7
Commuting to job workplace: Cycle	0.4	0.4	1.5	-0.5	-0.0	-0.9	0.6	1.2	-0.5	-0.4	-0.4	-0.6	-0.4
Myopia	1.2	1.7	3.8	1.4	0.6	-0.4	-0.2	-0.8	0.2	1.9	1.9	1.6	1.9
Vascular/heart problems diagnosed by doctor	0.8	2.2	3.8	1.7	1.2	0.9	1.6	-1.0	0.6	2.0	1.9	1.3	1.9
Cholesterol lowering medication	0.5	0.7	3.9	-0.8	-2.0	-0.4	-0.2	0.6	-0.3	-0.8	-0.8	-0.6	-0.8
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	2.0	1.2	-0.9	0.1	-1.4	-1.0	-1.3	1.3	1.4	1.3	1.4
Pain experienced in last month	3.6	6.0	11.0	3.3	0.9	1.6	2.1	0.5	2.1	3.0	3.1	3.0	3.1
Supplements: Calcium	0.3	0.4	0.9	1.0	0.9	0.1	0.3	0.2	-0.5	0.7	0.7	0.1	0.7
Basal cell carcinoma (self-reported)	0.3	0.3	1.7	-0.0	0.9	0.4	0.6	1.3	0.4	-0.1	-0.1	-0.0	-0.2
Heart attack/myocardial infarction (self-reported)	0.3	0.3	1.1	-0.4	0.2	-0.9	-1.1	0.3	-0.7	-0.5	-0.5	-0.3	-0.4
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	4.3	-1.3	-1.3	-0.5	-1.7	0.4	-2.1	-1.4	-1.3	-1.0	-1.3
Heart disease (siblings)	1.1	1.4	3.0	-1.2	-1.7	-0.1	-1.2	-1.6	0.0	-1.3	-1.3	-0.8	-1.3
Alcohol drinker status: Previous	0.2	0.3	0.7	0.4	-0.4	0.8	0.1	0.7	0.2	0.5	0.3	0.8	0.3
Pack years of smoking	0.6	0.9	3.1	-0.8	-1.6	-0.2	-1.8	-0.3	1.2	-0.7	-0.6	-0.5	-0.6
Impedance of whole body	3.6	18.4	28.5	5.1	1.0	5.3	1.7	-1.6	4.0	5.2	5.1	5.2	5.0
Leg fat mass (left)	0.3	1.3	2.7	-1.6	0.3	-1.6	-1.4	-0.7	-0.9	-1.1	-1.0	-1.3	-1.0
Arm predicted mass (left)	1.2	6.1	12.0	-3.0	0.1	-3.5	-1.0	0.4	-2.3	-2.9	-2.9	-3.1	-2.8