Best TWAS P=1.83e-14 · Best GWAS P=3.99e-13 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | MED20 | 0.11 | 0.05 | lasso | 4 | 0.08 | 9.4e-07 | 6.9 | -6.8 | 8.0e-12 | -0.81 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | USP49 | 0.13 | 0.02 | lasso | 4 | 0.02 | 2.4e-02 | 7.3 | 6.6 | 3.9e-11 | 0.93 | 0.01 | 0.97 | FALSE |
| 3 | GTEx | Lung | USP49 | 0.09 | 0.08 | lasso | 2 | 0.05 | 6.2e-05 | 7.3 | 7.2 | 4.8e-13 | 0.99 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Testis | MED20 | 0.13 | 0.03 | lasso | 6 | 0.00 | 2.0e-01 | 7.2 | -7.1 | 1.1e-12 | -0.99 | 0.02 | 0.90 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | PGC | 0.13 | 0.06 | blup | 520 | 0.06 | 3.2e-08 | -5.2 | 5.4 | 6.4e-08 | 0.57 | 0.99 | 0.01 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CCND3 | 0.04 | 0.00 | blup | 99 | 0.01 | 1.8e-03 | 7.2 | -6.0 | 1.9e-09 | -0.69 | 0.01 | 0.56 | FALSE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | MED20 | 0.05 | 0.00 | blup | 50 | 0.04 | 2.8e-03 | -2.7 | -6.6 | 3.9e-11 | -0.85 | 0.02 | 0.74 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MED20 | 0.04 | 0.03 | lasso | 3 | 0.04 | 7.3e-05 | 6.9 | -7.0 | 2.9e-12 | -0.97 | 0.01 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | MED20 | 0.09 | 0.07 | lasso | 5 | 0.07 | 3.4e-04 | 7.2 | -7.7 | 1.8e-14 | -0.99 | 0.01 | 0.98 | TRUE |
| 10 | The Cancer Genome Atlas | Stomach Adenocarcinoma | MED20 | 0.03 | 0.05 | lasso | 2 | 0.04 | 1.2e-03 | 6.9 | -7.4 | 1.7e-13 | -0.96 | 0.01 | 0.92 | FALSE |