Hub : Genes

USP49

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1270	0.0450	0.0015	0.016	NA	0.010	NA	0.015	2.0e-02	NA	0.05200	NA	2.3e-02
2	GTEx	Lung	0.0854	0.0331	0.0051	0.075	NA	0.045	NA	0.053	2.1e-06	NA	0.00023	NA	6.2e-05
3	GTEx	Ovary	0.3040	0.1120	0.0041	-0.008	NA	0.062	NA	0.013	5.6e-01	NA	0.01300	NA	1.5e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.1	1.8	2.8	1.7	1.3	-0.8
Bipolar Disorder or Schizophrenia	1.0	2.3	3.8	2.0	1.6	0.8
Depressed Affect (Nagel 2018)	0.9	1.9	5.3	0.6	0.3	-2.3
Depression (Nagel 2018)	2.0	3.1	3.9	-1.6	-1.6	-2.0
Intelligence (Savage-Jansen 2018)	0.4	1.2	1.4	-1.2	-1.1	0.9
Neuroticism (Nagel 2018)	0.6	1.3	3.7	-0.1	-0.5	-1.9
Schizophrenia (2018)	0.5	1.1	1.5	1.2	0.9	1.0
Schizophrenia vs Biploar Disorder	0.8	1.1	2.9	-0.5	-0.4	1.7
Worry (Nagel 2018)	0.3	0.7	1.6	-0.4	-0.4	-1.3
Alzheimer’s Disease (in mother)	2.9	3.4	4.3	-1.5	-1.9	-2.1
Alzheimer’s Disease (in father)	0.2	0.2	0.4	0.7	0.2	-0.3
Alzheimer’s Disease (including proxy)	1.1	1.6	2.2	-0.8	-1.4	-1.5
Crohns Disease (2017)	0.2	0.3	0.5	0.7	0.5	-0.4
Irritable Bowel Disease (IBD)	0.5	1.2	1.7	1.3	0.9	-1.0
Ulcerative Colitis (UC)	0.5	0.9	1.7	1.3	0.9	-0.2
Major Depression (MDD)	0.0	0.1	0.1	0.3	-0.2	-0.2
Reaction Time	1.6	3.1	7.6	-0.9	-1.0	2.7
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.1	-0.7	-0.5	1.1
Breast Cancer	0.3	0.6	1.1	-0.2	-0.9	-1.0
Ovarian Cancer	0.7	1.0	1.5	-1.2	-1.1	0.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	3.1	4.5	6.4	-2.4	-2.5	1.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.6	1.2	-0.7	-0.5	-1.1
Coronary Artery Disease (CAD)	1.0	1.2	1.7	1.1	1.3	0.9
Crohns Disease (2012)	0.3	0.5	1.2	0.3	0.6	-1.1
Mean Putamen Volume	0.3	0.3	0.8	-0.3	-0.4	-0.9
Fasting Glucose	1.6	1.9	5.0	0.8	0.3	-2.2
HbA1C	0.1	0.1	0.4	-0.6	-0.1	0.1
HDL Cholesterol	0.2	0.4	0.5	-0.5	-0.7	-0.7
LDL Cholesterol	0.0	0.1	0.1	-0.2	-0.0	0.3
Lupus	0.8	1.2	3.2	0.5	-0.3	-1.8
Neuroticism (2016)	0.2	0.2	0.6	0.8	0.2	-0.2
Primary Biliary Cirrhosis	0.4	0.5	1.6	0.0	0.0	1.3
Rheumatoid Arthritis	1.3	1.8	2.5	-1.6	-1.4	-1.0
Schizophrenia (2014)	0.2	0.4	0.9	0.6	0.3	0.9
Triglycerides	0.0	0.1	0.2	0.2	-0.1	0.4
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	-0.2	0.1	0.5
Ulcerative Colitis	2.9	4.2	7.2	2.7	2.1	-0.9
Blood Eosinophil Count	0.3	2.7	4.4	-1.3	-1.3	-2.1
Blood Platelet Count	1.1	13.0	19.9	4.3	4.5	0.9
Blood Red Count	24.2	234.0	466.6	-8.0	-13.1	-21.6
Blood White Count	0.4	3.2	5.0	2.2	2.1	-0.2
Heel T-Score	0.2	1.9	2.3	1.3	1.4	1.5
BMI	2.3	13.3	19.8	-4.4	-4.5	-0.9
Height	1.3	25.2	36.0	-5.8	-6.0	2.3
Waist Hip Ratio (WHR)	0.8	3.7	3.8	1.9	1.9	-1.9
Systolic Blood Pressure	0.5	2.5	4.2	1.8	2.0	-0.1
Smoking Status	0.7	1.8	2.3	1.0	1.4	1.5
Allergy or Eczema	2.3	6.0	13.1	1.8	1.3	-3.6
Cardiovascular Disease	0.0	0.1	0.4	-0.6	0.0	-0.1
Hypothyroidism (self reported)	0.7	1.7	2.9	-1.7	-1.5	-0.0
Respiratory disease	0.3	0.8	1.2	0.6	1.1	-0.9
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.6	-0.6	0.2	1.3
Lung FEV1/FVC ratio	0.3	1.4	2.5	-1.2	-1.6	0.5
Lung FVC	0.2	0.9	2.3	0.3	0.5	-1.5
Neuroticism	0.8	1.9	5.7	0.0	0.0	-2.4
Chronotype (morning person)	1.8	4.2	12.3	0.4	0.3	3.5
Hair Pigment	0.3	8.1	12.3	-3.5	-3.5	0.2
Tanning	2.1	25.9	41.3	6.0	6.4	-0.1
Hand grip strength (left)	2.5	6.7	9.6	-3.1	-3.0	-1.2
Number of treatments/medications taken	2.4	4.3	6.4	1.5	2.1	-2.5
Average weekly spirits intake	0.3	0.3	0.7	-0.3	-0.5	0.8
Sensitivity / hurt feelings	1.6	2.7	3.7	-1.9	-1.9	-0.9
Frequency of depressed mood in last 2 weeks	3.0	4.1	5.7	-2.1	-2.4	-1.5
Hearing difficulty/problems: Yes	0.8	1.2	2.3	1.1	1.5	0.2
Relative age of first facial hair	4.0	8.2	14.2	-2.6	-1.9	3.8
Other serious medical condition/disability diagnosed by doctor	2.4	3.2	8.5	-0.2	-1.0	-2.9
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	0.2	0.3	0.5
Ever had hysterectomy (womb removed)	4.2	4.8	5.4	-2.3	-1.9	2.3
Systolic blood pressure, automated reading	0.0	0.1	0.2	0.4	0.2	0.3
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.8	0.2	0.9	0.1
Angina	0.8	1.1	2.0	1.1	1.4	0.0
Medication for hormone replacement therapy	0.2	0.2	0.4	-0.6	-0.2	0.5
Vitamin and mineral supplements	1.1	1.4	4.0	-0.5	-0.0	2.0
Supplements: Zinc	0.1	0.1	0.2	-0.2	-0.4	-0.2
Medication: Co-codamol	2.4	2.8	4.8	2.2	1.7	-0.8
Medication: Metformin	1.0	1.4	2.9	-1.0	-0.3	1.7
Diabetes (father)	0.4	0.5	1.3	-0.2	-0.0	-1.2
Diabetes (mother)	0.0	0.1	0.1	-0.1	-0.0	0.4
Severe depression (siblings)	1.9	2.1	2.9	-1.6	-1.7	-1.0
Pack years adult smoking proportion	1.7	2.5	3.5	1.9	1.5	1.3
Impedance of leg (right)	7.4	36.0	58.2	7.1	7.6	-0.4
Leg fat-free mass (left)	9.0	47.8	72.6	-8.4	-8.5	0.8
Trunk fat percentage	0.1	0.5	0.6	-0.8	-0.7	0.6
Hand grip strength (right)	3.1	8.3	13.5	-3.7	-3.4	0.1
Townsend deprivation index at recruitment	1.2	1.8	2.3	1.5	1.4	-1.0
Current tobacco smoking	0.5	0.8	1.6	0.5	0.7	1.3
Average weekly fortified wine intake	1.1	1.3	2.1	1.4	1.3	-0.3
Maternal smoking around birth	0.8	1.2	2.2	-1.5	-1.2	0.1
Fed-up feelings	0.5	1.0	2.4	0.5	0.5	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	1.5	-1.2	-0.8	-1.2
Relative age voice broke	6.6	10.1	12.6	-3.6	-2.6	3.3
Taking other prescription medications	3.1	4.8	5.7	2.4	2.1	-2.0
Age when periods started (menarche)	2.0	4.7	5.4	-2.3	-1.9	2.3
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	2.4	-1.4	-0.9	1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	1.6	-1.2	-1.2	1.0
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	0.4	0.2	0.0
Qualifications: CSEs or equivalent	0.3	0.4	1.1	-0.1	0.4	-1.1
Serious illness, injury or assault to yourself	0.4	0.5	1.0	-1.0	-0.8	-0.0
High blood pressure	0.4	1.1	1.7	-1.3	-0.9	0.9
Hayfever, allergic rhinitis or eczema	2.1	4.5	12.3	1.0	0.5	-3.5
Multivitamins +/- minerals	0.3	0.3	0.7	0.5	-0.0	-0.9
Stomach or abdominal pain in last month	4.6	5.8	15.4	-1.0	-1.0	-3.9
Supplements: Glucosamine	1.0	1.3	1.5	-1.2	-1.1	-1.2
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	2.3	-0.0	-0.1	-1.5
Medication: Atenolol	0.4	0.5	0.8	0.4	0.9	-0.7
Medication: Levothyroxine sodium	0.3	0.5	0.6	-0.8	-0.6	-0.8
Sitting height	2.2	15.6	22.3	-4.7	-4.7	1.6
Chronic bronchitis/emphysema (father)	0.5	0.6	0.8	-0.6	-0.8	-0.9
High blood pressure (mother)	0.5	0.7	1.1	-1.1	-0.8	-0.6
Body mass index (BMI)	2.4	10.4	16.5	-3.8	-4.1	-0.6
Impedance of leg (left)	7.6	37.1	59.7	7.2	7.7	-0.3
Leg predicted mass (left)	8.9	47.4	72.0	-8.3	-8.5	0.9
Trunk fat mass	1.5	6.2	9.5	-3.0	-3.1	0.4
Waist circumference	2.1	7.7	12.7	-3.2	-3.6	-0.1
Number of incorrect matches in round	0.2	0.4	0.7	-0.5	-0.8	0.4
Past tobacco smoking	2.1	3.9	5.2	-2.2	-2.3	-1.4
Alcohol usually taken with meals	1.1	1.9	4.7	-0.8	-0.5	-2.2
Nervous feelings	0.0	0.0	0.1	0.1	0.0	0.3
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.4	3.3	-1.8	-1.8	-0.9
Hearing difficulty/problems with background noise	0.2	0.3	0.5	0.4	0.4	-0.7
Hair/balding pattern: Pattern 2	0.3	0.4	0.6	0.8	0.7	-0.1
Had menopause	0.1	0.1	0.4	0.6	0.2	0.1
Had other major operations	0.1	0.2	0.4	0.4	0.6	-0.0
Forced vital capacity (FVC)	0.2	0.7	1.2	-1.0	-1.1	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.7	0.1	-0.1	0.8
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.4	-0.1	0.2	0.7
Qualifications: None of the above	1.8	3.8	7.1	1.9	2.7	0.7
Financial difficulties in last 2 years	0.9	1.3	3.3	-0.2	-0.7	-1.8
Mouth/teeth dental problems	0.3	0.4	0.6	-0.7	-0.4	-0.8
Heart attack	0.3	0.3	0.9	0.1	0.9	-0.3
Allergy	0.8	1.7	5.1	0.3	0.2	2.2
Pain all over the body in last month	0.7	0.8	1.6	-0.7	-0.5	-1.3
Diabetes (self-reported)	0.7	1.1	3.1	-0.3	0.1	1.8
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	4.1	-0.5	-0.6	-2.0
Medication: Ramipril	2.1	2.6	6.5	-1.1	-0.5	2.5
Medication: Simvastatin	1.1	1.6	2.5	1.5	1.6	-0.2
Fluid intelligence score	0.7	1.5	4.4	-0.5	-0.1	2.1
Illnesses of siblings	1.4	2.0	5.5	0.2	0.8	2.3
Neuroticism score	0.4	0.9	2.6	0.1	-0.2	-1.6
Weight	5.4	26.6	41.0	-6.2	-6.4	0.6
Impedance of arm (right)	4.3	20.1	30.4	5.1	5.5	2.0
Arm fat percentage (right)	0.8	3.0	4.8	-2.1	-2.2	0.1
Trunk fat-free mass	8.8	50.4	78.3	-8.5	-8.8	0.3
Hip circumference	4.5	19.4	29.1	-5.3	-5.4	0.8
Time employed in main current job	0.5	0.6	1.2	-0.4	-0.6	-1.1
Alcohol intake versus 10 years previously	0.9	1.4	3.8	-0.0	-0.5	-1.9
Father’s age at death	0.4	0.5	0.9	-0.7	-0.5	-0.9
Worrier / anxious feelings	0.5	0.9	1.4	1.2	1.1	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	1.5	-1.2	-1.2	-0.6
Falls in the last year	0.7	1.0	1.7	-0.5	-1.0	-1.3
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	-0.5	0.0	0.3
Number of live births	2.5	3.6	4.7	1.4	2.0	2.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	2.3	-1.4	-1.5	-0.1
Pulse rate	0.7	1.1	2.4	0.9	-0.1	-1.6
Happiness	0.3	0.4	0.6	-0.6	-0.8	-0.3
Noisy workplace	0.1	0.2	0.3	-0.5	-0.4	-0.2
Qualifications: A levels/AS levels or equivalent	3.0	6.7	7.6	-2.8	-2.7	-2.4
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.7	3.8	-1.9	-1.7	-1.2
Mouth/teeth dental problems: Dentures	1.1	1.8	3.9	1.0	0.8	2.0
Asthma	0.1	0.2	0.4	-0.0	0.6	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	1.5	1.0	1.2	-0.9
Medication: Cholesterol lowering	0.1	0.1	0.2	-0.3	-0.2	-0.5
Depression (self-reported)	1.7	2.1	3.7	1.2	0.9	-1.9
Medication: Lansoprazole	3.4	3.9	5.3	1.5	2.3	-2.0
Prospective memory result	0.6	0.7	1.4	0.6	1.2	-0.6
Lung cancer (father)	0.1	0.1	0.2	-0.2	-0.4	0.2
Illnesses of mother	0.9	1.1	2.9	0.5	0.4	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.4	3.8	-1.8	-2.0	-0.1
Pulse wave Arterial Stiffness index	0.4	0.5	0.7	0.5	0.7	-0.8
Impedance of arm (left)	3.8	17.4	25.6	4.5	5.1	2.5
Arm fat mass (right)	3.1	12.6	19.9	-4.2	-4.5	0.1
Trunk predicted mass	8.9	50.8	79.2	-8.6	-8.9	0.3
Standing height	2.7	27.1	38.3	-6.2	-6.1	2.5
Length of working week for main job	4.5	5.0	7.5	-2.7	-2.7	-0.2
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.2	0.1	0.4
Breastfed as a baby	0.3	0.4	0.8	-0.0	-0.6	-0.9
Tense / ‘highly strung’	0.5	0.8	2.4	-0.2	-0.1	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.4	1.6	1.0	-0.9
Hair/balding pattern: Pattern 4	0.4	1.0	2.8	0.5	0.2	-1.7
Birth weight of first child	0.9	1.7	2.1	-1.5	-1.5	-0.9
Peak expiratory flow (PEF)	0.5	1.1	1.7	-1.3	-1.1	-0.6
Pulse wave reflection index	0.1	0.1	0.2	-0.5	0.1	0.0
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	-0.4	-0.2	-0.2
Loud music exposure frequency	1.0	1.1	1.6	-1.2	-0.7	1.2
Qualifications: O levels/GCSEs or equivalent	2.7	4.4	6.1	-1.5	-2.2	-2.5
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.5	0.5	0.3	0.7
Blood clot in the leg (DVT)	0.2	0.2	0.4	0.5	0.6	-0.3
Medication: Paracetamol	1.1	1.8	2.2	1.3	1.2	-1.5
Headache pain in last month	0.3	0.5	0.9	1.0	0.5	-0.6
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	0.9	0.8	0.8	1.0
Glaucoma (self-reported)	0.2	0.3	0.7	-0.2	-0.9	-0.1
Gout (self-reported)	0.8	1.0	2.1	-0.6	-0.8	-1.4
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	0.7	-0.9	-0.7	-0.5
Medication: Amlodipine	0.4	0.6	0.8	0.8	0.9	-0.5
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.6	-0.0	0.1	-1.3
Birth weight	0.4	1.0	2.0	-0.8	-1.4	0.4
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.3	-0.3	-0.7	-1.5
High blood pressure (siblings)	0.6	0.8	1.4	-0.6	-0.8	-1.2
Forced vital capacity (FVC), Best measure	0.5	1.9	3.0	-1.6	-1.7	-0.3
Body fat percentage	0.1	0.2	0.3	-0.5	-0.6	-0.0
Leg fat percentage (right)	0.2	0.7	1.9	0.1	-0.2	-1.4
Arm fat-free mass (right)	8.2	41.9	64.3	-7.8	-8.0	0.3
Exposure to tobacco smoke outside home	3.0	4.0	7.1	-1.3	-2.7	-1.7
Comparative body size at age 10	3.1	8.6	11.5	-3.4	-3.3	1.8
Number of full brothers	0.1	0.1	0.2	0.4	-0.1	0.0
Worry too long after embarrassment	0.2	0.3	0.8	0.9	0.4	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.3	0.5	0.2	-0.5
Wheeze or whistling in the chest in last year	0.3	0.6	1.1	0.6	1.0	-0.7
Number of children fathered	0.7	0.8	1.1	0.7	0.9	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	1.6	-1.0	-0.7	1.3
Age at first live birth	4.0	7.0	9.1	-3.0	-2.8	2.0
Pulse wave peak to peak time	1.0	1.2	1.5	-1.0	-1.1	1.2
Health satisfaction	0.4	0.5	1.0	-1.0	-0.7	-0.1
Shortness of breath walking on level ground	0.3	0.4	0.5	-0.7	-0.7	0.4
Qualifications: College or University degree	1.1	3.5	5.9	-2.4	-2.0	0.6
Eye problems/disorders: None of the above	0.1	0.1	0.3	-0.6	-0.2	-0.3
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	0.0	0.1	0.3
Emphysema/chronic bronchitis	0.5	0.5	1.1	-0.6	-0.2	1.1
Medication for pain relief, constipation, heartburn	0.7	1.2	2.4	-0.6	-0.9	1.5
Neck or shoulder pain in last month	0.6	0.9	1.9	-0.0	-0.8	-1.4
Medication: Blood pressure	0.3	0.5	0.8	-0.7	-0.5	-0.9
Angina (self-reported)	1.0	1.3	2.4	1.1	1.6	-0.2
Migraine (self-reported)	0.8	0.9	2.7	-0.3	-0.1	-1.6
Medication: Ibuprofen	1.0	1.2	1.5	1.0	1.2	-0.9
Medication: Allopurinol	0.3	0.4	0.9	-0.5	-0.9	-0.2
Medication: Omeprazole	2.6	3.1	3.7	1.7	1.6	-1.9
Medication: Seretide 50 evohaler	0.5	0.6	1.1	0.8	1.0	0.3
Mean time to correctly identify matches	1.7	3.3	8.9	-0.6	-0.8	3.0
Heart disease (mother)	0.5	0.7	0.8	0.8	0.9	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.4	0.5	0.5	0.6
Whole body fat mass	1.7	7.0	11.1	-3.1	-3.3	-0.1
Leg fat mass (right)	1.7	6.6	10.2	-2.9	-3.2	-1.1
Arm predicted mass (right)	7.5	38.2	58.7	-7.5	-7.7	0.1
Pulse rate, automated reading	2.3	7.5	11.4	3.4	2.5	-2.2
Alcohol intake frequency.	1.0	2.2	6.4	-0.2	-0.5	-2.5
Comparative height size at age 10	0.2	0.8	1.7	-0.9	-1.3	0.1
Number of full sisters	0.7	0.9	1.4	-1.2	-1.0	0.4
Suffer from ‘nerves’	1.6	2.6	4.6	-1.7	-2.1	0.4
Overall health rating	0.3	0.6	1.0	1.0	0.8	0.1
Chest pain or discomfort	0.7	1.1	2.7	0.7	0.2	-1.6
Had major operations	0.7	0.8	0.9	-0.9	-0.9	-0.8
Age at last live birth	3.2	4.7	7.5	-2.7	-2.2	1.3
Family relationship satisfaction	1.2	1.5	2.4	-1.6	-1.4	0.5
Leg pain on walking	0.7	0.9	1.5	1.2	1.1	-0.1
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	5.1	2.3	1.4	-0.0
Commuting to job workplace: Car/motor vehicle	1.3	1.5	2.3	-1.5	-1.5	0.0
Illness, injury, bereavement, stress in last 2 years	1.6	1.9	2.5	1.4	1.6	1.2
Medication: Aspirin	0.5	0.6	1.3	0.7	1.1	-0.4
Supplements: Vitamin C	3.1	3.6	5.9	-1.3	-1.8	-2.4
Knee pain experienced in last month	0.0	0.0	0.1	0.2	0.2	-0.2
Hypertension (Self-reported)	0.5	1.3	2.2	-1.5	-1.0	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.5	0.5	0.7	-0.1
Illnesses of father: Heart disease	0.5	0.7	1.1	1.1	0.7	-0.8
Illnesses of siblings: Diabetes	0.8	1.0	2.1	-0.6	-0.7	-1.4
Smoking status: Previous	2.6	3.9	5.1	2.3	2.2	1.3
Forced expiratory volume in 1-second (FEV1), predicted	2.4	5.0	9.4	-3.1	-2.3	-0.5
Whole body fat-free mass	9.4	53.5	82.6	-8.8	-9.1	0.5
Leg fat-free mass (right)	9.5	50.7	76.9	-8.6	-8.8	1.0
Arm fat percentage (left)	0.8	3.1	4.9	-2.1	-2.2	0.3
Average weekly red wine intake	3.7	5.5	9.7	-3.1	-2.6	-0.2
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.1	-1.0	-0.9	-0.6
Mood swings	0.7	1.3	3.4	0.6	0.1	-1.8
Loneliness, isolation	0.5	0.6	0.9	-0.6	-0.8	-0.9
Long-standing illness, disability or infirmity	1.8	2.8	6.5	1.2	0.6	-2.5
Ever had bowel cancer screening	5.6	6.5	12.2	-1.6	-2.2	-3.5
Diabetes diagnosed by doctor	0.6	1.0	2.4	0.3	0.8	1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	-0.4	0.0	0.3
Friendships satisfaction	0.3	0.3	0.8	-0.2	-0.3	0.9
Qualifications: nursing, teaching	3.6	5.6	6.7	-2.6	-2.6	-1.9
Commuting to job workplace: Walk	0.2	0.2	0.6	0.0	-0.2	-0.8
Eye problems/disorders: Cataract	0.5	0.5	0.7	0.8	0.8	0.5
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.3	0.5	0.4	-1.5
Medication for cholesterol	0.1	0.1	0.2	0.5	-0.1	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	3.0	-1.7	-1.6	-0.8
Back pain experienced in last month	0.7	1.0	2.8	0.1	-0.4	-1.7
Mineral and other dietary supplements	2.7	3.7	9.6	-0.9	-0.7	3.1
Breast cancer (self-reported)	1.3	1.6	3.6	1.9	1.0	0.2
Asthma (self-reported)	0.1	0.1	0.3	0.0	0.4	-0.5
Osteoporosis (self-reported)	4.2	5.2	10.6	1.6	1.6	-3.3
Osteoarthritis (self-reported)	0.4	0.5	1.0	0.7	0.1	-1.0
Medication: Aspirin	0.8	1.1	2.2	1.0	1.5	-0.1
Medication: Gliclazide	0.7	0.8	1.8	0.6	0.5	1.3
Illnesses of father: None of the above (group 1)	0.8	1.0	2.7	-0.4	0.2	1.7
Smoking status: Current	0.5	0.7	1.1	0.6	0.8	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	1.4	-0.8	-1.2	-1.2
Whole body water mass	9.5	54.0	83.4	-8.8	-9.1	0.5
Leg predicted mass (right)	9.5	50.8	77.0	-8.6	-8.8	0.9
Arm fat mass (left)	3.3	13.5	21.1	-4.4	-4.6	0.1
Number of self-reported non-cancer illnesses	0.9	1.6	4.6	0.4	0.3	-2.1
Average weekly champagne plus white wine intake	1.0	1.4	2.1	-1.5	-1.4	-0.3
Miserableness	0.3	0.5	0.6	0.5	0.7	-0.8
Guilty feelings	0.3	0.4	0.8	0.9	0.6	-0.2
Wears glasses or contact lenses	2.1	2.4	3.8	1.9	1.2	-1.5
Ever taken oral contraceptive pill	0.8	0.8	1.3	1.1	1.1	0.0
Hearing aid user	0.3	0.4	0.5	0.6	0.7	-0.5
Mother’s age at death	0.4	0.5	1.1	-1.0	-0.6	0.0
Financial situation satisfaction	1.0	1.3	3.0	-1.7	-0.9	-0.2
Tinnitus: Yes, now most or all of the time	1.3	1.5	2.8	1.7	1.3	-0.3
Commuting to job workplace: Public transport	0.9	1.0	1.3	-1.0	-0.8	1.2
Eye problems/disorders: Glaucoma	0.9	1.0	1.9	-0.7	-1.4	0.9
Medication: Blood pressure	0.2	0.3	0.5	-0.2	0.6	0.7
Pain type(s) experienced in last month: Hip pain	1.5	1.9	5.5	0.3	-0.3	-2.4
Supplements: Fish oil (including cod liver oil)	2.9	3.8	10.5	0.7	0.8	-3.2
High cholesterol (Self-reported)	0.3	0.5	0.8	-0.8	-0.3	-0.9
Medication: Bendroflumethiazide	0.5	0.8	2.3	-0.4	-0.1	1.5
Medication: Paracetamol	0.4	0.7	0.9	0.7	0.8	-1.0
Medication: Lisinopril	0.5	0.7	1.6	-1.3	-0.7	-0.1
Medication: Atorvastatin	0.1	0.1	0.2	-0.5	-0.0	-0.1
Illnesses of father: High blood pressure	1.4	1.8	2.4	-1.2	-1.5	-1.3
Alcohol drinker status: Never	1.2	1.4	2.5	-0.7	-1.1	-1.6
Ever smoked	2.2	3.9	4.3	2.0	2.1	1.8
Basal metabolic rate	8.6	47.6	72.8	-8.3	-8.5	0.7
Leg fat percentage (left)	0.1	0.4	1.3	0.1	-0.2	-1.1
Arm fat-free mass (left)	7.9	40.2	62.7	-7.6	-7.9	0.1
Number of operations (self-reported)	0.7	1.0	1.2	-1.1	-0.8	1.1
Average weekly beer plus cider intake	1.1	1.6	4.7	-0.3	0.1	2.2
Irritability	0.1	0.1	0.3	0.1	0.2	-0.5
Risk taking	0.1	0.2	0.3	-0.5	0.0	0.5
Ever had prostate specific antigen (PSA) test	0.8	1.0	1.5	1.1	1.2	0.3
Fractured/broken bones in last 5 years	1.2	1.6	2.7	-1.6	-1.3	-0.5
Age started oral contraceptive pill	0.2	0.3	0.6	-0.3	-0.5	0.8
Diastolic blood pressure, automated reading	0.4	1.3	2.2	-1.1	-1.5	-0.8
Ever depressed for a whole week	0.3	0.4	0.9	0.4	0.1	1.0
Unable to work because of sickness or disability	4.1	5.3	7.4	2.7	2.7	-1.2
Commuting to job workplace: Cycle	2.2	2.6	4.8	1.6	2.2	0.7
Myopia	0.1	0.2	0.6	-0.0	0.0	-0.8
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.6	0.7	0.1	-0.4
Cholesterol lowering medication	0.6	0.8	1.6	0.8	1.3	-0.6
Medication: Omeprazole (e.g. Zanprol)	3.7	4.5	5.3	2.3	1.8	-2.3
Pain experienced in last month	0.5	0.8	1.2	0.7	1.1	0.9
Supplements: Calcium	0.8	0.9	2.3	-0.3	-0.5	-1.5
Basal cell carcinoma (self-reported)	1.4	1.7	2.2	-1.4	-1.0	1.5
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.3	0.3	1.1	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.4	0.5	-0.2
Heart disease (siblings)	3.0	3.6	5.8	2.4	2.2	-0.2
Alcohol drinker status: Previous	1.0	1.2	1.7	1.3	0.9	-1.0
Pack years of smoking	1.6	2.3	3.6	1.9	1.5	1.0
Impedance of whole body	6.4	32.6	52.3	6.6	7.2	1.3
Leg fat mass (left)	1.6	6.1	9.7	-2.8	-3.1	-0.9
Arm predicted mass (left)	8.2	41.5	64.5	-7.8	-8.0	0.3