TWAS hub - USP49

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1270	0.0450	0.0015	0.016	NA	0.010	NA	0.015	2.0e-02	NA	0.05200	NA	2.3e-02
2	GTEx	Lung	0.0854	0.0331	0.0051	0.075	NA	0.045	NA	0.053	2.1e-06	NA	0.00023	NA	6.2e-05
3	GTEx	Ovary	0.3040	0.1120	0.0041	-0.008	NA	0.062	NA	0.013	5.6e-01	NA	0.01300	NA	1.5e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Blood Red Count	24.2	234.0	466.6	-8.0	-13.1	-21.6
Leg fat-free mass (right)	9.5	50.7	76.9	-8.6	-8.8	1.0
Whole body water mass	9.5	54.0	83.4	-8.8	-9.1	0.5
Leg predicted mass (right)	9.5	50.8	77.0	-8.6	-8.8	0.9
Whole body fat-free mass	9.4	53.5	82.6	-8.8	-9.1	0.5
Leg fat-free mass (left)	9.0	47.8	72.6	-8.4	-8.5	0.8
Leg predicted mass (left)	8.9	47.4	72.0	-8.3	-8.5	0.9
Trunk predicted mass	8.9	50.8	79.2	-8.6	-8.9	0.3
Trunk fat-free mass	8.8	50.4	78.3	-8.5	-8.8	0.3
Basal metabolic rate	8.6	47.6	72.8	-8.3	-8.5	0.7
Arm fat-free mass (right)	8.2	41.9	64.3	-7.8	-8.0	0.3
Arm predicted mass (left)	8.2	41.5	64.5	-7.8	-8.0	0.3
Arm fat-free mass (left)	7.9	40.2	62.7	-7.6	-7.9	0.1
Impedance of leg (left)	7.6	37.1	59.7	7.2	7.7	-0.3
Arm predicted mass (right)	7.5	38.2	58.7	-7.5	-7.7	0.1
Impedance of leg (right)	7.4	36.0	58.2	7.1	7.6	-0.4
Relative age voice broke	6.6	10.1	12.6	-3.6	-2.6	3.3
Impedance of whole body	6.4	32.6	52.3	6.6	7.2	1.3
Ever had bowel cancer screening	5.6	6.5	12.2	-1.6	-2.2	-3.5
Weight	5.4	26.6	41.0	-6.2	-6.4	0.6
Stomach or abdominal pain in last month	4.6	5.8	15.4	-1.0	-1.0	-3.9
Hip circumference	4.5	19.4	29.1	-5.3	-5.4	0.8
Length of working week for main job	4.5	5.0	7.5	-2.7	-2.7	-0.2
Impedance of arm (right)	4.3	20.1	30.4	5.1	5.5	2.0
Ever had hysterectomy (womb removed)	4.2	4.8	5.4	-2.3	-1.9	2.3
Osteoporosis (self-reported)	4.2	5.2	10.6	1.6	1.6	-3.3
Unable to work because of sickness or disability	4.1	5.3	7.4	2.7	2.7	-1.2
Relative age of first facial hair	4.0	8.2	14.2	-2.6	-1.9	3.8
Age at first live birth	4.0	7.0	9.1	-3.0	-2.8	2.0
Impedance of arm (left)	3.8	17.4	25.6	4.5	5.1	2.5
Average weekly red wine intake	3.7	5.5	9.7	-3.1	-2.6	-0.2
Medication: Omeprazole (e.g. Zanprol)	3.7	4.5	5.3	2.3	1.8	-2.3
Qualifications: nursing, teaching	3.6	5.6	6.7	-2.6	-2.6	-1.9
Medication: Lansoprazole	3.4	3.9	5.3	1.5	2.3	-2.0
Arm fat mass (left)	3.3	13.5	21.1	-4.4	-4.6	0.1
Age at last live birth	3.2	4.7	7.5	-2.7	-2.2	1.3
Age at First Birth	3.1	4.5	6.4	-2.4	-2.5	1.1
Hand grip strength (right)	3.1	8.3	13.5	-3.7	-3.4	0.1
Taking other prescription medications	3.1	4.8	5.7	2.4	2.1	-2.0
Arm fat mass (right)	3.1	12.6	19.9	-4.2	-4.5	0.1
Comparative body size at age 10	3.1	8.6	11.5	-3.4	-3.3	1.8
Supplements: Vitamin C	3.1	3.6	5.9	-1.3	-1.8	-2.4
Frequency of depressed mood in last 2 weeks	3.0	4.1	5.7	-2.1	-2.4	-1.5
Qualifications: A levels/AS levels or equivalent	3.0	6.7	7.6	-2.8	-2.7	-2.4
Exposure to tobacco smoke outside home	3.0	4.0	7.1	-1.3	-2.7	-1.7
Heart disease (siblings)	3.0	3.6	5.8	2.4	2.2	-0.2
Alzheimer’s Disease (in mother)	2.9	3.4	4.3	-1.5	-1.9	-2.1
Ulcerative Colitis	2.9	4.2	7.2	2.7	2.1	-0.9
Supplements: Fish oil (including cod liver oil)	2.9	3.8	10.5	0.7	0.8	-3.2
Standing height	2.7	27.1	38.3	-6.2	-6.1	2.5
Qualifications: O levels/GCSEs or equivalent	2.7	4.4	6.1	-1.5	-2.2	-2.5
Mineral and other dietary supplements	2.7	3.7	9.6	-0.9	-0.7	3.1
Medication: Omeprazole	2.6	3.1	3.7	1.7	1.6	-1.9
Smoking status: Previous	2.6	3.9	5.1	2.3	2.2	1.3
Hand grip strength (left)	2.5	6.7	9.6	-3.1	-3.0	-1.2
Number of live births	2.5	3.6	4.7	1.4	2.0	2.2
Number of treatments/medications taken	2.4	4.3	6.4	1.5	2.1	-2.5
Other serious medical condition/disability diagnosed by doctor	2.4	3.2	8.5	-0.2	-1.0	-2.9
Medication: Co-codamol	2.4	2.8	4.8	2.2	1.7	-0.8
Body mass index (BMI)	2.4	10.4	16.5	-3.8	-4.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	2.4	5.0	9.4	-3.1	-2.3	-0.5
BMI	2.3	13.3	19.8	-4.4	-4.5	-0.9
Allergy or Eczema	2.3	6.0	13.1	1.8	1.3	-3.6
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.7	3.8	-1.9	-1.7	-1.2
Pulse rate, automated reading	2.3	7.5	11.4	3.4	2.5	-2.2
Sitting height	2.2	15.6	22.3	-4.7	-4.7	1.6
Ever smoked	2.2	3.9	4.3	2.0	2.1	1.8
Commuting to job workplace: Cycle	2.2	2.6	4.8	1.6	2.2	0.7
Tanning	2.1	25.9	41.3	6.0	6.4	-0.1
Hayfever, allergic rhinitis or eczema	2.1	4.5	12.3	1.0	0.5	-3.5
Waist circumference	2.1	7.7	12.7	-3.2	-3.6	-0.1
Past tobacco smoking	2.1	3.9	5.2	-2.2	-2.3	-1.4
Medication: Ramipril	2.1	2.6	6.5	-1.1	-0.5	2.5
Wears glasses or contact lenses	2.1	2.4	3.8	1.9	1.2	-1.5
Depression (Nagel 2018)	2.0	3.1	3.9	-1.6	-1.6	-2.0
Age when periods started (menarche)	2.0	4.7	5.4	-2.3	-1.9	2.3
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	5.1	2.3	1.4	-0.0
Severe depression (siblings)	1.9	2.1	2.9	-1.6	-1.7	-1.0
Chronotype (morning person)	1.8	4.2	12.3	0.4	0.3	3.5
Qualifications: None of the above	1.8	3.8	7.1	1.9	2.7	0.7
Long-standing illness, disability or infirmity	1.8	2.8	6.5	1.2	0.6	-2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	3.0	-1.7	-1.6	-0.8
Pack years adult smoking proportion	1.7	2.5	3.5	1.9	1.5	1.3
Depression (self-reported)	1.7	2.1	3.7	1.2	0.9	-1.9
Mean time to correctly identify matches	1.7	3.3	8.9	-0.6	-0.8	3.0
Whole body fat mass	1.7	7.0	11.1	-3.1	-3.3	-0.1
Leg fat mass (right)	1.7	6.6	10.2	-2.9	-3.2	-1.1
Reaction Time	1.6	3.1	7.6	-0.9	-1.0	2.7
Fasting Glucose	1.6	1.9	5.0	0.8	0.3	-2.2
Sensitivity / hurt feelings	1.6	2.7	3.7	-1.9	-1.9	-0.9
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	2.4	-1.4	-0.9	1.5
Suffer from ‘nerves’	1.6	2.6	4.6	-1.7	-2.1	0.4
Illness, injury, bereavement, stress in last 2 years	1.6	1.9	2.5	1.4	1.6	1.2
Pack years of smoking	1.6	2.3	3.6	1.9	1.5	1.0
Leg fat mass (left)	1.6	6.1	9.7	-2.8	-3.1	-0.9
Trunk fat mass	1.5	6.2	9.5	-3.0	-3.1	0.4
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.4	3.3	-1.8	-1.8	-0.9
Pain type(s) experienced in last month: Hip pain	1.5	1.9	5.5	0.3	-0.3	-2.4
Illnesses of siblings	1.4	2.0	5.5	0.2	0.8	2.3
Illnesses of father: High blood pressure	1.4	1.8	2.4	-1.2	-1.5	-1.3
Basal cell carcinoma (self-reported)	1.4	1.7	2.2	-1.4	-1.0	1.5
Rheumatoid Arthritis	1.3	1.8	2.5	-1.6	-1.4	-1.0
Height	1.3	25.2	36.0	-5.8	-6.0	2.3
Commuting to job workplace: Car/motor vehicle	1.3	1.5	2.3	-1.5	-1.5	0.0
Breast cancer (self-reported)	1.3	1.6	3.6	1.9	1.0	0.2
Tinnitus: Yes, now most or all of the time	1.3	1.5	2.8	1.7	1.3	-0.3
Townsend deprivation index at recruitment	1.2	1.8	2.3	1.5	1.4	-1.0
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	4.1	-0.5	-0.6	-2.0
Family relationship satisfaction	1.2	1.5	2.4	-1.6	-1.4	0.5
Alcohol drinker status: Never	1.2	1.4	2.5	-0.7	-1.1	-1.6
Fractured/broken bones in last 5 years	1.2	1.6	2.7	-1.6	-1.3	-0.5
Bipolar Disorder (2018)	1.1	1.8	2.8	1.7	1.3	-0.8
Alzheimer’s Disease (including proxy)	1.1	1.6	2.2	-0.8	-1.4	-1.5
Blood Platelet Count	1.1	13.0	19.9	4.3	4.5	0.9
Vitamin and mineral supplements	1.1	1.4	4.0	-0.5	-0.0	2.0
Average weekly fortified wine intake	1.1	1.3	2.1	1.4	1.3	-0.3
Alcohol usually taken with meals	1.1	1.9	4.7	-0.8	-0.5	-2.2
Medication: Simvastatin	1.1	1.6	2.5	1.5	1.6	-0.2
Mouth/teeth dental problems: Dentures	1.1	1.8	3.9	1.0	0.8	2.0
Medication: Paracetamol	1.1	1.8	2.2	1.3	1.2	-1.5
Qualifications: College or University degree	1.1	3.5	5.9	-2.4	-2.0	0.6
Average weekly beer plus cider intake	1.1	1.6	4.7	-0.3	0.1	2.2
Bipolar Disorder or Schizophrenia	1.0	2.3	3.8	2.0	1.6	0.8
Coronary Artery Disease (CAD)	1.0	1.2	1.7	1.1	1.3	0.9
Medication: Metformin	1.0	1.4	2.9	-1.0	-0.3	1.7
Supplements: Glucosamine	1.0	1.3	1.5	-1.2	-1.1	-1.2
Loud music exposure frequency	1.0	1.1	1.6	-1.2	-0.7	1.2
Pulse wave peak to peak time	1.0	1.2	1.5	-1.0	-1.1	1.2
Angina (self-reported)	1.0	1.3	2.4	1.1	1.6	-0.2
Medication: Ibuprofen	1.0	1.2	1.5	1.0	1.2	-0.9
Alcohol intake frequency.	1.0	2.2	6.4	-0.2	-0.5	-2.5
Average weekly champagne plus white wine intake	1.0	1.4	2.1	-1.5	-1.4	-0.3
Financial situation satisfaction	1.0	1.3	3.0	-1.7	-0.9	-0.2
Alcohol drinker status: Previous	1.0	1.2	1.7	1.3	0.9	-1.0
Depressed Affect (Nagel 2018)	0.9	1.9	5.3	0.6	0.3	-2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	1.5	-1.2	-0.8	-1.2
Financial difficulties in last 2 years	0.9	1.3	3.3	-0.2	-0.7	-1.8
Alcohol intake versus 10 years previously	0.9	1.4	3.8	-0.0	-0.5	-1.9
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	1.5	1.0	1.2	-0.9
Illnesses of mother	0.9	1.1	2.9	0.5	0.4	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.4	1.6	1.0	-0.9
Birth weight of first child	0.9	1.7	2.1	-1.5	-1.5	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	1.6	-1.0	-0.7	1.3
Number of self-reported non-cancer illnesses	0.9	1.6	4.6	0.4	0.3	-2.1
Commuting to job workplace: Public transport	0.9	1.0	1.3	-1.0	-0.8	1.2
Eye problems/disorders: Glaucoma	0.9	1.0	1.9	-0.7	-1.4	0.9
Schizophrenia vs Biploar Disorder	0.8	1.1	2.9	-0.5	-0.4	1.7
Lupus	0.8	1.2	3.2	0.5	-0.3	-1.8
Waist Hip Ratio (WHR)	0.8	3.7	3.8	1.9	1.9	-1.9
Neuroticism	0.8	1.9	5.7	0.0	0.0	-2.4
Hearing difficulty/problems: Yes	0.8	1.2	2.3	1.1	1.5	0.2
Angina	0.8	1.1	2.0	1.1	1.4	0.0
Maternal smoking around birth	0.8	1.2	2.2	-1.5	-1.2	0.1
Allergy	0.8	1.7	5.1	0.3	0.2	2.2
Arm fat percentage (right)	0.8	3.0	4.8	-2.1	-2.2	0.1
Gout (self-reported)	0.8	1.0	2.1	-0.6	-0.8	-1.4
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.3	-0.3	-0.7	-1.5
Migraine (self-reported)	0.8	0.9	2.7	-0.3	-0.1	-1.6
Illnesses of siblings: Diabetes	0.8	1.0	2.1	-0.6	-0.7	-1.4
Arm fat percentage (left)	0.8	3.1	4.9	-2.1	-2.2	0.3
Medication: Aspirin	0.8	1.1	2.2	1.0	1.5	-0.1
Illnesses of father: None of the above (group 1)	0.8	1.0	2.7	-0.4	0.2	1.7
Ever taken oral contraceptive pill	0.8	0.8	1.3	1.1	1.1	0.0
Ever had prostate specific antigen (PSA) test	0.8	1.0	1.5	1.1	1.2	0.3
Supplements: Calcium	0.8	0.9	2.3	-0.3	-0.5	-1.5
Ovarian Cancer	0.7	1.0	1.5	-1.2	-1.1	0.4
Smoking Status	0.7	1.8	2.3	1.0	1.4	1.5
Hypothyroidism (self reported)	0.7	1.7	2.9	-1.7	-1.5	-0.0
Pain all over the body in last month	0.7	0.8	1.6	-0.7	-0.5	-1.3
Diabetes (self-reported)	0.7	1.1	3.1	-0.3	0.1	1.8
Fluid intelligence score	0.7	1.5	4.4	-0.5	-0.1	2.1
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	1.5	-1.2	-1.2	-0.6
Falls in the last year	0.7	1.0	1.7	-0.5	-1.0	-1.3
Pulse rate	0.7	1.1	2.4	0.9	-0.1	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.4	3.8	-1.8	-2.0	-0.1
Number of children fathered	0.7	0.8	1.1	0.7	0.9	-1.1
Medication for pain relief, constipation, heartburn	0.7	1.2	2.4	-0.6	-0.9	1.5
Number of full sisters	0.7	0.9	1.4	-1.2	-1.0	0.4
Chest pain or discomfort	0.7	1.1	2.7	0.7	0.2	-1.6
Had major operations	0.7	0.8	0.9	-0.9	-0.9	-0.8
Leg pain on walking	0.7	0.9	1.5	1.2	1.1	-0.1
Mood swings	0.7	1.3	3.4	0.6	0.1	-1.8
Back pain experienced in last month	0.7	1.0	2.8	0.1	-0.4	-1.7
Medication: Gliclazide	0.7	0.8	1.8	0.6	0.5	1.3
Number of operations (self-reported)	0.7	1.0	1.2	-1.1	-0.8	1.1
Neuroticism (Nagel 2018)	0.6	1.3	3.7	-0.1	-0.5	-1.9
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	1.6	-1.2	-1.2	1.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	2.3	-0.0	-0.1	-1.5
Prospective memory result	0.6	0.7	1.4	0.6	1.2	-0.6
High blood pressure (siblings)	0.6	0.8	1.4	-0.6	-0.8	-1.2
Neck or shoulder pain in last month	0.6	0.9	1.9	-0.0	-0.8	-1.4
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.1	-1.0	-0.9	-0.6
Diabetes diagnosed by doctor	0.6	1.0	2.4	0.3	0.8	1.6
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.3	0.5	0.4	-1.5
Cholesterol lowering medication	0.6	0.8	1.6	0.8	1.3	-0.6
Schizophrenia (2018)	0.5	1.1	1.5	1.2	0.9	1.0
Irritable Bowel Disease (IBD)	0.5	1.2	1.7	1.3	0.9	-1.0
Ulcerative Colitis (UC)	0.5	0.9	1.7	1.3	0.9	-0.2
Body Mass Index (BMI) (2010)	0.5	0.6	1.2	-0.7	-0.5	-1.1
Systolic Blood Pressure	0.5	2.5	4.2	1.8	2.0	-0.1
Current tobacco smoking	0.5	0.8	1.6	0.5	0.7	1.3
Fed-up feelings	0.5	1.0	2.4	0.5	0.5	-1.6
Chronic bronchitis/emphysema (father)	0.5	0.6	0.8	-0.6	-0.8	-0.9
High blood pressure (mother)	0.5	0.7	1.1	-1.1	-0.8	-0.6
Time employed in main current job	0.5	0.6	1.2	-0.4	-0.6	-1.1
Worrier / anxious feelings	0.5	0.9	1.4	1.2	1.1	0.2
Tense / ‘highly strung’	0.5	0.8	2.4	-0.2	-0.1	-1.6
Peak expiratory flow (PEF)	0.5	1.1	1.7	-1.3	-1.1	-0.6
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	0.9	0.8	0.8	1.0
Forced vital capacity (FVC), Best measure	0.5	1.9	3.0	-1.6	-1.7	-0.3
Emphysema/chronic bronchitis	0.5	0.5	1.1	-0.6	-0.2	1.1
Medication: Seretide 50 evohaler	0.5	0.6	1.1	0.8	1.0	0.3
Heart disease (mother)	0.5	0.7	0.8	0.8	0.9	0.7
Medication: Aspirin	0.5	0.6	1.3	0.7	1.1	-0.4
Hypertension (Self-reported)	0.5	1.3	2.2	-1.5	-1.0	0.9
Illnesses of father: Heart disease	0.5	0.7	1.1	1.1	0.7	-0.8
Loneliness, isolation	0.5	0.6	0.9	-0.6	-0.8	-0.9
Eye problems/disorders: Cataract	0.5	0.5	0.7	0.8	0.8	0.5
Smoking status: Current	0.5	0.7	1.1	0.6	0.8	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	1.4	-0.8	-1.2	-1.2
Medication: Bendroflumethiazide	0.5	0.8	2.3	-0.4	-0.1	1.5
Medication: Lisinopril	0.5	0.7	1.6	-1.3	-0.7	-0.1
Pain experienced in last month	0.5	0.8	1.2	0.7	1.1	0.9
Intelligence (Savage-Jansen 2018)	0.4	1.2	1.4	-1.2	-1.1	0.9
Primary Biliary Cirrhosis	0.4	0.5	1.6	0.0	0.0	1.3
Blood White Count	0.4	3.2	5.0	2.2	2.1	-0.2
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.6	-0.6	0.2	1.3
Diabetes (father)	0.4	0.5	1.3	-0.2	-0.0	-1.2
Serious illness, injury or assault to yourself	0.4	0.5	1.0	-1.0	-0.8	-0.0
High blood pressure	0.4	1.1	1.7	-1.3	-0.9	0.9
Medication: Atenolol	0.4	0.5	0.8	0.4	0.9	-0.7
Neuroticism score	0.4	0.9	2.6	0.1	-0.2	-1.6
Father’s age at death	0.4	0.5	0.9	-0.7	-0.5	-0.9
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	2.3	-1.4	-1.5	-0.1
Pulse wave Arterial Stiffness index	0.4	0.5	0.7	0.5	0.7	-0.8
Hair/balding pattern: Pattern 4	0.4	1.0	2.8	0.5	0.2	-1.7
Medication: Amlodipine	0.4	0.6	0.8	0.8	0.9	-0.5
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.6	-0.0	0.1	-1.3
Birth weight	0.4	1.0	2.0	-0.8	-1.4	0.4
Health satisfaction	0.4	0.5	1.0	-1.0	-0.7	-0.1
Osteoarthritis (self-reported)	0.4	0.5	1.0	0.7	0.1	-1.0
Mother’s age at death	0.4	0.5	1.1	-1.0	-0.6	0.0
Medication: Paracetamol	0.4	0.7	0.9	0.7	0.8	-1.0
Diastolic blood pressure, automated reading	0.4	1.3	2.2	-1.1	-1.5	-0.8
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.3	0.3	1.1	-0.5
Worry (Nagel 2018)	0.3	0.7	1.6	-0.4	-0.4	-1.3
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.1	-0.7	-0.5	1.1
Breast Cancer	0.3	0.6	1.1	-0.2	-0.9	-1.0
Crohns Disease (2012)	0.3	0.5	1.2	0.3	0.6	-1.1
Mean Putamen Volume	0.3	0.3	0.8	-0.3	-0.4	-0.9
Blood Eosinophil Count	0.3	2.7	4.4	-1.3	-1.3	-2.1
Respiratory disease	0.3	0.8	1.2	0.6	1.1	-0.9
Lung FEV1/FVC ratio	0.3	1.4	2.5	-1.2	-1.6	0.5
Hair Pigment	0.3	8.1	12.3	-3.5	-3.5	0.2
Average weekly spirits intake	0.3	0.3	0.7	-0.3	-0.5	0.8
Qualifications: CSEs or equivalent	0.3	0.4	1.1	-0.1	0.4	-1.1
Multivitamins +/- minerals	0.3	0.3	0.7	0.5	-0.0	-0.9
Medication: Levothyroxine sodium	0.3	0.5	0.6	-0.8	-0.6	-0.8
Hair/balding pattern: Pattern 2	0.3	0.4	0.6	0.8	0.7	-0.1
Mouth/teeth dental problems	0.3	0.4	0.6	-0.7	-0.4	-0.8
Heart attack	0.3	0.3	0.9	0.1	0.9	-0.3
Happiness	0.3	0.4	0.6	-0.6	-0.8	-0.3
Breastfed as a baby	0.3	0.4	0.8	-0.0	-0.6	-0.9
Headache pain in last month	0.3	0.5	0.9	1.0	0.5	-0.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	0.7	-0.9	-0.7	-0.5
Wheeze or whistling in the chest in last year	0.3	0.6	1.1	0.6	1.0	-0.7
Shortness of breath walking on level ground	0.3	0.4	0.5	-0.7	-0.7	0.4
Medication: Blood pressure	0.3	0.5	0.8	-0.7	-0.5	-0.9
Medication: Allopurinol	0.3	0.4	0.9	-0.5	-0.9	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.4	0.5	0.5	0.6
Overall health rating	0.3	0.6	1.0	1.0	0.8	0.1
Friendships satisfaction	0.3	0.3	0.8	-0.2	-0.3	0.9
Miserableness	0.3	0.5	0.6	0.5	0.7	-0.8
Guilty feelings	0.3	0.4	0.8	0.9	0.6	-0.2
Hearing aid user	0.3	0.4	0.5	0.6	0.7	-0.5
High cholesterol (Self-reported)	0.3	0.5	0.8	-0.8	-0.3	-0.9
Ever depressed for a whole week	0.3	0.4	0.9	0.4	0.1	1.0
Alzheimer’s Disease (in father)	0.2	0.2	0.4	0.7	0.2	-0.3
Crohns Disease (2017)	0.2	0.3	0.5	0.7	0.5	-0.4
HDL Cholesterol	0.2	0.4	0.5	-0.5	-0.7	-0.7
Neuroticism (2016)	0.2	0.2	0.6	0.8	0.2	-0.2
Schizophrenia (2014)	0.2	0.4	0.9	0.6	0.3	0.9
Heel T-Score	0.2	1.9	2.3	1.3	1.4	1.5
Lung FVC	0.2	0.9	2.3	0.3	0.5	-1.5
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.8	0.2	0.9	0.1
Medication for hormone replacement therapy	0.2	0.2	0.4	-0.6	-0.2	0.5
Number of incorrect matches in round	0.2	0.4	0.7	-0.5	-0.8	0.4
Hearing difficulty/problems with background noise	0.2	0.3	0.5	0.4	0.4	-0.7
Forced vital capacity (FVC)	0.2	0.7	1.2	-1.0	-1.1	-0.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.5	0.5	0.3	0.7
Blood clot in the leg (DVT)	0.2	0.2	0.4	0.5	0.6	-0.3
Glaucoma (self-reported)	0.2	0.3	0.7	-0.2	-0.9	-0.1
Leg fat percentage (right)	0.2	0.7	1.9	0.1	-0.2	-1.4
Worry too long after embarrassment	0.2	0.3	0.8	0.9	0.4	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.3	0.5	0.2	-0.5
Comparative height size at age 10	0.2	0.8	1.7	-0.9	-1.3	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.5	0.5	0.7	-0.1
Commuting to job workplace: Walk	0.2	0.2	0.6	0.0	-0.2	-0.8
Medication: Blood pressure	0.2	0.3	0.5	-0.2	0.6	0.7
Age started oral contraceptive pill	0.2	0.3	0.6	-0.3	-0.5	0.8
HbA1C	0.1	0.1	0.4	-0.6	-0.1	0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	-0.2	0.1	0.5
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	0.2	0.3	0.5
Supplements: Zinc	0.1	0.1	0.2	-0.2	-0.4	-0.2
Trunk fat percentage	0.1	0.5	0.6	-0.8	-0.7	0.6
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	0.4	0.2	0.0
Had menopause	0.1	0.1	0.4	0.6	0.2	0.1
Had other major operations	0.1	0.2	0.4	0.4	0.6	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.7	0.1	-0.1	0.8
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.4	-0.1	0.2	0.7
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	-0.5	0.0	0.3
Noisy workplace	0.1	0.2	0.3	-0.5	-0.4	-0.2
Asthma	0.1	0.2	0.4	-0.0	0.6	-0.4
Medication: Cholesterol lowering	0.1	0.1	0.2	-0.3	-0.2	-0.5
Lung cancer (father)	0.1	0.1	0.2	-0.2	-0.4	0.2
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.2	0.1	0.4
Pulse wave reflection index	0.1	0.1	0.2	-0.5	0.1	0.0
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	-0.4	-0.2	-0.2
Body fat percentage	0.1	0.2	0.3	-0.5	-0.6	-0.0
Number of full brothers	0.1	0.1	0.2	0.4	-0.1	0.0
Eye problems/disorders: None of the above	0.1	0.1	0.3	-0.6	-0.2	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	-0.4	0.0	0.3
Medication for cholesterol	0.1	0.1	0.2	0.5	-0.1	-0.4
Asthma (self-reported)	0.1	0.1	0.3	0.0	0.4	-0.5
Medication: Atorvastatin	0.1	0.1	0.2	-0.5	-0.0	-0.1
Leg fat percentage (left)	0.1	0.4	1.3	0.1	-0.2	-1.1
Irritability	0.1	0.1	0.3	0.1	0.2	-0.5
Risk taking	0.1	0.2	0.3	-0.5	0.0	0.5
Myopia	0.1	0.2	0.6	-0.0	0.0	-0.8
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.6	0.7	0.1	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.4	0.5	-0.2
Major Depression (MDD)	0.0	0.1	0.1	0.3	-0.2	-0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.1	0.1	-0.2	-0.0	0.3
Triglycerides	0.0	0.1	0.2	0.2	-0.1	0.4
Cardiovascular Disease	0.0	0.1	0.4	-0.6	0.0	-0.1
Systolic blood pressure, automated reading	0.0	0.1	0.2	0.4	0.2	0.3
Diabetes (mother)	0.0	0.1	0.1	-0.1	-0.0	0.4
Nervous feelings	0.0	0.0	0.1	0.1	0.0	0.3
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	0.0	0.1	0.3
Knee pain experienced in last month	0.0	0.0	0.1	0.2	0.2	-0.2

Hub : Genes

USP49

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Trait associations