[Hub]/) : Traits : Impedance of leg (right) : ← →

chr8:66,645,549-68,096,452

Best TWAS P=1.44e-10 · Best GWAS P=1.76e-08 conditioned to 0.0325

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Esophagus Muscularis	C8orf46	0.39	0.22	enet	30	0.18	8.5e-11	-4.6	-6.4	1.4e-10	-0.62	0.39	0.60	TRUE
8	The Cancer Genome Atlas	Prostate Adenocarcinoma	ADHFE1	0.06	0.03	enet	12	0.04	1.9e-05	4.2	5.4	5.1e-08	0.47	0.01	0.90	FALSE
1	GTEx	Artery Aorta	C8orf46	0.27	0.26	enet	23	0.22	3.7e-12	-4.6	-5.4	5.3e-08	-0.50	0.35	0.64	FALSE
5	GTEx	Lung	C8orf46	0.23	0.17	enet	22	0.12	1.2e-09	-4.6	-5.4	8.5e-08	-0.62	0.36	0.63	FALSE
6	GTEx	Skin Not Sun Exposed Suprapubic	C8orf46	0.10	0.10	enet	8	0.10	3.8e-06	-4.6	-5.3	1.4e-07	-0.57	0.36	0.56	FALSE
4	GTEx	Heart Left Ventricle	ADHFE1	0.29	0.22	enet	14	0.22	4.2e-12	4.4	5.2	1.8e-07	0.52	0.45	0.53	FALSE
7	GTEx	Testis	C8orf46	0.63	0.54	enet	52	0.52	1.4e-26	-4.6	-5.2	2.0e-07	-0.54	0.35	0.64	FALSE
2	GTEx	Colon Transverse	C8orf46	0.19	0.06	enet	11	0.03	1.6e-02	4.3	-5.2	2.1e-07	-0.60	0.10	0.57	FALSE