Best TWAS P=1.44e-10 · Best GWAS P=1.76e-08 conditioned to 0.0325
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | C8orf46 | 0.27 | 0.26 | enet | 23 | 0.22 | 3.7e-12 | -4.6 | -5.4 | 5.3e-08 | -0.50 | 0.35 | 0.64 | FALSE |
| 2 | GTEx | Colon Transverse | C8orf46 | 0.19 | 0.06 | enet | 11 | 0.03 | 1.6e-02 | 4.3 | -5.2 | 2.1e-07 | -0.60 | 0.10 | 0.57 | FALSE |
| 3 | GTEx | Esophagus Muscularis | C8orf46 | 0.39 | 0.22 | enet | 30 | 0.18 | 8.5e-11 | -4.6 | -6.4 | 1.4e-10 | -0.62 | 0.39 | 0.60 | TRUE |
| 4 | GTEx | Heart Left Ventricle | ADHFE1 | 0.29 | 0.22 | enet | 14 | 0.22 | 4.2e-12 | 4.4 | 5.2 | 1.8e-07 | 0.52 | 0.45 | 0.53 | FALSE |
| 5 | GTEx | Lung | C8orf46 | 0.23 | 0.17 | enet | 22 | 0.12 | 1.2e-09 | -4.6 | -5.4 | 8.5e-08 | -0.62 | 0.36 | 0.63 | FALSE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | C8orf46 | 0.10 | 0.10 | enet | 8 | 0.10 | 3.8e-06 | -4.6 | -5.3 | 1.4e-07 | -0.57 | 0.36 | 0.56 | FALSE |
| 7 | GTEx | Testis | C8orf46 | 0.63 | 0.54 | enet | 52 | 0.52 | 1.4e-26 | -4.6 | -5.2 | 2.0e-07 | -0.54 | 0.35 | 0.64 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ADHFE1 | 0.06 | 0.03 | enet | 12 | 0.04 | 1.9e-05 | 4.2 | 5.4 | 5.1e-08 | 0.47 | 0.01 | 0.90 | FALSE |