TWAS
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Traits
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Impedance of leg (right)
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chr8:88,801,153-89,582,625
Best TWAS P=2.5e-28 · Best GWAS P=1.59e-28 conditioned to 3.67e-06
88.8M
88.9M
89M
89.1M
89.2M
89.3M
89.4M
89.5M
89.6M
0
5
10
15
20
25
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
5
The Cancer Genome Atlas
Thyroid Carcinoma
MMP16
0.10
0.09
lasso
4
0.08
2.9e-08
11.0
11.0
2.5e-28
0.85
0.01
0.99
TRUE
1
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
MMP16
0.12
0.07
lasso
4
0.08
4.3e-09
11.0
7.0
2.0e-12
0.80
0.00
1.00
TRUE
2
The Cancer Genome Atlas
Kidney Renal Papillary Cell Carcinoma
MMP16
0.10
0.08
blup
131
0.05
1.3e-03
10.9
8.9
8.6e-19
0.79
0.01
0.98
FALSE
3
The Cancer Genome Atlas
Lung Adenocarcinoma
MMP16
0.04
0.02
lasso
3
0.03
6.3e-05
8.1
6.8
1.4e-11
0.79
0.01
0.95
FALSE
4
The Cancer Genome Atlas
Prostate Adenocarcinoma
MMP16
0.07
0.05
blup
133
0.04
1.7e-05
6.8
5.5
3.4e-08
0.74
0.02
0.97
FALSE