TWAS hub - MMP16

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Head and Neck Squamous Cell Carcinoma	0.0516	0.0259	6.6e-03	-0.002	0.001	0.000	NA	-0.002	7.4e-01	2.0e-01	3.6e-01	NA	5.5e-01
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.1174	0.0426	1.1e-06	0.067	0.065	0.074	NA	0.078	4.7e-08	8.9e-08	1.0e-08	NA	4.3e-09
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0990	0.0450	8.6e-04	0.075	0.046	0.039	NA	0.019	4.2e-05	1.3e-03	2.6e-03	NA	2.7e-02
4	TCGA	Liver Hepatocellular Carcinoma	0.2270	0.0810	1.6e-05	0.049	0.120	0.164	NA	0.094	2.4e-03	2.8e-06	3.7e-08	NA	3.6e-05
5	TCGA	Lung Adenocarcinoma	0.0416	0.0202	1.8e-03	0.016	0.028	0.032	NA	0.034	5.0e-03	2.8e-04	1.1e-04	NA	6.4e-05
6	TCGA	Prostate Adenocarcinoma	0.0719	0.0274	4.5e-06	0.048	0.045	0.028	NA	0.032	7.8e-06	1.7e-05	5.4e-04	NA	2.4e-04
7	TCGA	Thyroid Carcinoma	0.0980	0.0330	5.1e-06	0.085	0.047	0.075	NA	0.081	1.2e-08	2.3e-05	8.7e-08	NA	2.9e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Irritability	11.2	19.0	32.0	3.5	5.1	5.2	4.7	2.5	2.6	5.7
Impedance of leg (right)	10.9	52.9	121.8	4.6	7.0	8.9	4.9	6.8	5.5	11.0
Impedance of leg (left)	10.7	52.1	127.7	4.7	7.0	8.7	4.8	6.4	5.1	11.3
Impedance of whole body	7.9	40.3	93.4	4.3	6.2	7.8	4.1	5.8	4.4	9.7
Hand grip strength (left)	7.7	20.3	24.7	-4.3	-4.1	-5.0	-4.8	-4.7	-3.6	-4.9
Waist Hip Ratio (WHR)	6.2	27.7	58.5	3.5	5.6	5.7	4.7	4.2	4.5	7.7
Impedance of arm (left)	5.3	24.5	50.4	3.8	5.0	6.1	3.3	4.8	3.3	7.1
Impedance of arm (right)	5.2	24.2	50.5	3.8	5.1	5.8	3.7	4.5	3.2	7.1
Age started oral contraceptive pill	5.0	6.3	9.2	2.8	2.6	2.3	1.7	2.5	2.4	3.0
Schizophrenia (2014)	4.8	10.6	17.0	2.2	3.3	4.1	2.8	3.2	3.4	3.3
Average weekly spirits intake	4.5	5.5	11.4	-2.4	-1.7	-2.6	-1.7	-3.4	-1.8	-2.3
Schizophrenia (2018)	4.4	9.1	16.6	2.1	3.0	4.1	2.3	3.1	2.9	3.2
Hand grip strength (right)	4.2	11.4	14.4	-3.2	-3.3	-3.4	-3.8	-3.6	-3.1	-3.2
Exposure to tobacco smoke at home	4.0	4.5	6.7	1.5	2.4	2.3	2.0	0.9	2.5	2.6
Bipolar Disorder or Schizophrenia	3.9	9.4	16.4	1.9	3.0	4.1	2.3	3.2	3.7	2.8
Tinnitus: Yes, now most or all of the time	3.9	4.6	6.2	2.1	2.4	2.3	2.3	1.7	2.5	1.5
Pack years of smoking	3.7	5.4	8.6	2.3	2.9	2.4	2.9	1.3	2.2	1.9
Heel bone mineral density (BMD) T-score, automated (right)	3.6	8.3	20.3	-1.2	-3.1	-3.5	-2.4	-1.9	-2.2	-4.5
Pack years adult smoking proportion	3.4	5.1	8.1	2.0	2.9	2.5	2.8	1.3	2.3	1.7
Coronary Artery Disease (CAD)	3.0	3.6	8.5	-0.9	-0.5	-2.9	-1.6	-2.5	-2.6	-0.3
Number of incorrect matches in round	3.0	5.0	13.1	-2.8	-2.5	-1.6	-0.9	-2.1	-3.6	-0.4
Heel T-Score	2.9	23.4	49.8	-3.1	-4.6	-6.1	-4.5	-4.0	-3.1	-7.1
Medication: Co-codamol	2.8	3.3	5.9	-1.6	-1.2	-2.1	-2.0	-2.4	-1.5	-1.5
Medication: Aspirin	2.8	3.7	9.9	-0.9	-2.0	-2.5	-1.4	-0.7	-1.5	-3.1
Heel bone mineral density (BMD) T-score, automated (left)	2.7	6.0	15.5	-1.1	-3.3	-2.6	-1.3	-1.6	-1.9	-3.9
Mouth/teeth dental problems: Bleeding gums	2.7	3.5	10.2	1.6	1.8	1.4	2.0	1.5	-0.3	3.2
Leg fat-free mass (right)	2.7	14.4	43.0	-1.9	-3.0	-4.9	-2.1	-3.6	-1.8	-6.6
Leg predicted mass (right)	2.7	14.2	42.1	-1.9	-3.0	-4.9	-2.1	-3.6	-1.8	-6.5
Chronotype (morning person)	2.6	6.1	11.2	2.3	1.9	3.3	1.7	3.3	2.0	2.3
Ever had hysterectomy (womb removed)	2.6	3.0	5.9	1.7	1.5	2.4	0.8	1.8	1.9	1.5
Eye problems/disorders: Cataract	2.6	3.0	6.6	1.3	1.7	2.6	1.4	1.9	0.7	1.9
Mouth/teeth dental problems: Mouth ulcers	2.6	4.1	9.2	2.0	2.0	2.3	1.9	0.9	1.5	3.0
Respiratory disease	2.5	5.5	9.4	1.7	2.8	2.5	2.8	1.9	0.8	3.1
Emphysema/chronic bronchitis	2.5	2.8	5.8	1.4	1.1	2.3	2.4	0.6	1.1	2.0
Medication: Aspirin	2.5	3.3	8.8	-0.8	-1.7	-2.5	-1.3	-0.8	-1.4	-3.0
Loneliness, isolation	2.5	3.4	6.1	2.3	1.7	1.5	2.5	1.7	0.8	2.0
Illnesses of father: None of the above (group 1)	2.5	3.1	7.0	1.1	1.9	2.0	2.6	1.2	0.9	2.0
Fed-up feelings	2.4	4.3	8.3	1.4	2.1	2.9	2.1	1.5	0.9	2.8
Had other major operations	2.4	3.0	4.9	-1.3	-1.7	-2.1	-2.2	-1.6	-0.1	-2.1
Schizophrenia vs Biploar Disorder	2.3	3.0	8.5	0.1	0.9	2.9	1.7	2.1	0.3	2.1
Qualifications: CSEs or equivalent	2.3	3.0	7.0	-1.6	-1.5	-1.8	-1.1	-2.6	-1.9	-1.0
Medication: Ramipril	2.3	3.0	5.6	-1.4	-1.6	-1.9	-2.4	-1.9	-1.2	-1.5
Number of operations (self-reported)	2.3	3.4	5.0	-1.1	-2.1	-2.1	-2.2	-2.0	-0.9	-1.9
Diabetes (father)	2.2	2.7	5.3	-1.7	-1.8	-1.4	-1.3	-1.6	-2.3	-1.3
Peak expiratory flow (PEF)	2.2	5.2	9.1	-0.9	-1.8	-3.0	-2.2	-2.2	-2.1	-3.0
Hypertension (Self-reported)	2.2	6.2	13.9	-1.6	-2.4	-3.2	-1.1	-2.3	-3.7	-2.2
Whole body fat-free mass	2.2	12.5	36.8	-1.9	-2.8	-4.8	-2.0	-3.2	-1.3	-6.1
Whole body water mass	2.2	12.6	36.4	-2.0	-2.8	-4.8	-2.0	-3.3	-1.2	-6.0
Vascular/heart problems diagnosed by doctor	2.2	5.9	13.5	1.3	2.4	3.2	1.0	2.0	3.7	2.4
Leg fat-free mass (left)	2.1	11.0	36.9	-1.6	-2.5	-4.3	-1.6	-3.0	-1.0	-6.1
Leg predicted mass (left)	2.1	11.2	37.2	-1.7	-2.5	-4.3	-1.7	-3.0	-1.1	-6.1
Verbal and Numeric Reasoning (VNR)	2.0	4.8	16.0	3.0	1.8	0.8	4.0	1.7	1.4	0.4
High blood pressure	2.0	5.7	14.1	-1.4	-2.2	-3.2	-0.9	-2.1	-3.8	-2.0
Trunk fat-free mass	2.0	11.3	30.9	-2.0	-2.7	-4.7	-2.0	-3.0	-1.2	-5.6
Trunk predicted mass	2.0	11.6	31.9	-2.1	-2.8	-4.7	-2.0	-3.1	-1.2	-5.6
Alcohol intake frequency.	2.0	4.5	7.1	-2.7	-1.7	-2.4	-1.9	-1.8	-1.6	-2.6
Long-standing illness, disability or infirmity	2.0	3.0	7.3	1.2	1.8	1.3	2.7	1.2	1.6	1.8
Taking other prescription medications	1.9	2.9	6.2	2.0	1.7	1.2	2.5	1.0	0.9	1.9
Supplements: Calcium	1.9	2.1	3.8	-1.5	-2.0	-1.6	-1.6	-1.1	-1.2	-1.1
Neuroticism score	1.8	3.7	8.4	1.3	1.9	2.0	2.9	0.7	0.6	2.7
Average weekly beer plus cider intake	1.8	2.7	6.9	0.9	1.6	1.1	2.6	1.2	1.6	1.8
Body Mass Index (BMI) (2010)	1.7	2.4	5.9	-0.8	-1.2	-1.9	-1.4	-1.6	-0.6	-2.4
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.2	5.2	-0.6	-0.9	-1.7	-1.8	-2.3	-1.3	-1.1
Tense / ‘highly strung’	1.7	2.8	5.2	1.1	1.6	2.0	2.3	0.9	1.0	2.1
Arm fat-free mass (left)	1.7	8.4	22.3	-1.8	-2.2	-4.1	-1.9	-2.7	-0.7	-4.7
Cardiovascular Disease	1.6	5.1	11.5	-1.5	-2.3	-2.7	-1.2	-2.3	-3.4	-1.6
Lung FEV1/FVC ratio	1.6	8.0	16.2	-1.9	-3.3	-3.8	-1.7	-1.9	-2.2	-4.0
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	8.2	1.7	1.0	0.5	2.9	0.8	1.0	1.1
Asthma	1.6	3.2	6.7	1.1	2.2	1.7	2.6	0.9	-0.0	2.4
Arm fat-free mass (right)	1.6	8.2	24.8	-1.7	-2.4	-3.7	-1.9	-2.6	-0.7	-5.0
Medication for pain relief, constipation, heartburn	1.6	2.8	6.6	0.6	0.7	2.6	1.1	2.5	1.5	1.5
Basal metabolic rate	1.6	9.1	28.3	-1.6	-2.2	-4.1	-1.6	-2.8	-0.7	-5.3
Arm predicted mass (left)	1.6	7.9	21.3	-1.8	-2.1	-4.0	-1.7	-2.6	-0.5	-4.6
Depressed Affect (Nagel 2018)	1.5	3.1	5.6	1.9	1.9	1.8	2.4	0.8	0.3	2.2
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.4	4.9	0.6	1.3	1.1	2.2	1.8	0.6	2.2
Medication: Lansoprazole	1.5	1.7	4.5	0.6	1.8	0.2	1.5	0.1	1.2	2.1
Arm predicted mass (right)	1.5	7.7	22.6	-1.6	-2.2	-3.7	-1.7	-2.5	-0.7	-4.8
Asthma (self-reported)	1.5	3.0	6.2	1.1	2.2	1.5	2.5	0.7	-0.1	2.5
Age at First Birth	1.4	2.1	6.0	0.9	1.2	1.3	1.1	2.5	1.0	1.5
Primary Biliary Cirrhosis	1.4	2.0	3.8	1.2	1.0	1.6	0.9	1.7	1.9	1.2
Relative age voice broke	1.4	2.2	5.2	-1.6	-0.6	-1.5	-1.2	-2.3	-1.8	0.7
Multivitamins +/- minerals	1.4	1.8	4.5	-1.3	-1.4	-2.1	-1.2	-1.5	-0.0	-1.0
Depression (self-reported)	1.4	1.7	4.6	1.6	2.1	0.4	0.0	0.8	0.7	1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	6.1	-1.2	-2.3	-1.4	-1.6	-0.9	-1.6	-2.5
Systolic Blood Pressure	1.3	6.4	11.8	-3.4	-2.6	-2.1	-1.6	-2.7	-3.0	-1.8
Nervous feelings	1.3	2.3	5.5	1.0	2.0	1.3	1.3	1.0	1.4	2.3
Noisy workplace	1.3	1.6	4.9	-1.3	-1.1	-1.3	-0.5	-1.0	-2.2	-0.5
Ever highly irritable/argumentative for 2 days	1.3	1.5	3.1	0.7	1.2	1.5	1.1	1.7	0.7	1.4
High blood pressure (siblings)	1.3	1.9	4.3	-1.0	-1.0	-2.0	-1.5	-0.1	-0.7	-2.1
Pulse wave peak to peak time	1.3	1.5	3.0	1.4	0.3	1.7	0.7	1.4	1.4	-1.0
Health satisfaction	1.3	1.7	3.3	0.9	1.1	1.8	1.7	0.0	0.8	1.7
Neuroticism (Nagel 2018)	1.2	2.7	5.7	1.6	1.9	1.2	2.4	0.1	-0.1	2.4
Hearing difficulty/problems with background noise	1.2	2.0	4.5	1.1	1.2	1.7	2.1	0.7	0.1	1.8
Allergy	1.2	2.8	8.2	0.3	-0.9	-2.3	-2.9	-0.4	0.0	-2.3
Pulse wave reflection index	1.2	1.4	3.3	-0.9	-0.5	-1.8	-0.9	-1.5	-1.7	-0.2
Commuting to job workplace: Walk	1.2	1.3	5.5	-0.6	0.6	1.2	1.0	-0.3	-0.3	2.3
BMI	1.1	6.3	19.5	-1.0	-1.9	-3.1	-1.4	-2.5	-1.3	-4.4
Body mass index (BMI)	1.1	4.8	17.3	-1.1	-1.8	-2.7	-0.7	-1.9	-0.9	-4.2
Falls in the last year	1.1	1.4	3.3	-0.9	-1.2	-1.5	0.8	-0.9	-1.8	-0.9
Pulse wave Arterial Stiffness index	1.1	1.2	2.7	-1.3	-0.1	-1.6	-0.6	-1.2	-1.1	1.1
Number of children fathered	1.1	1.2	3.1	-0.6	-0.8	-1.8	-1.3	-0.4	-0.8	-1.4
Medication: Ibuprofen	1.1	1.4	3.0	-0.1	-0.6	-1.5	-1.4	-1.7	-1.2	-0.8
Leg pain on walking	1.1	1.4	5.6	-0.5	-0.7	-0.7	0.4	-2.4	-1.5	0.6
Mood swings	1.1	2.0	4.5	1.0	1.9	1.2	1.8	-0.1	-0.1	2.1
Medication for cholesterol	1.1	1.7	3.5	0.4	0.4	1.8	1.0	1.9	1.9	0.4
Financial situation satisfaction	1.1	1.4	4.6	-1.0	-1.4	-1.0	-0.3	-0.9	-2.1	0.1
Medication: Blood pressure	1.1	2.0	5.2	-0.8	-1.0	-2.3	-0.1	-0.9	-2.1	-1.4
Ever smoked	1.1	1.9	4.0	-0.9	-2.0	-0.9	0.5	-1.5	-2.0	-1.1
Diastolic blood pressure, automated reading	1.1	3.4	4.8	-2.0	-1.9	-1.8	-1.5	-1.9	-2.2	-1.5
Heart disease (siblings)	1.1	1.4	4.3	2.1	0.8	0.4	0.5	1.6	1.2	-0.3
Bipolar Disorder (2018)	1.0	1.5	5.3	0.4	1.0	1.4	0.9	1.3	2.3	0.4
Neuroticism (2016)	1.0	1.4	2.9	1.3	1.7	0.3	1.0	-0.0	1.6	1.2
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	3.1	-0.7	-0.4	-1.0	-1.7	-0.8	-0.6	-1.2
High blood pressure (mother)	1.0	1.4	1.8	-1.2	-1.3	-1.3	-1.0	-0.6	-1.3	-1.3
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.4	0.6	1.4	1.1	0.9	1.0	1.4	1.5
Hip circumference	1.0	4.5	15.9	-1.3	-1.8	-2.7	-1.1	-1.4	-0.3	-4.0
Alcohol intake versus 10 years previously	1.0	1.5	5.4	-1.3	0.3	0.7	2.3	1.0	0.4	1.3
Leg fat percentage (right)	1.0	3.6	5.6	1.6	2.0	1.9	2.2	1.6	2.4	1.5
Wheeze or whistling in the chest in last year	1.0	1.9	4.5	1.4	1.6	1.0	2.1	0.2	0.4	1.7
Qualifications: College or University degree	1.0	3.3	5.4	2.3	2.3	1.2	1.5	1.7	1.3	2.1
Illnesses of father: High blood pressure	1.0	1.2	2.2	-0.6	-1.3	-1.1	-1.5	-0.8	-1.1	-1.0
Hearing difficulty/problems: Yes	0.9	1.4	3.3	1.6	0.9	1.2	1.8	0.7	0.4	1.1
Medication for hormone replacement therapy	0.9	1.0	3.8	0.3	0.9	0.3	-1.9	-0.7	0.2	1.3
Sitting height	0.9	6.6	12.5	-1.8	-1.5	-3.5	-2.7	-2.4	-1.8	-3.4
Diabetes (self-reported)	0.9	1.3	3.1	-1.3	-1.3	-1.2	-0.6	-0.4	-0.9	-1.7
Age at last live birth	0.9	1.3	3.7	-0.8	-0.5	-1.9	-1.2	-0.3	-1.7	-0.0
Major Depression (MDD)	0.8	0.9	3.3	-0.3	-0.8	-0.4	-0.5	-1.3	-1.8	-0.5
Neuroticism	0.8	2.0	6.0	0.9	1.3	1.1	2.1	-0.2	-0.5	2.4
Sensitivity / hurt feelings	0.8	1.4	4.2	0.9	1.0	1.1	2.0	0.7	0.3	1.3
Relative age of first facial hair	0.8	1.7	6.0	0.3	0.7	1.6	1.4	0.6	0.5	2.4
Trunk fat percentage	0.8	3.4	5.3	1.6	2.1	1.9	1.7	1.9	2.3	1.3
Average weekly fortified wine intake	0.8	1.0	3.1	0.9	1.8	0.2	0.9	0.4	0.6	1.3
Hayfever, allergic rhinitis or eczema	0.8	1.7	4.4	-1.8	-0.4	1.4	2.1	0.2	-0.3	1.5
Hair/balding pattern: Pattern 2	0.8	1.0	2.8	-1.7	-1.2	-0.6	-0.4	-1.1	-0.6	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.4	3.7	0.9	1.6	0.7	0.6	1.2	0.5	1.9
Prospective memory result	0.8	1.0	2.2	0.6	0.8	1.5	1.2	0.6	0.0	1.4
Breastfed as a baby	0.8	1.0	2.0	0.6	0.3	1.2	1.3	1.2	1.4	-0.3
Glaucoma (self-reported)	0.8	0.9	3.1	1.0	0.7	0.1	0.7	1.8	1.0	-0.5
Body fat percentage	0.8	3.0	4.7	1.4	1.9	1.8	1.8	1.7	2.2	1.2
Exposure to tobacco smoke outside home	0.8	1.1	2.1	-1.4	-1.0	-1.2	-1.2	-0.7	-0.8	-0.9
Mean time to correctly identify matches	0.8	1.5	3.9	-1.2	-0.9	-1.1	-1.3	-0.8	-2.0	-0.8
Comparative height size at age 10	0.8	4.5	8.3	1.9	1.8	2.1	2.9	2.0	2.0	2.0
Suffer from ‘nerves’	0.8	1.3	5.1	0.5	1.5	-0.8	0.5	-2.3	0.1	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	1.7	1.3	0.5	1.2	0.8	1.3	0.7	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.3	0.0	-0.6	-1.0	-0.6	-1.5	-1.3	-0.6
Worry (Nagel 2018)	0.7	1.4	3.3	1.0	1.5	0.6	1.7	0.1	0.5	1.8
Rheumatoid Arthritis	0.7	0.9	2.6	-1.4	-0.8	-0.1	0.1	-1.1	-1.6	-0.3
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.9	1.2	0.8	0.9	1.4	0.7	0.3	1.1
Severe depression (siblings)	0.7	0.8	2.2	0.3	0.6	1.0	1.5	0.1	0.2	1.3
Townsend deprivation index at recruitment	0.7	1.0	1.7	0.9	1.2	1.1	0.8	-0.5	0.7	1.3
Serious illness, injury or assault to yourself	0.7	0.9	2.5	0.5	0.1	0.7	1.6	1.3	0.8	0.7
Father’s age at death	0.7	0.9	3.8	-1.9	-1.0	-0.6	-0.7	0.0	-0.8	0.2
Lung cancer (father)	0.7	0.8	2.6	0.4	-0.3	0.7	0.6	1.6	0.9	-0.9
Comparative body size at age 10	0.7	2.0	5.5	2.4	1.6	0.9	0.3	0.7	2.2	-0.3
Number of full brothers	0.7	0.9	1.5	1.0	1.2	-0.0	1.0	-0.1	1.2	1.2
Shortness of breath walking on level ground	0.7	0.9	2.6	-0.3	-0.4	-1.2	0.5	-1.6	-1.1	-0.4
Eye problems/disorders: None of the above	0.7	0.8	2.3	-0.8	-0.5	-0.9	-1.2	-1.5	0.2	-0.2
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.2	-0.6	-0.6	-0.5	-0.6	1.1	0.9	-1.5
Smoking status: Current	0.7	1.0	3.3	-0.6	-0.6	-0.9	-0.2	-1.8	-0.0	-1.6
Leg fat percentage (left)	0.7	2.4	3.7	1.4	1.7	1.4	1.9	1.1	1.8	1.3
Commuting to job workplace: Cycle	0.7	0.8	1.3	0.6	0.7	1.2	0.8	1.1	0.9	0.9
Alzheimer’s Disease (including proxy)	0.6	0.8	3.0	-1.3	-0.3	-0.5	-1.7	-0.5	-0.7	0.1
Lupus	0.6	1.0	4.4	-0.3	-0.4	-2.1	-0.3	-1.1	-0.8	-0.5
Vitamin and mineral supplements	0.6	0.8	2.4	1.3	0.3	1.6	0.8	0.8	-0.3	0.0
Stomach or abdominal pain in last month	0.6	0.8	1.8	1.4	0.3	-0.5	0.4	-1.0	-0.7	-1.2
Supplements: Glucosamine	0.6	0.8	2.0	0.6	1.0	-0.7	-1.0	0.5	1.4	0.7
Mouth/teeth dental problems	0.6	0.9	3.2	-1.8	-0.9	-0.5	-0.9	-0.1	-0.3	-1.0
Fluid intelligence score	0.6	1.2	5.7	1.4	0.6	-0.0	2.4	0.3	0.4	-0.2
Illnesses of siblings	0.6	0.8	2.6	-0.4	0.4	0.7	1.3	-0.5	-0.6	1.6
Weight	0.6	2.8	11.8	-0.4	-0.8	-2.4	-0.3	-1.3	0.2	-3.4
Time employed in main current job	0.6	0.7	2.0	-0.8	-1.4	0.2	-0.0	0.3	-1.1	-0.9
Number of live births	0.6	0.9	2.7	-0.6	-1.1	-0.5	-1.6	-0.8	-0.3	-0.9
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	4.5	-0.4	-1.2	-1.3	-1.8	-0.9	-1.1	-2.1
Medication: Paracetamol	0.6	1.0	2.1	0.7	1.5	-0.6	1.1	-1.3	0.1	1.0
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.5	0.8	1.2	1.0	1.0	0.6	0.3	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.5	-0.9	-0.8	0.7	0.1	-1.2	-1.0	0.6
Angina (self-reported)	0.6	0.7	1.9	1.0	0.5	0.5	0.8	1.4	0.8	-0.6
Heart disease (mother)	0.6	0.7	2.1	-1.1	-1.5	-0.4	-0.9	0.1	-0.1	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	2.2	-0.2	-1.0	-0.1	1.3	-0.3	-1.5	-0.6
Family relationship satisfaction	0.6	0.8	2.6	0.3	-0.6	-0.0	1.6	-0.7	-1.4	0.2
Supplements: Vitamin C	0.6	0.7	1.7	-0.9	-0.2	-1.3	-0.9	-0.9	-0.4	-0.4
Back pain experienced in last month	0.6	0.9	1.9	1.2	0.8	0.7	1.4	0.7	0.4	1.0
Commuting to job workplace: Public transport	0.6	0.7	1.5	0.9	0.5	-0.1	0.1	-1.0	-1.2	1.2
Eye problems/disorders: Glaucoma	0.6	0.7	2.3	0.6	0.5	0.4	1.3	1.5	0.6	-0.2
Fasting Glucose	0.5	0.6	1.5	-0.1	-0.1	-1.2	-0.3	-1.0	-1.0	-0.7
Ulcerative Colitis	0.5	0.7	1.6	1.2	-0.0	0.9	1.3	0.4	-0.9	0.2
Allergy or Eczema	0.5	1.2	4.8	-2.2	-0.7	1.0	0.7	0.5	-0.7	0.9
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.3	-0.7	-1.1	-1.0	-1.1	-0.6	-0.9	-1.0
Current tobacco smoking	0.5	0.8	2.9	-0.4	-0.3	-0.7	-0.4	-1.7	0.2	-1.3
Chronic bronchitis/emphysema (father)	0.5	0.6	1.6	0.6	0.8	-0.8	-0.9	0.4	1.3	0.5
Past tobacco smoking	0.5	0.9	2.2	0.6	1.4	0.3	-1.2	0.7	1.5	0.1
Qualifications: None of the above	0.5	1.0	2.4	-0.6	-0.8	-1.5	-1.6	-0.5	-0.2	-1.0
Financial difficulties in last 2 years	0.5	0.6	1.6	1.2	0.3	-1.1	0.7	-0.7	-0.7	0.0
Hair/balding pattern: Pattern 3	0.5	0.8	2.8	-0.5	-1.1	-0.6	-0.4	-0.5	-1.7	-0.5
Qualifications: A levels/AS levels or equivalent	0.5	1.2	3.7	0.2	1.2	1.2	0.6	1.0	0.5	1.9
Mouth/teeth dental problems: Dentures	0.5	0.9	3.1	1.8	-0.1	-0.7	0.7	-0.2	-0.0	-1.4
Length of working week for main job	0.5	0.5	1.7	0.8	1.1	0.1	-0.0	-0.1	0.1	1.3
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.8	1.0	1.4	0.4	0.2	-0.1	1.3	0.8
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.3	0.6	1.1	0.6	-0.9	0.6	-0.1	1.0
Neck or shoulder pain in last month	0.5	0.7	2.5	0.1	0.7	-0.1	0.5	-1.2	-0.0	1.6
Medication: Seretide 50 evohaler	0.5	0.6	2.2	1.0	0.7	0.6	1.5	-0.4	-0.2	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.3	0.3	1.1	-0.2	0.9	0.6	0.5	1.1
Illnesses of father: Heart disease	0.5	0.7	1.5	-0.4	-0.7	-0.8	-1.2	-1.0	0.1	-1.0
Pain type(s) experienced in last month: Hip pain	0.5	0.7	2.5	1.6	0.8	0.0	1.1	0.3	-0.2	-0.5
Supplements: Fish oil (including cod liver oil)	0.5	0.6	2.3	0.6	0.8	0.2	0.2	0.6	1.5	0.7
Medication: Bendroflumethiazide	0.5	0.8	1.3	-0.5	-1.1	-1.1	-0.7	0.2	-1.0	-1.1
Medication: Paracetamol	0.5	0.7	1.4	0.3	1.2	-0.8	1.1	-1.1	0.1	0.8
Alcohol drinker status: Never	0.5	0.6	1.7	-0.2	0.4	-0.8	-1.2	0.3	0.2	-1.3
Unable to work because of sickness or disability	0.5	0.6	2.2	-0.4	-0.4	0.9	1.5	-0.4	0.1	0.7
Cholesterol lowering medication	0.5	0.7	1.5	0.6	-0.5	-0.9	0.3	-0.9	-1.1	-1.2
Basal cell carcinoma (self-reported)	0.5	0.7	1.1	0.7	1.1	0.8	-0.3	1.0	1.1	0.5
Depression (Nagel 2018)	0.4	0.6	3.5	0.4	0.1	0.2	1.9	0.2	-0.3	0.4
Alzheimer’s Disease (in mother)	0.4	0.4	1.9	-0.7	0.2	-0.6	-1.4	0.0	0.3	0.0
Alzheimer’s Disease (in father)	0.4	0.4	1.3	-0.6	-0.4	0.4	-1.1	-0.2	-0.9	0.5
Ulcerative Colitis (UC)	0.4	0.8	1.8	1.0	0.3	1.3	1.3	0.9	0.1	0.7
Reaction Time	0.4	0.7	2.0	-0.8	-0.2	-0.4	-1.4	-0.6	-1.0	-0.7
Prostate Cancer	0.4	0.5	2.2	-0.5	-0.8	-0.5	-0.6	0.3	-1.5	0.1
Mean Putamen Volume	0.4	0.4	1.3	1.1	0.4	0.8	0.6	-0.1	0.6	-0.4
LDL Cholesterol	0.4	0.6	1.6	1.3	1.3	0.0	0.7	0.6	-0.1	0.4
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.8	1.3	0.7	-0.3	-0.7	0.1	0.4	-0.1
Tanning	0.4	4.8	8.6	-1.5	-2.8	-2.7	-1.6	-1.9	-1.2	-2.9
Ever used hormone-replacement therapy (HRT)	0.4	0.5	2.0	-0.1	0.3	-0.5	-0.2	-1.4	0.8	0.3
Angina	0.4	0.5	1.1	0.8	0.2	0.1	0.6	1.0	0.4	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.5	0.8	0.4	0.6	1.0	0.1	0.5	1.2
Medication: Levothyroxine sodium	0.4	0.7	3.0	0.2	-0.0	-1.7	-0.2	-1.0	-0.8	-0.0
Pulse rate	0.4	0.6	1.5	-0.9	-1.0	0.4	0.3	-1.2	-0.8	-0.2
Happiness	0.4	0.4	0.9	0.8	0.5	0.5	1.0	0.3	0.3	0.9
Illnesses of mother	0.4	0.5	1.4	1.2	0.5	0.3	0.7	-1.0	-0.6	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	4.0	0.2	-0.8	-1.1	-1.7	-0.1	-0.8	-2.0
Arm fat mass (right)	0.4	1.5	7.2	-0.2	-0.6	-1.5	0.3	-0.8	0.0	-2.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.3	1.0	1.0	0.9	-0.1	-0.2	0.4	1.2
Headache pain in last month	0.4	0.6	2.8	-0.3	0.8	0.7	0.4	0.0	0.0	1.7
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.6	0.4	0.4	-0.1	1.3	-0.6	-1.1	0.4
Migraine (self-reported)	0.4	0.6	1.7	-1.3	-1.1	0.5	-0.6	0.2	-0.5	0.2
Overall health rating	0.4	0.8	3.6	0.8	0.7	0.9	1.9	-0.2	0.2	0.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.1	-0.9	-0.0	0.3	-1.0	0.6	-0.4	-1.0
Smoking status: Previous	0.4	0.6	1.8	-0.2	-0.4	0.6	1.3	0.6	-0.7	1.0
Mineral and other dietary supplements	0.4	0.5	1.8	-0.6	-0.6	0.4	0.3	-0.0	-1.3	-0.8
Osteoporosis (self-reported)	0.4	0.5	2.1	-0.3	-0.3	-0.5	0.1	-0.7	-1.4	0.5
Osteoarthritis (self-reported)	0.4	0.6	1.5	1.0	1.2	-0.1	0.6	0.4	0.4	0.9
Wears glasses or contact lenses	0.4	0.4	1.0	-0.5	-0.1	-0.7	-0.3	0.8	-1.0	0.6
Intelligence (Savage-Jansen 2018)	0.3	0.9	3.2	1.4	0.1	-1.8	0.7	0.1	-0.5	-0.9
Irritable Bowel Disease (IBD)	0.3	0.8	2.9	0.7	0.8	1.7	0.4	0.6	0.8	0.8
Bipolar Disorder (2011)	0.3	0.3	0.6	0.8	0.3	-0.1	0.1	0.6	0.8	0.4
HbA1C	0.3	0.4	0.7	0.8	-0.4	0.4	-0.7	-0.7	-0.1	-0.8
Blood Red Count	0.3	3.0	7.5	-1.6	-2.7	-0.8	-0.6	-1.6	-1.6	-2.2
Hypothyroidism (self reported)	0.3	0.7	2.0	0.1	-0.3	-1.4	0.8	-0.8	-1.0	-0.8
Lung FVC	0.3	1.6	4.9	-0.2	-1.2	-1.0	-1.2	-1.0	-2.2	-1.2
Systolic blood pressure, automated reading	0.3	1.0	1.2	-1.1	-0.8	-1.0	-1.0	-1.0	-0.9	-1.0
Supplements: Zinc	0.3	0.3	0.8	-0.0	0.2	-0.8	-0.6	-0.6	0.9	0.2
Medication: Metformin	0.3	0.4	1.8	-0.0	-0.2	-0.6	-0.4	-0.3	-0.5	-1.4
Maternal smoking around birth	0.3	0.4	1.7	0.4	0.6	-0.3	0.0	-1.3	-0.3	0.6
Age when periods started (menarche)	0.3	0.8	1.9	0.4	0.8	0.5	-0.6	0.8	1.4	1.4
Medication: Atenolol	0.3	0.4	1.2	-0.3	-0.6	-0.4	0.1	0.7	-0.4	-1.1
Waist circumference	0.3	1.0	4.2	0.4	0.6	-0.0	2.1	0.7	1.2	-0.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.8	0.9	0.8	0.2	-0.4	0.2	0.5	0.7
Pain all over the body in last month	0.3	0.3	0.7	0.2	0.3	0.4	0.9	0.8	0.6	0.4
Medication: Simvastatin	0.3	0.5	1.1	-0.3	-0.0	-1.0	-0.5	-0.8	-0.8	-0.7
Medication: Cholesterol lowering	0.3	0.5	1.4	-1.2	-1.0	0.0	0.3	-0.1	-0.6	-0.7
Blood clot in the leg (DVT)	0.3	0.3	0.9	0.4	0.7	0.2	-0.6	0.6	0.9	0.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.0	0.7	-0.1	-1.4	0.6	-0.9	-0.9	0.1
Worry too long after embarrassment	0.3	0.5	1.9	0.2	0.8	-0.1	0.7	-0.3	-0.6	1.4
Medication: Blood pressure	0.3	0.6	1.7	-0.9	-0.8	-0.7	-0.1	0.1	-1.3	-0.5
Medication: Allopurinol	0.3	0.4	1.1	-0.8	-0.4	-0.6	-0.5	0.0	-0.2	-1.1
Medication: Omeprazole	0.3	0.4	1.0	-0.7	0.6	-1.0	-0.2	-0.9	-0.2	-0.0
Leg fat mass (right)	0.3	1.0	2.9	0.8	1.1	0.3	1.3	0.7	1.7	-0.5
Pulse rate, automated reading	0.3	1.1	2.5	-1.6	-1.2	-0.4	0.6	-1.1	-1.3	0.1
Number of full sisters	0.3	0.4	1.0	0.3	0.8	-1.0	0.7	-0.4	0.1	0.6
Had major operations	0.3	0.3	1.0	0.7	-0.5	0.2	1.0	0.3	0.4	-0.6
Illnesses of siblings: Diabetes	0.3	0.4	1.0	-0.6	0.1	-0.2	0.2	0.7	0.9	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	2.1	-0.4	0.0	0.6	0.2	1.0	1.5	-0.3
Average weekly red wine intake	0.3	0.4	1.3	0.7	0.9	-0.1	-0.5	0.0	1.1	0.1
Diabetes diagnosed by doctor	0.3	0.5	1.3	-0.7	-0.4	-0.8	-0.3	-0.5	-0.6	-1.1
Medication: Gliclazide	0.3	0.3	0.6	0.0	0.8	0.6	0.4	0.8	0.4	0.4
Arm fat mass (left)	0.3	1.0	5.5	-0.0	-0.2	-1.1	0.3	-0.5	0.4	-2.3
Guilty feelings	0.3	0.5	1.1	0.5	-0.6	0.1	1.0	-0.3	-1.0	-0.7
Ever taken oral contraceptive pill	0.3	0.3	0.9	0.5	0.3	0.9	0.9	0.1	-0.6	0.2
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.1	0.1	0.4	0.9	0.1	0.2	1.0	0.6
Ever depressed for a whole week	0.3	0.4	1.8	0.2	-0.1	-0.3	-1.3	-0.9	0.2	0.1
Myopia	0.3	0.5	1.2	-1.1	-0.4	0.3	-0.9	1.1	-0.1	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.7	-0.7	0.6	-0.8	0.0	-0.8	0.5	-0.1
Ovarian Cancer	0.2	0.3	0.8	0.3	-0.2	-0.7	0.1	-0.6	0.3	-0.9
HDL Cholesterol	0.2	0.3	0.6	0.2	-0.8	-0.7	0.1	0.2	-0.6	-0.8
Blood Eosinophil Count	0.2	1.6	7.1	1.2	1.0	1.0	2.7	0.6	0.4	0.4
Blood White Count	0.2	1.5	4.9	-0.1	-1.0	-0.6	1.5	-1.4	-2.2	-0.2
Height	0.2	3.7	8.6	1.4	2.0	1.7	0.7	2.7	2.9	1.1
Smoking Status	0.2	0.5	0.9	-0.5	-0.9	-0.3	0.9	-1.0	-0.6	-0.7
Diabetes (mother)	0.2	0.2	0.4	0.3	0.4	0.4	-0.5	-0.6	0.6	-0.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.8	-0.2	-0.3	-0.6	-0.3	-0.5	-0.9	-0.7
Trunk fat mass	0.2	0.8	2.2	0.9	1.0	0.3	1.0	0.7	1.5	-0.4
Had menopause	0.2	0.2	0.7	-0.5	-0.8	0.4	-0.4	0.2	-0.1	-0.4
Worrier / anxious feelings	0.2	0.4	1.3	-0.4	-0.2	-0.5	0.1	-0.8	-1.1	0.6
Standing height	0.2	2.2	4.6	1.6	2.0	0.5	0.8	1.3	2.1	1.2
Birth weight of first child	0.2	0.4	1.2	1.1	0.5	0.4	0.4	0.9	0.3	-0.5
Gout (self-reported)	0.2	0.3	1.1	-0.1	0.2	-0.8	-0.5	-0.1	0.1	-1.0
Medication: Amlodipine	0.2	0.3	1.7	0.3	-0.2	0.6	1.3	0.1	0.1	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.7	0.4	0.3	0.7	-0.4	-0.6	0.1
Age at first live birth	0.2	0.3	0.5	0.3	0.5	-0.6	-0.6	0.7	-0.5	0.4
Whole body fat mass	0.2	0.7	1.7	0.7	0.8	0.1	1.0	0.3	1.3	-0.7
Chest pain or discomfort	0.2	0.3	1.1	1.0	0.5	0.3	0.5	0.5	0.4	-0.2
Knee pain experienced in last month	0.2	0.3	0.8	0.9	0.6	0.1	0.1	-0.9	-0.4	0.4
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.5	-0.5	-0.5	-0.4	-0.2	-0.7	-0.6	-0.4
Ever had bowel cancer screening	0.2	0.2	0.9	-0.0	0.2	0.7	-0.3	0.1	0.9	-0.2
Friendships satisfaction	0.2	0.3	0.8	0.2	-0.7	-0.3	0.2	-0.5	-0.9	-0.3
Qualifications: nursing, teaching	0.2	0.2	0.7	-0.6	-0.1	-0.1	-0.4	-0.2	-0.8	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.5	-0.1	-0.7	-0.7	-0.2	0.3	-0.4	-0.5
Breast cancer (self-reported)	0.2	0.2	0.4	-0.6	-0.4	0.6	-0.3	-0.4	-0.3	0.3
Number of self-reported non-cancer illnesses	0.2	0.4	1.0	0.6	0.4	-0.4	1.0	0.0	-0.8	0.7
Miserableness	0.2	0.4	1.9	0.1	0.6	0.2	0.5	-0.5	-0.3	1.4
Medication: Lisinopril	0.2	0.3	1.5	0.5	0.2	0.0	0.5	1.2	-0.2	-0.4
Medication: Atorvastatin	0.2	0.3	1.0	-0.3	-1.0	0.5	0.4	-0.3	-0.1	-0.4
Fractured/broken bones in last 5 years	0.2	0.2	0.6	0.5	-0.1	-0.0	-0.7	-0.4	-0.7	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.5	0.4	0.7	0.0	-0.7	0.5	0.6	0.3
Alcohol drinker status: Previous	0.2	0.2	0.8	-0.2	0.3	0.1	0.6	-0.9	0.0	-0.1
Leg fat mass (left)	0.2	0.7	1.8	0.8	0.9	0.1	1.1	0.4	1.4	-0.6
Crohns Disease (2017)	0.1	0.3	0.6	-0.4	0.5	0.6	-0.8	-0.4	0.7	0.0
Crohns Disease (2012)	0.1	0.1	0.5	-0.1	0.7	0.2	-0.2	-0.0	0.3	0.1
Triglycerides	0.1	0.1	0.6	0.3	0.1	0.2	0.8	-0.1	0.2	-0.1
Blood Platelet Count	0.1	1.5	3.6	-0.2	0.3	0.6	1.7	1.1	-1.5	1.9
Number of treatments/medications taken	0.1	0.2	0.8	0.3	0.2	-0.7	-0.1	-0.9	-0.5	0.3
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.6	-0.1	-0.3	0.4	0.7	0.1	-0.2	0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	0.2	-0.4	0.2	-0.4	0.1	0.1	-0.3
Alcohol usually taken with meals	0.1	0.2	0.6	0.3	-0.1	-0.6	-0.8	0.2	-0.2	-0.0
Forced vital capacity (FVC)	0.1	0.4	1.1	0.5	-0.2	-0.2	-1.0	-0.4	-0.6	-1.1
Heart attack	0.1	0.1	0.4	-0.1	0.1	-0.4	-0.2	-0.2	-0.1	-0.6
Arm fat percentage (right)	0.1	0.5	2.1	0.3	0.1	-0.5	0.8	-0.2	0.5	-1.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	-0.5	-0.5	0.2	0.2	-0.1	-0.4	0.1
Hair/balding pattern: Pattern 4	0.1	0.3	0.9	0.5	-0.2	-0.2	-0.1	0.9	0.8	-0.6
Loud music exposure frequency	0.1	0.1	0.3	0.6	-0.1	0.6	0.4	-0.1	0.4	0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.7	-0.9	0.1	0.4	0.2	-0.5	-0.5	0.3
Birth weight	0.1	0.2	0.4	0.5	0.2	-0.2	0.0	0.6	0.6	-0.7
Forced vital capacity (FVC), Best measure	0.1	0.5	1.4	1.1	0.1	-0.4	-1.2	0.3	-0.3	-0.9
Arm fat percentage (left)	0.1	0.5	2.1	0.4	0.2	-0.1	0.8	-0.0	0.7	-1.5
Average weekly champagne plus white wine intake	0.1	0.1	0.4	-0.4	0.1	-0.4	0.1	0.6	-0.3	0.4
Hearing aid user	0.1	0.1	0.2	0.1	0.2	0.5	0.1	0.3	0.4	0.3
Mother’s age at death	0.1	0.2	0.4	-0.1	0.2	0.5	-0.3	0.5	0.6	0.5
High cholesterol (Self-reported)	0.1	0.2	0.9	0.0	-0.0	0.6	1.0	0.4	0.0	-0.1
Risk taking	0.1	0.1	0.4	-0.2	-0.2	0.6	-0.4	-0.5	-0.1	-0.2
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.5	-0.2	0.1	-0.5	-0.2	-0.4	-0.2	-0.7
Breast Cancer	0.0	0.1	0.3	0.2	-0.1	-0.6	0.4	0.1	0.0	0.0
Hair Pigment	0.0	0.2	0.8	0.5	0.5	-0.5	-0.0	0.0	-0.3	0.9
Pain experienced in last month	0.0	0.1	0.2	-0.1	-0.3	-0.4	-0.3	0.2	0.2	-0.3

Hub : Genes

MMP16

Models

Trait associations