TWAS
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Genes
Traits
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Traits
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Impedance of leg (right)
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chr9:12,410,173-13,977,570
Best TWAS P=1.58e-10 · Best GWAS P=4.61e-11 conditioned to 0.0584
12.4M
12.6M
12.8M
13M
13.2M
13.4M
13.6M
13.8M
14M
0
2
4
6
8
10
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Cells Transformed fibroblasts
MPDZ
0.30
0.35
enet
28
0.34
4.3e-26
6.6
-6.4
1.6e-10
-0.9
0
1
TRUE
2
GTEx
Nerve Tibial
MPDZ
0.21
0.15
enet
23
0.22
2.1e-15
6.6
-5.9
4.3e-09
-0.8
0
1
FALSE