TWAS
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Impedance of leg (right)
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chr10:71,736,472-73,345,380
Best TWAS P=1.42e-13 · Best GWAS P=5.09e-20 conditioned to 0.0611
71.8M
72M
72.2M
72.4M
72.6M
72.8M
73M
73.2M
73.4M
0
5
10
15
20
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
ROSMAP
Brain Pre-frontal Cortex
ADAMTS14
0.38
0.35
bslmm
710
0.47
3.9e-67
8.8
7.4
1.4e-13
0.79
0.02
0.98
TRUE
2
GTEx
Artery Tibial
PCBD1
0.19
0.01
lasso
6
0.01
3.0e-02
-5.2
5.9
4.6e-09
0.43
0.11
0.18
TRUE
1
CommonMind
Brain Pre-frontal Cortex
ADAMTS14
0.28
0.24
bslmm
733
0.35
7.9e-44
-3.0
6.7
2.2e-11
0.74
0.08
0.92
FALSE
4
The Cancer Genome Atlas
Breast Invasive Carcinoma
ADAMTS14
0.05
0.03
enet
17
0.03
3.4e-07
-3.0
5.8
7.6e-09
0.67
0.40
0.60
FALSE