Best TWAS P=1.72e-10 · Best GWAS P=1.34e-09 conditioned to 0.01
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | C10orf11 | 0.24 | 0.21 | lasso | 9 | 0.20 | 3.3e-16 | -6.0 | 6.2 | 5.2e-10 | -0.70 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | C10orf11 | 0.40 | 0.32 | enet | 11 | 0.27 | 2.2e-14 | -6.0 | 6.3 | 2.2e-10 | -0.68 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Adrenal Gland | C10orf11 | 0.24 | 0.22 | enet | 21 | 0.18 | 5.8e-07 | -6.0 | 6.0 | 2.0e-09 | -0.71 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Artery Aorta | VCL | 0.17 | 0.06 | lasso | 9 | 0.09 | 7.9e-06 | -4.0 | 5.8 | 7.8e-09 | 0.02 | 0.32 | 0.60 | TRUE |
| 5 | GTEx | Esophagus Muscularis | C10orf11 | 0.45 | 0.39 | enet | 42 | 0.38 | 5.1e-24 | -6.0 | 6.1 | 1.4e-09 | -0.65 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Lung | C10orf11 | 0.30 | 0.26 | lasso | 5 | 0.24 | 2.0e-18 | -6.0 | 6.1 | 8.8e-10 | -0.70 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Testis | ZNF503-AS2 | 0.16 | 0.02 | lasso | 4 | 0.06 | 1.3e-03 | -6.1 | -5.5 | 2.9e-08 | 0.91 | 0.00 | 0.96 | FALSE |
| 8 | GTEx | Thyroid | C10orf11 | 0.38 | 0.21 | lasso | 9 | 0.25 | 6.7e-19 | -5.6 | 6.4 | 1.7e-10 | -0.67 | 0.01 | 0.99 | TRUE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | VCL | 0.02 | 0.00 | blup | 57 | 0.01 | 5.7e-04 | -5.7 | 5.6 | 2.0e-08 | 0.05 | 0.00 | 0.91 | FALSE |
| 10 | The Cancer Genome Atlas | Lung Adenocarcinoma | VCL | 0.04 | 0.03 | lasso | 1 | 0.02 | 5.8e-04 | -5.3 | 5.3 | 1.1e-07 | 0.03 | 0.01 | 0.92 | FALSE |
| 11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | VCL | 0.08 | 0.06 | blup | 56 | 0.07 | 1.5e-07 | -5.7 | 5.5 | 3.7e-08 | 0.05 | 0.00 | 1.00 | FALSE |
| 12 | The Cancer Genome Atlas | Thyroid Carcinoma | VCL | 0.08 | 0.02 | blup | 57 | 0.05 | 7.6e-06 | -4.1 | 5.8 | 8.6e-09 | 0.06 | 0.10 | 0.78 | FALSE |