Best TWAS P=2.19e-17 · Best GWAS P=6.45e-49 conditioned to 2.6e-35
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LOC730102 | 0.18 | 0.12 | lasso | 9 | 0.12 | 1.4e-14 | -6.3 | 7.3 | 2.4e-13 | -0.31 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | RP11-568K15.1 | 0.38 | 0.21 | lasso | 9 | 0.20 | 1.3e-16 | -6.3 | 6.1 | 9.0e-10 | -0.27 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | RP11-568K15.1 | 0.29 | 0.04 | lasso | 4 | 0.14 | 9.4e-08 | 1.8 | 5.3 | 1.3e-07 | -0.24 | 0.72 | 0.02 | FALSE |
| 4 | GTEx | Artery Aorta | RP11-568K15.1 | 0.28 | 0.02 | lasso | 10 | 0.14 | 3.2e-08 | -6.3 | 5.6 | 2.5e-08 | -0.25 | 0.80 | 0.02 | FALSE |
| 5 | GTEx | Artery Tibial | RP11-568K15.1 | 0.14 | 0.10 | lasso | 4 | 0.10 | 2.0e-08 | -6.3 | 6.4 | 1.2e-10 | -0.28 | 0.98 | 0.00 | FALSE |
| 6 | GTEx | Breast Mammary Tissue | RP11-568K15.1 | 0.20 | 0.11 | lasso | 7 | 0.09 | 2.0e-05 | -6.3 | 5.7 | 1.3e-08 | -0.27 | 0.75 | 0.01 | FALSE |
| 7 | GTEx | Breast Mammary Tissue (Male) | RP11-568K15.1 | 0.15 | 0.18 | lasso | 3 | 0.15 | 2.1e-04 | -6.3 | 6.2 | 4.0e-10 | -0.28 | 0.06 | 0.08 | FALSE |
| 8 | GTEx | Cells Transformed fibroblasts | RP11-568K15.1 | 0.39 | 0.15 | lasso | 10 | 0.22 | 2.5e-16 | -4.6 | 5.5 | 3.5e-08 | -0.26 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Esophagus Mucosa | RP11-568K15.1 | 0.22 | 0.11 | lasso | 7 | 0.13 | 5.9e-09 | -6.3 | 5.9 | 4.5e-09 | -0.27 | 0.89 | 0.05 | FALSE |
| 10 | GTEx | Esophagus Muscularis | RP11-568K15.1 | 0.26 | 0.17 | lasso | 7 | 0.18 | 5.7e-11 | -6.3 | 5.6 | 2.4e-08 | -0.25 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Heart Atrial Appendage | RP11-568K15.1 | 0.22 | 0.17 | lasso | 6 | 0.18 | 2.7e-08 | -6.3 | 7.0 | 3.3e-12 | -0.29 | 0.92 | 0.01 | FALSE |
| 12 | GTEx | Lung | RP11-568K15.1 | 0.22 | 0.06 | lasso | 5 | 0.14 | 6.4e-11 | -6.3 | 6.2 | 6.1e-10 | -0.27 | 0.99 | 0.00 | FALSE |
| 13 | GTEx | Muscle Skeletal | SEC16B | 0.18 | 0.04 | lasso | 6 | 0.05 | 2.3e-05 | -6.3 | -6.0 | 1.4e-09 | 0.32 | 0.47 | 0.02 | FALSE |
| 14 | GTEx | Muscle Skeletal | RP4-798P15.3 | 0.18 | 0.02 | lasso | 6 | 0.04 | 1.7e-04 | -6.3 | -6.0 | 2.3e-09 | 0.32 | 0.28 | 0.03 | FALSE |
| 15 | GTEx | Nerve Tibial | RP11-568K15.1 | 0.44 | 0.15 | enet | 37 | 0.27 | 3.4e-19 | -6.3 | 5.8 | 5.2e-09 | -0.27 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Skin Sun Exposed Lower leg | RP11-568K15.1 | 0.11 | 0.05 | enet | 20 | 0.04 | 1.3e-04 | -6.3 | 8.5 | 2.2e-17 | -0.38 | 0.57 | 0.11 | TRUE |