Hub : Genes

SEC16B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0640	0.0280	1.0e-02	0.007	0.002	-0.002	0.004	0.002	4.2e-02	0.16	7.8e-01	0.083	1.7e-01
2	GTEx	Lung	0.1566	0.0612	4.7e-03	0.069	NA	0.071	NA	0.066	5.5e-06	NA	3.8e-06	NA	9.6e-06
3	GTEx	Muscle Skeletal	0.1822	0.0661	2.2e-04	0.037	NA	0.030	NA	0.046	1.3e-04	NA	6.0e-04	NA	2.4e-05
4	GTEx	Nerve Tibial	0.2378	0.0586	9.2e-06	0.123	NA	0.175	NA	0.177	4.8e-09	NA	2.0e-12	NA	1.4e-12
5	TCGA	Prostate Adenocarcinoma	0.0663	0.0347	8.3e-03	0.026	0.004	0.020	NA	0.028	8.8e-04	0.12	3.2e-03	NA	5.3e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.5	0.8	1.8	-1.3	-1.3	-0.3	0.8	-0.1
Bipolar Disorder or Schizophrenia	0.7	1.6	3.5	-1.9	-0.7	-1.7	-0.8	-0.6
Depressed Affect (Nagel 2018)	0.7	1.4	4.0	-0.3	-0.7	-1.2	-0.9	2.0
Depression (Nagel 2018)	2.2	3.3	9.5	-0.1	-0.2	-3.1	-2.5	0.8
Intelligence (Savage-Jansen 2018)	0.5	1.6	2.9	1.6	1.1	-0.5	-1.2	-1.7
Neuroticism (Nagel 2018)	0.5	1.1	2.4	-1.3	-0.4	-1.5	-1.1	0.3
Schizophrenia (2018)	0.8	1.7	4.0	-1.3	0.2	-2.0	-1.6	-0.6
Schizophrenia vs Biploar Disorder	0.8	1.1	3.4	-1.8	-0.2	-0.2	-0.7	-1.2
Worry (Nagel 2018)	0.8	1.7	5.2	-1.2	-0.4	-2.3	-1.0	-0.6
Alzheimer’s Disease (in mother)	1.1	1.2	2.2	0.0	1.5	0.3	1.5	1.3
Alzheimer’s Disease (in father)	2.1	2.2	5.2	-1.2	1.2	2.3	1.6	-0.6
Alzheimer’s Disease (including proxy)	1.1	1.6	2.4	-1.4	1.4	1.1	1.6	0.7
Crohns Disease (2017)	0.8	1.7	4.1	-1.0	-0.9	-2.0	-0.4	1.6
Irritable Bowel Disease (IBD)	0.7	1.7	4.2	-0.9	-0.2	-2.1	-0.6	1.8
Ulcerative Colitis (UC)	0.4	0.7	1.7	-0.4	0.5	-1.1	-0.2	1.3
Major Depression (MDD)	1.0	1.2	3.3	-0.6	0.7	-0.7	1.0	1.8
Reaction Time	0.7	1.3	2.6	-1.2	-0.2	1.2	1.0	-1.6
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.6	-0.2	1.1	0.3	-0.2	-1.6
Breast Cancer	0.9	2.2	3.6	1.9	0.0	1.8	1.9	-0.7
Ovarian Cancer	0.9	1.2	2.6	1.6	-1.3	0.4	-1.1	-0.8
Prostate Cancer	1.9	2.7	7.8	-1.5	-1.3	-0.9	-0.9	2.8
Age at First Birth	1.1	1.6	5.0	-0.8	2.2	0.4	1.5	0.5
Bipolar Disorder (2011)	0.7	0.7	1.9	-1.4	-0.5	-0.7	-0.0	1.0
Body Mass Index (BMI) (2010)	1.2	1.7	4.0	0.6	-1.6	2.0	1.1	0.3
Coronary Artery Disease (CAD)	1.1	1.3	3.1	1.6	-1.8	-0.4	-0.6	-0.5
Crohns Disease (2012)	0.6	1.0	3.2	-1.8	-0.3	-0.9	0.7	0.5
Mean Putamen Volume	0.3	0.3	1.0	-1.0	0.5	-0.2	0.3	0.6
Fasting Glucose	0.2	0.3	0.8	0.3	0.7	-0.2	-0.2	0.9
HbA1C	1.1	1.3	2.6	1.5	1.6	-0.7	-1.0	0.3
HDL Cholesterol	0.6	1.0	1.6	-1.3	0.6	-0.5	-1.3	-1.0
LDL Cholesterol	2.8	4.4	12.5	2.0	-0.3	-2.2	-3.5	0.4
Lupus	0.8	1.3	4.7	2.2	-0.3	-0.9	0.6	0.5
Neuroticism (2016)	0.9	1.3	2.6	-0.4	-1.1	-1.3	-1.6	0.9
Primary Biliary Cirrhosis	1.3	1.8	3.2	0.1	-1.6	-1.8	-1.5	1.1
Rheumatoid Arthritis	1.3	1.8	4.9	1.4	0.8	-2.2	-0.6	1.2
Schizophrenia (2014)	0.9	2.1	7.2	-2.7	-0.0	-1.5	-0.8	-0.6
Triglycerides	0.4	0.7	1.7	-0.9	-1.3	0.9	0.3	-0.1
Type 2 Diabetes (T2D) (2012)	1.7	1.9	7.1	-0.5	0.1	1.4	2.7	0.7
Ulcerative Colitis	0.6	0.8	2.8	-0.5	0.3	-0.9	-0.4	1.7
Blood Eosinophil Count	0.2	1.2	2.0	-1.1	-1.1	1.4	1.1	0.5
Blood Platelet Count	0.6	6.8	17.6	-4.2	0.5	-2.3	-0.6	3.2
Blood Red Count	0.1	0.9	2.4	1.6	-0.9	1.0	-0.2	0.1
Blood White Count	0.4	2.7	7.9	-2.8	-0.9	0.7	1.7	1.2
Heel T-Score	0.7	5.3	10.8	3.3	-2.3	-1.4	-2.6	1.3
BMI	3.7	21.3	52.9	3.1	-3.3	7.3	5.5	1.7
Height	0.4	8.4	12.8	2.3	2.5	3.2	3.6	-2.6
Waist Hip Ratio (WHR)	0.2	0.8	1.7	0.0	0.8	-1.1	-1.3	0.6
Systolic Blood Pressure	0.2	1.0	2.9	-0.1	1.2	-1.7	-0.8	0.4
Smoking Status	1.6	3.7	9.3	-2.0	-2.1	3.1	0.8	-0.2
Allergy or Eczema	0.7	1.9	5.8	0.3	2.4	-1.7	-0.7	0.6
Cardiovascular Disease	0.4	1.4	2.7	1.0	-0.4	1.1	1.6	1.4
Hypothyroidism (self reported)	0.6	1.4	4.6	-0.6	-1.0	0.9	0.6	-2.1
Respiratory disease	0.9	1.9	5.2	-1.8	0.2	2.3	0.6	-0.9
Type 2 Diabetes (T2D) (2018)	1.3	2.4	6.6	2.6	-0.1	0.9	2.1	0.5
Lung FEV1/FVC ratio	0.4	2.1	7.3	0.6	-2.7	1.4	0.5	-0.5
Lung FVC	0.5	2.5	9.2	-0.5	0.8	-3.0	-1.5	-0.0
Neuroticism	0.6	1.5	6.0	-2.4	-0.8	-0.8	0.2	0.6
Chronotype (morning person)	0.2	0.5	1.6	-0.5	-0.6	-0.1	-0.2	1.3
Hair Pigment	0.0	0.4	1.5	-0.5	-0.1	0.4	0.0	-1.2
Tanning	0.1	1.8	3.6	-1.9	-1.9	0.8	-0.1	-1.1
Hand grip strength (left)	0.4	1.1	3.8	0.9	0.6	0.6	0.0	-1.9
Number of treatments/medications taken	0.5	1.0	4.0	2.0	-0.2	0.1	0.4	0.8
Average weekly spirits intake	0.4	0.5	1.6	1.3	-0.0	0.1	0.6	0.5
Sensitivity / hurt feelings	0.5	0.8	3.1	-1.8	-0.7	-0.2	-0.4	-0.5
Frequency of depressed mood in last 2 weeks	1.2	1.7	5.3	-0.3	-0.0	-2.3	-1.5	1.0
Hearing difficulty/problems: Yes	0.4	0.6	0.9	-0.7	-0.8	1.0	0.1	-0.9
Relative age of first facial hair	1.2	2.4	4.2	-1.9	1.4	-2.0	-1.3	0.9
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	3.0	-1.1	-1.7	0.3	0.5	1.1
Ever used hormone-replacement therapy (HRT)	2.4	3.1	4.2	2.0	0.9	-2.1	-2.0	1.5
Ever had hysterectomy (womb removed)	0.4	0.5	1.7	1.3	0.7	-0.4	-0.4	0.1
Systolic blood pressure, automated reading	0.4	1.2	2.5	1.6	-0.2	-1.0	-1.4	-0.4
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.5	1.2	-0.1	-0.7	-0.6	1.1
Angina	0.5	0.7	1.7	0.2	-0.9	0.8	0.5	1.3
Medication for hormone replacement therapy	0.8	0.9	2.4	0.4	0.4	-1.3	-1.6	0.1
Vitamin and mineral supplements	0.4	0.5	1.9	0.6	-0.5	1.4	0.3	0.3
Supplements: Zinc	2.6	2.8	10.4	0.0	3.2	-1.1	1.5	0.4
Medication: Co-codamol	0.3	0.4	0.8	0.1	0.7	0.4	0.9	0.7
Medication: Metformin	1.0	1.4	2.8	1.6	-0.5	1.0	1.7	0.7
Diabetes (father)	0.2	0.3	0.6	-0.6	-0.8	0.5	0.2	-0.4
Diabetes (mother)	0.5	0.7	1.5	1.2	-0.5	0.5	0.9	0.6
Severe depression (siblings)	0.9	1.0	2.8	-1.0	-1.7	0.4	-1.1	0.2
Pack years adult smoking proportion	0.3	0.4	0.9	-0.4	-0.5	0.8	0.0	-1.0
Impedance of leg (right)	2.7	13.3	36.6	-1.4	3.5	-6.0	-3.9	-0.1
Leg fat-free mass (left)	3.1	16.5	46.6	1.8	-2.2	6.8	5.3	0.0
Trunk fat percentage	1.8	7.1	11.2	2.8	0.0	3.4	3.2	2.5
Hand grip strength (right)	0.2	0.7	1.6	-0.2	1.1	0.3	0.6	-1.3
Townsend deprivation index at recruitment	3.1	4.4	9.6	-2.3	-1.7	3.1	1.7	1.0
Current tobacco smoking	2.5	4.2	10.0	-2.5	-3.2	2.0	0.3	-0.4
Average weekly fortified wine intake	2.4	2.8	8.0	-1.3	2.8	-1.6	-0.9	1.0
Maternal smoking around birth	0.6	0.8	3.2	-0.8	-0.3	0.5	0.1	1.8
Fed-up feelings	1.2	2.2	3.9	0.1	-1.1	-1.9	-1.5	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	6.5	-0.7	0.0	-2.5	-2.1	-0.4
Relative age voice broke	1.9	2.9	4.6	-1.5	1.9	-2.1	-1.9	-0.1
Taking other prescription medications	0.2	0.4	0.5	0.6	0.4	0.6	0.7	0.7
Age when periods started (menarche)	1.3	3.2	9.4	-1.1	1.1	-3.1	-2.0	-0.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.6	1.2	-0.2	-0.5	-0.3	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	5.2	1.6	-2.3	0.4	-1.1	0.8
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	2.1	-1.4	-0.2	-0.1	0.9	0.6
Qualifications: CSEs or equivalent	0.2	0.3	1.0	0.6	0.1	-1.0	0.2	-0.4
Serious illness, injury or assault to yourself	0.5	0.7	1.7	-0.4	1.3	-1.0	-0.4	0.5
High blood pressure	0.4	1.0	2.0	1.4	0.5	0.9	0.7	1.3
Hayfever, allergic rhinitis or eczema	0.5	1.2	3.3	-0.0	1.8	-1.3	-0.6	0.8
Multivitamins +/- minerals	0.5	0.6	1.2	-0.5	-0.2	-1.1	-0.4	-1.1
Stomach or abdominal pain in last month	0.5	0.6	1.2	-1.1	-0.8	0.6	0.6	0.5
Supplements: Glucosamine	0.4	0.6	1.3	1.1	-0.1	-0.8	-0.7	0.6
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	1.6	-0.8	1.2	-1.1	0.1	1.2
Medication: Atenolol	0.6	0.8	2.4	-0.3	-0.9	0.6	0.4	1.5
Medication: Levothyroxine sodium	0.1	0.2	0.8	0.5	-0.3	0.1	-0.3	-0.9
Sitting height	0.5	3.7	10.4	0.5	0.5	2.5	3.2	-1.2
Chronic bronchitis/emphysema (father)	0.1	0.2	0.6	-0.8	-0.1	0.2	0.1	-0.3
High blood pressure (mother)	0.3	0.5	1.1	-1.0	-0.5	-0.3	-0.5	0.8
Body mass index (BMI)	3.0	13.0	28.6	3.4	-1.8	5.3	4.2	1.9
Impedance of leg (left)	2.9	14.3	40.3	-1.0	3.0	-6.3	-4.6	-0.2
Leg predicted mass (left)	3.1	16.2	45.7	1.8	-2.2	6.8	5.2	0.0
Trunk fat mass	2.4	10.5	20.5	3.2	-0.6	4.5	4.1	2.2
Waist circumference	2.7	10.0	21.6	3.4	-1.2	4.7	3.6	1.3
Number of incorrect matches in round	0.7	1.2	2.7	-0.5	-0.3	1.4	1.6	1.1
Past tobacco smoking	0.3	0.5	1.6	0.1	0.4	-1.0	-0.1	-1.3
Alcohol usually taken with meals	0.6	0.9	2.7	0.7	0.7	-1.6	-0.3	-0.8
Nervous feelings	1.0	1.9	7.3	-2.7	-0.5	-1.1	-0.9	-0.4
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	6.4	-1.2	-0.6	-2.5	-1.4	-0.3
Hearing difficulty/problems with background noise	0.7	1.1	3.0	-0.1	-1.7	1.2	0.1	-1.1
Hair/balding pattern: Pattern 2	0.3	0.3	0.8	0.4	0.8	-0.9	0.2	0.1
Had menopause	0.6	0.7	1.9	1.4	0.8	-0.0	-0.6	0.9
Had other major operations	1.7	2.1	3.4	-1.0	-1.4	1.8	1.4	-1.4
Forced vital capacity (FVC)	0.2	0.7	1.3	-1.1	0.3	-0.7	0.4	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	4.0	2.0	-1.7	-0.6	-1.4	1.5
Ever unenthusiastic/disinterested for a whole week	1.8	2.3	4.2	-1.2	2.0	0.7	1.5	1.6
Qualifications: None of the above	0.7	1.4	2.6	1.2	-1.2	1.6	1.3	0.2
Financial difficulties in last 2 years	0.2	0.3	0.6	-0.7	-0.3	0.8	0.5	-0.5
Mouth/teeth dental problems	0.2	0.3	1.3	-1.1	0.6	0.3	-0.1	-0.0
Heart attack	0.3	0.4	1.2	0.5	-1.1	0.6	0.4	0.3
Allergy	0.5	1.0	3.3	0.6	-1.8	0.1	0.2	-1.2
Pain all over the body in last month	1.1	1.2	2.5	-1.6	-0.9	0.6	-0.8	-1.2
Diabetes (self-reported)	1.6	2.4	10.7	3.3	-0.2	-0.7	0.5	0.8
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.3	0.5	-0.5	0.1	0.3	-0.4
Medication: Ramipril	1.5	1.9	5.5	-0.9	-2.4	1.2	1.1	0.7
Medication: Simvastatin	1.3	1.9	7.1	2.7	-0.5	-0.0	-0.6	1.4
Fluid intelligence score	0.3	0.6	1.3	-0.5	1.1	-0.4	-0.7	-0.8
Illnesses of siblings	0.8	1.1	2.4	-1.6	0.4	-1.3	-0.7	-1.0
Neuroticism score	0.5	1.1	3.8	-2.0	-1.1	-0.6	-0.1	0.1
Weight	3.2	15.8	37.4	3.7	-1.3	6.1	5.0	1.1
Impedance of arm (right)	1.3	6.3	16.6	-1.4	2.2	-4.1	-2.8	0.2
Arm fat percentage (right)	2.6	10.2	19.5	3.2	-0.9	4.4	3.8	2.4
Trunk fat-free mass	2.0	11.2	29.8	2.1	-1.8	5.5	4.3	-0.6
Hip circumference	2.9	12.4	31.8	2.4	-1.4	5.6	4.6	1.2
Time employed in main current job	0.8	0.9	3.4	0.7	-0.5	1.8	0.5	-0.1
Alcohol intake versus 10 years previously	1.7	2.5	5.9	1.3	-1.5	2.4	0.2	-1.6
Father’s age at death	0.8	1.1	2.4	-0.3	1.6	-0.8	-0.5	-1.5
Worrier / anxious feelings	0.8	1.4	4.4	-1.4	-0.3	0.1	0.7	-2.1
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	3.3	-0.5	-0.4	-1.8	-0.8	1.4
Falls in the last year	1.7	2.2	5.9	0.2	-2.4	-0.9	-2.1	0.0
Hair/balding pattern: Pattern 3	0.5	0.8	2.7	-0.3	1.6	-0.4	0.9	0.1
Number of live births	0.8	1.1	2.0	-1.0	-1.4	0.5	0.8	1.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.0	-1.0	-0.1	-0.8	0.8	-0.9
Pulse rate	0.6	1.0	2.1	-0.9	0.6	1.2	1.4	0.4
Happiness	3.4	4.2	9.9	-1.4	-0.6	-2.1	-2.1	3.1
Noisy workplace	2.3	2.8	12.9	0.5	-3.6	0.7	-0.6	0.0
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.3	-1.1	-1.1	-0.1	-0.1	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.6	0.6	-0.3	-0.4	-0.5	-0.8
Mouth/teeth dental problems: Dentures	0.6	1.0	3.2	0.5	-1.8	1.2	0.4	-0.3
Asthma	0.5	1.1	5.0	-0.4	-0.2	2.2	-0.4	-0.2
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	5.6	-0.2	2.4	-1.5	0.3	-0.8
Medication: Cholesterol lowering	0.4	0.7	1.7	1.1	-0.3	-0.0	0.6	1.3
Depression (self-reported)	2.8	3.4	8.5	-0.4	-0.4	-2.7	-2.9	0.9
Medication: Lansoprazole	1.2	1.4	4.0	2.0	-0.9	0.7	0.3	1.3
Prospective memory result	1.9	2.3	6.1	-0.1	0.4	2.3	2.5	0.1
Lung cancer (father)	0.8	0.9	2.3	-0.5	-1.5	0.9	1.0	0.3
Illnesses of mother	0.1	0.1	0.3	0.1	0.2	-0.5	-0.2	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.6	-0.4	0.2	-0.7	0.7	-0.7
Pulse wave Arterial Stiffness index	0.4	0.5	0.8	0.1	-0.7	0.9	0.7	-0.8
Impedance of arm (left)	1.5	6.9	19.0	-1.9	2.1	-4.4	-2.7	0.4
Arm fat mass (right)	3.3	13.7	31.4	3.5	-1.4	5.6	4.5	1.6
Trunk predicted mass	2.0	11.3	30.4	2.0	-1.8	5.5	4.3	-0.5
Standing height	0.3	3.1	5.3	1.2	1.0	2.2	2.3	-1.7
Length of working week for main job	0.6	0.7	1.9	0.4	-0.5	-0.4	-1.0	-1.4
Exposure to tobacco smoke at home	0.2	0.2	0.6	-0.4	0.8	-0.4	0.1	0.4
Breastfed as a baby	0.8	1.0	4.0	2.0	0.3	-0.2	-0.8	-0.1
Tense / ‘highly strung’	0.6	1.0	3.4	-1.0	-0.4	-1.8	-0.4	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.5	4.9	-1.0	-0.8	-2.2	-2.2	1.1
Hair/balding pattern: Pattern 4	0.4	1.0	2.5	0.2	-1.6	-0.6	-0.1	1.4
Birth weight of first child	0.3	0.6	2.5	0.3	0.4	0.4	1.6	-0.2
Peak expiratory flow (PEF)	0.8	1.8	5.0	-1.1	-1.2	1.0	2.2	-0.3
Pulse wave reflection index	0.7	0.9	2.9	0.7	-1.7	0.2	0.2	-1.0
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.3	-1.5	-0.1	-0.6	-0.6	1.1
Loud music exposure frequency	0.1	0.1	0.3	0.2	0.3	0.1	-0.5	-0.5
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	2.1	-0.5	-1.3	-0.1	-1.4	-1.4
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	3.9	2.0	0.7	-1.0	-0.2	-0.7
Blood clot in the leg (DVT)	0.8	1.1	4.9	-0.6	-0.3	-0.2	0.2	2.2
Medication: Paracetamol	0.7	1.2	3.3	1.1	1.8	-0.5	1.2	0.1
Headache pain in last month	1.2	2.1	3.6	-1.0	1.7	-1.9	-0.5	1.6
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	4.4	-2.0	0.1	-0.1	-0.6	-2.1
Glaucoma (self-reported)	0.6	0.7	2.3	1.5	0.7	-0.1	-0.4	0.7
Gout (self-reported)	0.1	0.2	0.3	0.4	0.1	0.6	0.4	-0.4
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	4.7	0.2	-0.2	1.3	0.7	-2.2
Medication: Amlodipine	1.4	1.9	4.5	0.1	1.1	1.9	2.1	-0.1
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.4	-1.2	-0.7	1.1	1.0	0.1
Birth weight	1.3	2.9	5.6	0.9	2.4	2.0	2.0	-0.5
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.0	-1.1	0.7	-0.2	0.2	1.4
High blood pressure (siblings)	1.1	1.5	3.0	1.7	-1.1	-0.1	-0.9	1.6
Forced vital capacity (FVC), Best measure	0.2	0.8	1.2	-1.0	1.1	-0.4	0.8	-1.0
Body fat percentage	1.9	7.6	11.4	3.4	-0.2	3.2	3.0	2.6
Leg fat percentage (right)	1.6	5.8	11.3	3.4	-0.1	2.5	2.4	2.3
Arm fat-free mass (right)	2.1	11.0	30.4	2.1	-1.6	5.5	4.2	-0.1
Exposure to tobacco smoke outside home	0.5	0.7	1.3	-1.1	-0.9	0.7	1.0	0.1
Comparative body size at age 10	5.4	14.9	35.6	2.4	-4.0	6.0	3.8	1.6
Number of full brothers	1.2	1.6	3.9	0.4	-0.9	-1.6	-2.0	0.7
Worry too long after embarrassment	1.2	2.0	4.2	-2.1	-0.6	1.4	0.9	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.6	-0.4	-1.3	-0.2	-1.0	0.2
Wheeze or whistling in the chest in last year	0.7	1.3	2.4	0.1	-1.6	0.2	-1.4	1.5
Number of children fathered	0.6	0.7	1.8	0.9	0.4	-0.3	-1.3	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.8	-0.3	0.8	1.4	0.2	-0.2
Age at first live birth	0.4	0.7	1.4	-1.1	1.2	-0.1	0.8	-0.1
Pulse wave peak to peak time	0.3	0.3	0.8	0.1	0.9	-0.7	-0.5	0.3
Health satisfaction	0.4	0.5	2.4	0.0	0.4	0.2	0.4	1.5
Shortness of breath walking on level ground	0.7	0.9	1.8	-0.9	0.2	1.3	0.6	1.2
Qualifications: College or University degree	0.4	1.2	2.7	-0.1	1.6	-1.5	-1.0	-0.6
Eye problems/disorders: None of the above	0.1	0.1	0.4	-0.2	-0.6	0.4	0.1	0.0
Mouth/teeth dental problems: Loose teeth	1.7	2.0	6.8	2.6	1.7	-0.3	0.3	0.1
Emphysema/chronic bronchitis	0.9	1.0	2.6	-0.1	-0.7	1.6	1.3	-0.1
Medication for pain relief, constipation, heartburn	1.0	1.7	3.8	-1.7	-0.7	1.9	0.7	-0.7
Neck or shoulder pain in last month	0.1	0.1	0.3	0.1	0.0	0.3	0.5	-0.1
Medication: Blood pressure	0.5	0.9	1.3	1.1	-0.5	1.0	1.0	1.1
Angina (self-reported)	0.6	0.7	1.9	0.1	-0.9	0.8	0.6	1.4
Migraine (self-reported)	1.6	2.0	7.0	-2.6	-1.7	-0.0	0.4	-0.2
Medication: Ibuprofen	1.0	1.1	3.7	-0.5	1.9	-1.2	0.2	-0.6
Medication: Allopurinol	0.5	0.7	2.3	1.5	0.5	0.5	0.6	-0.2
Medication: Omeprazole	3.5	4.2	7.4	2.7	0.2	-2.4	-2.6	-0.7
Medication: Seretide 50 evohaler	1.7	2.0	4.9	-2.0	-0.5	2.2	0.9	0.1
Mean time to correctly identify matches	0.5	0.9	2.6	-0.3	-0.8	1.0	0.3	-1.6
Heart disease (mother)	0.5	0.7	1.5	1.2	0.8	-0.3	0.0	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.6	-0.5	-1.3	-0.0	0.1	1.2
Whole body fat mass	2.8	11.5	22.4	3.6	-1.0	4.7	4.1	2.1
Leg fat mass (right)	2.6	10.1	20.0	3.6	-1.0	4.5	3.6	1.9
Arm predicted mass (right)	2.0	10.5	28.3	2.3	-1.4	5.3	4.1	0.2
Pulse rate, automated reading	0.2	0.7	2.4	-1.6	-0.2	0.8	0.6	0.2
Alcohol intake frequency.	0.5	1.3	3.2	1.0	-1.8	1.2	-0.2	0.8
Comparative height size at age 10	0.7	4.0	9.3	3.0	-0.8	2.6	1.7	-0.6
Number of full sisters	0.5	0.6	1.6	-0.1	-1.3	1.2	0.1	0.2
Suffer from ‘nerves’	1.5	2.4	7.8	0.1	-0.8	-1.8	-2.8	-0.5
Overall health rating	0.1	0.2	0.4	0.3	-0.5	0.3	0.4	0.6
Chest pain or discomfort	0.4	0.6	1.8	-1.3	-0.4	0.6	0.4	0.9
Had major operations	0.2	0.3	0.4	-0.5	0.2	-0.6	-0.6	0.4
Age at last live birth	0.7	1.0	3.4	-1.8	-0.7	0.5	1.0	-0.0
Family relationship satisfaction	0.8	0.9	2.8	-1.7	0.4	-1.0	-0.0	0.9
Leg pain on walking	1.0	1.3	3.2	-0.7	-1.2	1.8	1.1	0.3
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	3.2	-1.6	-1.8	0.7	-0.1	0.6
Commuting to job workplace: Car/motor vehicle	1.4	1.6	3.2	1.7	-0.1	-1.3	-1.8	-0.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.9	0.7	0.8	-1.0	-0.3	-0.7
Medication: Aspirin	1.1	1.4	3.7	1.9	-0.0	-0.3	0.5	1.8
Supplements: Vitamin C	0.3	0.4	1.4	-1.2	0.4	0.6	0.4	0.2
Knee pain experienced in last month	0.5	0.7	1.8	0.1	-1.3	0.0	-0.8	1.0
Hypertension (Self-reported)	0.3	1.0	1.8	1.3	-0.4	1.3	0.4	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.7	3.1	6.0	2.4	-0.1	-1.9	-2.3	1.0
Illnesses of father: Heart disease	1.9	2.6	7.1	0.8	0.3	-2.1	-0.6	2.7
Illnesses of siblings: Diabetes	1.0	1.3	3.7	0.5	1.2	1.0	1.9	-0.2
Smoking status: Previous	0.2	0.4	0.8	0.8	-0.0	0.5	-0.3	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	4.6	0.3	-0.0	1.3	1.1	-2.1
Whole body fat-free mass	2.4	13.7	37.5	2.2	-2.0	6.1	4.7	-0.2
Leg fat-free mass (right)	2.9	15.4	43.6	1.9	-2.4	6.6	4.9	-0.2
Arm fat percentage (left)	2.5	10.1	18.2	2.9	-1.0	4.3	3.9	2.8
Average weekly red wine intake	0.9	1.3	2.2	-0.5	1.5	-0.9	-1.0	1.5
Handedness (chirality/laterality): Left-handed	1.4	1.7	5.3	2.3	1.0	-0.1	-0.8	-1.2
Mood swings	0.1	0.2	0.3	-0.2	-0.3	-0.5	0.6	0.5
Loneliness, isolation	0.7	1.0	2.1	-1.1	-1.4	-0.5	-0.9	0.8
Long-standing illness, disability or infirmity	1.6	2.5	6.8	-0.3	-2.6	2.0	0.7	1.0
Ever had bowel cancer screening	0.7	0.8	2.4	0.4	-1.5	0.9	-0.3	-0.6
Diabetes diagnosed by doctor	2.1	3.5	15.1	3.9	0.5	-0.2	1.1	0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.0	-1.7	-0.9	0.6	1.1	1.0
Friendships satisfaction	1.6	2.0	5.1	-1.4	-0.6	-1.3	-1.0	2.3
Qualifications: nursing, teaching	0.9	1.3	2.1	-0.7	-1.3	-0.8	-1.5	1.3
Commuting to job workplace: Walk	0.2	0.2	0.5	-0.2	-0.4	-0.1	-0.5	0.7
Eye problems/disorders: Cataract	0.2	0.3	0.5	-0.5	0.6	-0.4	0.2	0.7
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.3	-0.7	-0.2	-0.6	-0.1	-1.2
Medication for cholesterol	0.4	0.7	2.2	-1.5	-1.0	-0.3	0.1	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.5	-1.2	-0.4	0.9	-0.3	0.7
Back pain experienced in last month	0.1	0.2	0.9	1.0	-0.1	-0.1	0.0	-0.2
Mineral and other dietary supplements	0.5	0.7	1.1	-1.0	-0.8	0.9	0.1	-1.1
Breast cancer (self-reported)	0.5	0.6	2.0	-1.4	-0.1	0.7	0.1	-0.7
Asthma (self-reported)	0.5	1.1	5.2	-0.2	0.1	2.3	-0.3	-0.3
Osteoporosis (self-reported)	0.6	0.8	2.0	-0.7	-0.5	-0.9	-0.1	1.4
Osteoarthritis (self-reported)	0.4	0.5	1.6	0.5	-0.1	1.3	-0.0	0.7
Medication: Aspirin	1.6	2.0	5.1	2.2	0.1	-0.3	0.5	2.3
Medication: Gliclazide	0.8	0.9	3.0	1.2	0.2	0.3	1.7	0.4
Illnesses of father: None of the above (group 1)	0.8	1.0	3.0	-1.7	-0.8	0.6	0.1	1.0
Smoking status: Current	2.2	3.5	7.2	-2.5	-2.7	2.0	0.4	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	6.5	0.8	1.0	-2.6	-0.4	0.5
Whole body water mass	2.5	14.2	39.3	2.2	-2.1	6.3	4.7	-0.3
Leg predicted mass (right)	3.0	15.8	44.8	1.9	-2.4	6.7	5.0	-0.2
Arm fat mass (left)	3.3	13.6	29.3	3.2	-1.2	5.4	4.7	2.1
Number of self-reported non-cancer illnesses	0.9	1.6	4.8	1.4	0.0	-0.9	-0.8	2.2
Average weekly champagne plus white wine intake	0.6	0.8	2.0	0.1	0.5	0.9	0.9	-1.4
Miserableness	0.7	1.2	6.0	0.0	-0.2	-0.0	-0.3	2.4
Guilty feelings	0.2	0.3	0.8	-0.4	0.9	-0.3	-0.5	-0.0
Wears glasses or contact lenses	0.4	0.5	1.5	0.5	0.3	-0.5	0.6	1.2
Ever taken oral contraceptive pill	0.4	0.4	0.8	-0.6	0.8	0.2	0.4	-0.9
Hearing aid user	1.1	1.3	3.2	1.1	-0.1	1.3	1.8	0.5
Mother’s age at death	0.3	0.4	1.0	-0.2	1.0	-0.6	0.8	0.4
Financial situation satisfaction	0.8	1.0	2.1	-0.4	-1.4	-0.4	-1.3	0.8
Tinnitus: Yes, now most or all of the time	1.1	1.2	3.0	0.8	1.3	0.6	1.7	-0.6
Commuting to job workplace: Public transport	0.8	1.0	3.2	0.2	-1.8	1.2	0.6	-0.1
Eye problems/disorders: Glaucoma	0.7	0.8	2.3	0.8	1.5	0.6	0.4	0.8
Medication: Blood pressure	0.9	1.6	5.0	1.0	-0.0	2.2	1.4	-0.4
Pain type(s) experienced in last month: Hip pain	0.7	0.8	3.8	0.6	-1.9	0.2	0.0	0.0
Supplements: Fish oil (including cod liver oil)	0.3	0.5	1.4	1.2	0.6	-0.5	-0.3	-0.2
High cholesterol (Self-reported)	0.7	1.2	3.5	1.4	-0.6	-0.4	-0.3	1.9
Medication: Bendroflumethiazide	0.8	1.2	3.0	1.2	-0.0	1.7	0.6	-1.0
Medication: Paracetamol	0.8	1.2	3.1	0.5	1.8	-0.4	1.2	0.9
Medication: Lisinopril	1.0	1.3	3.2	0.4	-0.8	1.8	1.3	0.9
Medication: Atorvastatin	0.1	0.2	0.4	0.5	-0.6	-0.1	0.5	-0.1
Illnesses of father: High blood pressure	1.4	1.8	2.3	1.5	1.4	-1.4	-0.8	-1.3
Alcohol drinker status: Never	0.7	0.8	2.1	0.7	-1.5	0.0	-1.1	-0.6
Ever smoked	0.1	0.2	0.4	-0.4	-0.4	0.7	0.2	0.6
Basal metabolic rate	2.7	14.9	40.2	2.6	-2.0	6.3	4.9	-0.0
Leg fat percentage (left)	1.7	6.2	13.8	3.7	-0.4	2.6	2.2	2.4
Arm fat-free mass (left)	2.6	13.0	34.5	2.7	-1.6	5.9	4.5	-0.1
Number of operations (self-reported)	0.3	0.4	0.8	-0.4	-0.9	0.4	-0.8	0.7
Average weekly beer plus cider intake	1.1	1.6	3.6	0.3	0.2	-1.7	-1.9	1.0
Irritability	1.0	1.7	5.5	-2.3	-1.3	-0.1	0.8	0.6
Risk taking	0.7	1.1	4.4	-0.0	-2.1	0.9	-0.1	-0.4
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.9	-0.0	-0.2	1.2	1.4	0.0
Fractured/broken bones in last 5 years	1.3	1.7	4.8	-2.2	1.1	0.4	1.4	0.3
Age started oral contraceptive pill	1.0	1.3	3.7	1.4	0.4	-0.9	-1.9	-0.1
Diastolic blood pressure, automated reading	0.2	0.6	1.1	1.0	-0.9	0.2	-1.1	-0.1
Ever depressed for a whole week	1.0	1.3	3.3	1.2	1.8	0.4	1.1	0.6
Unable to work because of sickness or disability	0.1	0.1	0.5	-0.0	-0.7	-0.1	-0.3	-0.2
Commuting to job workplace: Cycle	1.3	1.6	3.8	-1.3	-0.2	1.9	1.6	0.0
Myopia	0.5	0.7	1.9	1.4	0.0	1.0	-0.2	-0.7
Vascular/heart problems diagnosed by doctor	0.6	1.7	3.8	-1.3	-0.9	-0.8	-1.2	-1.9
Cholesterol lowering medication	0.4	0.6	1.1	1.0	-1.0	0.9	0.1	0.3
Medication: Omeprazole (e.g. Zanprol)	2.7	3.2	6.2	2.5	0.8	-1.9	-2.3	-0.7
Pain experienced in last month	0.0	0.1	0.2	-0.0	-0.1	0.5	0.0	-0.2
Supplements: Calcium	0.6	0.6	1.7	-0.0	-0.8	0.0	1.3	-0.8
Basal cell carcinoma (self-reported)	1.6	1.9	4.7	0.4	-1.1	2.2	-1.1	1.6
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.3	0.7	-1.1	0.7	0.4	0.4
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	3.4	-0.8	-0.4	-0.4	-0.2	1.8
Heart disease (siblings)	0.5	0.6	1.5	0.9	-1.2	-0.3	-0.7	0.5
Alcohol drinker status: Previous	0.8	0.9	3.0	-0.6	0.5	0.2	1.7	0.8
Pack years of smoking	0.2	0.4	1.1	-0.2	-0.4	0.7	0.1	-1.0
Impedance of whole body	2.3	11.6	32.0	-1.9	3.2	-5.7	-3.5	0.1
Leg fat mass (left)	2.8	10.8	21.4	3.9	-1.2	4.6	3.6	1.8
Arm predicted mass (left)	2.4	12.0	31.9	2.6	-1.5	5.7	4.4	-0.1