Hub : Genes

SEC16B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0640 0.0280 1.0e-02 0.007 0.002 -0.002 0.004 0.002 4.2e-02 0.16 7.8e-01 0.083 1.7e-01
2 GTEx Lung 0.1566 0.0612 4.7e-03 0.069 NA 0.071 NA 0.066 5.5e-06 NA 3.8e-06 NA 9.6e-06
3 GTEx Muscle Skeletal 0.1822 0.0661 2.2e-04 0.037 NA 0.030 NA 0.046 1.3e-04 NA 6.0e-04 NA 2.4e-05
4 GTEx Nerve Tibial 0.2378 0.0586 9.2e-06 0.123 NA 0.175 NA 0.177 4.8e-09 NA 2.0e-12 NA 1.4e-12
5 TCGA Prostate Adenocarcinoma 0.0663 0.0347 8.3e-03 0.026 0.004 0.020 NA 0.028 8.8e-04 0.12 3.2e-03 NA 5.3e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.5 0.8 1.8 -1.3 -1.3 -0.3 0.8 -0.1
Bipolar Disorder or Schizophrenia 0.7 1.6 3.5 -1.9 -0.7 -1.7 -0.8 -0.6
Depressed Affect (Nagel 2018) 0.7 1.4 4.0 -0.3 -0.7 -1.2 -0.9 2.0
Depression (Nagel 2018) 2.2 3.3 9.5 -0.1 -0.2 -3.1 -2.5 0.8
Intelligence (Savage-Jansen 2018) 0.5 1.6 2.9 1.6 1.1 -0.5 -1.2 -1.7
Neuroticism (Nagel 2018) 0.5 1.1 2.4 -1.3 -0.4 -1.5 -1.1 0.3
Schizophrenia (2018) 0.8 1.7 4.0 -1.3 0.2 -2.0 -1.6 -0.6
Schizophrenia vs Biploar Disorder 0.8 1.1 3.4 -1.8 -0.2 -0.2 -0.7 -1.2
Worry (Nagel 2018) 0.8 1.7 5.2 -1.2 -0.4 -2.3 -1.0 -0.6
Alzheimer’s Disease (in mother) 1.1 1.2 2.2 0.0 1.5 0.3 1.5 1.3
Alzheimer’s Disease (in father) 2.1 2.2 5.2 -1.2 1.2 2.3 1.6 -0.6
Alzheimer’s Disease (including proxy) 1.1 1.6 2.4 -1.4 1.4 1.1 1.6 0.7
Crohns Disease (2017) 0.8 1.7 4.1 -1.0 -0.9 -2.0 -0.4 1.6
Irritable Bowel Disease (IBD) 0.7 1.7 4.2 -0.9 -0.2 -2.1 -0.6 1.8
Ulcerative Colitis (UC) 0.4 0.7 1.7 -0.4 0.5 -1.1 -0.2 1.3
Major Depression (MDD) 1.0 1.2 3.3 -0.6 0.7 -0.7 1.0 1.8
Reaction Time 0.7 1.3 2.6 -1.2 -0.2 1.2 1.0 -1.6
Verbal and Numeric Reasoning (VNR) 0.3 0.8 2.6 -0.2 1.1 0.3 -0.2 -1.6
Breast Cancer 0.9 2.2 3.6 1.9 0.0 1.8 1.9 -0.7
Ovarian Cancer 0.9 1.2 2.6 1.6 -1.3 0.4 -1.1 -0.8
Prostate Cancer 1.9 2.7 7.8 -1.5 -1.3 -0.9 -0.9 2.8
Age at First Birth 1.1 1.6 5.0 -0.8 2.2 0.4 1.5 0.5
Bipolar Disorder (2011) 0.7 0.7 1.9 -1.4 -0.5 -0.7 -0.0 1.0
Body Mass Index (BMI) (2010) 1.2 1.7 4.0 0.6 -1.6 2.0 1.1 0.3
Coronary Artery Disease (CAD) 1.1 1.3 3.1 1.6 -1.8 -0.4 -0.6 -0.5
Crohns Disease (2012) 0.6 1.0 3.2 -1.8 -0.3 -0.9 0.7 0.5
Mean Putamen Volume 0.3 0.3 1.0 -1.0 0.5 -0.2 0.3 0.6
Fasting Glucose 0.2 0.3 0.8 0.3 0.7 -0.2 -0.2 0.9
HbA1C 1.1 1.3 2.6 1.5 1.6 -0.7 -1.0 0.3
HDL Cholesterol 0.6 1.0 1.6 -1.3 0.6 -0.5 -1.3 -1.0
LDL Cholesterol 2.8 4.4 12.5 2.0 -0.3 -2.2 -3.5 0.4
Lupus 0.8 1.3 4.7 2.2 -0.3 -0.9 0.6 0.5
Neuroticism (2016) 0.9 1.3 2.6 -0.4 -1.1 -1.3 -1.6 0.9
Primary Biliary Cirrhosis 1.3 1.8 3.2 0.1 -1.6 -1.8 -1.5 1.1
Rheumatoid Arthritis 1.3 1.8 4.9 1.4 0.8 -2.2 -0.6 1.2
Schizophrenia (2014) 0.9 2.1 7.2 -2.7 -0.0 -1.5 -0.8 -0.6
Triglycerides 0.4 0.7 1.7 -0.9 -1.3 0.9 0.3 -0.1
Type 2 Diabetes (T2D) (2012) 1.7 1.9 7.1 -0.5 0.1 1.4 2.7 0.7
Ulcerative Colitis 0.6 0.8 2.8 -0.5 0.3 -0.9 -0.4 1.7
Blood Eosinophil Count 0.2 1.2 2.0 -1.1 -1.1 1.4 1.1 0.5
Blood Platelet Count 0.6 6.8 17.6 -4.2 0.5 -2.3 -0.6 3.2
Blood Red Count 0.1 0.9 2.4 1.6 -0.9 1.0 -0.2 0.1
Blood White Count 0.4 2.7 7.9 -2.8 -0.9 0.7 1.7 1.2
Heel T-Score 0.7 5.3 10.8 3.3 -2.3 -1.4 -2.6 1.3
BMI 3.7 21.3 52.9 3.1 -3.3 7.3 5.5 1.7
Height 0.4 8.4 12.8 2.3 2.5 3.2 3.6 -2.6
Waist Hip Ratio (WHR) 0.2 0.8 1.7 0.0 0.8 -1.1 -1.3 0.6
Systolic Blood Pressure 0.2 1.0 2.9 -0.1 1.2 -1.7 -0.8 0.4
Smoking Status 1.6 3.7 9.3 -2.0 -2.1 3.1 0.8 -0.2
Allergy or Eczema 0.7 1.9 5.8 0.3 2.4 -1.7 -0.7 0.6
Cardiovascular Disease 0.4 1.4 2.7 1.0 -0.4 1.1 1.6 1.4
Hypothyroidism (self reported) 0.6 1.4 4.6 -0.6 -1.0 0.9 0.6 -2.1
Respiratory disease 0.9 1.9 5.2 -1.8 0.2 2.3 0.6 -0.9
Type 2 Diabetes (T2D) (2018) 1.3 2.4 6.6 2.6 -0.1 0.9 2.1 0.5
Lung FEV1/FVC ratio 0.4 2.1 7.3 0.6 -2.7 1.4 0.5 -0.5
Lung FVC 0.5 2.5 9.2 -0.5 0.8 -3.0 -1.5 -0.0
Neuroticism 0.6 1.5 6.0 -2.4 -0.8 -0.8 0.2 0.6
Chronotype (morning person) 0.2 0.5 1.6 -0.5 -0.6 -0.1 -0.2 1.3
Hair Pigment 0.0 0.4 1.5 -0.5 -0.1 0.4 0.0 -1.2
Tanning 0.1 1.8 3.6 -1.9 -1.9 0.8 -0.1 -1.1
Hand grip strength (left) 0.4 1.1 3.8 0.9 0.6 0.6 0.0 -1.9
Number of treatments/medications taken 0.5 1.0 4.0 2.0 -0.2 0.1 0.4 0.8
Average weekly spirits intake 0.4 0.5 1.6 1.3 -0.0 0.1 0.6 0.5
Sensitivity / hurt feelings 0.5 0.8 3.1 -1.8 -0.7 -0.2 -0.4 -0.5
Frequency of depressed mood in last 2 weeks 1.2 1.7 5.3 -0.3 -0.0 -2.3 -1.5 1.0
Hearing difficulty/problems: Yes 0.4 0.6 0.9 -0.7 -0.8 1.0 0.1 -0.9
Relative age of first facial hair 1.2 2.4 4.2 -1.9 1.4 -2.0 -1.3 0.9
Other serious medical condition/disability diagnosed by doctor 0.9 1.1 3.0 -1.1 -1.7 0.3 0.5 1.1
Ever used hormone-replacement therapy (HRT) 2.4 3.1 4.2 2.0 0.9 -2.1 -2.0 1.5
Ever had hysterectomy (womb removed) 0.4 0.5 1.7 1.3 0.7 -0.4 -0.4 0.1
Systolic blood pressure, automated reading 0.4 1.2 2.5 1.6 -0.2 -1.0 -1.4 -0.4
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 1.5 1.2 -0.1 -0.7 -0.6 1.1
Angina 0.5 0.7 1.7 0.2 -0.9 0.8 0.5 1.3
Medication for hormone replacement therapy 0.8 0.9 2.4 0.4 0.4 -1.3 -1.6 0.1
Vitamin and mineral supplements 0.4 0.5 1.9 0.6 -0.5 1.4 0.3 0.3
Supplements: Zinc 2.6 2.8 10.4 0.0 3.2 -1.1 1.5 0.4
Medication: Co-codamol 0.3 0.4 0.8 0.1 0.7 0.4 0.9 0.7
Medication: Metformin 1.0 1.4 2.8 1.6 -0.5 1.0 1.7 0.7
Diabetes (father) 0.2 0.3 0.6 -0.6 -0.8 0.5 0.2 -0.4
Diabetes (mother) 0.5 0.7 1.5 1.2 -0.5 0.5 0.9 0.6
Severe depression (siblings) 0.9 1.0 2.8 -1.0 -1.7 0.4 -1.1 0.2
Pack years adult smoking proportion 0.3 0.4 0.9 -0.4 -0.5 0.8 0.0 -1.0
Impedance of leg (right) 2.7 13.3 36.6 -1.4 3.5 -6.0 -3.9 -0.1
Leg fat-free mass (left) 3.1 16.5 46.6 1.8 -2.2 6.8 5.3 0.0
Trunk fat percentage 1.8 7.1 11.2 2.8 0.0 3.4 3.2 2.5
Hand grip strength (right) 0.2 0.7 1.6 -0.2 1.1 0.3 0.6 -1.3
Townsend deprivation index at recruitment 3.1 4.4 9.6 -2.3 -1.7 3.1 1.7 1.0
Current tobacco smoking 2.5 4.2 10.0 -2.5 -3.2 2.0 0.3 -0.4
Average weekly fortified wine intake 2.4 2.8 8.0 -1.3 2.8 -1.6 -0.9 1.0
Maternal smoking around birth 0.6 0.8 3.2 -0.8 -0.3 0.5 0.1 1.8
Fed-up feelings 1.2 2.2 3.9 0.1 -1.1 -1.9 -1.5 2.0
Frequency of unenthusiasm / disinterest in last 2 weeks 1.7 2.3 6.5 -0.7 0.0 -2.5 -2.1 -0.4
Relative age voice broke 1.9 2.9 4.6 -1.5 1.9 -2.1 -1.9 -0.1
Taking other prescription medications 0.2 0.4 0.5 0.6 0.4 0.6 0.7 0.7
Age when periods started (menarche) 1.3 3.2 9.4 -1.1 1.1 -3.1 -2.0 -0.2
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 1.6 1.2 -0.2 -0.5 -0.3 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.0 5.2 1.6 -2.3 0.4 -1.1 0.8
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 2.1 -1.4 -0.2 -0.1 0.9 0.6
Qualifications: CSEs or equivalent 0.2 0.3 1.0 0.6 0.1 -1.0 0.2 -0.4
Serious illness, injury or assault to yourself 0.5 0.7 1.7 -0.4 1.3 -1.0 -0.4 0.5
High blood pressure 0.4 1.0 2.0 1.4 0.5 0.9 0.7 1.3
Hayfever, allergic rhinitis or eczema 0.5 1.2 3.3 -0.0 1.8 -1.3 -0.6 0.8
Multivitamins +/- minerals 0.5 0.6 1.2 -0.5 -0.2 -1.1 -0.4 -1.1
Stomach or abdominal pain in last month 0.5 0.6 1.2 -1.1 -0.8 0.6 0.6 0.5
Supplements: Glucosamine 0.4 0.6 1.3 1.1 -0.1 -0.8 -0.7 0.6
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 1.6 -0.8 1.2 -1.1 0.1 1.2
Medication: Atenolol 0.6 0.8 2.4 -0.3 -0.9 0.6 0.4 1.5
Medication: Levothyroxine sodium 0.1 0.2 0.8 0.5 -0.3 0.1 -0.3 -0.9
Sitting height 0.5 3.7 10.4 0.5 0.5 2.5 3.2 -1.2
Chronic bronchitis/emphysema (father) 0.1 0.2 0.6 -0.8 -0.1 0.2 0.1 -0.3
High blood pressure (mother) 0.3 0.5 1.1 -1.0 -0.5 -0.3 -0.5 0.8
Body mass index (BMI) 3.0 13.0 28.6 3.4 -1.8 5.3 4.2 1.9
Impedance of leg (left) 2.9 14.3 40.3 -1.0 3.0 -6.3 -4.6 -0.2
Leg predicted mass (left) 3.1 16.2 45.7 1.8 -2.2 6.8 5.2 0.0
Trunk fat mass 2.4 10.5 20.5 3.2 -0.6 4.5 4.1 2.2
Waist circumference 2.7 10.0 21.6 3.4 -1.2 4.7 3.6 1.3
Number of incorrect matches in round 0.7 1.2 2.7 -0.5 -0.3 1.4 1.6 1.1
Past tobacco smoking 0.3 0.5 1.6 0.1 0.4 -1.0 -0.1 -1.3
Alcohol usually taken with meals 0.6 0.9 2.7 0.7 0.7 -1.6 -0.3 -0.8
Nervous feelings 1.0 1.9 7.3 -2.7 -0.5 -1.1 -0.9 -0.4
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.0 6.4 -1.2 -0.6 -2.5 -1.4 -0.3
Hearing difficulty/problems with background noise 0.7 1.1 3.0 -0.1 -1.7 1.2 0.1 -1.1
Hair/balding pattern: Pattern 2 0.3 0.3 0.8 0.4 0.8 -0.9 0.2 0.1
Had menopause 0.6 0.7 1.9 1.4 0.8 -0.0 -0.6 0.9
Had other major operations 1.7 2.1 3.4 -1.0 -1.4 1.8 1.4 -1.4
Forced vital capacity (FVC) 0.2 0.7 1.3 -1.1 0.3 -0.7 0.4 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.3 4.0 2.0 -1.7 -0.6 -1.4 1.5
Ever unenthusiastic/disinterested for a whole week 1.8 2.3 4.2 -1.2 2.0 0.7 1.5 1.6
Qualifications: None of the above 0.7 1.4 2.6 1.2 -1.2 1.6 1.3 0.2
Financial difficulties in last 2 years 0.2 0.3 0.6 -0.7 -0.3 0.8 0.5 -0.5
Mouth/teeth dental problems 0.2 0.3 1.3 -1.1 0.6 0.3 -0.1 -0.0
Heart attack 0.3 0.4 1.2 0.5 -1.1 0.6 0.4 0.3
Allergy 0.5 1.0 3.3 0.6 -1.8 0.1 0.2 -1.2
Pain all over the body in last month 1.1 1.2 2.5 -1.6 -0.9 0.6 -0.8 -1.2
Diabetes (self-reported) 1.6 2.4 10.7 3.3 -0.2 -0.7 0.5 0.8
Hayfever/allergic rhinitis (self-reported) 0.1 0.2 0.3 0.5 -0.5 0.1 0.3 -0.4
Medication: Ramipril 1.5 1.9 5.5 -0.9 -2.4 1.2 1.1 0.7
Medication: Simvastatin 1.3 1.9 7.1 2.7 -0.5 -0.0 -0.6 1.4
Fluid intelligence score 0.3 0.6 1.3 -0.5 1.1 -0.4 -0.7 -0.8
Illnesses of siblings 0.8 1.1 2.4 -1.6 0.4 -1.3 -0.7 -1.0
Neuroticism score 0.5 1.1 3.8 -2.0 -1.1 -0.6 -0.1 0.1
Weight 3.2 15.8 37.4 3.7 -1.3 6.1 5.0 1.1
Impedance of arm (right) 1.3 6.3 16.6 -1.4 2.2 -4.1 -2.8 0.2
Arm fat percentage (right) 2.6 10.2 19.5 3.2 -0.9 4.4 3.8 2.4
Trunk fat-free mass 2.0 11.2 29.8 2.1 -1.8 5.5 4.3 -0.6
Hip circumference 2.9 12.4 31.8 2.4 -1.4 5.6 4.6 1.2
Time employed in main current job 0.8 0.9 3.4 0.7 -0.5 1.8 0.5 -0.1
Alcohol intake versus 10 years previously 1.7 2.5 5.9 1.3 -1.5 2.4 0.2 -1.6
Father’s age at death 0.8 1.1 2.4 -0.3 1.6 -0.8 -0.5 -1.5
Worrier / anxious feelings 0.8 1.4 4.4 -1.4 -0.3 0.1 0.7 -2.1
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.3 3.3 -0.5 -0.4 -1.8 -0.8 1.4
Falls in the last year 1.7 2.2 5.9 0.2 -2.4 -0.9 -2.1 0.0
Hair/balding pattern: Pattern 3 0.5 0.8 2.7 -0.3 1.6 -0.4 0.9 0.1
Number of live births 0.8 1.1 2.0 -1.0 -1.4 0.5 0.8 1.2
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.0 -1.0 -0.1 -0.8 0.8 -0.9
Pulse rate 0.6 1.0 2.1 -0.9 0.6 1.2 1.4 0.4
Happiness 3.4 4.2 9.9 -1.4 -0.6 -2.1 -2.1 3.1
Noisy workplace 2.3 2.8 12.9 0.5 -3.6 0.7 -0.6 0.0
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.3 -1.1 -1.1 -0.1 -0.1 -0.4
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.6 0.6 -0.3 -0.4 -0.5 -0.8
Mouth/teeth dental problems: Dentures 0.6 1.0 3.2 0.5 -1.8 1.2 0.4 -0.3
Asthma 0.5 1.1 5.0 -0.4 -0.2 2.2 -0.4 -0.2
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.7 5.6 -0.2 2.4 -1.5 0.3 -0.8
Medication: Cholesterol lowering 0.4 0.7 1.7 1.1 -0.3 -0.0 0.6 1.3
Depression (self-reported) 2.8 3.4 8.5 -0.4 -0.4 -2.7 -2.9 0.9
Medication: Lansoprazole 1.2 1.4 4.0 2.0 -0.9 0.7 0.3 1.3
Prospective memory result 1.9 2.3 6.1 -0.1 0.4 2.3 2.5 0.1
Lung cancer (father) 0.8 0.9 2.3 -0.5 -1.5 0.9 1.0 0.3
Illnesses of mother 0.1 0.1 0.3 0.1 0.2 -0.5 -0.2 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 0.6 -0.4 0.2 -0.7 0.7 -0.7
Pulse wave Arterial Stiffness index 0.4 0.5 0.8 0.1 -0.7 0.9 0.7 -0.8
Impedance of arm (left) 1.5 6.9 19.0 -1.9 2.1 -4.4 -2.7 0.4
Arm fat mass (right) 3.3 13.7 31.4 3.5 -1.4 5.6 4.5 1.6
Trunk predicted mass 2.0 11.3 30.4 2.0 -1.8 5.5 4.3 -0.5
Standing height 0.3 3.1 5.3 1.2 1.0 2.2 2.3 -1.7
Length of working week for main job 0.6 0.7 1.9 0.4 -0.5 -0.4 -1.0 -1.4
Exposure to tobacco smoke at home 0.2 0.2 0.6 -0.4 0.8 -0.4 0.1 0.4
Breastfed as a baby 0.8 1.0 4.0 2.0 0.3 -0.2 -0.8 -0.1
Tense / ‘highly strung’ 0.6 1.0 3.4 -1.0 -0.4 -1.8 -0.4 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.7 2.5 4.9 -1.0 -0.8 -2.2 -2.2 1.1
Hair/balding pattern: Pattern 4 0.4 1.0 2.5 0.2 -1.6 -0.6 -0.1 1.4
Birth weight of first child 0.3 0.6 2.5 0.3 0.4 0.4 1.6 -0.2
Peak expiratory flow (PEF) 0.8 1.8 5.0 -1.1 -1.2 1.0 2.2 -0.3
Pulse wave reflection index 0.7 0.9 2.9 0.7 -1.7 0.2 0.2 -1.0
Ever highly irritable/argumentative for 2 days 0.7 0.9 2.3 -1.5 -0.1 -0.6 -0.6 1.1
Loud music exposure frequency 0.1 0.1 0.3 0.2 0.3 0.1 -0.5 -0.5
Qualifications: O levels/GCSEs or equivalent 0.8 1.2 2.1 -0.5 -1.3 -0.1 -1.4 -1.4
Mouth/teeth dental problems: Bleeding gums 0.9 1.2 3.9 2.0 0.7 -1.0 -0.2 -0.7
Blood clot in the leg (DVT) 0.8 1.1 4.9 -0.6 -0.3 -0.2 0.2 2.2
Medication: Paracetamol 0.7 1.2 3.3 1.1 1.8 -0.5 1.2 0.1
Headache pain in last month 1.2 2.1 3.6 -1.0 1.7 -1.9 -0.5 1.6
Medication for cholesterol, blood pressure or diabetes 1.1 1.8 4.4 -2.0 0.1 -0.1 -0.6 -2.1
Glaucoma (self-reported) 0.6 0.7 2.3 1.5 0.7 -0.1 -0.4 0.7
Gout (self-reported) 0.1 0.2 0.3 0.4 0.1 0.6 0.4 -0.4
Hypothyroidism/myxoedema (self-reported) 0.7 1.4 4.7 0.2 -0.2 1.3 0.7 -2.2
Medication: Amlodipine 1.4 1.9 4.5 0.1 1.1 1.9 2.1 -0.1
Medication: Ventolin 100micrograms inhaler 0.6 0.8 1.4 -1.2 -0.7 1.1 1.0 0.1
Birth weight 1.3 2.9 5.6 0.9 2.4 2.0 2.0 -0.5
Chronic bronchitis/emphysema (mother) 0.7 0.8 2.0 -1.1 0.7 -0.2 0.2 1.4
High blood pressure (siblings) 1.1 1.5 3.0 1.7 -1.1 -0.1 -0.9 1.6
Forced vital capacity (FVC), Best measure 0.2 0.8 1.2 -1.0 1.1 -0.4 0.8 -1.0
Body fat percentage 1.9 7.6 11.4 3.4 -0.2 3.2 3.0 2.6
Leg fat percentage (right) 1.6 5.8 11.3 3.4 -0.1 2.5 2.4 2.3
Arm fat-free mass (right) 2.1 11.0 30.4 2.1 -1.6 5.5 4.2 -0.1
Exposure to tobacco smoke outside home 0.5 0.7 1.3 -1.1 -0.9 0.7 1.0 0.1
Comparative body size at age 10 5.4 14.9 35.6 2.4 -4.0 6.0 3.8 1.6
Number of full brothers 1.2 1.6 3.9 0.4 -0.9 -1.6 -2.0 0.7
Worry too long after embarrassment 1.2 2.0 4.2 -2.1 -0.6 1.4 0.9 -1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.6 1.6 -0.4 -1.3 -0.2 -1.0 0.2
Wheeze or whistling in the chest in last year 0.7 1.3 2.4 0.1 -1.6 0.2 -1.4 1.5
Number of children fathered 0.6 0.7 1.8 0.9 0.4 -0.3 -1.3 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.8 -0.3 0.8 1.4 0.2 -0.2
Age at first live birth 0.4 0.7 1.4 -1.1 1.2 -0.1 0.8 -0.1
Pulse wave peak to peak time 0.3 0.3 0.8 0.1 0.9 -0.7 -0.5 0.3
Health satisfaction 0.4 0.5 2.4 0.0 0.4 0.2 0.4 1.5
Shortness of breath walking on level ground 0.7 0.9 1.8 -0.9 0.2 1.3 0.6 1.2
Qualifications: College or University degree 0.4 1.2 2.7 -0.1 1.6 -1.5 -1.0 -0.6
Eye problems/disorders: None of the above 0.1 0.1 0.4 -0.2 -0.6 0.4 0.1 0.0
Mouth/teeth dental problems: Loose teeth 1.7 2.0 6.8 2.6 1.7 -0.3 0.3 0.1
Emphysema/chronic bronchitis 0.9 1.0 2.6 -0.1 -0.7 1.6 1.3 -0.1
Medication for pain relief, constipation, heartburn 1.0 1.7 3.8 -1.7 -0.7 1.9 0.7 -0.7
Neck or shoulder pain in last month 0.1 0.1 0.3 0.1 0.0 0.3 0.5 -0.1
Medication: Blood pressure 0.5 0.9 1.3 1.1 -0.5 1.0 1.0 1.1
Angina (self-reported) 0.6 0.7 1.9 0.1 -0.9 0.8 0.6 1.4
Migraine (self-reported) 1.6 2.0 7.0 -2.6 -1.7 -0.0 0.4 -0.2
Medication: Ibuprofen 1.0 1.1 3.7 -0.5 1.9 -1.2 0.2 -0.6
Medication: Allopurinol 0.5 0.7 2.3 1.5 0.5 0.5 0.6 -0.2
Medication: Omeprazole 3.5 4.2 7.4 2.7 0.2 -2.4 -2.6 -0.7
Medication: Seretide 50 evohaler 1.7 2.0 4.9 -2.0 -0.5 2.2 0.9 0.1
Mean time to correctly identify matches 0.5 0.9 2.6 -0.3 -0.8 1.0 0.3 -1.6
Heart disease (mother) 0.5 0.7 1.5 1.2 0.8 -0.3 0.0 1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.6 -0.5 -1.3 -0.0 0.1 1.2
Whole body fat mass 2.8 11.5 22.4 3.6 -1.0 4.7 4.1 2.1
Leg fat mass (right) 2.6 10.1 20.0 3.6 -1.0 4.5 3.6 1.9
Arm predicted mass (right) 2.0 10.5 28.3 2.3 -1.4 5.3 4.1 0.2
Pulse rate, automated reading 0.2 0.7 2.4 -1.6 -0.2 0.8 0.6 0.2
Alcohol intake frequency. 0.5 1.3 3.2 1.0 -1.8 1.2 -0.2 0.8
Comparative height size at age 10 0.7 4.0 9.3 3.0 -0.8 2.6 1.7 -0.6
Number of full sisters 0.5 0.6 1.6 -0.1 -1.3 1.2 0.1 0.2
Suffer from ‘nerves’ 1.5 2.4 7.8 0.1 -0.8 -1.8 -2.8 -0.5
Overall health rating 0.1 0.2 0.4 0.3 -0.5 0.3 0.4 0.6
Chest pain or discomfort 0.4 0.6 1.8 -1.3 -0.4 0.6 0.4 0.9
Had major operations 0.2 0.3 0.4 -0.5 0.2 -0.6 -0.6 0.4
Age at last live birth 0.7 1.0 3.4 -1.8 -0.7 0.5 1.0 -0.0
Family relationship satisfaction 0.8 0.9 2.8 -1.7 0.4 -1.0 -0.0 0.9
Leg pain on walking 1.0 1.3 3.2 -0.7 -1.2 1.8 1.1 0.3
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 3.2 -1.6 -1.8 0.7 -0.1 0.6
Commuting to job workplace: Car/motor vehicle 1.4 1.6 3.2 1.7 -0.1 -1.3 -1.8 -0.4
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 0.9 0.7 0.8 -1.0 -0.3 -0.7
Medication: Aspirin 1.1 1.4 3.7 1.9 -0.0 -0.3 0.5 1.8
Supplements: Vitamin C 0.3 0.4 1.4 -1.2 0.4 0.6 0.4 0.2
Knee pain experienced in last month 0.5 0.7 1.8 0.1 -1.3 0.0 -0.8 1.0
Hypertension (Self-reported) 0.3 1.0 1.8 1.3 -0.4 1.3 0.4 1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.7 3.1 6.0 2.4 -0.1 -1.9 -2.3 1.0
Illnesses of father: Heart disease 1.9 2.6 7.1 0.8 0.3 -2.1 -0.6 2.7
Illnesses of siblings: Diabetes 1.0 1.3 3.7 0.5 1.2 1.0 1.9 -0.2
Smoking status: Previous 0.2 0.4 0.8 0.8 -0.0 0.5 -0.3 0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 4.6 0.3 -0.0 1.3 1.1 -2.1
Whole body fat-free mass 2.4 13.7 37.5 2.2 -2.0 6.1 4.7 -0.2
Leg fat-free mass (right) 2.9 15.4 43.6 1.9 -2.4 6.6 4.9 -0.2
Arm fat percentage (left) 2.5 10.1 18.2 2.9 -1.0 4.3 3.9 2.8
Average weekly red wine intake 0.9 1.3 2.2 -0.5 1.5 -0.9 -1.0 1.5
Handedness (chirality/laterality): Left-handed 1.4 1.7 5.3 2.3 1.0 -0.1 -0.8 -1.2
Mood swings 0.1 0.2 0.3 -0.2 -0.3 -0.5 0.6 0.5
Loneliness, isolation 0.7 1.0 2.1 -1.1 -1.4 -0.5 -0.9 0.8
Long-standing illness, disability or infirmity 1.6 2.5 6.8 -0.3 -2.6 2.0 0.7 1.0
Ever had bowel cancer screening 0.7 0.8 2.4 0.4 -1.5 0.9 -0.3 -0.6
Diabetes diagnosed by doctor 2.1 3.5 15.1 3.9 0.5 -0.2 1.1 0.9
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 3.0 -1.7 -0.9 0.6 1.1 1.0
Friendships satisfaction 1.6 2.0 5.1 -1.4 -0.6 -1.3 -1.0 2.3
Qualifications: nursing, teaching 0.9 1.3 2.1 -0.7 -1.3 -0.8 -1.5 1.3
Commuting to job workplace: Walk 0.2 0.2 0.5 -0.2 -0.4 -0.1 -0.5 0.7
Eye problems/disorders: Cataract 0.2 0.3 0.5 -0.5 0.6 -0.4 0.2 0.7
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.3 -0.7 -0.2 -0.6 -0.1 -1.2
Medication for cholesterol 0.4 0.7 2.2 -1.5 -1.0 -0.3 0.1 -0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.5 -1.2 -0.4 0.9 -0.3 0.7
Back pain experienced in last month 0.1 0.2 0.9 1.0 -0.1 -0.1 0.0 -0.2
Mineral and other dietary supplements 0.5 0.7 1.1 -1.0 -0.8 0.9 0.1 -1.1
Breast cancer (self-reported) 0.5 0.6 2.0 -1.4 -0.1 0.7 0.1 -0.7
Asthma (self-reported) 0.5 1.1 5.2 -0.2 0.1 2.3 -0.3 -0.3
Osteoporosis (self-reported) 0.6 0.8 2.0 -0.7 -0.5 -0.9 -0.1 1.4
Osteoarthritis (self-reported) 0.4 0.5 1.6 0.5 -0.1 1.3 -0.0 0.7
Medication: Aspirin 1.6 2.0 5.1 2.2 0.1 -0.3 0.5 2.3
Medication: Gliclazide 0.8 0.9 3.0 1.2 0.2 0.3 1.7 0.4
Illnesses of father: None of the above (group 1) 0.8 1.0 3.0 -1.7 -0.8 0.6 0.1 1.0
Smoking status: Current 2.2 3.5 7.2 -2.5 -2.7 2.0 0.4 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 6.5 0.8 1.0 -2.6 -0.4 0.5
Whole body water mass 2.5 14.2 39.3 2.2 -2.1 6.3 4.7 -0.3
Leg predicted mass (right) 3.0 15.8 44.8 1.9 -2.4 6.7 5.0 -0.2
Arm fat mass (left) 3.3 13.6 29.3 3.2 -1.2 5.4 4.7 2.1
Number of self-reported non-cancer illnesses 0.9 1.6 4.8 1.4 0.0 -0.9 -0.8 2.2
Average weekly champagne plus white wine intake 0.6 0.8 2.0 0.1 0.5 0.9 0.9 -1.4
Miserableness 0.7 1.2 6.0 0.0 -0.2 -0.0 -0.3 2.4
Guilty feelings 0.2 0.3 0.8 -0.4 0.9 -0.3 -0.5 -0.0
Wears glasses or contact lenses 0.4 0.5 1.5 0.5 0.3 -0.5 0.6 1.2
Ever taken oral contraceptive pill 0.4 0.4 0.8 -0.6 0.8 0.2 0.4 -0.9
Hearing aid user 1.1 1.3 3.2 1.1 -0.1 1.3 1.8 0.5
Mother’s age at death 0.3 0.4 1.0 -0.2 1.0 -0.6 0.8 0.4
Financial situation satisfaction 0.8 1.0 2.1 -0.4 -1.4 -0.4 -1.3 0.8
Tinnitus: Yes, now most or all of the time 1.1 1.2 3.0 0.8 1.3 0.6 1.7 -0.6
Commuting to job workplace: Public transport 0.8 1.0 3.2 0.2 -1.8 1.2 0.6 -0.1
Eye problems/disorders: Glaucoma 0.7 0.8 2.3 0.8 1.5 0.6 0.4 0.8
Medication: Blood pressure 0.9 1.6 5.0 1.0 -0.0 2.2 1.4 -0.4
Pain type(s) experienced in last month: Hip pain 0.7 0.8 3.8 0.6 -1.9 0.2 0.0 0.0
Supplements: Fish oil (including cod liver oil) 0.3 0.5 1.4 1.2 0.6 -0.5 -0.3 -0.2
High cholesterol (Self-reported) 0.7 1.2 3.5 1.4 -0.6 -0.4 -0.3 1.9
Medication: Bendroflumethiazide 0.8 1.2 3.0 1.2 -0.0 1.7 0.6 -1.0
Medication: Paracetamol 0.8 1.2 3.1 0.5 1.8 -0.4 1.2 0.9
Medication: Lisinopril 1.0 1.3 3.2 0.4 -0.8 1.8 1.3 0.9
Medication: Atorvastatin 0.1 0.2 0.4 0.5 -0.6 -0.1 0.5 -0.1
Illnesses of father: High blood pressure 1.4 1.8 2.3 1.5 1.4 -1.4 -0.8 -1.3
Alcohol drinker status: Never 0.7 0.8 2.1 0.7 -1.5 0.0 -1.1 -0.6
Ever smoked 0.1 0.2 0.4 -0.4 -0.4 0.7 0.2 0.6
Basal metabolic rate 2.7 14.9 40.2 2.6 -2.0 6.3 4.9 -0.0
Leg fat percentage (left) 1.7 6.2 13.8 3.7 -0.4 2.6 2.2 2.4
Arm fat-free mass (left) 2.6 13.0 34.5 2.7 -1.6 5.9 4.5 -0.1
Number of operations (self-reported) 0.3 0.4 0.8 -0.4 -0.9 0.4 -0.8 0.7
Average weekly beer plus cider intake 1.1 1.6 3.6 0.3 0.2 -1.7 -1.9 1.0
Irritability 1.0 1.7 5.5 -2.3 -1.3 -0.1 0.8 0.6
Risk taking 0.7 1.1 4.4 -0.0 -2.1 0.9 -0.1 -0.4
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.9 -0.0 -0.2 1.2 1.4 0.0
Fractured/broken bones in last 5 years 1.3 1.7 4.8 -2.2 1.1 0.4 1.4 0.3
Age started oral contraceptive pill 1.0 1.3 3.7 1.4 0.4 -0.9 -1.9 -0.1
Diastolic blood pressure, automated reading 0.2 0.6 1.1 1.0 -0.9 0.2 -1.1 -0.1
Ever depressed for a whole week 1.0 1.3 3.3 1.2 1.8 0.4 1.1 0.6
Unable to work because of sickness or disability 0.1 0.1 0.5 -0.0 -0.7 -0.1 -0.3 -0.2
Commuting to job workplace: Cycle 1.3 1.6 3.8 -1.3 -0.2 1.9 1.6 0.0
Myopia 0.5 0.7 1.9 1.4 0.0 1.0 -0.2 -0.7
Vascular/heart problems diagnosed by doctor 0.6 1.7 3.8 -1.3 -0.9 -0.8 -1.2 -1.9
Cholesterol lowering medication 0.4 0.6 1.1 1.0 -1.0 0.9 0.1 0.3
Medication: Omeprazole (e.g. Zanprol) 2.7 3.2 6.2 2.5 0.8 -1.9 -2.3 -0.7
Pain experienced in last month 0.0 0.1 0.2 -0.0 -0.1 0.5 0.0 -0.2
Supplements: Calcium 0.6 0.6 1.7 -0.0 -0.8 0.0 1.3 -0.8
Basal cell carcinoma (self-reported) 1.6 1.9 4.7 0.4 -1.1 2.2 -1.1 1.6
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.3 0.7 -1.1 0.7 0.4 0.4
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 3.4 -0.8 -0.4 -0.4 -0.2 1.8
Heart disease (siblings) 0.5 0.6 1.5 0.9 -1.2 -0.3 -0.7 0.5
Alcohol drinker status: Previous 0.8 0.9 3.0 -0.6 0.5 0.2 1.7 0.8
Pack years of smoking 0.2 0.4 1.1 -0.2 -0.4 0.7 0.1 -1.0
Impedance of whole body 2.3 11.6 32.0 -1.9 3.2 -5.7 -3.5 0.1
Leg fat mass (left) 2.8 10.8 21.4 3.9 -1.2 4.6 3.6 1.8
Arm predicted mass (left) 2.4 12.0 31.9 2.6 -1.5 5.7 4.4 -0.1