Best TWAS P=1.88e-13 · Best GWAS P=4.74e-14 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | IPO9 | 0.21 | 0.09 | enet | 36 | 0.13 | 2.3e-15 | 6.933 | 5.2 | 1.7e-07 | -0.32 | 0.26 | 0.74 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | SHISA4 | 0.09 | 0.04 | lasso | 3 | 0.03 | 1.5e-03 | 5.520 | 5.8 | 5.4e-09 | -0.57 | 0.19 | 0.38 | FALSE |
| 3 | GTEx | Esophagus Muscularis | LMOD1 | 0.16 | 0.09 | enet | 9 | 0.08 | 7.8e-06 | -7.499 | 7.0 | 2.0e-12 | -0.98 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Esophagus Muscularis | RP11-307B6.3 | 0.20 | 0.12 | lasso | 3 | 0.12 | 5.6e-08 | -7.499 | 6.9 | 4.6e-12 | -0.97 | 0.01 | 0.99 | FALSE |
| 5 | METSIM | Adipose | LMOD1 | 0.09 | 0.07 | bslmm | 496 | 0.07 | 4.8e-10 | -7.340 | 7.4 | 1.9e-13 | -0.96 | 0.02 | 0.98 | TRUE |
| 6 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | LMOD1 | 0.07 | 0.06 | blup | 59 | 0.03 | 2.1e-02 | -7.344 | 6.0 | 2.5e-09 | -0.90 | 0.01 | 0.87 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LMOD1 | 0.04 | 0.07 | enet | 6 | 0.05 | 9.4e-07 | 5.766 | 6.5 | 9.5e-11 | -0.75 | 0.25 | 0.74 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | LMOD1 | 0.04 | 0.01 | blup | 59 | 0.01 | 5.7e-02 | -7.235 | 7.0 | 2.7e-12 | -0.83 | 0.01 | 0.81 | FALSE |
| 9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | LMOD1 | 0.08 | -0.01 | blup | 59 | 0.01 | 1.3e-01 | 0.089 | 5.5 | 4.5e-08 | -0.78 | 0.01 | 0.42 | FALSE |