Best TWAS P=6.98e-09 · Best GWAS P=6.48e-08 conditioned to 0.638
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | FES | 0.21 | 0.09 | lasso | 5 | 0.05 | 1.3e-03 | 5.1 | -5.1 | 3.0e-07 | -0.71 | 0.02 | 0.95 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | FES | 0.28 | 0.17 | enet | 21 | 0.20 | 2.8e-15 | 5.1 | -5.5 | 3.8e-08 | -0.91 | 0.01 | 0.99 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FES | 0.06 | 0.05 | blup | 46 | 0.07 | 7.4e-14 | 5.1 | -5.8 | 7.0e-09 | -0.90 | 0.01 | 0.99 | TRUE |
| 4 | The Cancer Genome Atlas | Colon Adenocarcinoma | FES | 0.08 | 0.07 | blup | 46 | 0.06 | 3.4e-04 | 5.0 | -5.6 | 2.2e-08 | -0.92 | 0.01 | 0.98 | FALSE |
| 5 | The Cancer Genome Atlas | Glioblastoma Multiforme | FES | 0.12 | 0.06 | enet | 6 | 0.06 | 5.7e-03 | 5.3 | -5.2 | 2.5e-07 | -0.95 | 0.00 | 0.91 | FALSE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FES | 0.06 | 0.03 | blup | 46 | 0.05 | 5.6e-06 | 5.3 | -5.5 | 5.1e-08 | -0.82 | 0.01 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FES | 0.10 | 0.07 | enet | 5 | 0.05 | 2.8e-06 | 5.3 | -5.4 | 7.0e-08 | -0.99 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | FES | 0.05 | 0.04 | lasso | 2 | 0.04 | 2.2e-05 | 5.1 | -5.6 | 1.9e-08 | -0.90 | 0.01 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FES | 0.08 | 0.07 | enet | 7 | 0.08 | 4.2e-09 | 5.1 | -5.3 | 1.2e-07 | -0.82 | 0.01 | 0.98 | FALSE |
| 10 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | FES | 0.32 | 0.26 | lasso | 2 | 0.25 | 2.0e-09 | 5.1 | -5.1 | 3.0e-07 | -0.73 | 0.02 | 0.98 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | FES | 0.30 | 0.30 | lasso | 7 | 0.32 | 1.3e-31 | 5.1 | -5.5 | 4.8e-08 | -0.85 | 0.01 | 0.98 | FALSE |