Best TWAS P=1.04e-14 · Best GWAS P=9.42e-11 conditioned to 0.178
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | ADAMTS17 | 0.14 | 0.00 | enet | 19 | 0.02 | 5.0e-03 | 5.3 | -5.7 | 1.3e-08 | -0.08 | 0.19 | 0.22 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | ADAMTS17 | 0.20 | 0.00 | enet | 20 | 0.05 | 2.2e-03 | -5.2 | -6.6 | 4.8e-11 | 0.00 | 0.12 | 0.12 | TRUE |
| 3 | GTEx | Adipose Visceral Omentum | CTD-3076O17.1 | 0.21 | 0.00 | lasso | 6 | 0.00 | 6.2e-01 | -6.4 | -7.7 | 1.0e-14 | -0.71 | 0.02 | 0.80 | TRUE |
| 4 | GTEx | Esophagus Mucosa | CTD-3076O17.1 | 0.28 | 0.10 | lasso | 6 | 0.11 | 4.7e-08 | -6.3 | -5.4 | 7.3e-08 | -0.59 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Heart Atrial Appendage | ADAMTS17 | 0.22 | 0.00 | lasso | 4 | 0.09 | 9.6e-05 | -2.2 | -5.2 | 1.8e-07 | -0.38 | 0.04 | 0.70 | FALSE |
| 6 | GTEx | Lung | CTD-3076O17.1 | 0.15 | 0.09 | enet | 13 | 0.09 | 2.8e-07 | -6.3 | -6.2 | 5.3e-10 | -0.57 | 0.01 | 0.99 | FALSE |
| 7 | GTEx | Pancreas | CTD-3076O17.1 | 0.24 | 0.11 | enet | 6 | 0.11 | 2.7e-05 | -6.2 | -7.0 | 2.3e-12 | -0.58 | 0.01 | 0.98 | FALSE |
| 8 | GTEx | Testis | ADAMTS17 | 0.30 | 0.24 | lasso | 2 | 0.22 | 6.7e-10 | -6.1 | -6.1 | 1.1e-09 | -0.62 | 0.02 | 0.98 | FALSE |
| 9 | GTEx | Testis | CTD-3076O17.1 | 0.45 | 0.17 | enet | 19 | 0.14 | 1.0e-06 | -6.1 | -6.2 | 5.8e-10 | -0.66 | 0.02 | 0.98 | FALSE |