[Hub]/) : Traits : Impedance of leg (right) : ← →

chr16:2,741,812-4,696,654

Best TWAS P=1.26e-11 · Best GWAS P=9.25e-17 conditioned to 4.3e-11

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
24	ROSMAP	Brain Pre-frontal Cortex	RP11-462G12.1	0.11	0.07	enet	18	0.06	1.1e-08	8.1	6.8	1.3e-11	0.86	0.00	1.00	TRUE
27	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	NLRC3	0.07	0.02	blup	39	0.01	7.4e-02	5.1	6.4	1.6e-10	-0.12	0.02	0.77	TRUE
25	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	NLRC3	0.05	0.01	blup	39	0.02	9.8e-03	-5.5	6.1	9.0e-10	-0.09	0.02	0.70	FALSE
36	The Cancer Genome Atlas	Rectum Adenocarcinoma	NLRC3	0.32	0.08	enet	10	0.23	3.3e-06	-4.2	6.1	1.1e-09	-0.14	0.01	0.82	FALSE
6	GTEx	Brain Frontal Cortex BA9	NLRC3	0.50	0.18	enet	30	0.33	1.6e-09	-4.0	6.0	2.4e-09	0.03	0.44	0.06	FALSE
29	The Cancer Genome Atlas	Colon Adenocarcinoma	NLRC3	0.14	0.04	blup	39	0.10	1.9e-06	-4.9	5.9	4.8e-09	-0.09	0.04	0.85	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	NLRC3	0.32	0.28	enet	17	0.35	8.2e-41	-4.2	5.8	5.4e-09	-0.10	0.83	0.15	FALSE
7	GTEx	Brain Hippocampus	CLUAP1	0.37	0.10	lasso	5	0.09	4.9e-03	-4.5	-5.8	5.7e-09	0.02	0.17	0.06	FALSE
19	GTEx	Pancreas	CLUAP1	0.28	0.21	lasso	3	0.24	2.3e-10	-5.5	-5.7	1.4e-08	0.03	0.99	0.00	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	NLRC3	0.42	0.25	lasso	6	0.36	1.2e-38	-4.2	5.7	1.5e-08	-0.07	0.46	0.53	FALSE
14	GTEx	Heart Atrial Appendage	NLRC3	0.27	0.07	lasso	3	0.08	2.2e-04	-4.2	5.6	1.7e-08	-0.07	0.29	0.08	FALSE
1	GTEx	Artery Aorta	CLUAP1	0.40	0.33	enet	18	0.33	5.4e-19	-4.2	-5.6	1.9e-08	0.08	1.00	0.00	FALSE
18	GTEx	Ovary	NLRC3	0.40	0.11	lasso	7	0.16	9.5e-05	-5.6	5.6	2.1e-08	-0.07	0.31	0.05	FALSE
21	GTEx	Skin Sun Exposed Lower leg	CLUAP1	0.34	0.25	lasso	6	0.27	1.1e-22	-5.2	-5.6	2.3e-08	0.04	1.00	0.00	FALSE
3	GTEx	Brain Caudate basal ganglia	NLRC3	0.41	0.11	lasso	4	0.24	2.0e-07	-4.2	5.6	2.5e-08	-0.06	0.46	0.03	FALSE
12	GTEx	Esophagus Muscularis	NLRC3	0.48	0.29	lasso	6	0.36	5.1e-23	-4.2	5.6	2.5e-08	-0.07	1.00	0.00	FALSE
31	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NLRC3	0.04	0.02	lasso	3	0.03	2.1e-04	3.4	5.6	2.6e-08	-0.15	0.01	0.94	FALSE
10	GTEx	Colon Transverse	CLUAP1	0.25	0.09	lasso	3	0.14	2.0e-07	-4.2	-5.5	3.2e-08	0.06	0.89	0.00	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	NLRC3	0.09	0.07	lasso	5	0.10	2.9e-19	-4.2	5.5	4.4e-08	-0.07	0.74	0.25	FALSE
2	GTEx	Artery Tibial	NLRC3	0.39	0.26	lasso	7	0.36	1.5e-29	-4.2	5.4	6.8e-08	-0.08	1.00	0.00	FALSE
20	GTEx	Pituitary	CLUAP1	0.32	0.26	lasso	3	0.17	5.6e-05	-5.6	-5.4	7.5e-08	0.02	0.18	0.05	FALSE
13	GTEx	Heart Atrial Appendage	CLUAP1	0.40	0.16	enet	13	0.29	2.3e-13	-4.0	-5.3	8.6e-08	0.07	1.00	0.00	FALSE
16	GTEx	Nerve Tibial	CLUAP1	0.53	0.27	lasso	7	0.42	9.9e-32	-4.2	-5.4	8.6e-08	0.01	1.00	0.00	FALSE
32	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NLRC3	0.35	0.08	lasso	6	0.17	4.4e-10	3.4	5.3	9.1e-08	-0.11	0.28	0.71	FALSE
28	The Cancer Genome Atlas	Colon Adenocarcinoma	BTBD12	0.05	0.01	blup	41	0.02	1.5e-02	5.0	-5.3	1.4e-07	0.14	0.01	0.53	FALSE
37	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	NLRC3	0.33	0.00	blup	40	0.02	9.3e-02	-4.2	5.2	1.5e-07	-0.14	0.02	0.40	FALSE
15	GTEx	Lung	ZSCAN32	0.08	0.02	lasso	3	0.02	6.3e-03	-5.2	-5.2	1.6e-07	0.04	0.04	0.71	FALSE
8	GTEx	Breast Mammary Tissue	CLUAP1	0.26	0.13	lasso	8	0.13	4.6e-07	-4.2	-5.2	1.7e-07	0.05	1.00	0.00	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	NLRC3	0.29	0.16	lasso	3	0.18	5.1e-07	-4.2	5.2	1.9e-07	-0.05	0.81	0.01	FALSE
17	GTEx	Nerve Tibial	NLRC3	0.29	0.24	lasso	3	0.32	8.7e-23	-4.2	5.2	1.9e-07	-0.06	1.00	0.00	FALSE
23	GTEx	Whole Blood	CLUAP1	0.07	0.02	lasso	3	0.01	6.5e-02	-5.3	-5.2	2.3e-07	0.03	0.17	0.03	FALSE
9	GTEx	Colon Sigmoid	CLUAP1	0.47	0.32	lasso	9	0.34	1.1e-12	-4.0	-5.2	2.4e-07	0.04	1.00	0.00	FALSE
22	GTEx	Spleen	CLUAP1	0.31	0.23	lasso	5	0.26	3.0e-07	-3.8	-5.2	2.4e-07	0.06	0.34	0.04	FALSE
34	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	NLRC3	0.36	0.20	enet	18	0.25	2.9e-10	-4.2	5.2	2.4e-07	-0.07	0.12	0.88	FALSE
30	The Cancer Genome Atlas	Glioblastoma Multiforme	NLRC3	0.32	0.11	lasso	5	0.21	4.3e-07	-4.2	5.1	2.8e-07	-0.08	0.05	0.63	FALSE
4	GTEx	Brain Cerebellar Hemisphere	NLRC3	0.40	0.39	lasso	2	0.40	2.1e-11	-4.2	5.1	2.9e-07	-0.02	0.94	0.00	FALSE
5	GTEx	Brain Cerebellum	SLX4	0.33	0.14	lasso	3	0.10	6.8e-04	-5.2	5.1	3.0e-07	-0.01	0.16	0.05	FALSE