Hub : Genes

ZSCAN32

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Coronary	0.2520	0.098	0.00490	-0.008	NA	0.016	NA	-0.006	0.7800	NA	0.09500	NA	0.61000
2	GTEx	Brain Cerebellum	0.2890	0.086	0.00013	0.030	NA	0.079	NA	0.099	0.0460	NA	0.00240	NA	0.00074
3	GTEx	Lung	0.0811	0.034	0.00630	0.024	NA	0.003	NA	0.023	0.0059	NA	0.18000	NA	0.00630
4	GTEx	Thyroid	0.0930	0.041	0.00890	0.014	NA	0.039	NA	0.015	0.0260	NA	0.00052	NA	0.02500

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.1	1.7	3.6	1.3	-0.5	-1.1	1.9
Bipolar Disorder or Schizophrenia	0.3	0.8	2.4	0.1	0.6	0.6	1.5
Depressed Affect (Nagel 2018)	1.5	3.1	7.0	2.3	-0.6	-2.6	0.1
Depression (Nagel 2018)	3.0	4.6	12.1	3.5	-0.1	-2.0	1.4
Intelligence (Savage-Jansen 2018)	0.4	1.2	3.8	-0.6	-0.8	1.9	-0.2
Neuroticism (Nagel 2018)	1.3	3.0	6.9	2.6	-1.3	-1.9	0.2
Schizophrenia (2018)	0.6	1.3	2.9	-0.8	1.2	1.7	0.4
Schizophrenia vs Biploar Disorder	3.0	3.9	5.2	-0.9	2.3	2.2	-2.2
Worry (Nagel 2018)	1.7	3.6	9.1	3.0	-1.9	-1.3	-0.0
Alzheimer’s Disease (in mother)	0.7	0.8	1.1	-0.9	-1.0	0.5	-1.0
Alzheimer’s Disease (in father)	0.9	0.9	1.9	-0.5	1.4	-0.6	-1.1
Alzheimer’s Disease (including proxy)	0.6	0.9	2.4	-0.7	0.3	0.7	-1.6
Crohns Disease (2017)	0.5	1.2	2.0	1.2	0.3	1.1	1.4
Irritable Bowel Disease (IBD)	0.8	2.0	5.8	0.6	0.2	-1.3	2.4
Ulcerative Colitis (UC)	1.4	2.7	5.5	0.0	-0.1	-2.3	2.3
Major Depression (MDD)	1.8	2.2	5.1	2.3	-0.7	0.5	1.7
Reaction Time	0.8	1.5	3.0	0.8	1.2	-1.7	0.9
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.9	-0.1	-1.3	1.7	0.0
Breast Cancer	0.2	0.6	0.9	0.2	0.9	0.7	1.0
Ovarian Cancer	0.4	0.5	1.0	1.0	-0.5	0.5	-0.7
Prostate Cancer	1.1	1.5	2.1	-1.4	-0.1	1.4	1.4
Age at First Birth	0.6	0.8	2.5	0.4	-0.5	1.6	0.7
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	2.9	3.9	14.9	-0.9	0.2	3.9	0.2
Coronary Artery Disease (CAD)	0.6	0.7	2.8	-0.1	-0.0	-0.1	1.7
Crohns Disease (2012)	1.5	2.4	6.3	0.4	0.9	2.5	1.5
Mean Putamen Volume	0.5	0.6	1.3	-0.0	-0.9	0.4	1.1
Fasting Glucose	0.5	0.6	1.9	0.4	-1.4	-0.4	0.5
HbA1C	0.4	0.5	0.9	0.6	0.4	0.7	-1.0
HDL Cholesterol	0.9	1.5	5.6	-2.4	0.3	-0.6	-0.3
LDL Cholesterol	1.4	2.1	4.0	2.0	-0.8	-1.9	0.6
Lupus	0.4	0.6	1.5	0.3	0.5	0.8	1.2
Neuroticism (2016)	0.6	0.8	1.4	1.1	-0.6	-0.3	-1.2
Primary Biliary Cirrhosis	0.5	0.6	1.8	-1.3	0.7	0.2	-0.4
Rheumatoid Arthritis	0.5	0.7	2.1	-0.5	-0.2	-1.4	-0.5
Schizophrenia (2014)	1.3	2.9	4.9	-1.6	1.9	2.2	0.6
Triglycerides	0.4	0.7	1.4	1.2	1.1	-0.3	-0.0
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.9	-0.5	-0.9	0.5	0.5
Ulcerative Colitis	1.1	1.6	4.4	0.6	0.0	-1.3	2.1
Blood Eosinophil Count	0.4	3.1	9.2	1.6	3.0	-0.5	0.6
Blood Platelet Count	0.1	1.4	3.0	0.0	1.5	-0.4	-1.7
Blood Red Count	0.2	1.8	5.1	-1.2	2.2	0.8	-0.4
Blood White Count	0.4	3.1	12.2	0.2	-0.1	-3.5	-0.5
Heel T-Score	0.4	2.8	9.2	0.9	-0.8	3.0	0.7
BMI	1.9	11.2	35.8	-1.6	2.5	6.0	0.5
Height	0.3	5.9	15.7	2.5	-4.0	-0.2	-1.2
Waist Hip Ratio (WHR)	1.6	7.2	21.2	-0.2	0.2	-4.6	-2.8
Systolic Blood Pressure	0.4	2.2	5.1	1.7	-0.3	-2.3	-0.9
Smoking Status	1.0	2.3	5.8	1.2	2.4	-1.4	-0.2
Allergy or Eczema	0.9	2.4	7.6	1.3	-0.4	-2.8	0.0
Cardiovascular Disease	0.7	2.4	6.3	2.5	0.2	-1.2	1.3
Hypothyroidism (self reported)	0.3	0.7	1.8	0.4	1.4	0.4	-0.7
Respiratory disease	1.4	3.2	5.6	1.9	1.7	-2.4	0.5
Type 2 Diabetes (T2D) (2018)	1.5	2.9	8.9	0.8	-0.2	3.0	1.4
Lung FEV1/FVC ratio	0.3	1.3	3.0	-0.5	-1.4	1.7	0.1
Lung FVC	7.2	36.5	125.4	4.0	-2.1	-11.2	0.1
Neuroticism	0.9	2.2	5.1	2.3	-0.6	-1.8	0.6
Chronotype (morning person)	0.6	1.4	4.5	-1.1	-2.1	-0.2	0.1
Hair Pigment	0.1	2.1	5.5	-0.7	2.4	1.4	0.4
Tanning	0.0	0.6	2.1	0.0	0.2	-1.4	-0.5
Hand grip strength (left)	1.6	4.3	8.7	-1.7	-2.9	2.1	-1.0
Number of treatments/medications taken	0.5	0.8	2.9	-0.3	-0.1	-1.7	0.6
Average weekly spirits intake	0.7	0.8	1.7	-0.1	-1.1	-1.3	-0.6
Sensitivity / hurt feelings	0.3	0.5	1.9	0.2	0.1	0.5	-1.4
Frequency of depressed mood in last 2 weeks	1.9	2.6	8.3	2.9	-0.9	-1.1	0.4
Hearing difficulty/problems: Yes	0.6	0.9	2.4	-0.4	-0.1	1.0	1.5
Relative age of first facial hair	1.2	2.4	6.1	1.8	-0.2	-2.5	-0.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	1.9	0.8	0.6	1.1	1.4
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.8	0.9	0.7	-0.6	-0.7
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	-0.1	-0.2	-0.5	-0.4
Systolic blood pressure, automated reading	0.2	0.6	1.5	1.2	0.7	-0.7	0.1
Eye problems/disorders: Diabetes related eye disease	2.2	2.4	6.8	-0.4	-1.6	2.6	0.2
Angina	0.8	1.1	2.0	0.5	-1.4	-0.3	1.4
Medication for hormone replacement therapy	0.2	0.2	0.3	-0.3	-0.3	-0.5	-0.6
Vitamin and mineral supplements	1.1	1.5	3.9	0.7	-2.0	1.2	-0.1
Supplements: Zinc	0.5	0.5	1.4	0.5	0.7	-0.2	-1.2
Medication: Co-codamol	1.1	1.3	3.3	-0.6	0.5	1.8	1.2
Medication: Metformin	1.7	2.5	5.4	-0.4	-0.4	2.0	2.3
Diabetes (father)	1.8	2.2	5.6	0.3	-2.4	0.1	-1.8
Diabetes (mother)	1.3	1.6	3.8	0.9	-0.9	2.0	1.1
Severe depression (siblings)	3.1	3.5	11.9	1.0	0.6	0.7	-3.5
Pack years adult smoking proportion	0.1	0.2	0.2	-0.4	0.5	0.4	0.4
Impedance of leg (right)	1.5	7.3	27.5	0.1	-1.1	-5.2	-0.6
Leg fat-free mass (left)	0.9	5.0	18.1	-0.7	-0.7	4.3	-1.0
Trunk fat percentage	2.0	8.1	20.4	-2.2	2.6	4.5	0.7
Hand grip strength (right)	1.5	4.1	14.1	-1.2	-3.8	0.0	-0.9
Townsend deprivation index at recruitment	0.3	0.5	1.1	-0.1	0.8	-0.3	-1.1
Current tobacco smoking	1.4	2.3	4.9	1.2	-0.6	-1.6	-2.2
Average weekly fortified wine intake	0.8	0.9	3.1	1.8	-0.6	-0.4	-0.2
Maternal smoking around birth	0.8	1.2	1.8	0.6	1.4	1.1	1.2
Fed-up feelings	1.8	3.2	6.5	2.5	0.3	-2.4	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.2	5.4	2.3	0.7	-1.2	1.2
Relative age voice broke	0.4	0.6	1.0	-1.0	-0.4	-0.7	-1.0
Taking other prescription medications	1.1	1.7	6.0	0.6	0.2	-0.4	2.4
Age when periods started (menarche)	1.5	3.5	8.1	2.4	0.5	-2.8	0.1
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.4	-0.5	-0.9	-1.2	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	4.1	-0.7	0.4	2.0	-0.7
Tinnitus: Yes, but not now, but have in the past	2.0	2.2	6.1	0.3	-0.8	-1.4	-2.5
Qualifications: CSEs or equivalent	0.3	0.4	1.1	1.0	0.0	-0.5	-0.2
Serious illness, injury or assault to yourself	0.8	1.0	3.1	0.7	-1.8	-0.4	-0.5
High blood pressure	0.4	1.2	2.7	1.7	0.3	-0.6	1.4
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.2	0.8	0.1	-1.5	0.5
Multivitamins +/- minerals	1.1	1.4	2.8	-1.7	0.1	-1.2	-1.3
Stomach or abdominal pain in last month	0.7	0.9	2.2	1.5	-1.1	0.1	-0.0
Supplements: Glucosamine	0.9	1.1	4.0	-2.0	0.5	0.0	0.6
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.6	-0.2	1.2	-0.3	-1.3
Medication: Atenolol	1.2	1.5	3.4	-0.8	-1.8	-0.8	1.1
Medication: Levothyroxine sodium	0.6	1.1	3.6	1.9	0.4	-0.7	-0.2
Sitting height	0.7	5.2	16.3	0.3	-4.0	1.1	-1.8
Chronic bronchitis/emphysema (father)	2.5	2.9	7.7	-0.3	2.0	2.8	0.1
High blood pressure (mother)	0.4	0.6	1.3	0.9	0.3	-0.3	-1.2
Body mass index (BMI)	1.9	8.0	26.6	-1.8	1.5	5.2	0.3
Impedance of leg (left)	1.1	5.5	21.1	0.2	-0.9	-4.6	-0.4
Leg predicted mass (left)	0.9	4.8	17.1	-0.7	-0.8	4.1	-1.0
Trunk fat mass	1.8	7.9	24.2	-2.2	1.6	4.9	0.1
Waist circumference	0.8	2.9	7.1	-1.5	1.2	2.7	-0.9
Number of incorrect matches in round	0.9	1.5	2.8	-1.2	1.7	-0.3	1.3
Past tobacco smoking	1.4	2.6	9.8	-0.0	-3.1	0.6	-0.2
Alcohol usually taken with meals	0.6	1.0	1.4	-1.2	-0.6	1.0	1.2
Nervous feelings	0.9	1.8	5.0	1.4	-2.2	-0.1	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.9	1.4	-0.4	-0.7	0.9
Hearing difficulty/problems with background noise	2.0	3.3	9.8	-0.0	1.8	0.3	3.1
Hair/balding pattern: Pattern 2	0.4	0.5	1.2	0.0	1.1	-0.3	-0.7
Had menopause	0.1	0.2	0.4	-0.1	0.4	-0.3	0.6
Had other major operations	1.9	2.3	3.7	-1.1	1.9	1.8	-1.0
Forced vital capacity (FVC)	4.6	17.6	48.2	3.8	-2.1	-6.9	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	5.1	-1.1	0.8	2.2	-1.4
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.8	1.3	-0.2	-0.3	0.9
Qualifications: None of the above	0.7	1.4	4.9	-0.0	-0.8	-2.2	-0.2
Financial difficulties in last 2 years	2.1	2.9	6.9	1.3	-2.6	-1.5	-0.8
Mouth/teeth dental problems	0.4	0.6	2.3	-0.3	0.3	1.5	-0.2
Heart attack	0.1	0.1	0.2	-0.5	-0.2	0.2	0.5
Allergy	0.8	1.8	3.8	-1.6	-0.9	1.9	0.3
Pain all over the body in last month	0.9	1.0	1.4	-0.4	-1.2	-1.2	-1.0
Diabetes (self-reported)	2.9	4.4	14.7	0.4	0.3	3.8	1.7
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.9	0.3	-0.2	-1.7	-0.8
Medication: Ramipril	2.8	3.6	11.1	3.3	0.3	1.3	1.2
Medication: Simvastatin	1.5	2.2	3.7	0.2	1.4	1.8	1.9
Fluid intelligence score	0.9	1.9	6.0	-0.3	-0.5	2.4	1.1
Illnesses of siblings	0.6	0.9	1.8	0.0	1.3	1.3	-0.0
Neuroticism score	0.6	1.3	3.9	2.0	-0.8	-0.8	0.3
Weight	1.3	6.3	22.3	-1.5	0.4	4.7	-0.7
Impedance of arm (right)	1.2	5.7	9.7	1.9	3.1	-3.1	0.3
Arm fat percentage (right)	2.1	8.4	21.5	-1.8	3.0	4.6	0.4
Trunk fat-free mass	0.7	4.1	6.7	-0.7	-2.6	2.3	-1.9
Hip circumference	1.5	6.5	25.0	-0.9	0.5	5.0	-0.4
Time employed in main current job	1.2	1.3	3.0	-1.2	-1.7	0.9	0.5
Alcohol intake versus 10 years previously	0.6	0.9	1.9	-0.7	0.3	-1.1	-1.4
Father’s age at death	0.4	0.5	1.0	0.6	-0.7	-1.0	0.6
Worrier / anxious feelings	1.3	2.5	4.9	2.2	-2.1	-0.6	-0.8
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	3.9	1.5	-1.2	-2.0	-1.5
Falls in the last year	1.3	1.8	5.8	2.4	0.3	-1.0	0.3
Hair/balding pattern: Pattern 3	0.7	1.0	2.6	-0.6	-0.8	0.7	-1.6
Number of live births	2.3	3.3	6.5	2.5	1.6	-1.9	-0.7
Forced expiratory volume in 1-second (FEV1)	4.1	14.0	32.4	3.2	-3.2	-5.7	-1.6
Pulse rate	1.1	1.8	6.2	0.5	0.3	-2.5	-0.9
Happiness	0.8	1.0	1.8	-1.4	0.4	0.5	1.3
Noisy workplace	2.1	2.6	7.7	1.5	0.8	-2.8	-0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.9	-0.0	-0.5	0.4	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.5	1.2	-0.4	0.8	0.9
Mouth/teeth dental problems: Dentures	0.7	1.2	2.0	-1.4	-0.8	-1.4	-0.3
Asthma	0.9	1.8	4.2	1.3	0.8	-2.1	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	2.0	0.1	0.3	-1.4	0.3
Medication: Cholesterol lowering	1.7	2.6	4.9	0.1	1.3	2.2	2.0
Depression (self-reported)	0.5	0.6	1.6	0.6	-0.8	-1.2	0.2
Medication: Lansoprazole	0.6	0.7	1.5	1.0	0.3	-1.2	0.4
Prospective memory result	1.2	1.4	3.7	-1.9	-0.8	0.0	-1.1
Lung cancer (father)	0.7	0.8	2.0	0.2	0.4	-1.4	-1.0
Illnesses of mother	0.6	0.8	2.3	-1.5	0.7	0.6	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	4.5	14.5	40.0	3.4	-2.5	-6.3	-0.6
Pulse wave Arterial Stiffness index	0.6	0.7	1.5	0.1	0.7	-0.9	1.2
Impedance of arm (left)	1.2	5.4	8.9	2.1	3.0	-2.9	0.4
Arm fat mass (right)	2.0	8.2	25.8	-1.8	2.0	5.1	-0.2
Trunk predicted mass	0.7	4.0	6.4	-0.6	-2.5	2.4	-1.9
Standing height	0.3	2.7	5.5	0.8	-2.3	-0.2	-2.2
Length of working week for main job	1.4	1.5	3.1	-1.6	-0.3	1.8	0.6
Exposure to tobacco smoke at home	0.6	0.7	1.4	1.1	0.5	0.2	-1.2
Breastfed as a baby	0.6	0.8	1.5	-1.0	-0.7	-0.4	1.2
Tense / ‘highly strung’	0.6	1.1	2.8	1.2	-0.2	-1.7	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	2.3	3.5	6.5	2.6	-1.4	-1.7	1.6
Hair/balding pattern: Pattern 4	2.3	5.5	14.4	-2.7	0.5	3.8	-0.0
Birth weight of first child	2.6	4.7	10.8	-2.3	-0.3	3.3	1.6
Peak expiratory flow (PEF)	2.3	5.3	9.9	2.3	-3.1	-2.1	-1.2
Pulse wave reflection index	0.8	1.0	1.5	-0.5	1.1	1.2	1.1
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.5	1.1	1.2	0.2	0.5
Loud music exposure frequency	1.5	1.6	5.5	2.4	0.4	0.7	-0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.7	-0.9	-0.1	-0.5	-0.7
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	2.8	1.2	0.5	-1.4	1.7
Blood clot in the leg (DVT)	0.9	1.2	2.8	1.7	0.8	-0.0	-1.1
Medication: Paracetamol	0.6	1.0	3.2	0.3	-0.4	-1.8	0.7
Headache pain in last month	1.0	1.6	3.3	1.3	-1.8	-0.4	1.2
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	3.5	0.2	-1.5	-1.9	-1.6
Glaucoma (self-reported)	0.7	0.9	2.1	1.4	-0.9	-0.6	0.5
Gout (self-reported)	1.5	2.1	4.8	-2.2	-1.6	-0.2	-1.0
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.0	1.4	1.4	0.6	0.4
Medication: Amlodipine	0.3	0.4	0.9	0.6	0.1	1.0	0.5
Medication: Ventolin 100micrograms inhaler	0.9	1.1	2.8	-0.7	-1.0	-1.7	-0.5
Birth weight	1.6	3.6	5.8	-1.3	-2.4	-1.3	-2.3
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.0	0.2	-0.9	-1.0	0.7
High blood pressure (siblings)	2.1	3.1	10.2	0.4	-1.3	-3.2	-0.5
Forced vital capacity (FVC), Best measure	5.0	18.4	55.0	3.9	-1.7	-7.4	-0.6
Body fat percentage	2.0	8.1	20.6	-2.3	2.4	4.5	0.5
Leg fat percentage (right)	1.3	4.8	12.3	-2.4	1.1	3.5	0.0
Arm fat-free mass (right)	1.0	5.1	12.3	-1.0	-2.3	3.5	-1.2
Exposure to tobacco smoke outside home	0.4	0.5	0.8	0.7	-0.6	-0.9	0.5
Comparative body size at age 10	2.4	6.6	24.6	0.7	0.9	5.0	-0.5
Number of full brothers	0.8	1.1	3.8	0.6	-0.0	-2.0	0.3
Worry too long after embarrassment	0.7	1.3	3.1	0.8	-1.8	1.1	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.6	0.6	-0.1	-0.2	0.8
Wheeze or whistling in the chest in last year	0.8	1.4	5.4	-0.3	0.2	-0.4	-2.3
Number of children fathered	1.2	1.4	3.5	-1.9	-0.8	-0.5	1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.1	-0.2	1.8	-1.1	1.0
Age at first live birth	0.2	0.3	0.5	0.6	0.6	0.7	0.0
Pulse wave peak to peak time	0.7	0.8	1.6	-0.1	-1.0	0.8	-1.3
Health satisfaction	0.7	0.9	1.7	0.2	1.3	-1.2	0.5
Shortness of breath walking on level ground	0.6	0.7	1.4	0.3	1.1	-0.3	-1.2
Qualifications: College or University degree	1.1	3.4	10.9	-1.4	-0.1	3.3	0.8
Eye problems/disorders: None of the above	0.2	0.2	0.5	0.1	0.7	0.0	-0.5
Mouth/teeth dental problems: Loose teeth	1.5	1.8	3.6	-1.9	1.6	0.8	0.7
Emphysema/chronic bronchitis	0.8	1.0	2.6	0.8	1.6	0.3	0.6
Medication for pain relief, constipation, heartburn	0.8	1.3	3.6	1.0	-0.5	1.9	-0.6
Neck or shoulder pain in last month	0.6	0.8	1.5	-1.1	-1.2	0.2	0.6
Medication: Blood pressure	0.6	1.1	2.0	0.3	0.8	1.4	1.3
Angina (self-reported)	0.8	1.0	2.4	0.4	-1.2	-0.4	1.5
Migraine (self-reported)	0.6	0.7	2.8	1.7	0.1	-0.1	0.1
Medication: Ibuprofen	0.6	0.7	2.5	0.1	0.5	-1.6	-0.1
Medication: Allopurinol	0.6	0.7	1.0	-1.0	-1.0	0.3	-0.9
Medication: Omeprazole	0.1	0.1	0.2	-0.2	0.1	-0.4	-0.5
Medication: Seretide 50 evohaler	0.8	0.9	2.5	0.0	-1.0	-0.3	-1.6
Mean time to correctly identify matches	0.6	1.2	1.9	-0.5	1.3	-1.4	0.9
Heart disease (mother)	2.0	2.4	7.4	2.7	-0.8	-1.1	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	2.2	-1.1	0.7	1.5	-0.1
Whole body fat mass	1.9	7.9	24.0	-2.2	1.6	4.9	-0.2
Leg fat mass (right)	1.7	6.5	21.0	-2.1	0.8	4.6	-0.2
Arm predicted mass (right)	0.9	4.8	11.0	-0.9	-2.4	3.3	-1.3
Pulse rate, automated reading	1.2	3.9	9.8	0.8	-0.8	-3.1	2.1
Alcohol intake frequency.	1.5	3.5	6.5	-1.8	-1.9	0.8	-2.5
Comparative height size at age 10	0.8	4.2	11.8	-2.0	-0.8	3.4	-0.5
Number of full sisters	0.3	0.4	1.0	-0.1	-1.0	-0.4	0.6
Suffer from ‘nerves’	1.8	2.9	4.2	2.0	-1.4	-2.0	1.2
Overall health rating	1.4	3.1	5.8	1.4	-0.8	-2.0	2.4
Chest pain or discomfort	0.7	0.9	1.7	0.6	-1.3	-0.1	1.3
Had major operations	1.8	2.1	4.1	1.9	2.0	-0.7	0.2
Age at last live birth	0.8	1.1	2.1	1.4	1.4	-0.1	0.7
Family relationship satisfaction	0.3	0.4	0.6	0.8	-0.7	0.0	0.7
Leg pain on walking	0.6	0.7	1.4	-0.7	-0.1	-1.2	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.0	-1.3	0.1	-0.9	-1.4
Commuting to job workplace: Car/motor vehicle	1.8	2.1	5.2	1.7	0.2	0.2	2.3
Illness, injury, bereavement, stress in last 2 years	1.0	1.3	3.5	-1.9	0.5	-0.6	-1.0
Medication: Aspirin	1.1	1.5	4.2	-0.4	1.1	0.6	2.1
Supplements: Vitamin C	1.0	1.1	2.4	0.4	0.8	-1.6	1.2
Knee pain experienced in last month	0.9	1.4	2.6	-1.6	0.3	-1.4	-1.0
Hypertension (Self-reported)	0.4	1.1	2.4	1.4	0.1	-0.3	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.3	-0.6	-1.3	-1.5	-0.1
Illnesses of father: Heart disease	0.4	0.5	1.4	-0.4	-0.5	-0.5	-1.2
Illnesses of siblings: Diabetes	0.7	0.8	3.3	0.1	0.1	1.8	-0.1
Smoking status: Previous	2.1	3.2	11.2	-0.8	3.3	0.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.4	3.0	6.4	-0.3	-2.3	-0.2	-2.5
Whole body fat-free mass	0.8	4.5	10.7	-0.8	-2.0	3.3	-1.6
Leg fat-free mass (right)	0.9	4.9	17.7	-0.5	-0.9	4.2	-0.9
Arm fat percentage (left)	2.3	9.0	24.4	-1.4	3.0	4.9	0.7
Average weekly red wine intake	3.4	5.1	11.7	-3.4	-1.7	2.3	-0.4
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.9	1.1	0.6	0.9	-1.7
Mood swings	0.8	1.5	2.2	1.5	1.0	-1.5	-0.7
Loneliness, isolation	0.6	0.8	1.9	0.7	0.6	1.4	0.8
Long-standing illness, disability or infirmity	1.6	2.4	5.1	2.3	1.1	-0.3	1.8
Ever had bowel cancer screening	1.2	1.4	3.2	-0.2	1.8	0.3	1.5
Diabetes diagnosed by doctor	2.2	3.6	10.3	0.2	0.3	3.2	2.0
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.0	0.1	-0.0	-1.4	-0.9
Friendships satisfaction	0.4	0.5	1.3	0.8	-0.1	1.1	-0.3
Qualifications: nursing, teaching	0.2	0.3	0.8	-0.9	-0.6	0.0	-0.2
Commuting to job workplace: Walk	0.9	1.0	2.0	1.4	0.7	-0.5	-1.1
Eye problems/disorders: Cataract	0.3	0.4	0.5	-0.7	-0.5	-0.4	0.7
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	7.0	2.7	-0.1	0.2	-1.2
Medication for cholesterol	0.5	0.8	1.4	-1.2	0.9	1.0	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	3.3	1.1	1.8	0.8	1.8
Back pain experienced in last month	0.4	0.5	1.1	1.1	0.1	-0.9	0.5
Mineral and other dietary supplements	0.2	0.3	1.1	1.1	0.3	0.3	-0.0
Breast cancer (self-reported)	0.3	0.3	1.1	-0.3	-1.1	-0.0	0.1
Asthma (self-reported)	0.7	1.5	3.8	1.0	0.8	-1.9	-0.6
Osteoporosis (self-reported)	0.2	0.3	0.6	0.8	0.7	0.0	0.1
Osteoarthritis (self-reported)	0.2	0.2	0.6	-0.8	0.4	0.1	0.3
Medication: Aspirin	1.7	2.2	5.0	-0.5	1.4	1.2	2.2
Medication: Gliclazide	1.0	1.1	3.0	-0.6	0.9	1.7	0.4
Illnesses of father: None of the above (group 1)	1.2	1.4	3.0	-1.5	-0.5	0.5	1.7
Smoking status: Current	1.8	2.8	5.9	1.3	-0.4	-1.8	-2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.1	8.7	23.6	2.9	-1.7	-4.9	0.0
Whole body water mass	0.8	4.5	11.0	-0.8	-2.0	3.3	-1.6
Leg predicted mass (right)	0.9	4.8	17.6	-0.3	-0.8	4.2	-0.8
Arm fat mass (left)	2.2	8.9	28.3	-1.8	2.0	5.3	-0.2
Number of self-reported non-cancer illnesses	2.0	3.5	7.8	2.8	0.9	-1.9	1.2
Average weekly champagne plus white wine intake	0.1	0.1	0.3	0.2	-0.2	-0.5	0.3
Miserableness	1.6	2.9	4.7	2.1	-1.3	-2.2	0.8
Guilty feelings	0.3	0.4	1.7	0.0	0.2	1.3	-0.1
Wears glasses or contact lenses	0.8	0.9	1.1	-1.0	-1.0	-0.8	-1.1
Ever taken oral contraceptive pill	1.3	1.4	4.2	0.5	-0.7	-2.0	-0.9
Hearing aid user	1.1	1.3	2.4	-0.5	1.6	-1.2	0.9
Mother’s age at death	1.1	1.4	3.4	1.1	0.7	0.7	1.8
Financial situation satisfaction	0.6	0.8	1.2	0.7	-0.9	-0.7	1.1
Tinnitus: Yes, now most or all of the time	2.4	2.8	4.6	2.1	1.3	-1.4	1.8
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.5	-0.4	-0.0	-0.4
Eye problems/disorders: Glaucoma	0.5	0.6	1.0	1.0	-0.4	-0.7	1.0
Medication: Blood pressure	0.9	1.7	3.6	1.9	-1.0	-1.1	1.0
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.4	-1.2	-0.8	-1.2	-0.3
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.1	0.3	-0.6	-1.4	-1.1
High cholesterol (Self-reported)	0.9	1.7	3.6	0.1	0.7	1.6	1.9
Medication: Bendroflumethiazide	0.4	0.6	1.9	0.3	0.7	-1.4	0.2
Medication: Paracetamol	1.0	1.6	4.2	0.6	-0.5	-2.1	1.2
Medication: Lisinopril	0.2	0.3	0.5	-0.2	-0.3	0.6	0.7
Medication: Atorvastatin	1.0	1.3	4.0	-0.2	-1.0	2.0	0.4
Illnesses of father: High blood pressure	0.4	0.5	0.8	0.5	-0.8	-0.9	-0.5
Alcohol drinker status: Never	0.1	0.1	0.3	0.2	0.3	-0.5	-0.4
Ever smoked	0.5	0.9	3.3	0.0	1.8	-0.4	-0.5
Basal metabolic rate	0.9	4.9	13.7	-1.1	-1.6	3.7	-1.5
Leg fat percentage (left)	1.6	5.7	16.6	-2.2	1.2	4.1	0.1
Arm fat-free mass (left)	0.9	4.8	10.8	-1.1	-2.1	3.3	-1.6
Number of operations (self-reported)	0.3	0.4	1.0	0.8	0.2	-1.0	-0.3
Average weekly beer plus cider intake	1.8	2.7	8.5	0.7	2.9	-1.3	0.1
Irritability	0.4	0.8	1.8	0.5	1.3	0.6	0.8
Risk taking	1.7	2.5	6.8	-2.6	0.7	0.8	1.5
Ever had prostate specific antigen (PSA) test	1.1	1.2	2.5	0.6	1.4	-0.4	1.6
Fractured/broken bones in last 5 years	0.0	0.1	0.1	-0.3	-0.1	-0.3	0.2
Age started oral contraceptive pill	0.7	0.9	2.5	1.6	0.5	-0.2	0.8
Diastolic blood pressure, automated reading	0.0	0.1	0.4	0.6	0.2	-0.3	-0.0
Ever depressed for a whole week	0.7	0.8	1.9	0.5	-0.8	0.6	1.4
Unable to work because of sickness or disability	1.6	2.1	4.4	1.1	-1.6	-2.1	0.1
Commuting to job workplace: Cycle	1.2	1.4	3.0	1.4	-0.1	0.9	-1.7
Myopia	0.2	0.3	0.5	-0.5	0.5	-0.7	0.2
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.6	-1.3	0.1	0.8	-1.1
Cholesterol lowering medication	0.5	0.8	1.8	-0.4	-1.0	1.4	0.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.7	0.5	-0.6	-0.9	-0.1
Pain experienced in last month	0.5	0.8	3.0	-0.5	0.2	1.7	-0.3
Supplements: Calcium	0.4	0.4	1.2	0.5	-0.0	0.5	1.1
Basal cell carcinoma (self-reported)	1.3	1.5	4.9	-0.1	-0.7	-0.7	2.2
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.4	-0.6	0.1	0.1	0.7
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.8	1.7	0.4	-0.3	-1.3
Heart disease (siblings)	1.3	1.6	3.4	-1.8	-1.7	0.4	-0.2
Alcohol drinker status: Previous	0.9	1.0	1.9	-1.4	0.9	1.0	-0.5
Pack years of smoking	0.3	0.4	0.5	-0.6	0.6	0.7	0.6
Impedance of whole body	0.9	4.4	14.2	1.3	1.3	-3.8	0.1
Leg fat mass (left)	1.8	7.1	23.6	-2.0	0.9	4.9	-0.2
Arm predicted mass (left)	1.1	5.4	11.0	-1.5	-2.5	3.3	-1.4