[Hub]/) : Traits : Impedance of leg (right) : ← →

chr17:15,149,905-16,895,160

Best TWAS P=2.95e-09 · Best GWAS P=2.52e-08 conditioned to 0.487

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
30	YFS	Blood	PIGL	0.02	0.02	blup	279	0.02	1.5e-06	3.4	5.9	2.9e-09	0.88	0.18	0.82	TRUE
18	GTEx	Pancreas	TTC19	0.12	0.09	enet	9	0.07	8.5e-04	5.0	-5.8	7.0e-09	-0.86	0.14	0.63	FALSE
4	GTEx	Artery Aorta	TTC19	0.06	0.00	lasso	3	0.00	7.1e-01	4.9	-5.8	8.2e-09	-0.87	0.08	0.30	FALSE
33	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ADORA2B	0.28	0.24	enet	14	0.27	7.3e-16	5.0	5.8	8.2e-09	0.95	0.02	0.98	FALSE
25	GTEx	Whole Blood	ADORA2B	0.08	0.00	lasso	5	0.00	2.5e-01	4.2	5.8	8.5e-09	0.85	0.04	0.69	FALSE
36	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ADORA2B	0.13	0.17	blup	37	0.16	8.2e-08	5.2	5.7	1.0e-08	0.96	0.01	0.99	FALSE
23	GTEx	Spleen	ADORA2B	0.23	0.27	enet	10	0.24	7.4e-07	5.0	5.7	1.4e-08	0.96	0.05	0.95	FALSE
38	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ADORA2B	0.10	0.07	enet	9	0.08	5.0e-06	4.9	5.6	2.4e-08	0.94	0.01	0.98	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	ADORA2B	0.15	0.13	lasso	3	0.12	3.8e-07	5.6	5.5	2.9e-08	1.00	0.02	0.97	FALSE
37	The Cancer Genome Atlas	Lung Adenocarcinoma	ZSWIM7	0.05	0.05	blup	48	0.05	3.3e-06	5.0	5.5	4.3e-08	0.98	0.02	0.98	FALSE
19	GTEx	Pancreas	ADORA2B	0.12	0.16	enet	9	0.14	1.5e-06	5.5	5.4	5.1e-08	0.99	0.03	0.96	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	TTC19	0.14	0.24	lasso	10	0.27	1.2e-34	5.5	5.4	6.1e-08	0.95	0.02	0.98	FALSE
8	GTEx	Brain Frontal Cortex BA9	ZSWIM7	0.15	0.21	lasso	3	0.20	6.3e-06	5.5	5.4	6.3e-08	0.99	0.04	0.95	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ADORA2B	0.06	0.07	blup	304	0.07	5.0e-09	4.7	5.4	6.5e-08	0.92	0.06	0.94	FALSE
21	GTEx	Skin Sun Exposed Lower leg	ADORA2B	0.12	0.17	lasso	4	0.17	3.1e-14	5.5	5.4	6.6e-08	1.00	0.03	0.97	FALSE
41	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZSWIM7	0.15	0.25	enet	13	0.26	2.0e-27	5.2	5.4	7.1e-08	0.99	0.01	0.99	FALSE
6	GTEx	Brain Cerebellar Hemisphere	ADORA2B	0.16	0.00	lasso	9	-0.01	5.6e-01	5.5	5.3	1.0e-07	0.96	0.04	0.66	FALSE
9	GTEx	Brain Hypothalamus	ZSWIM7	0.13	0.18	lasso	2	0.14	3.8e-04	5.5	5.3	1.1e-07	0.99	0.04	0.86	FALSE
17	GTEx	Muscle Skeletal	ZSWIM7	0.22	0.42	enet	15	0.42	9.6e-45	5.0	5.3	1.3e-07	0.98	0.15	0.85	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZSWIM7	0.06	0.10	lasso	2	0.09	1.4e-17	5.3	5.3	1.3e-07	0.99	0.01	0.99	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	ADORA2B	0.09	0.11	lasso	5	0.10	5.7e-13	5.3	5.3	1.4e-07	0.98	0.04	0.96	FALSE
7	GTEx	Brain Cerebellum	ZSWIM7	0.25	0.13	lasso	4	0.12	2.6e-04	5.2	-5.3	1.5e-07	-0.98	0.04	0.95	FALSE
24	GTEx	Spleen	ZSWIM7	0.37	0.39	lasso	7	0.40	2.8e-11	5.3	-5.2	1.5e-07	-0.99	0.05	0.95	FALSE
2	GTEx	Adipose Subcutaneous	ADORA2B	0.16	0.23	lasso	4	0.26	1.7e-21	5.0	5.2	1.6e-07	0.98	0.07	0.93	FALSE
3	GTEx	Adipose Visceral Omentum	ADORA2B	0.13	0.16	lasso	3	0.16	1.8e-08	5.2	5.2	1.6e-07	0.99	0.04	0.96	FALSE
27	METSIM	Adipose	ADORA2B	0.10	0.20	lasso	3	0.20	4.2e-29	5.2	5.2	1.6e-07	0.98	0.04	0.96	FALSE
40	The Cancer Genome Atlas	Prostate Adenocarcinoma	ADORA2B	0.14	0.19	lasso	3	0.20	8.0e-21	5.0	5.2	1.7e-07	0.96	0.02	0.98	FALSE
39	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TTC19	0.10	0.11	lasso	1	0.09	9.6e-05	5.2	-5.2	1.9e-07	-0.98	0.04	0.95	FALSE
12	GTEx	Cells EBV-transformed lymphocytes	TTC19	0.15	0.05	lasso	4	0.08	1.6e-03	5.5	-5.2	2.1e-07	-0.99	0.04	0.93	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	NCOR1	0.03	0.04	blup	97	0.04	8.1e-06	5.3	5.2	2.1e-07	0.99	0.04	0.96	FALSE
11	GTEx	Breast Mammary Tissue (Male)	TTC19	0.13	0.08	lasso	3	0.01	1.6e-01	5.5	-5.2	2.2e-07	-0.99	0.04	0.71	FALSE
15	GTEx	Lung	ADORA2B	0.19	0.09	lasso	4	0.07	3.2e-06	5.0	5.2	2.2e-07	0.97	0.04	0.96	FALSE
16	GTEx	Muscle Skeletal	ADORA2B	0.27	0.44	lasso	3	0.45	5.3e-48	5.0	5.2	2.2e-07	0.98	0.21	0.79	FALSE
5	GTEx	Artery Tibial	ADORA2B	0.23	0.42	lasso	3	0.42	1.2e-35	5.0	5.1	2.7e-07	0.98	0.17	0.83	FALSE
26	GTEx	Whole Blood	ZSWIM7	0.08	0.01	enet	22	0.01	2.4e-02	2.5	5.1	2.7e-07	0.30	0.06	0.16	FALSE
32	The Cancer Genome Atlas	Colon Adenocarcinoma	ZSWIM7	0.04	0.02	blup	44	0.03	5.0e-03	5.5	5.1	2.7e-07	0.99	0.02	0.78	FALSE
10	GTEx	Breast Mammary Tissue	TTC19	0.07	0.05	enet	6	0.05	2.0e-03	4.8	-5.1	2.8e-07	-0.98	0.09	0.87	FALSE
14	GTEx	Heart Atrial Appendage	ADORA2B	0.19	0.14	lasso	10	0.13	2.4e-06	5.4	5.1	2.8e-07	0.98	0.04	0.96	FALSE
13	GTEx	Cells Transformed fibroblasts	ADORA2B	0.18	0.11	enet	15	0.15	2.2e-11	2.4	5.1	2.9e-07	0.23	0.98	0.01	FALSE
22	GTEx	Spleen	TTC19	0.28	0.06	enet	12	0.03	7.0e-02	5.0	-5.1	3.0e-07	-0.88	0.12	0.61	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZSWIM7	0.19	0.32	lasso	4	0.32	5.9e-37	5.0	5.1	3.1e-07	0.98	0.03	0.97	FALSE