[Hub]/) : Traits : Impedance of leg (right) : ← →

chr17:17,017,584-18,923,818

Best TWAS P=2.22e-09 · Best GWAS P=3.4e-09 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
31	YFS	Blood	SREBF1	0.07	0.11	lasso	7	0.11	2.2e-33	5.9	-6.0	2.2e-09	-0.99	0.01	0.99	TRUE
27	GTEx	Testis	ALKBH5	0.18	0.06	enet	14	0.11	1.3e-05	2.5	-5.9	4.3e-09	-0.60	0.20	0.68	FALSE
7	GTEx	Brain Cerebellum	TOM1L2	0.10	0.06	lasso	5	0.02	6.6e-02	5.8	-5.8	6.0e-09	-0.93	0.06	0.76	FALSE
23	GTEx	Muscle Skeletal	TOM1L2	0.08	0.11	lasso	6	0.10	5.3e-10	5.6	-5.8	7.8e-09	-0.98	0.06	0.94	FALSE
29	METSIM	Adipose	ALKBH5	0.08	0.05	blup	285	0.04	3.0e-07	-5.0	-5.7	9.4e-09	-0.55	0.56	0.44	FALSE
20	GTEx	Lung	TOM1L2	0.07	0.02	lasso	6	0.03	1.4e-03	5.2	-5.7	1.3e-08	-0.86	0.13	0.86	FALSE
6	GTEx	Brain Caudate basal ganglia	ALKBH5	0.12	0.00	lasso	6	0.03	4.4e-02	4.7	-5.6	1.8e-08	-0.75	0.13	0.39	FALSE
4	GTEx	Adipose Visceral Omentum	TOM1L2	0.15	0.13	lasso	4	0.11	3.6e-06	5.6	-5.6	1.9e-08	-0.96	0.10	0.90	FALSE
15	GTEx	Esophagus Mucosa	DRG2	0.06	0.00	enet	19	0.01	1.3e-01	4.6	-5.6	1.9e-08	-0.65	0.11	0.15	FALSE
28	GTEx	Whole Blood	SREBF1	0.04	0.06	lasso	5	0.05	2.4e-05	5.5	-5.6	2.6e-08	-0.96	0.06	0.94	FALSE
36	The Cancer Genome Atlas	Stomach Adenocarcinoma	SREBF1	0.04	0.03	blup	32	0.02	7.8e-03	4.7	5.5	2.9e-08	0.94	0.02	0.68	FALSE
1	CommonMind	Brain Pre-frontal Cortex	TOM1L2	0.19	0.24	bslmm	425	0.24	2.4e-29	5.6	-5.5	3.0e-08	-0.95	0.02	0.98	FALSE
12	GTEx	Colon Sigmoid	RP11-258F1.1	0.09	0.01	lasso	13	0.00	2.1e-01	-5.1	-5.5	3.1e-08	-0.56	0.08	0.19	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	TOM1L2	0.15	0.11	blup	414	0.10	1.4e-12	5.6	-5.5	3.2e-08	-0.85	0.03	0.97	FALSE
24	GTEx	Muscle Skeletal	AC122129.1	0.13	0.14	lasso	4	0.13	7.3e-13	5.3	-5.5	4.0e-08	-0.96	0.19	0.81	FALSE
14	GTEx	Esophagus Mucosa	ALKBH5	0.09	0.08	lasso	8	0.06	9.3e-05	-5.0	-5.5	4.3e-08	-0.51	0.27	0.42	FALSE
16	GTEx	Esophagus Mucosa	LLGL1	0.38	0.39	lasso	6	0.39	8.0e-28	-5.4	-5.5	4.4e-08	-0.38	0.14	0.86	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	TOM1L2	0.01	0.01	blup	83	0.01	1.8e-03	4.7	-5.5	4.6e-08	-0.95	0.05	0.83	FALSE
8	GTEx	Breast Mammary Tissue	ALKBH5	0.07	0.09	enet	6	0.08	6.1e-05	-5.1	-5.4	5.9e-08	-0.57	0.24	0.32	FALSE
11	GTEx	Cells Transformed fibroblasts	TOM1L2	0.05	0.00	enet	14	0.00	2.8e-01	3.2	-5.4	6.4e-08	-0.71	0.07	0.73	FALSE
2	GTEx	Adipose Subcutaneous	TOM1L2	0.04	0.04	lasso	3	0.04	5.3e-04	5.6	-5.4	6.8e-08	-0.95	0.10	0.88	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	ALKBH5	0.05	0.04	lasso	1	0.03	9.1e-05	-5.4	-5.4	6.8e-08	-0.38	0.00	0.99	FALSE
21	GTEx	Lung	RP11-258F1.1	0.05	0.00	lasso	5	0.00	4.1e-01	4.5	-5.4	6.9e-08	-0.85	0.10	0.52	FALSE
10	GTEx	Cells Transformed fibroblasts	CCDC144B	0.06	0.02	enet	10	0.06	2.9e-05	-3.1	-5.4	8.1e-08	-0.48	0.08	0.86	FALSE
22	GTEx	Muscle Skeletal	ALKBH5	0.10	0.09	lasso	3	0.07	2.0e-07	-5.1	-5.3	8.9e-08	-0.43	0.50	0.50	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	LLGL1	0.10	0.04	lasso	7	0.04	7.5e-05	-5.0	-5.3	9.5e-08	-0.38	0.01	0.99	FALSE
18	GTEx	Esophagus Muscularis	TOM1L2	0.06	0.07	enet	12	0.05	4.3e-04	5.2	-5.3	9.6e-08	-0.87	0.20	0.78	FALSE
13	GTEx	Colon Transverse	ALKBH5	0.16	0.08	lasso	4	0.07	3.4e-04	-5.1	-5.3	1.1e-07	-0.40	0.22	0.34	FALSE
19	GTEx	Heart Atrial Appendage	AC122129.1	0.15	0.02	enet	9	0.08	1.4e-04	3.0	-5.3	1.2e-07	-0.58	0.17	0.46	FALSE
5	GTEx	Artery Aorta	RP11-258F1.1	0.11	0.12	lasso	5	0.10	4.7e-06	-5.0	-5.2	1.6e-07	-0.41	0.46	0.47	FALSE
3	GTEx	Adipose Subcutaneous	RP11-258F1.1	0.19	0.13	lasso	4	0.12	3.6e-10	-5.1	-5.2	1.8e-07	-0.46	0.50	0.50	FALSE
17	GTEx	Esophagus Mucosa	MIEF2	0.11	0.07	lasso	10	0.06	1.0e-04	-5.1	-5.2	2.2e-07	-0.43	0.27	0.64	FALSE
26	GTEx	Skin Sun Exposed Lower leg	RP11-258F1.1	0.12	0.10	lasso	5	0.09	9.9e-08	-5.1	-5.2	2.2e-07	-0.47	0.48	0.51	FALSE
33	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ALKBH5	0.07	0.05	blup	63	0.05	2.1e-03	-5.1	-5.2	2.2e-07	-0.42	0.01	0.86	FALSE
9	GTEx	Cells Transformed fibroblasts	SREBF1	0.09	0.01	lasso	11	0.01	3.2e-02	5.2	5.2	2.4e-07	0.81	0.12	0.45	FALSE
25	GTEx	Skin Sun Exposed Lower leg	DRG2	0.06	0.07	lasso	4	0.08	6.5e-07	4.6	-5.1	2.9e-07	-0.80	0.21	0.78	FALSE