TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Impedance of leg (right)
:
←
→
chr19:46,923,752-48,717,332
Best TWAS P=6.78e-19 · Best GWAS P=2.17e-36 conditioned to 2.66e-17
47M
47.5M
48M
48.5M
0
10
20
30
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Cells EBV-transformed lymphocytes
SAE1
0.21
0.09
lasso
3
0.07
2.0e-03
7.0
8.9
6.8e-19
0.77
0.06
0.67
TRUE
3
GTEx
Thyroid
CCDC9
0.22
0.09
lasso
4
0.16
3.6e-12
2.2
-6.4
1.5e-10
-0.32
0.98
0.00
TRUE
4
METSIM
Adipose
SAE1
0.12
0.04
lasso
5
0.07
1.7e-10
6.2
8.3
8.7e-17
0.61
0.61
0.39
FALSE
5
YFS
Blood
SAE1
0.07
0.02
enet
18
0.05
3.6e-16
7.6
6.8
1.3e-11
0.56
0.99
0.01
FALSE
1
CommonMind
Brain Pre-frontal Cortex
NAPA
0.06
0.00
bslmm
381
0.01
7.2e-03
-1.1
5.6
1.8e-08
0.30
0.06
0.08
FALSE