TWAS hub - SAE1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.2060	0.0650	1.5e-03	0.088	NA	0.070	NA	0.074	8.1e-04	NA	2.7e-03	NA	2.0e-03
2	METSIM	Adipose	0.1222	0.0345	1.7e-07	0.040	0.042	0.052	0.043	0.069	1.2e-06	5.8e-07	2.7e-08	3.8e-07	1.7e-10
3	YFS	Blood	0.0717	0.0171	4.5e-11	0.022	0.039	0.051	0.045	0.047	6.3e-08	1.1e-12	3.6e-16	2.1e-14	3.1e-15

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Impedance of leg (right)	13.3	64.6	78.8	8.9	8.3	6.8
Impedance of whole body	12.8	65.2	74.8	8.7	8.3	7.2
Body Mass Index (BMI) (2010)	12.5	17.2	21.2	-4.6	-4.4	-3.3
Impedance of leg (left)	12.5	60.8	73.4	8.6	8.1	6.6
Impedance of arm (left)	11.6	53.5	57.6	7.6	7.4	6.9
Impedance of arm (right)	10.9	50.6	52.3	7.2	7.0	7.1
BMI	10.0	58.0	72.8	-8.5	-7.4	-6.8
Triglycerides	9.8	16.1	18.2	-4.2	-4.3	-3.5
Body mass index (BMI)	9.7	41.4	49.8	-7.1	-6.5	-5.7
Diabetes diagnosed by doctor	9.6	15.8	17.1	-4.1	-3.9	-3.9
Leg fat-free mass (right)	9.4	50.1	58.6	-7.4	-7.7	-6.1
Leg predicted mass (left)	9.2	48.7	56.4	-7.2	-7.5	-6.1
Leg predicted mass (right)	9.2	49.1	57.9	-7.3	-7.6	-6.0
Leg fat-free mass (left)	9.1	48.3	56.1	-7.2	-7.5	-6.1
Medication: Levothyroxine sodium	9.1	15.4	19.4	-4.3	-4.4	-2.8
Arm predicted mass (left)	9.1	46.2	52.6	-6.9	-7.2	-6.2
Intelligence (Savage-Jansen 2018)	8.3	25.4	26.7	-5.1	-5.2	-4.9
Arm fat-free mass (left)	8.2	41.7	47.6	-6.5	-6.9	-5.9
Arm fat-free mass (right)	8.1	41.7	45.2	-6.5	-6.7	-6.2
Whole body water mass	8.0	45.7	53.5	-6.8	-7.3	-6.1
Basal metabolic rate	8.0	44.1	51.6	-6.7	-7.2	-6.0
Diabetes (self-reported)	7.7	11.9	13.5	-3.4	-3.3	-3.7
Whole body fat-free mass	7.7	44.1	52.0	-6.7	-7.2	-6.0
Weight	7.6	37.5	41.2	-6.3	-6.4	-5.6
Arm predicted mass (right)	7.6	38.8	43.3	-6.1	-6.6	-6.0
Worry (Nagel 2018)	7.4	15.6	16.2	4.0	3.8	4.0
Medication: Metformin	7.4	10.5	11.4	-3.4	-3.3	-3.0
Waist circumference	7.0	25.5	27.6	-5.2	-5.2	-4.7
Arm fat mass (left)	7.0	28.9	34.3	-5.9	-5.5	-4.8
Pulse wave Arterial Stiffness index	6.8	8.0	10.2	3.2	2.8	2.5
Medication: Gliclazide	6.8	7.7	9.1	-2.8	-3.0	-2.4
Leg fat mass (left)	6.8	26.6	30.7	-5.5	-5.1	-4.8
Taking other prescription medications	6.6	10.2	12.2	-3.5	-3.4	-2.7
Arm fat mass (right)	6.6	27.0	32.4	-5.7	-5.4	-4.5
Primary Biliary Cirrhosis	6.5	9.2	11.4	3.4	3.0	2.7
Worrier / anxious feelings	6.4	12.0	12.9	3.4	3.4	3.6
Comparative body size at age 10	6.4	17.7	26.1	-5.1	-4.3	-3.0
Leg fat mass (right)	6.4	25.0	28.9	-5.4	-4.9	-4.6
Handedness (chirality/laterality): Left-handed	6.4	7.7	12.6	3.6	3.2	0.4
HDL Cholesterol	6.3	10.5	14.2	3.8	3.2	2.6
Wheeze or whistling in the chest in last year	6.3	11.3	14.0	-3.7	-3.3	-3.1
Pulse wave peak to peak time	6.3	7.4	8.9	-3.0	-2.8	-2.4
Hypothyroidism/myxoedema (self-reported)	5.8	11.3	15.6	-3.5	-4.0	-2.4
Trunk fat-free mass	5.7	32.9	39.8	-5.7	-6.3	-5.2
Medication: Aspirin	5.7	7.5	8.9	-3.0	-3.0	-2.2
Medication for cholesterol	5.7	8.7	11.1	3.2	3.3	2.2
Trunk predicted mass	5.6	32.3	39.1	-5.6	-6.2	-5.1
Age when periods started (menarche)	5.5	13.3	17.3	3.7	3.0	4.2
Long-standing illness, disability or infirmity	5.5	8.4	8.7	-2.9	-2.9	-3.0
Verbal and Numeric Reasoning (VNR)	5.4	13.0	15.2	-3.9	-3.5	-3.4
Ulcerative Colitis	5.3	7.6	8.8	2.6	2.7	3.0
Eye problems/disorders: Cataract	5.2	6.1	7.3	-2.7	-2.7	-1.9
Cholesterol lowering medication	5.2	7.6	10.9	-3.3	-3.1	-1.4
Number of live births	5.1	7.2	9.9	2.7	3.1	2.1
Tense / ‘highly strung’	5.1	8.5	11.0	3.0	3.3	2.3
Hypothyroidism (self reported)	5.0	11.5	17.3	-3.5	-4.2	-2.2
Medication: Aspirin	4.7	6.1	8.5	-2.9	-2.7	-1.6
Whole body fat mass	4.6	19.4	21.9	-4.7	-4.4	-4.1
Neuroticism (Nagel 2018)	4.3	10.1	11.3	3.3	2.9	3.4
Nervous feelings	4.2	7.9	10.3	2.9	3.2	2.2
Hearing aid user	4.2	4.7	5.3	-2.3	-2.2	-2.0
Medication: Lisinopril	4.2	5.5	8.9	-3.0	-2.5	-1.1
Blood Red Count	4.1	39.5	63.5	8.0	6.8	3.0
Number of treatments/medications taken	4.1	7.3	11.9	-3.5	-2.9	-1.3
Ulcerative Colitis (UC)	4.0	7.5	9.7	2.6	3.1	2.4
Blood White Count	4.0	29.8	44.5	4.3	6.7	5.2
Hip circumference	4.0	17.4	20.4	-4.5	-4.3	-3.6
Eye problems/disorders: None of the above	4.0	4.7	5.6	1.8	2.4	2.3
Breast Cancer	3.9	9.3	13.8	-2.7	-2.6	-3.7
Coronary Artery Disease (CAD)	3.9	4.6	5.1	-2.2	-2.2	-1.9
Type 2 Diabetes (T2D) (2018)	3.9	7.3	7.6	-2.7	-2.7	-2.8
Trunk fat mass	3.8	16.5	18.1	-4.3	-4.1	-3.8
Medication: Blood pressure	3.8	7.2	10.7	-3.0	-3.3	-1.4
Pulse wave reflection index	3.5	4.3	4.9	2.2	2.1	2.0
Arm fat percentage (right)	3.4	13.2	17.2	-4.2	-3.6	-3.0
Arm fat percentage (left)	3.4	13.6	17.8	-4.2	-3.6	-3.1
Chest pain or discomfort	3.3	4.8	5.3	-2.0	-2.2	-2.3
Supplements: Zinc	3.1	3.4	5.1	-2.2	-2.0	-1.0
Medication: Atenolol	3.1	3.9	4.9	-2.1	-2.2	-1.6
Leg pain on walking	3.1	3.9	5.2	-1.7	-1.9	-2.3
Risk taking	3.1	4.5	11.5	-0.6	-1.3	-3.4
Fractured/broken bones in last 5 years	3.1	4.0	5.8	-2.1	-2.4	-1.4
Relative age voice broke	3.0	4.6	5.0	2.2	2.0	2.1
Frequency of tiredness / lethargy in last 2 weeks	3.0	4.9	8.5	-1.8	-2.9	-1.8
Diastolic blood pressure, automated reading	3.0	9.3	11.9	3.5	3.0	2.7
Mean Putamen Volume	2.9	3.3	4.9	-2.2	-2.2	-0.6
Serious illness, injury or assault of a close relative in last 2 years	2.9	3.3	3.7	-1.9	-1.9	-1.7
Medication: Atorvastatin	2.9	3.5	6.7	-2.6	-1.8	-0.8
Leg fat percentage (left)	2.7	9.8	11.6	-3.4	-3.0	-2.9
Ever had prostate specific antigen (PSA) test	2.6	3.0	4.3	1.5	2.1	1.6
Systolic Blood Pressure	2.5	12.6	18.0	3.4	2.9	4.2
Prospective memory result	2.5	3.1	3.4	-1.7	-1.8	-1.7
Number of self-reported non-cancer illnesses	2.5	4.3	6.2	-2.0	-2.5	-1.6
Guilty feelings	2.5	3.8	4.4	2.1	2.0	1.7
Vascular/heart problems diagnosed by doctor	2.5	6.9	10.7	2.8	3.3	1.4
Alzheimer’s Disease (in father)	2.4	2.6	5.2	0.5	1.6	2.3
Cardiovascular Disease	2.4	8.0	11.4	-3.4	-3.2	-1.7
Angina	2.3	3.0	3.5	-1.8	-1.9	-1.5
Ever used hormone-replacement therapy (HRT)	2.2	2.8	4.1	-1.2	-1.6	-2.0
Number of incorrect matches in round	2.2	3.7	5.8	2.3	2.4	-0.1
Body fat percentage	2.2	8.8	10.6	-3.2	-2.9	-2.7
Leg fat percentage (right)	2.2	8.1	9.7	-3.1	-2.8	-2.7
Angina (self-reported)	2.2	2.8	3.3	-1.7	-1.8	-1.5
Major Depression (MDD)	2.1	2.5	3.5	1.3	1.9	1.5
Respiratory disease	2.1	4.7	9.8	-3.1	-1.8	-1.0
Past tobacco smoking	2.1	3.9	5.1	2.3	2.2	1.4
Mouth/teeth dental problems	2.1	3.2	5.4	1.2	1.7	2.3
Asthma (self-reported)	2.1	4.2	7.9	-2.8	-2.0	-0.9
Neuroticism (2016)	2.0	2.8	3.6	1.9	1.7	1.4
High blood pressure (mother)	2.0	2.8	7.7	0.2	0.8	2.8
Heart attack	2.0	2.5	3.6	-1.9	-1.7	-1.1
Alcohol intake versus 10 years previously	2.0	3.0	5.7	-0.6	-1.7	-2.4
Asthma	2.0	4.0	7.4	-2.7	-1.9	-1.1
Trunk fat percentage	1.9	7.5	9.0	-3.0	-2.7	-2.5
Blood Eosinophil Count	1.8	14.2	16.9	3.5	4.1	3.6
Medication: Co-codamol	1.8	2.1	3.1	-1.1	-1.5	-1.8
Neuroticism score	1.8	3.8	4.3	2.1	1.7	2.0
Hair/balding pattern: Pattern 3	1.8	2.7	3.9	-2.0	-1.8	-1.1
Happiness	1.8	2.2	3.3	1.1	1.5	1.8
Suffer from ‘nerves’	1.8	2.9	5.8	2.4	1.6	0.6
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	2.9	1.7	1.5	1.2
Hypertension (Self-reported)	1.8	5.1	8.2	-2.5	-2.9	-0.9
Ever smoked	1.8	3.1	3.7	-1.6	-1.9	-1.7
Depressed Affect (Nagel 2018)	1.7	3.5	5.4	1.8	1.3	2.3
Rheumatoid Arthritis	1.7	2.3	3.0	1.7	1.3	1.5
Diabetes (father)	1.7	2.1	2.8	-1.7	-1.0	-1.6
High blood pressure	1.7	4.8	7.8	-2.3	-2.8	-1.0
Heart attack/myocardial infarction (self-reported)	1.7	2.2	2.9	-1.7	-1.6	-1.0
Lupus	1.6	2.4	5.5	2.4	1.1	0.7
Illnesses of siblings: Diabetes	1.6	2.0	3.2	-1.8	-1.4	-0.9
Smoking status: Previous	1.6	2.4	3.9	-2.0	-1.7	-0.6
High cholesterol (Self-reported)	1.6	2.8	6.3	-2.5	-1.3	-0.5
Systolic blood pressure, automated reading	1.5	4.3	4.9	2.2	2.0	2.0
Gout (self-reported)	1.5	2.0	2.6	1.2	1.6	1.5
Medication: Ventolin 100micrograms inhaler	1.5	1.9	3.6	-1.9	-1.4	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	2.0	3.7	-0.7	-1.3	-1.9
Osteoporosis (self-reported)	1.5	1.8	3.9	0.8	0.9	2.0
Supplements: Fish oil (including cod liver oil)	1.5	2.0	3.2	-1.8	-1.3	1.1
Blood Platelet Count	1.4	16.6	28.5	2.9	3.5	5.3
Neuroticism	1.4	3.3	4.9	2.2	1.4	1.7
Hand grip strength (right)	1.4	3.9	6.7	1.5	1.7	2.6
Townsend deprivation index at recruitment	1.4	2.0	3.3	-0.9	-1.3	-1.8
Falls in the last year	1.4	1.9	3.7	-1.9	-1.2	-0.8
Qualifications: College or University degree	1.4	4.4	5.5	-2.3	-1.9	-2.0
Had major operations	1.4	1.7	2.3	-1.5	-1.2	-1.2
Back pain experienced in last month	1.4	2.1	4.1	-1.4	-2.0	-0.1
Eye problems/disorders: Glaucoma	1.4	1.7	2.3	-1.4	-1.5	-0.8
Alcohol drinker status: Previous	1.4	1.6	2.2	-0.9	-1.4	-1.5
Fasting Glucose	1.3	1.5	2.4	-1.6	-1.2	-0.9
Hand grip strength (left)	1.3	3.3	6.1	1.4	1.4	2.5
Hair/balding pattern: Pattern 2	1.3	1.6	1.7	1.3	1.2	1.3
Mouth/teeth dental problems: Dentures	1.3	2.2	2.8	-1.7	-1.6	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	2.6	1.6	1.4	0.2
Medication: Omeprazole	1.3	1.6	2.8	-1.7	-1.1	-0.9
Overall health rating	1.3	2.8	3.1	-1.8	-1.7	-1.5
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	2.8	-0.6	-0.9	-1.7
Severe depression (siblings)	1.2	1.4	2.6	1.6	1.1	0.5
Alcohol usually taken with meals	1.2	1.9	4.2	1.3	2.0	0.2
Time employed in main current job	1.2	1.3	2.1	1.2	1.5	0.7
Noisy workplace	1.2	1.5	2.3	1.1	0.9	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	2.3	-1.4	-1.5	-1.2
Birth weight of first child	1.2	2.3	2.7	-1.6	-1.4	-1.5
Headache pain in last month	1.2	2.1	3.1	1.8	1.0	1.5
Number of children fathered	1.2	1.3	3.7	0.1	-0.5	1.9
Medication for pain relief, constipation, heartburn	1.2	2.0	2.9	1.7	1.7	0.6
Alcohol intake frequency.	1.2	2.8	5.4	-1.0	-1.4	-2.3
Unable to work because of sickness or disability	1.2	1.5	2.0	-1.2	-1.4	-1.0
Alzheimer’s Disease (in mother)	1.1	1.2	1.7	-1.2	-0.8	-1.3
Relative age of first facial hair	1.1	2.2	3.2	1.6	1.8	0.9
Current tobacco smoking	1.1	1.9	2.5	-1.1	-1.4	-1.6
Supplements: Vitamin C	1.1	1.3	2.3	-1.5	-1.2	0.0
Commuting to job workplace: Walk	1.1	1.1	1.6	-1.3	-0.8	1.1
Mineral and other dietary supplements	1.1	1.5	2.3	1.5	1.2	-0.9
Wears glasses or contact lenses	1.1	1.3	3.4	-0.3	-0.5	-1.8
Bipolar Disorder or Schizophrenia	1.0	2.5	3.5	1.9	1.4	1.3
Schizophrenia (2018)	1.0	2.1	4.1	2.0	1.3	0.7
Hearing difficulty/problems: Yes	1.0	1.6	2.4	1.4	1.6	0.7
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	2.8	1.7	1.1	0.7
Pain all over the body in last month	1.0	1.1	2.5	-0.2	-0.9	-1.6
Medication: Simvastatin	1.0	1.5	2.8	-1.7	-1.1	-0.6
Medication: Cholesterol lowering	1.0	1.6	3.4	-1.9	-0.7	-0.9
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	2.1	-1.4	-1.2	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.0	2.8	1.7	1.5	1.0
Ovarian Cancer	0.9	1.2	1.6	-1.3	-1.2	-0.8
Crohns Disease (2012)	0.9	1.4	1.7	1.2	1.3	1.1
Ever had hysterectomy (womb removed)	0.9	1.0	1.1	-1.0	-1.1	-0.9
Financial difficulties in last 2 years	0.9	1.1	1.3	-1.0	-1.1	-1.1
Fluid intelligence score	0.9	1.8	2.7	-1.6	-1.2	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.6	-0.4	-0.7	-1.6
Peak expiratory flow (PEF)	0.9	2.1	2.8	1.7	1.2	1.4
Medication: Amlodipine	0.9	1.3	2.2	-1.3	-1.5	-0.4
Irritable Bowel Disease (IBD)	0.8	1.9	2.7	1.6	1.5	0.8
LDL Cholesterol	0.8	1.2	2.1	-1.4	-1.2	0.4
Schizophrenia (2014)	0.8	1.7	2.9	1.7	0.7	1.3
Medication for hormone replacement therapy	0.8	0.9	1.5	-0.9	-1.2	-0.5
Qualifications: CSEs or equivalent	0.8	1.0	2.3	1.5	0.9	0.1
Serious illness, injury or assault to yourself	0.8	1.0	1.5	-1.2	-0.9	-0.8
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	1.4	-0.7	-1.1	-1.2
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	2.9	1.7	0.5	-0.1
Glaucoma (self-reported)	0.8	1.0	1.5	-0.4	-1.2	-1.1
Forced vital capacity (FVC), Best measure	0.8	2.8	5.0	2.2	1.4	1.1
Number of full brothers	0.8	1.0	1.7	-0.8	-1.3	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.3	0.1	-0.7	-1.5
Reaction Time	0.7	1.3	2.1	1.4	1.4	-0.2
Fed-up feelings	0.7	1.4	2.2	1.1	0.8	1.5
Stomach or abdominal pain in last month	0.7	0.9	1.5	-0.9	-1.2	-0.7
Breastfed as a baby	0.7	0.9	1.8	0.6	0.7	1.3
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.3	-0.9	-1.2	-0.5
Medication: Blood pressure	0.7	1.2	1.6	-1.3	-1.2	0.7
Mean time to correctly identify matches	0.7	1.3	2.3	1.2	1.5	-0.3
Pulse rate, automated reading	0.7	2.1	3.0	1.7	1.6	0.8
Family relationship satisfaction	0.7	0.9	1.2	-1.1	-1.0	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	0.9	-0.9	-1.0	-0.9
Illnesses of father: Heart disease	0.7	1.0	1.8	1.3	0.9	-0.7
Breast cancer (self-reported)	0.7	0.9	1.9	-1.4	-0.8	0.2
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.8	0.2	0.9	1.3
Ever depressed for a whole week	0.7	0.8	1.7	-0.8	-1.3	-0.1
Basal cell carcinoma (self-reported)	0.7	0.8	2.5	-1.6	-0.1	-0.1
Prostate Cancer	0.6	0.8	1.7	1.3	0.9	-0.3
Hayfever, allergic rhinitis or eczema	0.6	1.2	2.0	-0.7	-1.1	-1.4
Chronic bronchitis/emphysema (father)	0.6	0.8	1.1	-0.7	-1.0	-0.8
Medication: Ramipril	0.6	0.8	1.4	-0.9	-1.2	-0.3
Illnesses of siblings	0.6	0.9	1.3	1.1	1.1	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	3.6	1.9	1.2	0.7
Length of working week for main job	0.6	0.6	1.2	-1.1	-0.4	-0.7
Exposure to tobacco smoke at home	0.6	0.7	1.3	1.2	0.8	-0.3
Medication: Ibuprofen	0.6	0.7	1.2	-0.4	-0.8	-1.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.2	0.3	1.0	1.1
Commuting to job workplace: Public transport	0.6	0.7	1.3	-0.9	-1.1	-0.0
Medication: Bendroflumethiazide	0.6	1.0	2.1	-0.7	-1.4	-0.6
Supplements: Calcium	0.6	0.6	1.8	-0.3	-0.3	1.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.4	0.7	1.2	0.6
Bipolar Disorder (2018)	0.5	0.7	1.3	0.5	0.8	1.1
Smoking Status	0.5	1.2	1.5	-1.2	-1.1	-1.0
Average weekly spirits intake	0.5	0.7	1.5	-1.2	-0.7	-0.2
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.8	-0.6	-1.3	0.0
Father’s age at death	0.5	0.6	1.4	1.2	0.7	0.1
Depression (self-reported)	0.5	0.6	1.2	0.1	-0.7	-1.1
Hair/balding pattern: Pattern 4	0.5	1.3	1.7	-1.0	-1.1	-1.3
Birth weight	0.5	1.0	2.8	-0.0	-0.5	1.7
Worry too long after embarrassment	0.5	0.8	1.3	1.1	0.8	0.6
Medication: Allopurinol	0.5	0.6	0.9	0.5	0.9	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.6	1.6	-0.1	0.6
Mood swings	0.5	0.9	1.3	1.2	0.8	0.8
Ever had bowel cancer screening	0.5	0.6	0.8	-0.9	0.6	0.8
Smoking status: Current	0.5	0.8	1.6	-0.4	-0.8	-1.3
Miserableness	0.5	0.8	1.4	1.2	0.7	0.8
Number of operations (self-reported)	0.5	0.7	1.3	-1.1	-0.7	-0.7
Irritability	0.5	0.8	1.7	1.3	0.8	-0.4
Age started oral contraceptive pill	0.5	0.6	1.6	-1.3	-0.1	0.6
Schizophrenia vs Biploar Disorder	0.4	0.5	1.4	0.0	0.0	1.2
Diabetes (mother)	0.4	0.5	1.2	-1.1	-0.4	-0.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.0	-1.0	-0.6	-0.3
Hearing difficulty/problems with background noise	0.4	0.7	2.0	-1.4	-0.0	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.5	-1.2	-1.0	-0.4
Qualifications: None of the above	0.4	0.9	1.1	1.1	0.7	1.0
Allergy	0.4	1.0	1.2	1.1	0.9	1.0
Loud music exposure frequency	0.4	0.5	1.1	1.0	0.1	-0.6
Medication: Seretide 50 evohaler	0.4	0.4	0.9	-1.0	-0.5	0.2
Average weekly red wine intake	0.4	0.6	1.5	-0.5	0.3	-1.2
Loneliness, isolation	0.4	0.5	1.0	-0.8	-0.3	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.7	-0.8	-0.7	0.4
Heart disease (siblings)	0.4	0.5	1.1	1.0	0.6	-0.4
Depression (Nagel 2018)	0.3	0.4	1.1	0.3	0.0	1.0
Age at First Birth	0.3	0.4	1.0	-0.4	-0.3	-1.0
Heel T-Score	0.3	2.5	4.4	0.7	1.6	2.1
Tanning	0.3	4.1	7.3	1.1	2.0	2.7
Sitting height	0.3	2.4	4.8	0.3	-1.5	-2.2
Forced vital capacity (FVC)	0.3	1.0	2.2	1.5	0.4	0.9
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.6	0.1	-0.8	0.6
Illnesses of mother	0.3	0.4	0.9	-0.3	-0.4	-0.9
Blood clot in the leg (DVT)	0.3	0.4	0.8	0.6	0.9	0.0
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.9	1.0	0.2	-0.2
Exposure to tobacco smoke outside home	0.3	0.4	0.6	-0.8	-0.4	-0.6
Emphysema/chronic bronchitis	0.3	0.4	0.7	-0.9	-0.3	-0.6
Ever taken oral contraceptive pill	0.3	0.3	0.5	-0.7	-0.6	0.3
Mother’s age at death	0.3	0.4	0.8	0.2	-0.6	-0.9
Alcohol drinker status: Never	0.3	0.4	1.2	-1.1	-0.1	-0.1
Commuting to job workplace: Cycle	0.3	0.4	0.8	-0.3	-0.4	-0.9
Myopia	0.3	0.4	0.6	0.8	0.1	-0.8
Pain experienced in last month	0.3	0.4	0.9	-0.6	-0.0	-1.0
HbA1C	0.2	0.2	0.6	0.2	0.7	-0.2
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.3	0.6	-0.2	-0.5
Lung FEV1/FVC ratio	0.2	1.0	1.8	-0.7	-1.0	-1.3
Lung FVC	0.2	0.9	1.9	1.4	0.6	0.6
Chronotype (morning person)	0.2	0.5	0.9	-1.0	0.3	-0.7
Sensitivity / hurt feelings	0.2	0.3	0.8	0.1	0.3	0.9
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.5	-0.7	-0.6	-0.2
Average weekly fortified wine intake	0.2	0.2	0.3	-0.3	-0.4	-0.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	-0.0	-0.7	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.8	-0.7	-0.3	-0.9
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.6	-0.1	0.8	0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.4	1.2	0.2	0.5
Lung cancer (father)	0.2	0.2	0.5	0.3	-0.2	0.7
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.6	-0.8	-0.4	-0.2
Health satisfaction	0.2	0.3	0.6	-0.8	-0.5	-0.1
Shortness of breath walking on level ground	0.2	0.3	0.5	-0.7	-0.6	-0.0
Neck or shoulder pain in last month	0.2	0.3	0.8	0.2	-0.9	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.3	-0.3	0.6	0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	0.3	0.6	0.3
Osteoarthritis (self-reported)	0.2	0.3	0.4	-0.5	-0.3	-0.6
Financial situation satisfaction	0.2	0.3	0.5	0.6	0.7	-0.0
Medication: Paracetamol	0.2	0.3	0.6	0.8	0.3	0.5
Average weekly beer plus cider intake	0.2	0.3	0.6	-0.4	-0.4	-0.8
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	-0.3	0.3	0.4
Crohns Disease (2017)	0.1	0.3	0.8	0.1	-0.4	-0.9
Vitamin and mineral supplements	0.1	0.1	0.2	0.4	0.5	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	-0.2	-0.0	0.6
Multivitamins +/- minerals	0.1	0.1	0.2	-0.4	-0.4	-0.1
Supplements: Glucosamine	0.1	0.1	0.3	0.5	0.3	0.3
Had other major operations	0.1	0.1	0.3	0.5	0.2	-0.1
Pulse rate	0.1	0.2	0.3	0.3	0.5	-0.6
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.3	0.0	0.6	0.4
Medication: Lansoprazole	0.1	0.1	0.1	0.2	-0.1	0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.3	0.2	0.6	-0.2
Medication: Paracetamol	0.1	0.2	0.5	0.7	0.0	0.3
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	0.6	0.4	-0.1
High blood pressure (siblings)	0.1	0.2	0.4	-0.2	-0.5	0.6
Number of full sisters	0.1	0.2	0.4	0.0	-0.4	0.6
Age at last live birth	0.1	0.1	0.3	0.0	-0.2	-0.5
Qualifications: nursing, teaching	0.1	0.2	0.3	0.5	0.4	0.3
Average weekly champagne plus white wine intake	0.1	0.1	0.2	-0.4	-0.1	-0.5
Illnesses of father: High blood pressure	0.1	0.1	0.1	0.4	0.0	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.4	0.0	0.5
Pack years of smoking	0.1	0.1	0.2	0.2	0.2	0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Height	0.0	0.7	1.9	1.4	-0.4	0.1
Waist Hip Ratio (WHR)	0.0	0.2	0.4	0.7	0.3	-0.0
Allergy or Eczema	0.0	0.1	0.1	-0.3	-0.3	0.3
Hair Pigment	0.0	0.6	1.7	1.3	0.4	-0.3
Pack years adult smoking proportion	0.0	0.0	0.1	0.3	0.1	0.3
Maternal smoking around birth	0.0	0.0	0.1	0.0	0.1	-0.3
Had menopause	0.0	0.0	0.1	0.2	0.1	0.2
Standing height	0.0	0.4	0.9	0.9	-0.5	-0.2
Age at first live birth	0.0	0.0	0.0	0.2	0.1	0.0
Migraine (self-reported)	0.0	0.0	0.0	0.2	0.2	-0.2
Heart disease (mother)	0.0	0.1	0.1	-0.3	0.1	0.3
Comparative height size at age 10	0.0	0.2	0.4	0.1	-0.6	-0.5
Knee pain experienced in last month	0.0	0.1	0.2	-0.4	-0.2	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.1	0.1	-0.3	0.1
Friendships satisfaction	0.0	0.0	0.1	0.2	0.2	0.2
Illnesses of father: None of the above (group 1)	0.0	0.0	0.0	0.1	0.1	0.0

Hub : Genes

SAE1

Models

Trait associations