Best TWAS P=3.72e-10 · Best GWAS P=2.89e-08 conditioned to 0.423
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | AP2A1 | 0.18 | 0.09 | enet | 8 | 0.13 | 7.7e-09 | 4.5 | 6.0 | 1.5e-09 | 0.76 | 0.08 | 0.92 | FALSE |
| 2 | GTEx | Muscle Skeletal | AKT1S1 | 0.10 | 0.09 | lasso | 3 | 0.08 | 1.9e-08 | 5.5 | -5.5 | 4.9e-08 | -0.98 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Nerve Tibial | AP2A1 | 0.16 | 0.05 | lasso | 4 | 0.07 | 1.3e-05 | 4.9 | 6.3 | 3.7e-10 | 0.81 | 0.05 | 0.94 | TRUE |
| 4 | The Cancer Genome Atlas | Lung Adenocarcinoma | PNKP | 0.03 | 0.00 | blup | 46 | 0.02 | 4.0e-03 | 5.3 | 5.2 | 2.0e-07 | 0.79 | 0.01 | 0.33 | FALSE |