Best TWAS P=1.28e-18 · Best GWAS P=1.41e-51 conditioned to 2.21e-23
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | TMEM18 | 0.32 | 0.21 | lasso | 9 | 0.25 | 4.7e-20 | -7.4 | -8.5 | 1.5e-17 | -0.22 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | AC092159.2 | 0.29 | 0.14 | lasso | 14 | 0.19 | 4.2e-15 | -4.5 | -7.2 | 6.5e-13 | -0.16 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | TMEM18 | 0.23 | 0.14 | lasso | 4 | 0.17 | 5.7e-09 | -7.4 | -7.4 | 1.2e-13 | -0.14 | 0.99 | 0.00 | FALSE |
| 4 | GTEx | Adipose Visceral Omentum | AC092159.2 | 0.29 | 0.11 | enet | 41 | 0.14 | 1.5e-07 | -7.4 | -7.2 | 8.4e-13 | -0.12 | 0.92 | 0.00 | FALSE |
| 5 | GTEx | Artery Aorta | TMEM18 | 0.32 | 0.16 | lasso | 5 | 0.15 | 1.4e-08 | -7.4 | -7.9 | 2.2e-15 | -0.18 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Artery Aorta | AC092159.2 | 0.29 | 0.19 | enet | 9 | 0.23 | 9.7e-13 | -7.4 | -8.1 | 8.4e-16 | -0.18 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Artery Tibial | SH3YL1 | 0.10 | 0.02 | lasso | 3 | 0.01 | 2.9e-02 | 4.7 | 6.9 | 4.2e-12 | 0.09 | 0.65 | 0.02 | TRUE |
| 8 | GTEx | Artery Tibial | TMEM18 | 0.35 | 0.08 | enet | 28 | 0.19 | 9.2e-15 | -7.4 | -7.0 | 1.8e-12 | -0.18 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Artery Tibial | AC092159.2 | 0.38 | 0.24 | lasso | 5 | 0.30 | 5.6e-24 | -6.1 | -7.8 | 7.6e-15 | -0.18 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Cells Transformed fibroblasts | TMEM18 | 0.30 | 0.17 | enet | 10 | 0.23 | 2.5e-17 | -7.4 | -6.8 | 1.1e-11 | -0.10 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Cells Transformed fibroblasts | AC092159.2 | 0.26 | 0.17 | enet | 5 | 0.21 | 1.8e-15 | -7.4 | -7.5 | 8.1e-14 | -0.15 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Colon Transverse | SH3YL1 | 0.36 | 0.25 | lasso | 7 | 0.26 | 1.2e-12 | 4.6 | -5.1 | 2.8e-07 | 0.04 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Esophagus Mucosa | TMEM18 | 0.37 | 0.20 | lasso | 7 | 0.20 | 2.3e-13 | -7.4 | -7.9 | 3.2e-15 | -0.18 | 1.00 | 0.00 | FALSE |
| 14 | GTEx | Esophagus Mucosa | AC092159.2 | 0.27 | 0.18 | enet | 5 | 0.20 | 2.5e-13 | -7.4 | -8.2 | 3.2e-16 | -0.18 | 1.00 | 0.00 | FALSE |
| 15 | GTEx | Esophagus Muscularis | TMEM18 | 0.37 | 0.20 | lasso | 8 | 0.18 | 2.0e-11 | -6.1 | -7.9 | 3.2e-15 | -0.27 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Esophagus Muscularis | AC092159.2 | 0.26 | 0.16 | enet | 7 | 0.20 | 5.3e-12 | -6.1 | -6.1 | 1.1e-09 | -0.30 | 1.00 | 0.00 | FALSE |
| 17 | GTEx | Heart Atrial Appendage | TMEM18 | 0.26 | 0.16 | lasso | 7 | 0.09 | 5.0e-05 | -7.4 | -7.9 | 3.4e-15 | -0.22 | 0.82 | 0.08 | FALSE |
| 18 | GTEx | Heart Left Ventricle | SH3YL1 | 0.14 | 0.11 | enet | 16 | 0.10 | 8.2e-06 | 4.6 | 5.4 | 5.7e-08 | -0.05 | 0.80 | 0.01 | FALSE |
| 19 | GTEx | Heart Left Ventricle | TMEM18 | 0.22 | 0.19 | lasso | 7 | 0.16 | 8.3e-09 | -7.4 | -8.8 | 1.3e-18 | -0.18 | 0.99 | 0.00 | TRUE |
| 20 | GTEx | Heart Left Ventricle | AC092159.2 | 0.35 | 0.24 | lasso | 6 | 0.23 | 2.3e-12 | -7.4 | -8.3 | 1.2e-16 | -0.19 | 1.00 | 0.00 | FALSE |
| 21 | GTEx | Lung | TMEM18 | 0.13 | 0.11 | lasso | 2 | 0.10 | 4.5e-08 | -7.4 | -7.4 | 1.4e-13 | -0.16 | 0.99 | 0.00 | FALSE |
| 22 | GTEx | Lung | AC092159.2 | 0.22 | 0.17 | lasso | 3 | 0.18 | 1.1e-13 | -7.4 | -7.2 | 5.0e-13 | -0.13 | 1.00 | 0.00 | FALSE |
| 23 | GTEx | Muscle Skeletal | TMEM18 | 0.40 | 0.30 | lasso | 7 | 0.33 | 2.0e-33 | -6.1 | -6.3 | 3.2e-10 | -0.16 | 1.00 | 0.00 | FALSE |
| 24 | GTEx | Muscle Skeletal | AC092159.2 | 0.46 | 0.34 | enet | 18 | 0.39 | 1.1e-40 | -6.1 | -6.8 | 1.1e-11 | -0.16 | 1.00 | 0.00 | FALSE |
| 25 | GTEx | Nerve Tibial | SH3YL1 | 0.33 | 0.23 | enet | 35 | 0.25 | 5.6e-18 | 4.8 | 6.2 | 4.0e-10 | 0.07 | 1.00 | 0.00 | FALSE |
| 26 | GTEx | Nerve Tibial | TMEM18 | 0.22 | 0.01 | lasso | 8 | 0.05 | 3.2e-04 | -7.4 | -6.1 | 9.2e-10 | -0.20 | 0.64 | 0.02 | FALSE |
| 27 | GTEx | Nerve Tibial | AC092159.2 | 0.18 | 0.09 | lasso | 5 | 0.10 | 1.5e-07 | -6.1 | -6.7 | 1.6e-11 | -0.15 | 0.99 | 0.00 | FALSE |
| 28 | GTEx | Ovary | SH3YL1 | 0.48 | 0.29 | enet | 18 | 0.34 | 3.2e-09 | 4.6 | 5.8 | 5.9e-09 | 0.14 | 0.67 | 0.03 | FALSE |
| 29 | GTEx | Testis | AC092159.2 | 0.23 | 0.15 | lasso | 5 | 0.18 | 1.4e-08 | -7.4 | -6.4 | 1.2e-10 | -0.09 | 0.91 | 0.00 | FALSE |
| 30 | METSIM | Adipose | TMEM18 | 0.20 | 0.12 | lasso | 6 | 0.12 | 9.2e-17 | -7.4 | -7.9 | 3.9e-15 | -0.17 | 1.00 | 0.00 | FALSE |
| 31 | ROSMAP | Brain Pre-frontal Cortex | FAM150B | 0.06 | 0.01 | bslmm | 381 | 0.03 | 9.9e-05 | -5.4 | -6.7 | 2.7e-11 | -0.07 | 0.40 | 0.02 | FALSE |
| 32 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | TMEM18 | 0.06 | 0.04 | lasso | 3 | 0.04 | 2.8e-04 | -7.4 | -6.8 | 1.1e-11 | -0.10 | 0.12 | 0.21 | FALSE |
| 33 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TMEM18 | 0.13 | 0.08 | lasso | 3 | 0.08 | 7.8e-09 | -7.6 | -6.0 | 1.8e-09 | -0.09 | 1.00 | 0.00 | TRUE |
| 34 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SH3YL1 | 0.16 | 0.04 | blup | 67 | 0.06 | 5.6e-07 | 4.7 | -5.2 | 2.4e-07 | 0.02 | 0.03 | 0.96 | FALSE |
| 35 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TMEM18 | 0.12 | 0.05 | blup | 74 | 0.04 | 3.1e-05 | -7.4 | -7.0 | 3.4e-12 | -0.17 | 0.59 | 0.02 | TRUE |
| 36 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SH3YL1 | 0.20 | 0.05 | blup | 67 | 0.09 | 9.5e-06 | 4.7 | -5.2 | 2.4e-07 | 0.05 | 0.12 | 0.78 | FALSE |
| 37 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TMEM18 | 0.10 | 0.02 | lasso | 4 | 0.03 | 4.9e-04 | -7.4 | -6.3 | 2.5e-10 | -0.05 | 0.12 | 0.03 | TRUE |
| 38 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TMEM18 | 0.11 | 0.07 | blup | 74 | 0.06 | 6.0e-07 | -7.4 | -6.0 | 1.9e-09 | -0.11 | 0.97 | 0.00 | FALSE |
| 39 | The Cancer Genome Atlas | Stomach Adenocarcinoma | TMEM18 | 0.11 | 0.01 | blup | 74 | 0.04 | 1.3e-03 | -7.4 | -8.5 | 1.5e-17 | -0.23 | 0.11 | 0.04 | FALSE |