[Hub]/) : Traits : Impedance of leg (right) : ← →

chr2:15,703-1,384,725

Best TWAS P=1.28e-18 · Best GWAS P=1.41e-51 conditioned to 2.21e-23

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
19	GTEx	Heart Left Ventricle	TMEM18	0.22	0.19	lasso	7	0.16	8.3e-09	-7.4	-8.8	1.3e-18	-0.18	0.99	0.00	TRUE
35	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM18	0.12	0.05	blup	74	0.04	3.1e-05	-7.4	-7.0	3.4e-12	-0.17	0.59	0.02	TRUE
7	GTEx	Artery Tibial	SH3YL1	0.10	0.02	lasso	3	0.01	2.9e-02	4.7	6.9	4.2e-12	0.09	0.65	0.02	TRUE
37	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM18	0.10	0.02	lasso	4	0.03	4.9e-04	-7.4	-6.3	2.5e-10	-0.05	0.12	0.03	TRUE
33	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM18	0.13	0.08	lasso	3	0.08	7.8e-09	-7.6	-6.0	1.8e-09	-0.09	1.00	0.00	TRUE
1	GTEx	Adipose Subcutaneous	TMEM18	0.32	0.21	lasso	9	0.25	4.7e-20	-7.4	-8.5	1.5e-17	-0.22	1.00	0.00	FALSE
39	The Cancer Genome Atlas	Stomach Adenocarcinoma	TMEM18	0.11	0.01	blup	74	0.04	1.3e-03	-7.4	-8.5	1.5e-17	-0.23	0.11	0.04	FALSE
20	GTEx	Heart Left Ventricle	AC092159.2	0.35	0.24	lasso	6	0.23	2.3e-12	-7.4	-8.3	1.2e-16	-0.19	1.00	0.00	FALSE
14	GTEx	Esophagus Mucosa	AC092159.2	0.27	0.18	enet	5	0.20	2.5e-13	-7.4	-8.2	3.2e-16	-0.18	1.00	0.00	FALSE
6	GTEx	Artery Aorta	AC092159.2	0.29	0.19	enet	9	0.23	9.7e-13	-7.4	-8.1	8.4e-16	-0.18	1.00	0.00	FALSE
5	GTEx	Artery Aorta	TMEM18	0.32	0.16	lasso	5	0.15	1.4e-08	-7.4	-7.9	2.2e-15	-0.18	1.00	0.00	FALSE
13	GTEx	Esophagus Mucosa	TMEM18	0.37	0.20	lasso	7	0.20	2.3e-13	-7.4	-7.9	3.2e-15	-0.18	1.00	0.00	FALSE
15	GTEx	Esophagus Muscularis	TMEM18	0.37	0.20	lasso	8	0.18	2.0e-11	-6.1	-7.9	3.2e-15	-0.27	1.00	0.00	FALSE
17	GTEx	Heart Atrial Appendage	TMEM18	0.26	0.16	lasso	7	0.09	5.0e-05	-7.4	-7.9	3.4e-15	-0.22	0.82	0.08	FALSE
30	METSIM	Adipose	TMEM18	0.20	0.12	lasso	6	0.12	9.2e-17	-7.4	-7.9	3.9e-15	-0.17	1.00	0.00	FALSE
9	GTEx	Artery Tibial	AC092159.2	0.38	0.24	lasso	5	0.30	5.6e-24	-6.1	-7.8	7.6e-15	-0.18	1.00	0.00	FALSE
11	GTEx	Cells Transformed fibroblasts	AC092159.2	0.26	0.17	enet	5	0.21	1.8e-15	-7.4	-7.5	8.1e-14	-0.15	1.00	0.00	FALSE
3	GTEx	Adipose Visceral Omentum	TMEM18	0.23	0.14	lasso	4	0.17	5.7e-09	-7.4	-7.4	1.2e-13	-0.14	0.99	0.00	FALSE
21	GTEx	Lung	TMEM18	0.13	0.11	lasso	2	0.10	4.5e-08	-7.4	-7.4	1.4e-13	-0.16	0.99	0.00	FALSE
22	GTEx	Lung	AC092159.2	0.22	0.17	lasso	3	0.18	1.1e-13	-7.4	-7.2	5.0e-13	-0.13	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	AC092159.2	0.29	0.14	lasso	14	0.19	4.2e-15	-4.5	-7.2	6.5e-13	-0.16	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	AC092159.2	0.29	0.11	enet	41	0.14	1.5e-07	-7.4	-7.2	8.4e-13	-0.12	0.92	0.00	FALSE
8	GTEx	Artery Tibial	TMEM18	0.35	0.08	enet	28	0.19	9.2e-15	-7.4	-7.0	1.8e-12	-0.18	1.00	0.00	FALSE
10	GTEx	Cells Transformed fibroblasts	TMEM18	0.30	0.17	enet	10	0.23	2.5e-17	-7.4	-6.8	1.1e-11	-0.10	1.00	0.00	FALSE
24	GTEx	Muscle Skeletal	AC092159.2	0.46	0.34	enet	18	0.39	1.1e-40	-6.1	-6.8	1.1e-11	-0.16	1.00	0.00	FALSE
32	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TMEM18	0.06	0.04	lasso	3	0.04	2.8e-04	-7.4	-6.8	1.1e-11	-0.10	0.12	0.21	FALSE
27	GTEx	Nerve Tibial	AC092159.2	0.18	0.09	lasso	5	0.10	1.5e-07	-6.1	-6.7	1.6e-11	-0.15	0.99	0.00	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	FAM150B	0.06	0.01	bslmm	381	0.03	9.9e-05	-5.4	-6.7	2.7e-11	-0.07	0.40	0.02	FALSE
29	GTEx	Testis	AC092159.2	0.23	0.15	lasso	5	0.18	1.4e-08	-7.4	-6.4	1.2e-10	-0.09	0.91	0.00	FALSE
23	GTEx	Muscle Skeletal	TMEM18	0.40	0.30	lasso	7	0.33	2.0e-33	-6.1	-6.3	3.2e-10	-0.16	1.00	0.00	FALSE
25	GTEx	Nerve Tibial	SH3YL1	0.33	0.23	enet	35	0.25	5.6e-18	4.8	6.2	4.0e-10	0.07	1.00	0.00	FALSE
26	GTEx	Nerve Tibial	TMEM18	0.22	0.01	lasso	8	0.05	3.2e-04	-7.4	-6.1	9.2e-10	-0.20	0.64	0.02	FALSE
16	GTEx	Esophagus Muscularis	AC092159.2	0.26	0.16	enet	7	0.20	5.3e-12	-6.1	-6.1	1.1e-09	-0.30	1.00	0.00	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM18	0.11	0.07	blup	74	0.06	6.0e-07	-7.4	-6.0	1.9e-09	-0.11	0.97	0.00	FALSE
28	GTEx	Ovary	SH3YL1	0.48	0.29	enet	18	0.34	3.2e-09	4.6	5.8	5.9e-09	0.14	0.67	0.03	FALSE
18	GTEx	Heart Left Ventricle	SH3YL1	0.14	0.11	enet	16	0.10	8.2e-06	4.6	5.4	5.7e-08	-0.05	0.80	0.01	FALSE
34	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SH3YL1	0.16	0.04	blup	67	0.06	5.6e-07	4.7	-5.2	2.4e-07	0.02	0.03	0.96	FALSE
36	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SH3YL1	0.20	0.05	blup	67	0.09	9.5e-06	4.7	-5.2	2.4e-07	0.05	0.12	0.78	FALSE
12	GTEx	Colon Transverse	SH3YL1	0.36	0.25	lasso	7	0.26	1.2e-12	4.6	-5.1	2.8e-07	0.04	1.00	0.00	FALSE