Best TWAS P=1.26e-10 · Best GWAS P=9.67e-11 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SNAP47 | 0.23 | 0.19 | lasso | 7 | 0.19 | 5.7e-23 | -5.4 | 5.9 | 3.4e-09 | -0.33 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | CDC42BPA | 0.10 | 0.05 | lasso | 5 | 0.02 | 3.6e-03 | 4.6 | -6.0 | 2.7e-09 | 0.65 | 0.38 | 0.55 | FALSE |
| 3 | GTEx | Brain Cortex | SNAP47 | 0.21 | 0.05 | lasso | 9 | 0.04 | 2.2e-02 | -5.4 | 6.0 | 1.5e-09 | -0.34 | 0.04 | 0.71 | TRUE |
| 4 | GTEx | Cells Transformed fibroblasts | SNAP47 | 0.17 | 0.12 | enet | 18 | 0.12 | 1.9e-09 | -5.4 | 5.3 | 9.7e-08 | -0.24 | 0.03 | 0.97 | FALSE |
| 5 | GTEx | Esophagus Muscularis | ADCK3 | 0.07 | 0.02 | lasso | 5 | 0.01 | 4.1e-02 | 3.8 | -5.5 | 4.9e-08 | 0.49 | 0.10 | 0.66 | FALSE |
| 6 | GTEx | Muscle Skeletal | SNAP47 | 0.09 | 0.08 | lasso | 10 | 0.08 | 7.7e-08 | -5.4 | 5.6 | 2.8e-08 | -0.30 | 0.02 | 0.98 | FALSE |
| 7 | GTEx | Testis | SNAP47 | 0.23 | 0.21 | enet | 15 | 0.21 | 7.5e-10 | -5.4 | 5.4 | 6.8e-08 | -0.26 | 0.03 | 0.97 | TRUE |
| 8 | NTR | Blood | ADCK3 | 0.06 | 0.08 | enet | 9 | 0.08 | 2.5e-23 | 5.4 | 5.2 | 2.5e-07 | -0.45 | 0.70 | 0.30 | TRUE |
| 9 | YFS | Blood | JMJD4 | 0.11 | 0.12 | lasso | 4 | 0.12 | 3.7e-36 | -5.4 | -5.6 | 2.4e-08 | 0.35 | 0.02 | 0.98 | TRUE |
| 10 | The Cancer Genome Atlas | Colon Adenocarcinoma | PSEN2 | 0.14 | 0.06 | lasso | 4 | 0.07 | 5.4e-05 | -6.2 | 6.4 | 1.3e-10 | -0.42 | 0.00 | 1.00 | TRUE |
| 11 | The Cancer Genome Atlas | Colon Adenocarcinoma | SNAP47 | 0.05 | 0.05 | lasso | 3 | 0.06 | 2.4e-04 | -5.4 | 5.9 | 3.2e-09 | -0.34 | 0.01 | 0.91 | FALSE |
| 12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PSEN2 | 0.02 | 0.02 | blup | 51 | 0.02 | 1.6e-03 | -4.0 | 5.4 | 7.7e-08 | -0.39 | 0.02 | 0.73 | TRUE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SNAP47 | 0.08 | 0.06 | blup | 54 | 0.08 | 1.2e-09 | -5.4 | 5.5 | 2.8e-08 | -0.34 | 0.01 | 0.99 | FALSE |
| 14 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | SNAP47 | 0.07 | 0.05 | blup | 54 | 0.05 | 2.9e-03 | -5.4 | 5.9 | 3.8e-09 | -0.31 | 0.01 | 0.70 | FALSE |
| 15 | The Cancer Genome Atlas | Lung Adenocarcinoma | SNAP47 | 0.03 | 0.02 | enet | 4 | 0.02 | 1.5e-03 | -5.4 | 5.4 | 6.0e-08 | -0.27 | 0.01 | 0.97 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CABC1 | 0.08 | 0.02 | enet | 6 | 0.05 | 6.6e-06 | -6.2 | -5.6 | 1.8e-08 | 0.54 | 0.04 | 0.93 | FALSE |