[Hub]/) : Traits : Impedance of leg (right) : ← →

chr2:23,453,834-26,088,769

Best TWAS P=1.36e-13 · Best GWAS P=2.16e-14 conditioned to 0.0153

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ADCY3	0.16	0.12	lasso	10	0.14	3.2e-17	-6.7	6.4	1.6e-10	-0.05	0.01	0.99	FALSE
2	CommonMind	Brain Pre-frontal Cortex	UBXN2A	0.22	0.18	enet	28	0.24	3.0e-28	6.3	-6.8	1.3e-11	-0.93	0.01	0.99	FALSE
3	GTEx	Adipose Subcutaneous	ADCY3	0.07	0.04	lasso	6	0.01	3.2e-02	-6.2	-5.4	6.2e-08	-0.01	0.09	0.90	FALSE
4	GTEx	Adipose Visceral Omentum	PFN4	0.08	0.02	enet	14	0.04	3.1e-03	4.4	6.0	1.8e-09	0.66	0.04	0.60	FALSE
5	GTEx	Artery Tibial	ADCY3	0.21	0.14	lasso	6	0.15	4.3e-12	-5.0	-5.2	1.8e-07	0.02	0.95	0.05	FALSE
6	GTEx	Artery Tibial	RP11-443B20.1	0.17	0.08	enet	40	0.09	8.2e-08	-5.0	-5.4	7.9e-08	0.03	0.44	0.52	FALSE
7	GTEx	Breast Mammary Tissue	PFN4	0.08	0.04	enet	16	0.05	1.0e-03	4.4	5.3	9.3e-08	0.59	0.04	0.62	FALSE
8	GTEx	Breast Mammary Tissue (Female)	PFN4	0.11	0.12	enet	16	0.09	1.0e-03	3.9	5.2	2.1e-07	0.49	0.05	0.23	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	ADCY3	0.25	0.23	enet	10	0.12	9.2e-05	-6.2	6.1	1.0e-09	0.06	0.03	0.96	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	PFN4	0.18	0.13	lasso	12	0.12	8.9e-05	4.4	5.8	5.0e-09	0.78	0.09	0.75	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	RP11-443B20.1	0.13	0.13	enet	9	0.05	9.2e-03	-6.2	6.7	1.6e-11	0.03	0.02	0.96	TRUE
12	GTEx	Esophagus Gastroesophageal Junction	PFN4	0.13	0.01	lasso	12	0.01	9.7e-02	7.1	6.7	2.2e-11	0.73	0.07	0.45	FALSE
13	GTEx	Heart Atrial Appendage	UBXN2A	0.08	0.02	lasso	3	0.02	5.2e-02	7.1	6.6	4.4e-11	0.93	0.03	0.91	FALSE
14	GTEx	Heart Atrial Appendage	PFN4	0.22	0.06	lasso	7	0.10	2.8e-05	-3.0	6.3	2.7e-10	0.62	0.19	0.72	FALSE
15	GTEx	Heart Left Ventricle	PFN4	0.23	0.28	lasso	6	0.28	4.1e-15	4.3	5.3	1.1e-07	0.76	0.98	0.02	FALSE
16	GTEx	Nerve Tibial	ADCY3	0.09	0.05	enet	6	0.03	2.2e-03	-5.0	6.7	2.4e-11	-0.01	0.02	0.98	FALSE
17	GTEx	Nerve Tibial	RP11-443B20.1	0.07	0.03	enet	6	0.02	1.1e-02	-5.0	6.4	1.7e-10	-0.02	0.04	0.95	FALSE
18	GTEx	Whole Blood	DNAJC27	0.08	0.10	lasso	1	0.10	2.2e-09	-5.9	-5.9	3.3e-09	-0.02	0.78	0.22	FALSE
19	GTEx	Whole Blood	ADCY3	0.23	0.24	enet	24	0.27	5.5e-25	-5.7	-6.1	1.0e-09	-0.01	0.85	0.15	FALSE
20	GTEx	Whole Blood	RP11-443B20.1	0.21	0.17	enet	32	0.20	1.8e-18	-5.9	-6.3	3.0e-10	0.02	0.67	0.33	FALSE
21	METSIM	Adipose	PFN4	0.04	0.01	blup	306	0.03	1.9e-05	4.4	6.4	1.2e-10	0.72	0.20	0.68	FALSE
22	METSIM	Adipose	UBXN2A	0.07	0.03	bslmm	403	0.06	5.3e-10	2.5	5.1	3.1e-07	0.78	0.14	0.86	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	ADCY3	0.17	0.26	enet	32	0.26	6.8e-33	-5.7	6.0	1.5e-09	0.01	0.77	0.23	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	UBXN2A	0.03	0.01	lasso	4	0.02	2.2e-03	7.1	-7.4	1.4e-13	-0.80	0.03	0.93	TRUE
25	YFS	Blood	POMC	0.35	0.05	enet	71	0.19	5.7e-59	7.0	6.6	3.3e-11	-0.05	0.00	1.00	FALSE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EFR3B	0.03	0.05	lasso	1	0.04	1.9e-05	5.4	5.4	5.9e-08	-0.05	0.09	0.85	FALSE
27	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	POMC	0.16	0.05	blup	39	0.11	2.4e-12	7.0	5.7	9.4e-09	0.00	0.00	1.00	FALSE
28	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADCY3	0.03	0.02	blup	81	0.02	7.1e-04	-3.9	5.9	4.2e-09	0.05	0.04	0.93	FALSE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	UBXN2A	0.04	0.04	lasso	1	0.03	1.4e-04	7.1	-7.1	1.3e-12	-0.96	0.02	0.95	FALSE
30	The Cancer Genome Atlas	Lung Adenocarcinoma	DNAJC27	0.05	0.01	blup	46	0.04	3.2e-05	-3.0	5.2	1.6e-07	0.13	0.35	0.59	FALSE
31	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	POMC	0.19	0.01	blup	38	0.05	1.5e-04	7.0	5.7	1.0e-08	-0.06	0.00	0.85	FALSE
32	The Cancer Genome Atlas	Prostate Adenocarcinoma	POMC	0.11	0.08	enet	7	0.09	1.6e-09	2.8	5.6	1.9e-08	-0.04	0.13	0.87	FALSE
33	The Cancer Genome Atlas	Stomach Adenocarcinoma	POMC	0.14	0.00	blup	40	0.02	2.2e-02	3.2	5.5	3.0e-08	0.01	0.00	0.62	TRUE